{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:58:59Z","timestamp":1786489139090,"version":"build-2736575974"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s10735-023-10175-0","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T07:02:06Z","timestamp":1704178926000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Overview of the compromised mucosal integrity in celiac disease"],"prefix":"10.1007","volume":"55","author":[{"given":"Tannaz","family":"Taraz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohadeseh","family":"Mahmoudi-Ghehsareh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran","family":"Asri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Nazemalhosseini-Mojarad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Rezaei-Tavirani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Jahani-Sherafat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Naseh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Rostami-Nejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"10175_CR1","doi-asserted-by":"publisher","first-page":"4641","DOI":"10.4049\/jimmunol.178.7.4641","volume":"178","author":"RM Al-Sadi","year":"2007","unstructured":"Al-Sadi RM, Ma TY (2007) IL-1beta causes an increase in intestinal epithelial tight junction permeability. J Immunol 178:4641\u20134649. https:\/\/doi.org\/10.4049\/jimmunol.178.7.4641","journal-title":"J Immunol"},{"key":"10175_CR2","doi-asserted-by":"publisher","first-page":"e85345","DOI":"10.1371\/journal.pone.0085345","volume":"9","author":"R Al-Sadi","year":"2014","unstructured":"Al-Sadi R, Ye D, Boivin M, Guo S, Hashimi M, Ereifej L, Ma TY (2014) Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene. PLoS ONE 9:e85345. https:\/\/doi.org\/10.1371\/journal.pone.0085345","journal-title":"PLoS ONE"},{"key":"10175_CR3","doi-asserted-by":"publisher","first-page":"604054","DOI":"10.3389\/fimmu.2020.604054","volume":"11","author":"A Ali","year":"2020","unstructured":"Ali A, Tan H, Kaiko GE (2020) Role of the intestinal epithelium and its Interaction with the Microbiota in Food Allergy. Front Immunol 11:604054. https:\/\/doi.org\/10.3389\/fimmu.2020.604054","journal-title":"Front Immunol"},{"key":"10175_CR4","doi-asserted-by":"publisher","first-page":"a002584","DOI":"10.1101\/cshperspect.a002584","volume":"1","author":"JM Anderson","year":"2009","unstructured":"Anderson JM, Van Itallie CM (2009) Physiology and function of the tight junction. Cold Spring Harb Perspect Biol 1:a002584. https:\/\/doi.org\/10.1101\/cshperspect.a002584","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10175_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2180-10-316","volume":"10","author":"RC Anderson","year":"2010","unstructured":"Anderson RC, Cookson AL, McNabb WC, Park Z, McCann MJ, Kelly WJ, Roy NC (2010) Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation. BMC Microbiol 10:1\u201311","journal-title":"BMC Microbiol"},{"key":"10175_CR6","first-page":"48","volume":"7","author":"N Asri","year":"2019","unstructured":"Asri N, Rostami-Nejad M (2019) The facts of Celiac Disease; a Comprehensive Review. Int J Celiac Dis 7:48\u201352","journal-title":"Int J Celiac Dis"},{"key":"10175_CR7","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.bbamem.2007.08.029","volume":"1778","author":"E Ass\u00e9mat","year":"2008","unstructured":"Ass\u00e9mat E, Bazelli\u00e8res E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D (2008) Polarity complex proteins. Biochimica et Biophysica Acta (BBA) -. Biomembranes 1778:614\u2013630. https:\/\/doi.org\/10.1016\/j.bbamem.2007.08.029","journal-title":"Biomembranes"},{"key":"10175_CR8","doi-asserted-by":"publisher","first-page":"101523","DOI":"10.1016\/j.clinre.2020.08.002","volume":"45","author":"Y Aydemir","year":"2021","unstructured":"Aydemir Y, Erdogan B, T\u00fcrkeli A (2021) Vitamin D deficiency negatively affects both the intestinal epithelial integrity and bone metabolism in children with celiac Disease. Clin Res Hepatol Gastroenterol 45:101523. https:\/\/doi.org\/10.1016\/j.clinre.2020.08.002","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10175_CR9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1093\/advances\/nmz080","volume":"11","author":"KA Bascu\u00f1\u00e1n","year":"2020","unstructured":"Bascu\u00f1\u00e1n KA, Araya M, Roncoroni L, Doneda L, Elli L (2020) Dietary gluten as a conditioning factor of the gut microbiota in Celiac Disease. Adv Nutr 11:160\u2013174. https:\/\/doi.org\/10.1093\/advances\/nmz080","journal-title":"Adv Nutr"},{"key":"10175_CR10","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.pharmthera.2013.02.004","volume":"138","author":"D Bazzoun","year":"2013","unstructured":"Bazzoun D, Leli\u00e8vre S, Talhouk R (2013) Polarity proteins as regulators of cell junction complexes: implications for Breast cancer. Pharmacol Ther 138:418\u2013427. https:\/\/doi.org\/10.1016\/j.pharmthera.2013.02.004","journal-title":"Pharmacol