{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:08:03Z","timestamp":1790626083558,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Cultural and Educational Grant Agency Ministry of Education, Science, Research and Sport of the Slovak Republic","award":["008UPJ\u0160-4\/2024"],"award-info":[{"award-number":["008UPJ\u0160-4\/2024"]}]},{"name":"E\u00da project \"Replace\" at University of Veterinary medicine and Pharmacy in Ko\u0161ice","award":["FOOD-CT-2003-506487"],"award-info":[{"award-number":["FOOD-CT-2003-506487"]}]},{"name":"E\u00da project \"Replace\" at University of Veterinary medicine and Pharmacy in Ko\u0161ice","award":["FOOD-CT-2003-506487"],"award-info":[{"award-number":["FOOD-CT-2003-506487"]}]},{"DOI":"10.13039\/100030974","name":"Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100030974","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>We focused on investigation of <jats:italic>E. coli<\/jats:italic> infection influence on the turnover and apoptosis of intestinal mucosa. We have verified changes in proliferation and apoptosis in epithelial lining as well as in lamina propria of jejunum and colon of germ-free (GF) piglets as healthy control group and GF piglets in which at 5th day their gut was colonized with <jats:italic>E. coli<\/jats:italic> bacteria (ECK group). According to our results we detected significant increase in proliferation of the epithelial cells only in the jejunum of the ECK group, indicating a higher sensitivity to colonization with <jats:italic>E. coli<\/jats:italic>. Significant changes in the TUNEL assay and immunohistochemistry of other studied markers (TNF-\u03b1, Caspase-3 and HSP-70) were noted only in the lamina propria mucosae of both intestinal segments in the ECK group. In conclusion, we found that the commensal gut microbiota plays a role in regulation of the turnover rate in the epithelial lining, but also in the cells in the lamina propria mucosae in both intestinal segments, and that the host response is dependent on the colonising bacteria.<\/jats:p>","DOI":"10.1007\/s10735-024-10278-2","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T02:57:26Z","timestamp":1733281046000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intestinal mucosal turnover in germ-free piglets infected with E. coli"],"prefix":"10.1007","volume":"56","author":[{"given":"\u0160tefan","family":"T\u00f3th","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Fagov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Holodov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00edna","family":"\u010curgali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Mech\u00edrov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kunov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Maretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radom\u00edra","family":"Nemcov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u0148a","family":"Gancar\u010d\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Dankov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"10278_CR1","doi-asserted-by":"publisher","first-page":"5056","DOI":"10.1172\/JCI97912","volume":"128","author":"M Armacki","year":"2018","unstructured":"Armacki M, Trugenberger AK, Ellwanger AK et al (2018) Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure. J Clin Invest 128:5056\u20135072. https:\/\/doi.org\/10.1172\/JCI97912","journal-title":"J Clin Invest"},{"issue":"3","key":"10278_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1093\/nutrit\/nuv104","volume":"74","author":"ME Arnal","year":"2016","unstructured":"Arnal ME, Lalle\u2019s JP (2016) Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota. Nutr Rev 74(3):181\u2013197. https:\/\/doi.org\/10.1093\/nutrit\/nuv104","journal-title":"Nutr Rev"},{"key":"10278_CR3","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/bab.2233","volume":"69","author":"M Asadi","year":"2022","unstructured":"Asadi