{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:26:20Z","timestamp":1790871980051,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"333 talent project of Hebei Province","award":["A202005012"],"award-info":[{"award-number":["A202005012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s10735-023-10120-1","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T03:26:43Z","timestamp":1682479603000},"page":"173-181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Dexmedetomidine alleviates cerebral ischemia-reperfusion injury via inhibiting autophagy through PI3K\/Akt\/mTOR pathway"],"prefix":"10.1007","volume":"54","author":[{"given":"Jianli","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinv","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"10120_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3109\/14767058.2012.663176","volume":"25","author":"W Balduini","year":"2012","unstructured":"Balduini W, Carloni S, Buonocore G (2012) Autophagy in hypoxia-ischemia induced brain injury. J Matern Fetal Neonatal Med 25:30\u201334. https:\/\/doi.org\/10.3109\/14767058.2012.663176","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10120_CR24","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/15360288.2021.1914280","volume":"35","author":"H Bozorgi","year":"2021","unstructured":"Bozorgi H, Zamani M, Motaghi E, Eslami M (2021) Dexmedetomidine as an Analgesic Agent with Neuroprotective Properties: experimental and clinical aspects. J Pain Palliat Care Pharmacother 35:215\u2013225. https:\/\/doi.org\/10.1080\/15360288.2021.1914280","journal-title":"J Pain Palliat Care Pharmacother"},{"key":"10120_CR6","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1213\/ANE.0000000000004417","volume":"130","author":"S Bunte","year":"2020","unstructured":"Bunte S, Behmenburg F, Majewski N, Stroethoff M, Raupach A, Mathes A et al (2020) Characteristics of Dexmedetomidine Postconditioning in the Field of Myocardial Ischemia-Reperfusion Injury. Anesth Analg 130:90\u201398. https:\/\/doi.org\/10.1213\/ANE.0000000000004417","journal-title":"Anesth Analg"},{"key":"10120_CR8","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.3892\/mmr.2014.2034","volume":"9","author":"Y Cai","year":"2014","unstructured":"Cai Y, Xu H, Yan J, Zhang L, Lu Y (2014) Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia\/reperfusion injury. Mol Med Rep 9:1542\u20131550. https:\/\/doi.org\/10.3892\/mmr.2014.2034","journal-title":"Mol Med Rep"},{"key":"10120_CR14","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00210-018-1537-x","volume":"391","author":"SA El-Marasy","year":"2018","unstructured":"El-Marasy SA, Abdel-Rahman RF, Abd-Elsalam RM (2018) Neuroprotective effect of vildagliptin against cerebral ischemia in rats. Naunyn Schmiedebergs Arch Pharmacol 391:1133\u20131145. https:\/\/doi.org\/10.1007\/s00210-018-1537-x","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10120_CR12","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1039\/c5mb00101c","volume":"11","author":"T Ersahin","year":"2015","unstructured":"Ersahin T, Tuncbag N, Cetin-Atalay R (2015) The PI3K\/AKT\/mTOR interactive pathway. Mol Biosyst 11:1946\u20131954. https:\/\/doi.org\/10.1039\/c5mb00101c","journal-title":"Mol Biosyst"},{"key":"10120_CR5","doi-asserted-by":"publisher","first-page":"6257","DOI":"10.2174\/138161212803832272","volume":"18","author":"E Farag","year":"2012","unstructured":"Farag E, Argalious M, Abd-Elsayed A, Ebrahim Z, Doyle DJ (2012) The Use of Dexmedetomidine in Anesthesia and Intensive Care: a review. Curr Pharm Des 18:6257\u20136265. https:\/\/doi.org\/10.2174\/138161212803832272","journal-title":"Curr Pharm Des"},{"key":"10120_CR1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1474-4422(19)30030-4","volume":"18","author":"PB Gorelick","year":"2019","unstructured":"Gorelick