Ther"},{"key":"10175_CR11","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1007\/s10620-011-1947-9","volume":"57","author":"J Benjamin","year":"2012","unstructured":"Benjamin J, Makharia G, Ahuja V, Anand Rajan KD, Kalaivani M, Gupta SD, Joshi YK (2012) Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn\u2019s Disease: a randomized controlled trial. Dig Dis Sci 57:1000\u20131012. https:\/\/doi.org\/10.1007\/s10620-011-1947-9","journal-title":"Dig Dis Sci"},{"key":"10175_CR12","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.ceb.2005.08.012","volume":"17","author":"VM Braga","year":"2005","unstructured":"Braga VM, Yap AS (2005) The challenges of abundance: epithelial junctions and small GTPase signalling. Curr Opin Cell Biol 17:466\u2013474. https:\/\/doi.org\/10.1016\/j.ceb.2005.08.012","journal-title":"Curr Opin Cell Biol"},{"key":"10175_CR13","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12916-019-1380-z","volume":"17","author":"G Caio","year":"2019","unstructured":"Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, Fasano A (2019) Celiac Disease: a comprehensive current review. BMC Med 17:142. https:\/\/doi.org\/10.1186\/s12916-019-1380-z","journal-title":"BMC Med"},{"key":"10175_CR14","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.bbamem.2008.08.027","volume":"1788","author":"CT Capaldo","year":"2009","unstructured":"Capaldo CT, Nusrat A (2009) Cytokine regulation of tight junctions. Biochim Biophys Acta 1788:864\u2013871. https:\/\/doi.org\/10.1016\/j.bbamem.2008.08.027","journal-title":"Biochim Biophys Acta"},{"key":"10175_CR15","doi-asserted-by":"publisher","first-page":"101786","DOI":"10.1016\/j.jbc.2022.101786","volume":"298","author":"VG Castiglioni","year":"2022","unstructured":"Castiglioni VG, Ramalho JJ, Kroll JR, Stucchi R, van Beuzekom H, Schmidt R et al (2022) Identification and characterization of Crumbs polarity complex proteins in Caenorhabditis elegans. J Biol Chem 298:101786. https:\/\/doi.org\/10.1016\/j.jbc.2022.101786","journal-title":"J Biol Chem"},{"key":"10175_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","volume":"50","author":"C Chelakkot","year":"2018","unstructured":"Chelakkot C, Ghim J, Ryu SH (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 50:1\u20139. https:\/\/doi.org\/10.1038\/s12276-018-0126-x","journal-title":"Exp Mol Med"},{"key":"10175_CR18","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1039\/C6FO01347C","volume":"8","author":"Q Chen","year":"2017","unstructured":"Chen Q, Chen O, Martins IM, Hou H, Zhao X, Blumberg JB, Li B (2017) Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions. Food Funct 8:1144\u20131151","journal-title":"Food Funct"},{"key":"10175_CR17","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1039\/c9fo00123a","volume":"10","author":"M Chen","year":"2019","unstructured":"Chen M, Liu Y, Xiong S, Wu M, Li B, Ruan Z, Hu X (2019) Dietary l-tryptophan alleviated LPS-induced intestinal barrier injury by regulating tight junctions in a Caco-2 cell monolayer model. Food Funct 10:2390\u20132398. https:\/\/doi.org\/10.1039\/c9fo00123a","journal-title":"Food Funct"},{"key":"10175_CR19","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1309\/dtyr-a91g-8r0k-tm8m","volume":"125","author":"R Ciccocioppo","year":"2006","unstructured":"Ciccocioppo R, Finamore A, Ara C, Di Sabatino A, Mengheri E, Corazza GR (2006) Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac Disease. Am J Clin Pathol 125:502\u2013511. https:\/\/doi.org\/10.1309\/dtyr-a91g-8r0k-tm8m","journal-title":"Am J Clin Pathol"},{"key":"10175_CR20","doi-asserted-by":"crossref","unstructured":"Cifuentes-Munoz N, El Najjar F, Dutch RE (2020) Viral cell-to-cell spread: Conventional and non-conventional ways. In: Margaret Kielian, Thomas C. Mettenleiter, Marilyn J. Roossinck (eds) Advances in Virus Research, Academic Press, pp.\u00a085\u2013125","DOI":"10.1016\/bs.aivir.2020.09.002"},{"key":"10175_CR21","doi-asserted-by":"publisher","first-page":"7505","DOI":"10.3748\/wjg.v23.i42.7505","volume":"23","author":"B Cukrowska","year":"2017","unstructured":"Cukrowska B, Sowi\u0144ska A, Bier\u0142a JB, Czarnowska E, Rybak A, Grzybowska-Chlebowczyk U (2017) Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - key players in the pathogenesis of celiac Disease. World J Gastroenterol 23:7505\u20137518. https:\/\/doi.org\/10.3748\/wjg.v23.i42.7505","journal-title":"World J Gastroenterol"},{"key":"10175_CR22","doi-asserted-by":"publisher","unstructured":"Do MH, Lee E, Oh MJ, Kim Y, Park HY (2018) High-glucose or -Fructose Diet cause changes of the gut microbiota and metabolic disorders in mice without body weight change. Nutrients 10. https:\/\/doi.org\/10.3390\/nu10060761","DOI":"10.3390\/nu10060761"},{"key":"10175_CR23","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s10620-017-4738-0","volume":"63","author":"S