{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:57:09Z","timestamp":1787759829193,"version":"build-2784847793"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sepsis has a systemic inflammatory response syndrome caused by infection. While neutrophils play contradictory roles in different stages of sepsis. Neutrophils have been proven to play an antibacterial role by producing neutrophil extracellular traps (NETs). Although the NET is beneficial to bacteria resistance, abnormal NET increases tissue damage. The complement C5a receptor 1 (C5ar1) is a gene related to strong inflammatory reactions and is found to be associated with inflammatory factors. This study found that there were 45 down-regulated genes and 704 up-regulated genes in sepsis rats by transcriptome sequencing. And those genes were significantly related to inflammation and immunity by GO and KEGG enrichment analysis involving the chemokine signaling pathway, the Toll-like receptor (TLR) signaling pathway, and the Fc gamma R-mediated phagocytosis. Additionally, the C5ar1 gene was significantly upregulated with interesting potential in sepsis and used for further study. This study used cecum ligation and puncture (CLP) rats that were respectively injected intravenously with PBS or the lentivirus vector to explore the effect of C5ar1 on CLP rats. It demonstrated that silenced- C5ar1 inhibited the ALT, AST, BUN, and CREA levels, improved the lung and spleen injury, and reduced the TNF-\u03b1, IL-6, IL-1\u03b2, IL-10, cf-DNA, and cfDNA\/MPO levels. Additionally, silenced C5ar1 inhibited the TLR2, TLR4, and peptidylarginine deiminase 4 expression levels, which suggested the improvement of silenced C5ar1 on sepsis via inhibiting NETs and the TLR signaling pathway. This study provides a basis and new direction for the study of treatment on sepsis.<\/jats:p>","DOI":"10.1007\/s10735-023-10172-3","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T07:02:06Z","timestamp":1704178926000},"page":"69-81","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap"],"prefix":"10.1007","volume":"55","author":[{"given":"Bin","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qikai","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqiu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-4931","authenticated-orcid":false,"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"issue":"11","key":"10172_CR1","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s00011-016-0970-x","volume":"65","author":"C Bhan","year":"2016","unstructured":"Bhan C, Dipankar P, Chakraborty P, Sarangi PP (2016) Role of cellular events in the pathophysiology of sepsis. Inflamm Res 65(11):853\u2013868. https:\/\/doi.org\/10.1007\/s00011-016-0970-x","journal-title":"Inflamm Res"},{"issue":"8","key":"10172_CR2","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrmicro1710","volume":"5","author":"V Brinkmann","year":"2007","unstructured":"Brinkmann V, Zychlinsky A (2007) Beneficial suicide: why neutrophils die to make NETs. Nat Rev Microbiol 5(8):577\u2013582. https:\/\/doi.org\/10.1038\/nrmicro1710","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"10172_CR3","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.jhep.2018.07.005","volume":"69","author":"TN Bukong","year":"2018","unstructured":"Bukong TN, Cho Y, Iracheta-Vellve A, Saha B, Lowe P, Adejumo A, Furi I, Ambade A, Gyongyosi B, Catalano D, Kodys K, Szabo G (2018) Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use. J Hepatol 69(5):1145\u20131154. https:\/\/doi.org\/10.1016\/j.jhep.2018.07.005","journal-title":"J Hepatol"},{"issue":"1","key":"10172_CR4","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1038\/s41598-020-79607-1","volume":"11","author":"S Chakraborty","year":"2021","unstructured":"Chakraborty