M, Taghizadeh S, Kaviani E, Vakili O, Taheri-Anganeh M, Tahamtan M, Savardashtak A (2022) Caspase-3: structure, function, and biotechnological aspects. Biotechnol Appl Biochem 69:1633\u20131645. https:\/\/doi.org\/10.1002\/bab.2233","journal-title":"Biotechnol Appl Biochem"},{"issue":"14","key":"10278_CR4","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1101\/gad.1674008","volume":"22","author":"N Barker","year":"2008","unstructured":"Barker N, van de Wetering M, Clevers HC (2008) The intestinal stem cell. Genes Dev 22(14):1856\u20131864. https:\/\/doi.org\/10.1101\/gad.1674008","journal-title":"Genes Dev"},{"key":"10278_CR5","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/nrm1663","volume":"6","author":"JJ Blow","year":"2005","unstructured":"Blow JJ, Dutta A (2005) Preventing re-replication of chromosomal DNA. Nat Rev 6:476\u2013478. https:\/\/doi.org\/10.1038\/nrm1663","journal-title":"Nat Rev"},{"issue":"10","key":"10278_CR6","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/labinvest.370046","volume":"86","author":"TF Bullen","year":"2006","unstructured":"Bullen TF, Forrest S, Campbell F (2006) Characterization of epithelial cell shedding from human small intestine. Lab Invest 86(10):1052\u20131063. https:\/\/doi.org\/10.1038\/labinvest.370046","journal-title":"Lab Invest"},{"issue":"11","key":"10278_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2020.00344","volume":"344","author":"E Butkevych","year":"2020","unstructured":"Butkevych E, Lobo de S\u00e1 FD, Nattramilarasu PK, B\u00fccker R (2020) Contribution of epithelial apoptosis and subepithelial immune responses in campylobacter jejuni-induced barrier disruption. Front Microbiol 344(11):1\u201314. https:\/\/doi.org\/10.3389\/fmicb.2020.00344","journal-title":"Front Microbiol"},{"key":"10278_CR8","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.cellsig.2012.02.006","volume":"24","author":"L Cabal-Hierro","year":"2012","unstructured":"Cabal-Hierro L, Lazo PS (2012) Signal transduction by tumor necrosis factor receptors. Cell Signal 24:1297\u20131305. https:\/\/doi.org\/10.1016\/j.cellsig.2012.02.006","journal-title":"Cell Signal"},{"key":"10278_CR9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/978-3-319-19497-4_2","volume-title":"Caspases-key players in apoptosis. Proteases in apoptosis: pathways, protocols and translational advances","author":"CE Cade","year":"2015","unstructured":"Cade CE, Clark AC (2015) Caspases-key players in apoptosis. Proteases in apoptosis: pathways, protocols and translational advances. Springer, Berlin, pp 31\u201351"},{"issue":"2","key":"10278_CR10","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/MCG.0b013e31815a57a8","volume":"42","author":"EC Claud","year":"2008","unstructured":"Claud EC, Walker WA (2008) Bacterial colonization, probiotics, and necrotizing enterocolitis. J Clin Gastroenterol 42(2):46\u201352. https:\/\/doi.org\/10.1097\/MCG.0b013e31815a57a8","journal-title":"J Clin Gastroenterol"},{"issue":"2","key":"10278_CR11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2013.07.004","volume":"154","author":"HC Clevers","year":"2013","unstructured":"Clevers HC (2013) The intestinal crypt, a prototype stem cell compartment. Cell 154(2):274\u2013284. https:\/\/doi.org\/10.1016\/j.cell.2013.07.004","journal-title":"Cell"},{"key":"10278_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/ACI.0b013e32832b3f1d","volume":"9","author":"ME Conroy","year":"2009","unstructured":"Conroy ME, Shi HN, Walker WA (2009) The long-term health effects of neonatal microbial flora. Curr Opin Allergy Clin Immunol 9:197\u2013201. https:\/\/doi.org\/10.1097\/ACI.0b013e32832b3f1d","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10278_CR13","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s10735-022-10079-5","volume":"53","author":"M Dankov\u00e1","year":"2022","unstructured":"Dankov\u00e1 M, T\u00f3th \u0160, Holodov\u00e1 M et al (2022) Immunohistochemical visualisation of the enteric nervous system architecture in the germ-free piglets. J Mol Histol 53:773\u2013780. https:\/\/doi.org\/10.1007\/s10735-022-10079-5","journal-title":"J Mol Histol"},{"issue":"11","key":"10278_CR14","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.1128\/iai.61.11.4569-4574.1993","volume":"61","author":"L Eckmann","year":"1993","unstructured":"Eckmann L, Kagnoff MF, Fierer J (1993) Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect Immun 61(11):4569\u20134574. https:\/\/doi.org\/10.1128\/iai.61.11.4569-4574.1993","journal-title":"Infect Immun"},{"issue":"2","key":"10278_CR15","first-page":"237","volume":"14","author":"JA Goldner","year":"1938","unstructured":"Goldner JA (1938) Modification of the Masson trichrome technique for routine laboratory purposes. Am J Pathol 14(2):237\u2013243","journal-title":"Am J Pathol"},{"key":"10278_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.semcdb.2014.06.004","volume":"35","author":"C Gunther","year":"2014","unstructured":"Gunther C, Buchen B, Neurath MF, Becker C (2014) Regulation and pathophysiological role of epithelial turnover in the gut. Semin Cell Dev Biol 35:40\u201350. https:\/\/doi.org\/10.1016\/j.semcdb.2014.06.004","journal-title":"Semin Cell Dev Biol"},{"issue":"12","key":"10278_CR17","doi-asserted-by":"publisher","first-page":"3569","DOI":"10.1242\/jcs.107.12.3569","volume":"107","author":"PA Hall","year":"1994","unstructured":"Hall PA, Coates PJ, Ansari B, Hopwood D (1994) Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J Cell Sci 107(12):3569\u20133577. https:\/\/doi.org\/10.1242\/jcs.107.12.3569","journal-title":"J Cell Sci"},{"key":"10278_CR18","doi-asserted-by":"publisher","first-page":"574568","DOI":"10.4061\/2010\/574568","volume":"9","author":"M Hausmann","year":"2010","unstructured":"Hausmann M (2010) How bacteria-induced apoptosis of intestinal epithelial cells contributes to mucosal inflammation. Int J Inflam 9:574568. https:\/\/doi.org\/10.4061\/2010\/574568","journal-title":"Int J Inflam"},{"key":"10278_CR19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.tim.2004.01.001","volume":"12","author":"LV Hooper","year":"2004","unstructured":"Hooper LV (2004) Bacterial contributions to mammalian gut development. Trends Microbiol 12:129\u2013134. https:\/\/doi.org\/10.1016\/j.tim.2004.01.001","journal-title":"Trends Microbiol"},{"issue":"3","key":"10278_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2220\/biomedres.43.59","volume":"43","author":"T Iwanaga","year":"2022","unstructured":"Iwanaga T, Takahashi-Iwanaga H (2022) Disposal of intestinal apoptotic epithelial cells and their fate via divergent routes. Biomed Res 43(3):59\u201372. https:\/\/doi.org\/10.2220\/biomedres.43.59","journal-title":"Biomed Res"},{"issue":"1","key":"10278_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1172\/JCI117676","volume":"95","author":"HC Jung","year":"1995","unstructured":"Jung HC, Eckmann L, Yang SK, Panja A, Fierer J, Morzycka- Wroblewska E, Kagnoff MF (1995) A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 95(1):55\u201365. https:\/\/doi.org\/10.1172\/JCI117676","journal-title":"J Clin Invest"},{"key":"10278_CR22","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1203\/pdr.0b013e318045be83","volume":"61","author":"Y Kai-Larsen","year":"2007","unstructured":"Kai-Larsen Y, Bergsson G, Gudmundsson GH, Printz G, Jornvall H, Marchini G, Agerberth B (2007) Antimicrobial components of the neonatal gut affected upon colonization. Pediatr Res 61:530\u2013536. https:\/\/doi.org\/10.1203\/pdr.0b013e318045be83","journal-title":"Pediatr Res"},{"issue":"2","key":"10278_CR23","doi-asserted-by":"publisher","first-page":"143","DOI":"10.4049\/jimmunol.181.2.1143","volume":"181","author":"R Kajino-Sakamoto","year":"2008","unstructured":"Kajino-Sakamoto R, Inagaki M, Lippert E, Akira S, Robine S, Matsumoto K, Jobin C, Ninomiya-Tsuji J (2008) Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol 181(2):143\u20131152. https:\/\/doi.org\/10.4049\/jimmunol.181.2.1143","journal-title":"J Immunol"},{"issue":"5","key":"10278_CR24","doi-asserted-by":"publisher","first-page":"674","DOI":"10.3390\/biom10050674","volume":"10","author":"P Kapczuk","year":"2020","unstructured":"Kapczuk P, Kosik-Bogacka D, Kupnicka P et al (2020) The influence of selected gastrointestinal parasites on apoptosis in intestinal epithelial cells. Biomolecules 10(5):674. https:\/\/doi.org\/10.3390\/biom10050674","journal-title":"Biomolecules"},{"issue":"10","key":"10278_CR25","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1172\/JCI2466","volume":"102","author":"JM Kim","year":"1998","unstructured":"Kim JM, Eckmann L, Savidge TC, Lowe DC, Witth\u00f6ft T, Kagnoff MF (1998) Apoptosis of human intestinal epithelial cells after bacterial invasion. J Clin Invest 102(10):1815\u20131823. https:\/\/doi.org\/10.1172\/JCI2466","journal-title":"J Clin Invest"},{"key":"10278_CR26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.chom.2010.06.006","volume":"8","author":"M Kim","year":"2010","unstructured":"Kim M, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Sasakawa Ch (2010) Bacterial interactions with the host epithelium. Cell Host Microbe 8:20\u201335. https:\/\/doi.org\/10.1016\/j.chom.2010.06.006","journal-title":"Cell Host Microbe"},{"key":"10278_CR27","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/intimm\/dxu051","volume":"26","author":"M Leppkes","year":"2014","unstructured":"Leppkes M, Roulis M, Neurath MF, Kollias G, Becker Ch (2014) Pleiotropic functions of TNF-alpha in the regulation of the intestinal epithelial response to inflammation. Int Immunol 26:509\u2013515. https:\/\/doi.org\/10.1093\/intimm\/dxu051","journal-title":"Int Immunol"},{"key":"10278_CR28","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.3390\/molecules24081472","volume":"24","author":"Y Li","year":"2019","unstructured":"Li Y, Pan J, Gou M (2019) The anti-proliferation, cycle arrest and apoptotic inducing activity of Peperomin E on prostate cancer PC-3 cell line. Molecules 24:1472. https:\/\/doi.org\/10.3390\/molecules24081472","journal-title":"Molecules"},{"issue":"1","key":"10278_CR29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s40104-015-0040-1","volume":"6","author":"Y Liu","year":"2015","unstructured":"Liu Y (2015) Fatty acids, inflammation and intestinal health in pigs. J Anim Sci Biotechnol 6(1):41. https:\/\/doi.org\/10.1186\/s40104-015-0040-1","journal-title":"J Anim Sci Biotechnol"},{"issue":"4","key":"10278_CR30","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1053\/j.gastro.2011:01.004","volume":"140","author":"AM Marchiando","year":"2011","unstructured":"Marchiando AM, Shen L, Graham WV (2011) The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology 140(4):1208\u20131218. https:\/\/doi.org\/10.1053\/j.gastro.2011:01.004","journal-title":"Gastroenterology"},{"key":"10278_CR31","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1053\/gast.2002.30347","volume":"122","author":"E Mizoguchi","year":"2002","unstructured":"Mizoguchi E, Mizoguchi A, Takedatsu H et al (2002) Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology 122:134\u2013144. https:\/\/doi.org\/10.1053\/gast.2002.30347","journal-title":"Gastroenterology"},{"key":"10278_CR32","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1177\/44.7.8675993","volume":"44","author":"R Nagashima","year":"1996","unstructured":"Nagashima R, Maeda K, Imai Y, Takahashi T (1996) Lamina propria macrophages in the human gastrointestinal mucosa: their distribution, immunological phenotype, and function. J Histochem Cytochem 44:721\u2013731. https:\/\/doi.org\/10.1177\/44.7.8675993","journal-title":"J Histochem Cytochem"},{"key":"10278_CR33","doi-asserted-by":"publisher","first-page":"161","DOI":"10.5555\/uri:pii:001650859190473X","volume":"101","author":"K