Dong","year":"2018","unstructured":"Dong S, Singh TP, Wei X, Yao H, Wang H (2018) Protective effect of 1,25-Dihydroxy vitamin D3 on pepsin-trypsin-resistant Gliadin-Induced tight Junction injuries. Dig Dis Sci 63:92\u2013104. https:\/\/doi.org\/10.1007\/s10620-017-4738-0","journal-title":"Dig Dis Sci"},{"key":"10175_CR24","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1074\/jbc.M804783200","volume":"284","author":"BC Elias","year":"2009","unstructured":"Elias BC, Suzuki T, Seth A, Giorgianni F, Kal G, She L et al (2009) Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem 284:1559\u20131569. https:\/\/doi.org\/10.1074\/jbc.M804783200","journal-title":"J Biol Chem"},{"key":"10175_CR25","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1042\/bse0530141","volume":"53","author":"I Elsum","year":"2012","unstructured":"Elsum I, Yates L, Humbert PO, Richardson HE (2012) The scribble\u2013dlg\u2013lgl polarity module in development and cancer: from flies to man. Essays Biochem 53:141\u2013168. https:\/\/doi.org\/10.1042\/bse0530141","journal-title":"Essays Biochem"},{"key":"10175_CR26","doi-asserted-by":"publisher","first-page":"G1025","DOI":"10.1152\/ajpgi.90227.2008","volume":"295","author":"JB Ewaschuk","year":"2008","unstructured":"Ewaschuk JB, Diaz H, Meddings L, Diederichs B, Dmytrash A, Backer J, Looijer-van Langen M, Madsen KL (2008) Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function. Am J physiology-gastrointestinal Liver Physiol 295:G1025\u2013G1034","journal-title":"Am J physiology-gastrointestinal Liver Physiol"},{"key":"10175_CR27","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.cgh.2012.08.012","volume":"10","author":"A Fasano","year":"2012","unstructured":"Fasano A (2012a) Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol 10:1096\u20131100. https:\/\/doi.org\/10.1016\/j.cgh.2012.08.012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10175_CR28","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1749-6632.2012.06538.x","volume":"1258","author":"A Fasano","year":"2012","unstructured":"Fasano A (2012b) Zonulin, regulation of tight junctions, and autoimmune Diseases. Ann N Y Acad Sci 1258:25\u201333. https:\/\/doi.org\/10.1111\/j.1749-6632.2012.06538.x","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"10175_CR29","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.ceb.2009.07.003","volume":"21","author":"ME Feigin","year":"2009","unstructured":"Feigin ME, Muthuswamy SK (2009) Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol 21(5):694\u2013700. https:\/\/doi.org\/10.1016\/j.ceb.2009.07.003","journal-title":"Curr Opin Cell Biol"},{"key":"10175_CR30","doi-asserted-by":"publisher","first-page":"28589","DOI":"10.1038\/srep28589","volume":"6","author":"Y Gao","year":"2016","unstructured":"Gao Y, Lui W-y, Lee WM, Cheng CY (2016) Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in sertoli cells. Sci Rep 6:28589. https:\/\/doi.org\/10.1038\/srep28589","journal-title":"Sci Rep"},{"key":"10175_CR31","doi-asserted-by":"crossref","unstructured":"Ghosh S, Kaplan KJ, Schrum LW, Bonkovsky HL (2013) Cytoskeletal proteins: shaping progression of Hepatitis C Virus-Induced Liver Disease. In: Kwang WJ (ed) International Review of Cell and Molecular Biology. Academic Press, pp 279\u2013319","DOI":"10.1016\/B978-0-12-407699-0.00005-4"},{"key":"10175_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","volume":"124","author":"KR Groschwitz","year":"2009","unstructured":"Groschwitz KR, Hogan SP (2009) Intestinal barrier function: molecular regulation and Disease pathogenesis. J Allergy Clin Immunol 124:3\u201320. https:\/\/doi.org\/10.1016\/j.jaci.2009.05.038. quiz 21-22","journal-title":"J Allergy Clin Immunol"},{"key":"10175_CR33","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.bbamem.2007.07.012","volume":"1778","author":"A Hartsock","year":"2008","unstructured":"Hartsock A, Nelson WJ (2008) Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta 1778:660\u2013669. https:\/\/doi.org\/10.1016\/j.bbamem.2007.07.012","journal-title":"Biochim Biophys Acta"},{"key":"10175_CR34","doi-asserted-by":"publisher","unstructured":"Hatzfeld M, Keil R, Magin TM (2017) Desmosomes and intermediate filaments: their consequences for tissue mechanics. Cold Spring Harb Perspect Biol 9. https:\/\/doi.org\/10.1101\/cshperspect.a029157","DOI":"10.1101\/cshperspect.a029157"},{"key":"10175_CR35","doi-asserted-by":"publisher","unstructured":"Hong Y (2018) aPKC: the kinase that phosphorylates cell polarity. F1000Res, 7. https:\/\/doi.org\/10.12688\/f1000research.14427.1","DOI":"10.12688\/f1000research.14427.1"},{"key":"10175_CR36","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1242\/jcs.043174","volume":"122","author":"Y Horikoshi","year":"2009","unstructured":"Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H et al (2009) Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci 122:1595\u20131606. https:\/\/doi.org\/10.1242\/jcs.043174","journal-title":"J Cell Sci"},{"key":"10175_CR37","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1083\/jcb.143.1.95","volume":"143","author":"Y Izumi","year":"1998","unstructured":"Izumi Y, Hirose T, Tamai Y, Hirai S, Nagashima Y, Fujimoto T et al (1998) An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol 143:95\u2013106. https:\/\/doi.org\/10.1083\/jcb.143.1.95","journal-title":"J Cell Biol"},{"key":"10175_CR38","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1093\/jn\/129.7.1291","volume":"129","author":"S Ji","year":"1999","unstructured":"Ji S, Willis GM, Frank GR, Cornelius SG, Spurlock ME (1999) Soybean isoflavones, Genistein and Genistin, inhibit rat myoblast proliferation, Fusion and myotube protein synthesis. J Nutr 129:1291\u20131297. https:\/\/doi.org\/10.1093\/jn\/129.7.1291","journal-title":"J Nutr"},{"key":"10175_CR39","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/MCO.0b013e3283476e74","volume":"14","author":"Y Ji","year":"2011","unstructured":"Ji Y, Sakata Y, Tso P (2011) Nutrient-induced inflammation in the intestine. Curr Opin Clin Nutr Metab Care 14:315\u2013321. https:\/\/doi.org\/10.1097\/MCO.0b013e3283476e74","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10175_CR40","doi-asserted-by":"publisher","first-page":"G851","DOI":"10.1152\/ajpgi.00327.2009","volume":"298","author":"J Karczewski","year":"2010","unstructured":"Karczewski J, Troost FJ, Konings I, Dekker J, Kleerebezem M, Brummer R-JM, Wells JM (2010) Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier. Am J Physiol Gastrointest Liver Physiol 298:G851\u2013G859","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10175_CR41","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0301-4622(94)85023-2","volume":"50","author":"AP Kowalczyk","year":"1994","unstructured":"Kowalczyk AP, Stappenbeck TS, Parry DA, Palka HL, Virata ML, Bornslaeger EA et al (1994) Structure and function of desmosomal transmembrane core and plaque molecules. Biophys Chem 50:97\u2013112. https:\/\/doi.org\/10.1016\/0301-4622(94)85023-2","journal-title":"Biophys Chem"},{"key":"10175_CR42","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1053\/j.gastro.2008.03.023","volume":"135","author":"KM Lammers","year":"2008","unstructured":"Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K et al (2008) Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 135:194\u2013204e193. https:\/\/doi.org\/10.1053\/j.gastro.2008.03.023","journal-title":"Gastroenterology"},{"key":"10175_CR43","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1053\/j.gastro.2012.05.051","volume":"143","author":"C Lebreton","year":"2012","unstructured":"Lebreton C, M\u00e9nard S, Abed J, Moura IC, Coppo R, Dugave C, Monteiro RC, Fricot A, Traore MG, Griffin M et al (2012) Interactions among secretory immunoglobulin A, CD71, and Transglutaminase-2 affect permeability of intestinal epithelial cells to Gliadin Peptides. Gastroenterology 143:698\u2013707e694. https:\/\/doi.org\/10.1053\/j.gastro.2012.05.051","journal-title":"Gastroenterology"},{"key":"10175_CR44","first-page":"92","volume":"4","author":"A Lerner","year":"2016","unstructured":"Lerner A, Patricia J, Matthias T (2016) Nutrients, bugs and us: the short-chain fatty acids story in Celiac Disease. Int J Celiac Dis 4:92\u201394","journal-title":"Int J Celiac Dis"},{"key":"10175_CR45","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3945\/jn.108.101485","volume":"139","author":"N Li","year":"2009","unstructured":"Li N, Neu J (2009) Glutamine deprivation alters intestinal tight junctions via a PI3-K\/Akt mediated pathway in Caco-2 cells. J Nutr 139:710\u2013714. https:\/\/doi.org\/10.3945\/jn.108.101485","journal-title":"J Nutr"},{"key":"10175_CR46","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1159\/000479203","volume":"42","author":"Y Li","year":"2017","unstructured":"Li Y, Gao Y, Cui T, Yang T, Liu L, Li T, Chen J (2017) Retinoic acid facilitates toll-like receptor 4 expression to improve intestinal barrier function through retinoic acid receptor Beta. Cell Physiol Biochem 42:1390\u20131406. https:\/\/doi.org\/10.1159\/000479203","journal-title":"Cell Physiol Biochem"},{"key":"10175_CR47","doi-asserted-by":"publisher","unstructured":"Liang H, Dai Z, Kou J, Sun K, Chen J, Yang Y et al (2018) Dietary l-Tryptophan supplementation enhances the intestinal mucosal barrier function in weaned piglets: implication of Tryptophan-Metabolizing Microbiota. Int J Mol Sci 20. https:\/\/doi.org\/10.3390\/ijms20010020","DOI":"10.3390\/ijms20010020"},{"key":"10175_CR48","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/00005176-200501000-00006","volume":"40","author":"AA Lima","year":"2005","unstructured":"Lima AA, Brito LF, Ribeiro HB, Martins MC, Lustosa AP, Rocha EM et al (2005) Intestinal barrier function and weight gain in malnourished children taking glutamine