S, Winkelmann VE, Braum\u00fcller S, Palmer A, Schultze A, Klohs B, Ignatius A, Vater A, Fauler M, Frick M, Huber-Lang M (2021) Role of the C5a\u2013C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock. Sci Rep 11(1):2158. https:\/\/doi.org\/10.1038\/s41598-020-79607-1","journal-title":"Sci Rep"},{"issue":"1","key":"10172_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13054-019-2407-8","volume":"23","author":"DF Col\u00f3n","year":"2019","unstructured":"Col\u00f3n DF, Wanderley CW, Franchin M, Silva CM, Hiroki CH, Castanheira FVS, Donate PB, Lopes AH, Volpon LC, Kavaguti SK, Borges VF, Speck-Hernandez CA, Ramalho F, Carlotti AP, Carmona F, Alves-Filho JC, Liew FY, Cunha FQ (2019) Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis. Crit Care 23(1):113. https:\/\/doi.org\/10.1186\/s13054-019-2407-8","journal-title":"Crit Care"},{"issue":"2","key":"10172_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148142","volume":"11","author":"PG Czaikoski","year":"2016","unstructured":"Czaikoski PG, Mota JM, Nascimento DC, S\u00f4nego F, Castanheira FV, Melo PH, Scortegagna GT, Silva RL, Barroso-Sousa R, Souto FO, Pazin-Filho A, Figueiredo F, Alves-Filho JC, Cunha FQ (2016) Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis. PLoS ONE 11(2):e0148142. https:\/\/doi.org\/10.1371\/journal.pone.0148142","journal-title":"PLoS ONE"},{"issue":"1","key":"10172_CR7","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/imr.12499","volume":"274","author":"MJ Delano","year":"2016","unstructured":"Delano MJ, Ward PA (2016) The immune system\u2019s role in sepsis progression, resolution, and long-term outcome. Immunol Rev 274(1):330\u2013353. https:\/\/doi.org\/10.1111\/imr.12499","journal-title":"Immunol Rev"},{"issue":"3","key":"10172_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/sji.12580","volume":"86","author":"S Denk","year":"2017","unstructured":"Denk S, Taylor RP, Wiegner R, Cook EM, Lindorfer MA, Pfeiffer K, Paschke S, Eiseler T, Weiss M, Barth E, Lambris JD, Kalbitz M, Martin T, Barth H, Messerer DAC, Gebhard F, Huber-Lang MS (2017) Complement C5a-induced changes in neutrophil morphology during inflammation. Scand J Immunol 86(3):143\u2013155. https:\/\/doi.org\/10.1111\/sji.12580","journal-title":"Scand J Immunol"},{"key":"10172_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/ijms222312923","volume":"22","author":"Z Ding","year":"2021","unstructured":"Ding Z, Du F, Averitt VR, Jakobsson G, R\u00f6nnow CF, Rahman M, Schiopu A, Thorlacius H (2021) Targeting S100A9 reduces neutrophil recruitment, inflammation and lung damage in abdominal sepsis. Int J Mol Sci 22:23. https:\/\/doi.org\/10.3390\/ijms222312923","journal-title":"Int J Mol Sci"},{"key":"10172_CR10","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9767643","author":"X Du","year":"2022","unstructured":"Du X, Zhang M, Zhou H, Wang W, Zhang C, Zhang L, Qu Y, Li W, Liu X, Zhao M, Tu K, Li YQ (2022) Decoy nanozymes enable multitarget blockade of proinflammatory cascades for the treatment of multi-drug-resistant bacterial sepsis. Research. https:\/\/doi.org\/10.34133\/2022\/9767643","journal-title":"Research"},{"issue":"2","key":"10172_CR11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/jlb.3a1220-789rr","volume":"111","author":"A Hawez","year":"2022","unstructured":"Hawez A, Taha D, Algaber A, Madhi R, Rahman M, Thorlacius H (2022) MiR-155 regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis. J Leukoc Biol 111(2):391\u2013400. https:\/\/doi.org\/10.1002\/jlb.3a1220-789rr","journal-title":"J Leukoc Biol"},{"key":"10172_CR12","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01755-17","author":"JB Herrmann","year":"2018","unstructured":"Herrmann JB, Muenstermann M, Strobel L, Schubert-Unkmeir A, Woodruff TM, Gray-Owen SD, Klos A, Johswich