Nakamura","year":"1991","unstructured":"Nakamura K, Rokutan K, Marui N, Aoike A, Kawai K (1991) Induction of heat shock proteins and their implication in protection against ethanol-induced damage in cultured guinea pig gastric mucosal cells. Gastroenterology 101:161\u2013166. https:\/\/doi.org\/10.5555\/uri:pii:001650859190473X","journal-title":"Gastroenterology"},{"issue":"7135","key":"10278_CR34","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nature05698","volume":"446","author":"A Nenci","year":"2007","unstructured":"Nenci A, Becker C, Wullaert A, Gareus R, Van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M (2007) Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446(7135):557\u2013561. https:\/\/doi.org\/10.1038\/nature05698","journal-title":"Nature"},{"key":"10278_CR35","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41419-018-1275-5","volume":"10","author":"A Parker","year":"2019","unstructured":"Parker A, Vaux L, Patterson AM et al (2019) Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation. Cell Death Dis 10:108. https:\/\/doi.org\/10.1038\/s41419-018-1275-5","journal-title":"Cell Death Dis"},{"issue":"3","key":"10278_CR36","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1080\/19490976.2019.1690363","volume":"11","author":"Y Patil","year":"2020","unstructured":"Patil Y, Gooneratneb R, Ju XH (2020) Interactions between host and gut microbiota in domestic pigs: a review. Gut Microb 11(3):310\u2013334. https:\/\/doi.org\/10.1080\/19490976.2019.1690363","journal-title":"Gut Microb"},{"key":"10278_CR37","doi-asserted-by":"publisher","first-page":"651","DOI":"10.3181\/0709-MR-262","volume":"233","author":"JK Patterson","year":"2008","unstructured":"Patterson JK, Lei XG, Miller DD (2008) The pig as an experimental model for elucidating the mechanisms governing dietary influence on mineral absorption. Exp Biol Med 233:651\u2013664. https:\/\/doi.org\/10.3181\/0709-MR-262","journal-title":"Exp Biol Med"},{"key":"10278_CR38","doi-asserted-by":"publisher","first-page":"5183","DOI":"10.2527\/jas.2013-6759","volume":"91","author":"SC Pearce","year":"2013","unstructured":"Pearce SC, Mani V, Weber TE (2013) Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs. J Anim Sci 91:5183\u20135193. https:\/\/doi.org\/10.2527\/jas.2013-6759","journal-title":"J Anim Sci"},{"key":"10278_CR39","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1093\/jn\/134.3.641","volume":"134","author":"S Pi\u00e9","year":"2004","unstructured":"Pi\u00e9 S, Lall\u00e8s JP, Blazy F, Laffitte J, S\u00e8ve B, Oswald IP (2004) Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. J Nutr 134:641\u2013647. https:\/\/doi.org\/10.1093\/jn\/134.3.641","journal-title":"J Nutr"},{"key":"10278_CR40","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","volume":"118","author":"S Rakoff-Nahoum","year":"2004","unstructured":"Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118:229\u2013241. https:\/\/doi.org\/10.1016\/j.cell.2004.07.002","journal-title":"Cell"},{"key":"10278_CR41","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02144.x","author":"K Rokutan","year":"2000","unstructured":"Rokutan K (2000) Gastric mucosal protection and cell proliferation Role of heat shock proteins in gastric mucosal protection. J Gastroenterol Hepatol. https:\/\/doi.org\/10.1046\/j.1440-1746.2000.02144.x","journal-title":"J Gastroenterol Hepatol"},{"key":"10278_CR42","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-981-32-9717-3_3","volume":"1189","author":"T So","year":"2019","unstructured":"So T, Ishii N (2019) The TNF-TNFR family of co-signal molecules. Adv Exp Med Biol 1189:53\u201384. https:\/\/doi.org\/10.1007\/978-981-32-9717-3_3","journal-title":"Adv Exp Med Biol"},{"key":"10278_CR43","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0092-8674(93)90222-c","volume":"73","author":"LA Tartaglia","year":"1993","unstructured":"Tartaglia LA, Rothe M, Hu YF, Goeddel DV (1993) Tumour