supplemented enteral formula. J Pediatr Gastroenterol Nutr 40:28\u201335. https:\/\/doi.org\/10.1097\/00005176-200501000-00006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10175_CR49","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/MPG.0b013e31802eecdd","volume":"44","author":"NL Lima","year":"2007","unstructured":"Lima NL, Soares AM, Mota RM, Monteiro HS, Guerrant RL, Lima AA (2007) Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula. J Pediatr Gastroenterol Nutr 44:365\u2013374. https:\/\/doi.org\/10.1097\/MPG.0b013e31802eecdd","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10175_CR50","doi-asserted-by":"publisher","first-page":"31196","DOI":"10.1074\/jbc.272.49.31196","volume":"272","author":"RZ Lin","year":"1997","unstructured":"Lin RZ, Hu Z-W, Chin JH, Hoffman BB (1997) Heat shock activates c-Src tyrosine kinases and phosphatidylinositol 3-kinase in NIH3T3 fibroblasts. J Biol Chem 272:31196\u201331202","journal-title":"J Biol Chem"},{"key":"10175_CR53","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13619-020-00053-5","volume":"9","author":"Y Liu","year":"2020","unstructured":"Liu Y, Chen Y-G (2020) Intestinal epithelial plasticity and regeneration via cell dedifferentiation. Cell Regeneration 9:14. https:\/\/doi.org\/10.1186\/s13619-020-00053-5","journal-title":"Cell Regeneration"},{"key":"10175_CR51","doi-asserted-by":"publisher","first-page":"32889","DOI":"10.1038\/srep32889","volume":"6","author":"T Liu","year":"2016","unstructured":"Liu T, Shi Y, Du J, Ge X, Teng X, Liu L et al (2016) Vitamin D treatment attenuates 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced Colitis but not oxazolone-induced Colitis. Sci Rep 6:32889. https:\/\/doi.org\/10.1038\/srep32889","journal-title":"Sci Rep"},{"issue":"2","key":"10175_CR52","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/1750-3841.13603","volume":"82","author":"W Liu","year":"2017","unstructured":"Liu W, Mi S, Ruan Z, Li J, Shu X, Yao K et al (2017a) Dietary Tryptophan enhanced the expression of tight Junction protein ZO-1 in intestine. J Food Sci 82(2):562\u2013567. https:\/\/doi.org\/10.1111\/1750-3841.13603","journal-title":"J Food Sci"},{"key":"10175_CR54","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1007\/s00726-017-2450-1","volume":"49","author":"Y Liu","year":"2017","unstructured":"Liu Y, Wang X, Hou Y, Yin Y, Qiu Y, Wu G, Hu C-AA (2017b) Roles of amino acids in preventing and treating intestinal Diseases: recent studies with pig models. Amino Acids 49:1277\u20131291. https:\/\/doi.org\/10.1007\/s00726-017-2450-1","journal-title":"Amino Acids"},{"key":"10175_CR55","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1046\/j.1471-4159.2000.0740320.x","volume":"74","author":"R Lu","year":"2000","unstructured":"Lu R, Wang W, Uzzau S, Vigorito R, Zielke HR, Fasano A (2000) Affinity purification and partial characterization of the Zonulin\/Zonula occludens Toxin (zot) receptor from human brain. J Neurochem 74:320\u2013326. https:\/\/doi.org\/10.1046\/j.1471-4159.2000.0740320.x","journal-title":"J Neurochem"},{"key":"10175_CR56","doi-asserted-by":"publisher","unstructured":"Manninen Aki (2015) Epithelial polarity \u2013 Generating and integrating signals from the ECM with integrins. Exp Cell Res 16. https:\/\/doi.org\/10.1016\/j.yexcr.2015.01.003","DOI":"10.1016\/j.yexcr.2015.01.003"},{"key":"10175_CR57","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1084\/jem.20071204","volume":"205","author":"T Matysiak-Budnik","year":"2008","unstructured":"Matysiak-Budnik T, Moura IC, Arcos-Fajardo M, Lebreton C, M\u00e9nard S, Candalh C et al (2008) Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac Disease. J Exp Med 205:143\u2013154. https:\/\/doi.org\/10.1084\/jem.20071204","journal-title":"J Exp Med"},{"key":"10175_CR58","doi-asserted-by":"publisher","unstructured":"McCaffrey LM, Macara IG (2012) Signaling pathways in cell polarity. Cold Spring Harb Perspect Biol 4. https:\/\/doi.org\/10.1101\/cshperspect.a009654","DOI":"10.1101\/cshperspect.a009654"},{"key":"10175_CR59","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1007\/s10238-022-00987-x","volume":"23","author":"M Mozafarybazargany","year":"2023","unstructured":"Mozafarybazargany M, Khonsari M, Sokoty L, Ejtahed HS, Qorbani M (2023) The effects of probiotics on gastrointestinal symptoms and microbiota in patients with celiac Disease: a systematic review and meta-analysis on clinical trials. Clin Exp Med 23:2773\u20132788. https:\/\/doi.org\/10.1007\/s10238-022-00987-x","journal-title":"Clin Exp Med"},{"key":"10175_CR60","doi-asserted-by":"publisher","first-page":"e76006","DOI":"10.1371\/journal.pone.0076006","volume":"8","author":"M Nanayakkara","year":"2013","unstructured":"Nanayakkara M, Lania G, Maglio M, Kosova R, Sarno M et al (2013) Enterocyte Proliferation and Signaling are constitutively altered in Celiac Disease. PLoS ONE 