KO (2018) Complement C5a receptor 1 exacerbates the pathophysiology of N meningitidis sepsis and is a potential target for disease treatment. mBio. https:\/\/doi.org\/10.1128\/mBio.01755-17","journal-title":"mBio"},{"issue":"1","key":"10172_CR13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/shk.0000000000001695","volume":"56","author":"A Janicova","year":"2021","unstructured":"Janicova A, Relja B (2021) Neutrophil phenotypes and functions in trauma and trauma-related sepsis. Shock 56(1):16\u201329. https:\/\/doi.org\/10.1097\/shk.0000000000001695","journal-title":"Shock"},{"issue":"6","key":"10172_CR14","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.4049\/jimmunol.1600091","volume":"197","author":"M Kalbitz","year":"2016","unstructured":"Kalbitz M, Fattahi F, Herron TJ, Grailer JJ, Jajou L, Lu H, Huber-Lang M, Zetoune FS, Sarma JV, Day SM, Russell MW, Jalife J, Ward PA (2016) Complement destabilizes cardiomyocyte function in vivo after polymicrobial sepsis and in vitro. J Immunol 197(6):2353\u20132361. https:\/\/doi.org\/10.4049\/jimmunol.1600091","journal-title":"J Immunol"},{"issue":"3","key":"10172_CR15","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/QCO.0b013e3283528c9b","volume":"25","author":"MA Kovach","year":"2012","unstructured":"Kovach MA, Standiford TJ (2012) The function of neutrophils in sepsis. Curr Opin Infect Dis 25(3):321\u2013327. https:\/\/doi.org\/10.1097\/QCO.0b013e3283528c9b","journal-title":"Curr Opin Infect Dis"},{"issue":"1","key":"10172_CR16","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s10753-020-01334-6","volume":"44","author":"YL Liao","year":"2021","unstructured":"Liao YL, Zhou XY, Ji MH, Qiu LC, Chen XH, Gong CS, Lin Y, Guo YH, Yang JJ (2021) S100A9 Upregulation contributes to learning and memory impairments by promoting microglia M1 polarization in sepsis survivor mice. Inflammation 44(1):307\u2013320. https:\/\/doi.org\/10.1007\/s10753-020-01334-6","journal-title":"Inflammation"},{"key":"10172_CR17","doi-asserted-by":"publisher","first-page":"639735","DOI":"10.3389\/fimmu.2021.639735","volume":"12","author":"S Liu","year":"2021","unstructured":"Liu S, Wang X, She F, Zhang W, Liu H, Zhao X (2021) Effects of neutrophil-to-lymphocyte ratio combined with interleukin-6 in predicting 28-day mortality in patients with sepsis. Front Immunol 12:639735","journal-title":"Front Immunol"},{"issue":"2","key":"10172_CR18","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1097\/shk.0000000000000396","volume":"44","author":"SH Mai","year":"2015","unstructured":"Mai SH, Khan M, Dwivedi DJ, Ross CA, Zhou J, Gould TJ, Gross PL, Weitz JI, Fox-Robichaud AE, Liaw PC (2015) Delayed but not early treatment with DNase reduces organ damage and improves outcome in a murine model of sepsis. Shock 44(2):166\u2013172. https:\/\/doi.org\/10.1097\/shk.0000000000000396","journal-title":"Shock"},{"key":"10172_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108598","volume":"220","author":"DC Mastellos","year":"2020","unstructured":"Mastellos DC, Pires da Silva BGP, Fonseca BAL, Fonseca NP, Auxiliadora-Martins M, Mastaglio S, Ruggeri A, Sironi M, Radermacher P, Chrysanthopoulou A, Skendros P, Ritis K, Manfra I, Iacobelli S, Huber-Lang M, Nilsson B, Yancopoulou D, Connolly ES, Garlanda C, Ciceri F, Risitano AM, Calado RT, Lambris JD (2020) Complement C3 vs C5 inhibition in severe COVID-19: early clinical findings reveal differential biological efficacy. Clin Immunol 220:108598. https:\/\/doi.org\/10.1016\/j.clim.2020.108598","journal-title":"Clin Immunol"},{"issue":"12","key":"10172_CR20","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1182\/blood.2019000067","volume":"134","author":"EA Middleton","year":"2019","unstructured":"Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT (2019) Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood 134(12):911\u2013923. https:\/\/doi.org\/10.1182\/blood.2019000067","journal-title":"Blood"},{"issue":"2","key":"10172_CR21","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.imlet.2004.07.009","volume":"95","author":"G Monneret","year":"2004","unstructured":"Monneret G, Finck ME, Venet F, Debard AL, Boh\u00e9 J, Bienvenu J, Lepape A (2004) The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration. Immunol Lett 95(2):193\u2013198. https:\/\/doi.org\/10.1016\/j.imlet.2004.07.009","journal-title":"Immunol Lett"},{"issue":"1","key":"10172_CR22","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1080\/21505594.2019.1640035","volume":"10","author":"M Muenstermann","year":"2019","unstructured":"Muenstermann M, Strobel L, Klos A, Wetsel RA, Woodruff TM, K\u00f6hl J, Johswich KO (2019) Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections. Virulence 10(1):677\u2013694. https:\/\/doi.org\/10.1080\/21505594.2019.1640035","journal-title":"Virulence"},{"key":"10172_CR23","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.canlet.2021.12.027","volume":"529","author":"S Ortiz-Espinosa","year":"2022","unstructured":"Ortiz-Espinosa S, Morales X, Senent Y, Alignani D, Tavira B, Macaya I, Ruiz B, Moreno H, Rem\u00edrez A, Sainz C, Rodriguez-Pena A, Oyarbide A, Ariz M, Andueza MP, Valencia K, Teijeira A, Hoehlig K, Vater A, Rolfe B, Woodruff TM, Lopez-Picazo JM, Vicent S, Kochan G, Escors D, Gil-Bazo I, Perez-Gracia JL, Montuenga LM, Lambris JD, Ortiz de Solorzano C, Lecanda F, Ajona D, Pio R (2022) Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis. Cancer Lett 529:70\u201384. https:\/\/doi.org\/10.1016\/j.canlet.2021.12.027","journal-title":"Cancer Lett"},{"issue":"11","key":"10172_CR24","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1097\/01.ccm.0000145229.59014.6c","volume":"32","author":"EA Panacek","year":"2004","unstructured":"Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, Miller M, Barchuk WT, Fischkoff S, Kaul M, Teoh L, Van Meter L, Daum L, Lemeshow S, Hicklin G, Doig C (2004) Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab\u2019)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 32(11):2173\u20132182. https:\/\/doi.org\/10.1097\/01.ccm.0000145229.59014.6c","journal-title":"Crit Care Med"},{"issue":"2","key":"10172_CR25","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.jaci.2020.08.022","volume":"147","author":"CD Platt","year":"2021","unstructured":"Platt CD, Zaman F, Bainter W, Stafstrom K, Almutairi A, Reigle M, Weeks S, Geha RS, Chou J (2021) Efficacy and economics of targeted panel versus whole-exome sequencing in 878 patients with suspected primary immunodeficiency. J Allergy Clin Immunol 147(2):723\u2013726. https:\/\/doi.org\/10.1016\/j.jaci.2020.08.022","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"10172_CR26","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1152\/physiolgenomics.00046.2018","volume":"50","author":"JW Prokop","year":"2018","unstructured":"Prokop JW, May T, Strong K, Bilinovich SM, Bupp C, Rajasekaran S, Worthey EA, Lazar J (2018) Genome sequencing in the clinic: the past, present, and future of genomic medicine. Physiol Genomics 50(8):563\u2013579. https:\/\/doi.org\/10.1152\/physiolgenomics.00046.2018","journal-title":"Physiol Genomics"},{"issue":"11","key":"10172_CR27","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1038\/mp.2016.109","volume":"22","author":"S Riazuddin","year":"2017","unstructured":"Riazuddin S, Hussain M, Razzaq A, Iqbal Z, Shahzad M, Polla DL, Song Y, van Beusekom E, Khan AA, Tomas-Roca L, Rashid M, Zahoor MY, Wissink-Lindhout WM, Basra MAR, Ansar M, Agha Z, van Heeswijk K, Rasheed F, Van de Vorst M, Veltman JA, Gilissen C, Akram J, Kleefstra