necrosis factor\u2019s cytotoxic activity is signaled by the p55 TNF receptor. Cell 73:213\u2013216. https:\/\/doi.org\/10.1016\/0092-8674(93)90222-c","journal-title":"Cell"},{"key":"10278_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/jbcpp-2018-0036","volume":"30","author":"N Tatiya-Aphiradee","year":"2018","unstructured":"Tatiya-Aphiradee N, Chatuphonprasert W, Jarukamjorn K (2018) Immune response and inflammatory pathway of ulcerative colitis. J Basic Clin Physiol Pharmacol 30:1\u201310. https:\/\/doi.org\/10.1515\/jbcpp-2018-0036","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"10278_CR45","doi-asserted-by":"publisher","first-page":"122036","DOI":"10.1016\/j.lfs.2023.122036","volume":"331","author":"\u0160 T\u00f3th","year":"2023","unstructured":"T\u00f3th \u0160, Fagov\u00e1 Z, Holodov\u00e1 M et al (2023) Influence of Escherichia coli infection on intestinal mucosal barrier integrity of germ-free piglets. Life Sci 331:122036. https:\/\/doi.org\/10.1016\/j.lfs.2023.122036","journal-title":"Life Sci"},{"issue":"14","key":"10278_CR46","doi-asserted-by":"publisher","first-page":"11451","DOI":"10.3390\/ijms241411451","volume":"24","author":"H Wang","year":"2023","unstructured":"Wang H, Shan ChL, Gao B et al (2023) Yersiniabactin-producing E. coli Induces the pyroptosis of intestinal epithelial cells via the NLRP3 pathway and promotes gut inflammation. Int J Mol Sci 24(14):11451. https:\/\/doi.org\/10.3390\/ijms241411451","journal-title":"Int J Mol Sci"},{"key":"10278_CR47","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1007\/s00535-003-1380-8","volume":"39","author":"M Watanabe","year":"2004","unstructured":"Watanabe M, Otaka K, Mikami K et al (2004) Expression of a 72-kDa heat shock protein, and its protective function, in gastric mucosa in cirrhotic rats. J Gastroenterol 39:724\u2013733. https:\/\/doi.org\/10.1007\/s00535-003-1380-8","journal-title":"J Gastroenterol"},{"key":"10278_CR48","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1242\/dmm.013284","volume":"6","author":"JM Williams","year":"2013","unstructured":"Williams JM, Duckworth CA, Watson AJM, Frey MR, Miguel JC, Burkitt MD, Sutton R, Hughes KR, Hall LJ, Caama\u00f1o JH, Campbell BJ, Mark Pritchard D (2013) A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. Dis Model Mech 6:1388\u20131399. https:\/\/doi.org\/10.1242\/dmm.013284","journal-title":"Dis Model Mech"},{"issue":"1","key":"10278_CR49","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12917-022-03410-5","volume":"18","author":"YY Zhang","year":"2022","unstructured":"Zhang YY, Yi D, Xu H, Tan Z, Meng Y, Wu T (2022) Dietary supplementation with sodium gluconate improves the growth performance and intestinal function in weaned pigs challenged with a recombinant Escherichia coli strain. BMC Vet Res 18(1):303. https:\/\/doi.org\/10.1186\/s12917-022-03410-5","journal-title":"BMC Vet Res"},{"issue":"3","key":"10278_CR50","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s12192-009-0148-3","volume":"15","author":"X Zhong","year":"2010","unstructured":"Zhong X, Wang T, Zhang X, Li W (2010) Heat shock protein 70 is upregulated in the intestine of intrauterine growth retardation piglets. Cell Stress Chaperones 15(3):335\u2013342. https:\/\/doi.org\/10.1007\/s12192-009-0148-3","journal-title":"Cell Stress Chaperones"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-024-10278-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-024-10278-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-024-10278-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T02:27:51Z","timestamp":1738808871000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-024-10278-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10278"],"URL":"https:\/\/doi.org\/10.1007\/s10735-024-10278-2","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]},"assertion":[{"value":"16 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"24"}}