8:e76006. https:\/\/doi.org\/10.1371\/journal.pone.0076006","journal-title":"PLoS ONE"},{"key":"10175_CR61","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1242\/dev.053538","volume":"138","author":"J Nance","year":"2011","unstructured":"Nance J, Zallen JA (2011) Elaborating polarity: PAR proteins and the cytoskeleton. Development 138:799\u2013809. https:\/\/doi.org\/10.1242\/dev.053538","journal-title":"Development"},{"key":"10175_CR62","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3390\/microorganisms6040107","volume":"6","author":"MEM Obrenovich","year":"2018","unstructured":"Obrenovich MEM (2018) Leaky gut. Leaky Brain? Microorganisms 6:107. https:\/\/doi.org\/10.3390\/microorganisms6040107","journal-title":"Leaky Brain? Microorganisms"},{"key":"10175_CR63","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.tcb.2020.08.004","volume":"30","author":"T Otani","year":"2020","unstructured":"Otani T, Furuse M (2020) Tight Junction structure and function revisited. Trends Cell Biol 30:805\u2013817. https:\/\/doi.org\/10.1016\/j.tcb.2020.08.004","journal-title":"Trends Cell Biol"},{"key":"10175_CR64","doi-asserted-by":"publisher","first-page":"957","DOI":"10.3389\/fimmu.2020.00957","volume":"11","author":"F Pecora","year":"2020","unstructured":"Pecora F, Persico F, Gismondi P, Fornaroli F, Iuliano S, de\u2019Angelis GL, Esposito S (2020) Gut microbiota in Celiac Disease: is there any role for Probiotics? Front Immunol 11:957. https:\/\/doi.org\/10.3389\/fimmu.2020.00957","journal-title":"Front Immunol"},{"key":"10175_CR65","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/j.1749-6632.2009.04054.x","volume":"1165","author":"R Rao","year":"2009","unstructured":"Rao R (2009) Occludin phosphorylation in regulation of epithelial tight junctions. Ann N Y Acad Sci 1165:62\u201368. https:\/\/doi.org\/10.1111\/j.1749-6632.2009.04054.x","journal-title":"Ann N Y Acad Sci"},{"key":"10175_CR66","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nrm3775","volume":"15","author":"E Rodriguez-Boulan","year":"2014","unstructured":"Rodriguez-Boulan E, Macara IG (2014) Organization and Execution of the epithelial polarity programme. Nat Rev Mol Cell Biol 15:225\u2013242. https:\/\/doi.org\/10.1038\/nrm3775","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10175_CR67","doi-asserted-by":"publisher","unstructured":"Sander GR, Cummins AG, Henshall T, Powell BC, Schneeberger K, Roth S, Nieuwenhuis EES, Middendorp S (20052018) Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS LettDis Model Mech 579:4851\u20134855. https:\/\/doi.org\/10.1016\/j.febslet.2005.07.066","DOI":"10.1016\/j.febslet.2005.07.066"},{"key":"10175_CR68","doi-asserted-by":"publisher","unstructured":"Schoultz I, Keita \u00c5V (2020) The intestinal barrier and current techniques for the Assessment of Gut Permeability. Cells 9. https:\/\/doi.org\/10.3390\/cells9081909","DOI":"10.3390\/cells9081909"},{"key":"10175_CR69","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jcmgh.2016.12.006","volume":"3","author":"M Schumann","year":"2017","unstructured":"Schumann M, Siegmund B, Schulzke JD, Fromm M (2017) Celiac Disease: role of the epithelial barrier. Cell Mol Gastroenterol Hepatol 3:150\u2013162. https:\/\/doi.org\/10.1016\/j.jcmgh.2016.12.006","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10175_CR70","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.crfs.2021.04.004","volume":"4","author":"Sensoy Ilkay","year":"2021","unstructured":"Sensoy Ilkay (2021) A review on the food digestion in the digestive tract and the used in vitro models. Curr Res Food Sci 4:308\u2013319. https:\/\/doi.org\/10.1016\/j.crfs.2021.04.004","journal-title":"Curr Res Food Sci"},{"key":"10175_CR71","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/bcpt.12388","volume":"117","author":"IR Sequeira","year":"2015","unstructured":"Sequeira IR, Kruger MC, Hurst RD, Lentle RG (2015) Ascorbic acid may exacerbate aspirin-Induced increase in intestinal permeability. Basic Clin Pharmacol Toxicol 117:195\u2013203. https:\/\/doi.org\/10.1111\/bcpt.12388","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10175_CR72","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fnut.2020.00006","volume":"7","author":"N Sharma","year":"2020","unstructured":"Sharma N, Bhatia S, Chunduri V, Kaur S, Sharma S, Kapoor P, Kumari A, Garg M (2020) Pathogenesis of Celiac Disease and other Gluten Related disorders in wheat and strategies for mitigating them. Front Nutr 7:6. https:\/\/doi.org\/10.3389\/fnut.2020.00006","journal-title":"Front Nutr"},{"key":"10175_CR73","doi-asserted-by":"crossref","unstructured":"Standring Susan (2019) The anatomy of the small intestine. In (pp. 1\u201326)","DOI":"10.1007\/978-3-030-05240-9_1"},{"issue":"8","key":"10175_CR74","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s00018-017-2729-0","volume":"75","author":"T Steinbacher","year":"2018","unstructured":"Steinbacher