T, Assir MZ, Grozeva D, Carss K, Raymond FL, O\u2019Connor TD, Riazuddin SA, Khan SN, Ahmed ZM, de Brouwer APM, van Bokhoven H, Riazuddin S (2017) Exome sequencing of Pakistani consanguineous families identifies 30 novel candidate genes for recessive intellectual disability. Mol Psychiatry 22(11):1604\u20131614. https:\/\/doi.org\/10.1038\/mp.2016.109","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10172_CR28","doi-asserted-by":"publisher","first-page":"503","DOI":"10.4049\/jimmunol.170.1.503","volume":"170","author":"NC Riedemann","year":"2003","unstructured":"Riedemann NC, Neff TA, Guo RF, Bernacki KD, Laudes IJ, Sarma JV, Lambris JD, Ward PA (2003) Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol 170(1):503\u2013507. https:\/\/doi.org\/10.4049\/jimmunol.170.1.503","journal-title":"J Immunol"},{"issue":"10219","key":"10172_CR29","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/s0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, Fleischmann-Struzek C, Machado FR, Reinhart KK, Rowan K, Seymour CW, Watson RS, West TE, Marinho F, Hay SI, Lozano R, Lopez AD, Angus DC, Murray CJL, Naghavi M (2020) Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the global burden of disease study. Lancet 395(10219):200\u2013211. https:\/\/doi.org\/10.1016\/s0140-6736(19)32989-7","journal-title":"Lancet"},{"issue":"6","key":"10172_CR30","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.jid.2020.02.032","volume":"140","author":"AH Saeidian","year":"2020","unstructured":"Saeidian AH, Youssefian L, Vahidnezhad H, Uitto J (2020) Research techniques made simple: whole-transcriptome sequencing by RNA-Seq for diagnosis of monogenic disorders. J Invest Dermatol 140(6):1117\u20131126. https:\/\/doi.org\/10.1016\/j.jid.2020.02.032","journal-title":"J Invest Dermatol"},{"issue":"21","key":"10172_CR31","doi-asserted-by":"publisher","first-page":"3994","DOI":"10.1021\/acschemneuro.1c00244","volume":"12","author":"Y Shi","year":"2021","unstructured":"Shi Y, Jin Y, Li X, Chen C, Zhang Z, Liu X, Deng Y, Fan X, Wang C (2021) C5aR1 mediates the progression of inflammatory responses in the brain of rats in the early stage after ischemia and reperfusion. ACS Chem Neurosci 12(21):3994\u20134006. https:\/\/doi.org\/10.1021\/acschemneuro.1c00244","journal-title":"ACS Chem Neurosci"},{"issue":"11","key":"10172_CR32","doi-asserted-by":"publisher","first-page":"6151","DOI":"10.1172\/jci141374","volume":"130","author":"P Skendros","year":"2020","unstructured":"Skendros P, Mitsios A, Chrysanthopoulou A, Mastellos DC, Metallidis S, Rafailidis P, Ntinopoulou M, Sertaridou E, Tsironidou V, Tsigalou C, Tektonidou M, Konstantinidis T, Papagoras C, Mitroulis I, Germanidis G, Lambris JD, Ritis K (2020) Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis. J Clin Invest 130(11):6151\u20136157. https:\/\/doi.org\/10.1172\/jci141374","journal-title":"J Clin Invest"},{"key":"10172_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.685523","volume":"12","author":"M Sun","year":"2021","unstructured":"Sun M, Li J, Mao L, Wu J, Deng Z, He M, An S, Zeng Z, Huang Q, Chen Z (2021) p53 Deacetylation alleviates sepsis-induced acute kidney injury by promoting autophagy. Front Immunol 12:685523. https:\/\/doi.org\/10.3389\/fimmu.2021.685523","journal-title":"Front Immunol"},{"issue":"1","key":"10172_CR34","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1038\/s41467-019-10360-4","volume":"10","author":"PS Sung","year":"2019","unstructured":"Sung PS, Huang TF, Hsieh SL (2019) Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A\/TLR2. Nat Commun 10(1):2402. https:\/\/doi.org\/10.1038\/s41467-019-10360-4","journal-title":"Nat Commun"},{"issue":"4","key":"10172_CR35","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/jlb.3ru0620-375r","volume":"110","author":"C