PB (2019) The global burden of stroke: persistent and disabling. Lancet Neurol 18:417\u2013418. https:\/\/doi.org\/10.1016\/S1474-4422(19)30030-4","journal-title":"Lancet Neurol"},{"key":"10120_CR16","doi-asserted-by":"publisher","first-page":"7432","DOI":"10.1080\/21655979.2021.1974810","volume":"12","author":"L Jin","year":"2021","unstructured":"Jin L, Mo Y, Yue EL, Liu Y, Liu KY (2021) Ibrutinib ameliorates cerebral ischemia\/reperfusion injury through autophagy activation and PI3K\/Akt\/mTOR signaling pathway in diabetic mice. Bioengineered 12:7432\u20137445. https:\/\/doi.org\/10.1080\/21655979.2021.1974810","journal-title":"Bioengineered"},{"key":"10120_CR26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.neulet.2017.04.011","volume":"649","author":"E Kim","year":"2017","unstructured":"Kim E, Kim HC, Lee S, Ryu HG, Park YH, Kim JH et al (2017) Dexmedetomidine confers neuroprotection against transient global cerebral ischemia\/reperfusion injury in rats by inhibiting inflammation through inactivation of the TLR-4\/NF-\u03baB pathway. Neurosci Lett 649:20\u201327. https:\/\/doi.org\/10.1016\/j.neulet.2017.04.011","journal-title":"Neurosci Lett"},{"key":"10120_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/prp2.45","volume":"2","author":"J Lempi\u00e4inen","year":"2014","unstructured":"Lempi\u00e4inen J, Finckenberg P, Mervaala EE, Storvik M, Kaivola J, Lindstedt K et al (2014) Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury. Pharmacol Res Perspect 2:1\u201315. https:\/\/doi.org\/10.1002\/prp2.45","journal-title":"Pharmacol Res Perspect"},{"key":"10120_CR2","doi-asserted-by":"publisher","first-page":"116921","DOI":"10.1016\/j.lfs.2019.116921","volume":"236","author":"P Li","year":"2019","unstructured":"Li P, Zhang Y, Liu H (2019) The role of Wnt\/\u03b2-catenin pathway in the protection process by dexmedetomidine against cerebral ischemia\/reperfusion injury in rats. Life Sci 236:116921. https:\/\/doi.org\/10.1016\/j.lfs.2019.116921","journal-title":"Life Sci"},{"key":"10120_CR27","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3390\/brainsci11070846","volume":"11","author":"Z Liaquat","year":"2021","unstructured":"Liaquat Z, Xu X, Zilundu PLM, Fu R, Zhou L (2021) The current role of dexmedetomidine as neuroprotective agent: an updated review. Brain Sci 11:846. https:\/\/doi.org\/10.3390\/brainsci11070846","journal-title":"Brain Sci"},{"key":"10120_CR23","doi-asserted-by":"publisher","first-page":"152","DOI":"10.4103\/2045-9912.318860","volume":"11","author":"TY Liang","year":"2021","unstructured":"Liang TY, Peng SY, Ma M, Li HY, Wang Z, Chen G (2021) Protective effects of sevoflurane in cerebral ischemia reperfusion injury: a narrative review. Med Gas Res 11:152\u2013154. https:\/\/doi.org\/10.4103\/2045-9912.318860","journal-title":"Med Gas Res"},{"key":"10120_CR20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","volume":"20","author":"EZ Longa","year":"1989","unstructured":"Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84\u201391. https:\/\/doi.org\/10.1161\/01.STR.20.1.84","journal-title":"Stroke"},{"key":"10120_CR13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.4149\/gpb_2019024","volume":"38","author":"LY Lu","year":"2019","unstructured":"Lu LY, Liu Y, Gong YF, Zheng XY (2019) A preliminary report: Genistein attenuates cerebral ischemia injury in ovariectomized rats via regulation of the PI3K-Akt-mTOR pathway. Gen Physiol Biophys 38:389\u2013397. https:\/\/doi.org\/10.4149\/gpb_2019024","journal-title":"Gen Physiol Biophys"},{"key":"10120_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2017.00197","volume":"11","author":"C Luo","year":"2017","unstructured":"Luo C, Ouyang MW, Fang YY, Li SJ, Zhou Q, Fan J et al (2017) Dexmedetomidine protects mouse brain from ischemia-reperfusion injury