T, Kummer D, Ebnet K (2018) Junctional adhesion molecule-A: functional diversity through molecular promiscuity. Cell Mol Life Sci 75(8):1393\u20131409. https:\/\/doi.org\/10.1007\/s00018-017-2729-0","journal-title":"Cell Mol Life Sci"},{"key":"10175_CR75","doi-asserted-by":"crossref","unstructured":"Steinway SN, Saleh J, Koo B-K, Delacour D, Kim DH (2020) Human microphysiological models of intestinal tissue and gut microbiome. Front Bioeng Biotechnol 8","DOI":"10.3389\/fbioe.2020.00725"},{"key":"10175_CR76","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1016\/j.jmb.2018.01.011","volume":"430","author":"R Stephens","year":"2018","unstructured":"Stephens R, Lim K, Portela M, Kvansakul M, Humbert PO, Richardson HE (2018) The Scribble Cell Polarity Module in the regulation of cell signaling in tissue development and Tumorigenesis. J Mol Biol 430:3585\u20133612. https:\/\/doi.org\/10.1016\/j.jmb.2018.01.011","journal-title":"J Mol Biol"},{"key":"10175_CR77","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1080\/00365521.2016.1185463","volume":"51","author":"M Stio","year":"2016","unstructured":"Stio M, Retico L, Annese V, Bonanomi AG (2016) Vitamin D regulates the tight-junction protein expression in active ulcerative Colitis. Scand J Gastroenterol 51:1193\u20131199. https:\/\/doi.org\/10.1080\/00365521.2016.1185463","journal-title":"Scand J Gastroenterol"},{"issue":"4","key":"10175_CR78","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1091\/mbc.e03-08-0620","volume":"15","author":"SW Straight","year":"2004","unstructured":"Straight SW, Shin K, Fogg VC, Fan S, Liu CJ, Roh M, Margolis B (2004) Loss of PALS1 expression leads to tight junction and polarity defects. Mol Biol Cell 15(4):1981\u20131990. https:\/\/doi.org\/10.1091\/mbc.e03-08-0620","journal-title":"Mol Biol Cell"},{"key":"10175_CR79","doi-asserted-by":"publisher","first-page":"e13357","DOI":"10.1111\/asj.13357","volume":"91","author":"T Suzuki","year":"2020","unstructured":"Suzuki T (2020) Regulation of the intestinal barrier by nutrients: the role of tight junctions. Anim Sci J 91:e13357. https:\/\/doi.org\/10.1111\/asj.13357","journal-title":"Anim Sci J"},{"key":"10175_CR80","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3945\/jn.108.100867","volume":"139","author":"T Suzuki","year":"2009","unstructured":"Suzuki T, Hara H (2009) Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr 139:965\u2013974. https:\/\/doi.org\/10.3945\/jn.108.100867","journal-title":"J Nutr"},{"key":"10175_CR81","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3945\/jn.110.125633","volume":"141","author":"T Suzuki","year":"2011","unstructured":"Suzuki T, Tanabe S, Hara H (2011) Kaempferol enhances intestinal barrier function through the cytoskeletal association and expression of tight junction proteins in Caco-2 cells. J Nutr 141:87\u201394. https:\/\/doi.org\/10.3945\/jn.110.125633","journal-title":"J Nutr"},{"key":"10175_CR82","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12876-020-01390-0","volume":"20","author":"N Taraghikhah","year":"2020","unstructured":"Taraghikhah N, Ashtari S, Asri N, Shahbazkhani B, Al-Dulaimi D, Rostami-Nejad M, Rezaei-Tavirani M, Razzaghi MR, Zali MR (2020) An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects. BMC Gastroenterol 20:258. https:\/\/doi.org\/10.1186\/s12876-020-01390-0","journal-title":"BMC Gastroenterol"},{"key":"10175_CR83","doi-asserted-by":"publisher","first-page":"e0193764","DOI":"10.1371\/journal.pone.0193764","volume":"13","author":"\u00c3 Torinsson Naluai","year":"2018","unstructured":"Torinsson Naluai \u00c3, Saadat Vafa L, Gudjonsdottir AH, Arnell H, Browaldh L, Nilsson S, Agardh D (2018) Altered peripheral amino acid profile indicate a systemic impact of active celiac Disease and a possible role of amino acids in Disease pathogenesis. PLoS One 2018 13:e0193764. https:\/\/doi.org\/10.1371\/journal.pone.0193764","journal-title":"PLoS One 2018"},{"key":"10175_CR84","doi-asserted-by":"publisher","unstructured":"Tossou MCB, Liu H, Bai M, Chen S, Cai Y, Duraipandiyan V, Liu H, Adebowale TO, Al-Dhabi NA, Long L et al (2016) Effect of High Dietary Tryptophan on Intestinal Morphology and Tight Junction Protein of Weaned Pig. Biomed Res Int 2016:2912418. https:\/\/doi.org\/10.1155\/2016\/2912418","DOI":"10.1155\/2016\/2912418"},{"key":"10175_CR85","doi-asserted-by":"publisher","first-page":"e1308","DOI":"10.1371\/journal.pone.0001308","volume":"2","author":"SN Ukena","year":"2007","unstructured":"Ukena SN, Singh A, Dringenberg U, Engelhardt R, Seidler U, Hansen W, Bleich A, Bruder D, Franzke A, Rogler G (2007) Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS ONE 2:e1308","journal-title":"PLoS ONE"},{"key":"10175_CR86","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3945\/jn.110.135657","volume":"141","author":"D Ulluwishewa","year":"2011","unstructured":"Ulluwishewa D, Anderson RC, McNabb