Tan","year":"2021","unstructured":"Tan C, Aziz M, Wang P (2021) The vitals of NETs. J Leukoc Biol 110(4):797\u2013808. https:\/\/doi.org\/10.1002\/jlb.3ru0620-375r","journal-title":"J Leukoc Biol"},{"key":"10172_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02456","volume":"9","author":"X Wang","year":"2018","unstructured":"Wang X, Qiu L, Li Z, Wang XY, Yi H (2018) Understanding the multifaceted role of neutrophils in cancer and autoimmune diseases. Front Immunol 9:2456. https:\/\/doi.org\/10.3389\/fimmu.2018.02456","journal-title":"Front Immunol"},{"key":"10172_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2020.101947","volume":"64","author":"H Wen","year":"2020","unstructured":"Wen H, Zhang H, Wang W, Li Y (2020) Tetrahydropalmatine protects against acute lung injury induced by limb ischemia\/reperfusion through restoring PI3K\/AKT\/mTOR-mediated autophagy in rats. Pulm Pharmacol Ther 64:101947. https:\/\/doi.org\/10.1016\/j.pupt.2020.101947","journal-title":"Pulm Pharmacol Ther"},{"issue":"1","key":"10172_CR38","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/s41467-022-28172-4","volume":"13","author":"AS Wilson","year":"2022","unstructured":"Wilson AS, Randall KL, Pettitt JA, Ellyard JI, Blumenthal A, Enders A, Quah BJ, Bopp T, Parish CR, Br\u00fcstle A (2022) Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2. Nat Commun 13(1):528. https:\/\/doi.org\/10.1038\/s41467-022-28172-4","journal-title":"Nat Commun"},{"issue":"7","key":"10172_CR39","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/nnano.2017.54","volume":"12","author":"J Xue","year":"2017","unstructured":"Xue J, Zhao Z, Zhang L, Xue L, Shen S, Wen Y, Wei Z, Wang L, Kong L, Sun H, Ping Q, Mo R, Zhang C (2017) Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. Nat Nanotechnol 12(7):692\u2013700. https:\/\/doi.org\/10.1038\/nnano.2017.54","journal-title":"Nat Nanotechnol"},{"key":"10172_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.717652","volume":"12","author":"R Yang","year":"2021","unstructured":"Yang R, Yang H, Wei J, Li W, Yue F, Song Y, He X, Hu K (2021) Mechanisms underlying the effects of Lianhua Qingwen on sepsis-induced acute lung injury: a network pharmacology approach. Front Pharmacol 12:717652. https:\/\/doi.org\/10.3389\/fphar.2021.717652","journal-title":"Front Pharmacol"},{"key":"10172_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.616957","author":"FS Zetoune","year":"2020","unstructured":"Zetoune FS, Ward PA (2020) Role of complement and histones in sepsis. Front Med (Lausanne). https:\/\/doi.org\/10.3389\/fmed.2020.616957","journal-title":"Front Med (Lausanne)"},{"key":"10172_CR42","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/molecules24244452","volume":"24","author":"W Zhang","year":"2019","unstructured":"Zhang W, Ye L, Wang F, Zheng J, Tian X, Chen Y, Ding G, Yang Z (2019) Immunomodulatory effects of the meretrix meretrix oligopeptide (QLNWD) on immune-deficient mice. Molecules 24:24. https:\/\/doi.org\/10.3390\/molecules24244452","journal-title":"Molecules"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-023-10172-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-023-10172-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-023-10172-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T05:06:04Z","timestamp":1706763964000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-023-10172-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,2]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10172"],"URL":"https:\/\/doi.org\/10.1007\/s10735-023-10172-3","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,2]]},"assertion":[{"value":"16 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declared that no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}