via inhibiting neuronal autophagy through up-regulating HIF-1\u03b1. Front Cell Neurosci 11:1\u201313. https:\/\/doi.org\/10.3389\/fncel.2017.00197","journal-title":"Front Cell Neurosci"},{"key":"10120_CR17","doi-asserted-by":"publisher","first-page":"174554","DOI":"10.1016\/j.ejphar.2021.174554","volume":"911","author":"J Meng","year":"2021","unstructured":"Meng J, Ma H, Zhu Y, Zhao Q (2021) Dehydrocostuslactone attenuated oxygen and glucose deprivation\/reperfusion-induced PC12 cell injury through inhibition of apoptosis and autophagy by activating the PI3K\/AKT\/mTOR pathway. Eur J Pharmacol 911:174554. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174554","journal-title":"Eur J Pharmacol"},{"key":"10120_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12035-007-8013-9","volume":"37","author":"VP Nakka","year":"2008","unstructured":"Nakka VP, Gusain A, Mehta SL, Raghubir R (2008) Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities. Mol Neurobiol 37:7\u201338. https:\/\/doi.org\/10.1007\/s12035-007-8013-9","journal-title":"Mol Neurobiol"},{"key":"10120_CR31","doi-asserted-by":"publisher","first-page":"101707","DOI":"10.1016\/j.jchemneu.2019.101707","volume":"102","author":"D Nazarinia","year":"2019","unstructured":"Nazarinia D, Aboutaleb N, Gholamzadeh R, Nasseri Maleki S, Mokhtari B, Nikougoftar M (2019) Conditioned medium obtained from human amniotic mesenchymal stem cells attenuates focal cerebral ischemia\/reperfusion injury in rats by targeting mTOR pathway. J Chem Neuroanat 102:101707. https:\/\/doi.org\/10.1016\/j.jchemneu.2019.101707","journal-title":"J Chem Neuroanat"},{"key":"10120_CR3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bjane.2012.06.003","volume":"63","author":"RR Nunes","year":"2013","unstructured":"Nunes RR, Duval Neto GF, de Alencar JC, Franco SB, de Andrade NQ, Dumaresq DM et al (2013) Anesthetics, Cerebral Protection and Preconditioning. Braz J Anesthesiol 63:119\u2013128. https:\/\/doi.org\/10.1016\/j.bjane.2012.06.003","journal-title":"Braz J Anesthesiol"},{"key":"10120_CR21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s12640-017-9861-3","volume":"34","author":"F Ryan","year":"2018","unstructured":"Ryan F, Khodagholi F, Dargahi L, Minai-Tehrani D, Ahmadiani A (2018) Temporal pattern and crosstalk of necroptosis markers with autophagy and apoptosis Associated Proteins in ischemic Hippocampus. Neurotox Res 34:79\u201392. https:\/\/doi.org\/10.1007\/s12640-017-9861-3","journal-title":"Neurotox Res"},{"key":"10120_CR28","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.4103\/1673-5374.300725","volume":"16","author":"ZQ Shao","year":"2021","unstructured":"Shao ZQ, Dou SS, Zhu JG, Wang HQ, Wang CM, Cheng BH et al (2021) Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia\/reperfusion injury. Neural Regen Res 16:1044\u20131051. https:\/\/doi.org\/10.4103\/1673-5374.300725","journal-title":"Neural Regen Res"},{"key":"10120_CR19","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.biopha.2017.08.125","volume":"95","author":"M Shen","year":"2017","unstructured":"Shen M, Wang S, Wen X, Han XR, Wang YJ, Zhou XM et al (2017) Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K\/Akt\/mTOR signaling pathway in rats with traumatic brain injury. Biomed Pharmacother 95:885\u2013893. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.125","journal-title":"Biomed Pharmacother"},{"key":"10120_CR4","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/med.21817","volume":"42","author":"QZ Tuo","year":"2022","unstructured":"Tuo QZ, Zhang ST, Lei P (2022) Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications. Med Res Rev 42:259\u2013305. https:\/\/doi.org\/10.1002\/med.21817","journal-title":"Med Res Rev"},{"key":"10120_CR25","doi-asserted-by":"publisher","first-page":"7006","DOI":"10.1111\/ejn.15474","volume":"54","author":"K Unchiti","year":"2021","unstructured":"Unchiti K, Leurcharusmee P, Samerchua A, Pipanmekaporn T, Chattipakorn N, Chattipakorn SC (2021) The potential role of dexmedetomidine on neuroprotection and its possible mechanisms: evidence from in vitro and in vivo studies. Eur J Neurosci 54:7006\u20137047. https:\/\/doi.org\/10.1111\/ejn.15474","journal-title":"Eur J Neurosci"},{"key":"10120_CR30","doi-asserted-by":"publisher","first-page":"6121","DOI":"10.1007\/s12035-021-02523-6","volume":"58","author":"H Wasan","year":"2021","unstructured":"Wasan H, Singh S, Joshi B, Sharma U, Dinda AK, Reeta KH (2021) Post Stroke Safinamide Treatment attenuates neurological damage by modulating autophagy and apoptosis in experimental model of stroke in rats. Mol Neurobiol 58:6121\u20136135. https:\/\/doi.org\/10.1007\/s12035-021-02523-6","journal-title":"Mol Neurobiol"},{"key":"10120_CR18","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.5455\/2320-6012.ijrms20141161","volume":"2","author":"MH Zhang","year":"2014","unstructured":"Zhang MH, Zhou XM, Gao JL, Wang KJ, Cui JZ (2014) PI3K\/Akt\/mTOR pathway participates in neuroprotection by dexmedetomidine inhibits neuronic autophagy following traumatic brain injury in rats. Int J Res Med Sci 2:1569\u20131575. https:\/\/doi.org\/10.5455\/2320-6012.ijrms20141161","journal-title":"Int J Res Med Sci"},{"key":"10120_CR29","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.3390\/molecules24091838","volume":"24","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Zhang Y, Jin XF, Zhou XH, Dong XH, Yu WT et al (2019a) The role of Astragaloside IV against Cerebral Ischemia\/Reperfusion Injury: suppression of apoptosis via Promotion of P62-LC3-Autophagy. Molecules 24:1838. https:\/\/doi.org\/10.3390\/molecules24091838","journal-title":"Molecules"},{"key":"10120_CR32","doi-asserted-by":"publisher","first-page":"6736","DOI":"10.26355\/eurrev_201908_18565","volume":"23","author":"J Zhang","year":"2019","unstructured":"Zhang J, Jiang H, Liu DH, Wang GN (2019b) Effects of dexmedetomidine on myocardial ischemia-reperfusion injury through PI3K-Akt-mTOR signaling pathway. Eur Rev Med Pharmacol Sci 23:6736\u20136743. https:\/\/doi.org\/10.26355\/eurrev_2019b08_18565","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10120_CR11","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1007\/s10753-019-01082-2","volume":"42","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, Li S, Liu J, Wen Q, Yu J, Yu L et al (2019) Role of JNK Signaling Pathway in Dexmedetomidine Post-Conditioning-Induced reduction of the inflammatory response and Autophagy Effect of Focal Cerebral Ischemia Reperfusion Injury in rats. Inflammation 42:2181\u20132191. https:\/\/doi.org\/10.1007\/s10753-019-01082-2","journal-title":"Inflammation"},{"key":"10120_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2012.11.047","volume":"1494","author":"YM Zhu","year":"2013","unstructured":"Zhu YM, Wang CC, Chen L, Qian LB, Ma LL, Yu J et al (2013) Both PI3K\/Akt and ERK1\/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia\/reperfusion injury in rats. Brain Res 1494:1\u20138. https:\/\/doi.org\/10.1016\/j.brainres.2012.11.047","journal-title":"Brain Res"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-023-10120-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-023-10120-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-023-10120-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T03:42:46Z","timestamp":1685590966000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-023-10120-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10120"],"URL":"https:\/\/doi.org\/10.1007\/s10735-023-10120-1","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,26]]},"assertion":[{"value":"15 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}