WC, Moughan PJ, Wells JM, Roy NC (2011) Regulation of tight Junction permeability by Intestinal Bacteria and Dietary Components. J Nutr 141:769\u2013776. https:\/\/doi.org\/10.3945\/jn.110.135657","journal-title":"J Nutr"},{"key":"10175_CR87","doi-asserted-by":"publisher","first-page":"595","DOI":"10.3390\/ijms22020595","volume":"22","author":"CB Van Buiten","year":"2021","unstructured":"Van Buiten CB, Elias RJ (2021) Gliadin sequestration as a novel therapy for celiac Disease: a prospective application for polyphenols. Int J Mol Sci 22:595","journal-title":"Int J Mol Sci"},{"key":"10175_CR88","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1080\/17474124.2017.1343143","volume":"11","author":"M Vancamelbeke","year":"2017","unstructured":"Vancamelbeke M, Vermeire S (2017) The intestinal barrier: a fundamental role in health and Disease. Expert Rev Gastroenterol Hepatol 11:821\u2013834. https:\/\/doi.org\/10.1080\/17474124.2017.1343143","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10175_CR89","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1749-6632.2009.04037.x","volume":"1165","author":"J Visser","year":"2009","unstructured":"Visser J, Rozing J, Sapone A, Lammers K, Fasano A (2009) Tight junctions, intestinal permeability, and autoimmunity: celiac Disease and type 1 Diabetes paradigms. Ann N Y Acad Sci 1165:195\u2013205. https:\/\/doi.org\/10.1111\/j.1749-6632.2009.04037.x","journal-title":"Ann N Y Acad Sci"},{"key":"10175_CR90","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ceb.2003.12.002","volume":"16","author":"R Vogelmann","year":"2004","unstructured":"Vogelmann R, Amieva MR, Falkow S, Nelson WJ (2004) Breaking into the epithelial apical-junctional complex\u2013news from pathogen hackers. Curr Opin Cell Biol 16:86\u201393. https:\/\/doi.org\/10.1016\/j.ceb.2003.12.002","journal-title":"Curr Opin Cell Biol"},{"key":"10175_CR91","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/s0002-9440(10)62264-x","volume":"166","author":"F Wang","year":"2005","unstructured":"Wang F, Graham WV, Wang Y, Witkowski ED, Schwarz BT, Turner JR (2005) Interferon-gamma and Tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol 166:409\u2013419. https:\/\/doi.org\/10.1016\/s0002-9440(10)62264-x","journal-title":"Am J Pathol"},{"key":"10175_CR92","doi-asserted-by":"publisher","first-page":"222","DOI":"10.4062\/biomolther.2018.052","volume":"27","author":"PF Wang","year":"2019","unstructured":"Wang PF, Yao DH, Hu YY, Li Y (2019) Vitamin D improves intestinal barrier function in Cirrhosis rats by upregulating Heme Oxygenase-1 expression. Biomol Ther (Seoul) 27:222\u2013230. https:\/\/doi.org\/10.4062\/biomolther.2018.052","journal-title":"Biomol Ther (Seoul)"},{"key":"10175_CR93","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jphs.2019.06.012","volume":"140","author":"S Yamada","year":"2019","unstructured":"Yamada S, Kanda Y (2019) Retinoic acid promotes barrier functions in human iPSC-derived intestinal epithelial monolayers. J Pharmacol Sci 140:337\u2013344. https:\/\/doi.org\/10.1016\/j.jphs.2019.06.012","journal-title":"J Pharmacol Sci"},{"key":"10175_CR94","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.cell.2008.09.045","volume":"135","author":"L Zhan","year":"2008","unstructured":"Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK (2008) Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 135:865\u2013878. https:\/\/doi.org\/10.1016\/j.cell.2008.09.045","journal-title":"Cell"},{"key":"10175_CR95","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1017\/s0007114509289033","volume":"102","author":"B Zhang","year":"2009","unstructured":"Zhang B, Guo Y (2009) Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets. Br J Nutr 102:687\u2013693. https:\/\/doi.org\/10.1017\/s0007114509289033","journal-title":"Br J Nutr"},{"key":"10175_CR96","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1111\/j.1462-5822.2006.00836.x","volume":"9","author":"AA Zyrek","year":"2007","unstructured":"Zyrek AA, Cichon C, Helms S, Enders C, Sonnenborn U, Schmidt MA (2007) Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKC\u03b6 redistribution resulting in tight junction and epithelial barrier repair. Cell Microbiol 9:804\u2013816","journal-title":"Cell Microbiol"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-023-10175-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-023-10175-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-023-10175-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T05:05:35Z","timestamp":1706763935000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-023-10175-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,2]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10175"],"URL":"https:\/\/doi.org\/10.1007\/s10735-023-10175-0","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,2]]},"assertion":[{"value":"30 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}