{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:21:50Z","timestamp":1785237710001,"version":"3.55.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s10735-024-10283-5","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T15:17:43Z","timestamp":1735312663000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bolanthus turcicus: a promising antidiabetic with in-vitro antioxidant, enzyme inhibitory and antiadipogenic activities"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-2785","authenticated-orcid":false,"given":"Sibel","family":"\u00d6zda\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9448-8112","authenticated-orcid":false,"given":"\u0130pek","family":"Canatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1557-7393","authenticated-orcid":false,"given":"Gizem Ece","family":"Derici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-4571","authenticated-orcid":false,"given":"Murat","family":"Ko\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"issue":"1","key":"10283_CR79","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/jcb.26174","volume":"119","author":"MSH Akash","year":"2018","unstructured":"Akash MSH, Rehman K, Liaqat A (2018) Tumor necrosis Factor-Alpha: role in development of \u0131nsulin resistance and pathogenesis of type 2 diabetes mellitus. J Cell Biochem 119(1):105\u2013110","journal-title":"J Cell Biochem"},{"issue":"4","key":"10283_CR38","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2478\/acph-2018-0023","volume":"68","author":"A Akinrinde","year":"2018","unstructured":"Akinrinde A, Koekemoer T, Van De Venter M, Bradley G (2018) In vitro investigation of potential anti-diabetic activity of the corm extract of Hypoxis Argentea Harv. Ex Baker Acta Pharm 68(4):389\u2013440","journal-title":"Ex Baker Acta Pharm"},{"issue":"9","key":"10283_CR53","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3390\/biom9090430","volume":"9","author":"RK Al-Ishaq","year":"2019","unstructured":"Al-Ishaq RK, Abotaleb M, Kubatka P, Kajo K, B\u00fcsselberg D (2019) Flavonoids and their anti-diabetic effects: Cellular mechanisms and effects to Improve Blood Sugar levels. Biomolecules 9(9):430","journal-title":"Biomolecules"},{"key":"10283_CR23","first-page":"10","volume":"1","author":"S Al-Quran","year":"2008","unstructured":"Al-Quran S (2008) Taxonomical and pharmacological survey of therapeutic plants in Jordan. J Nat Prod 1:10\u201326","journal-title":"J Nat Prod"},{"issue":"20","key":"10283_CR80","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.2174\/1381612822666160307145801","volume":"22","author":"F Alam","year":"2016","unstructured":"Alam F, Islam MA, Khalil MI, Gan SH (2016) Metabolic control of type 2 diabetes by targeting the GLUT4 glucose transporter: intervention approaches. Curr Pharm Design 22(20):3034\u20133049","journal-title":"Curr Pharm Design"},{"issue":"3","key":"10283_CR32","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jep.2006.04.004","volume":"107","author":"H Ali","year":"2006","unstructured":"Ali H, Houghton PJ, Soumyanath A (2006) \u03b1-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. J Ethnopharmacol 107(3):449\u2013455","journal-title":"J Ethnopharmacol"},{"key":"10283_CR14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1051\/agro:2007022","volume":"27","author":"N Ameziane","year":"2007","unstructured":"Ameziane N, Boubaker H, Boudyach H, Msanda F, Jilal A, Benaoumar AA (2007) Antifungal activity of Moroccan plants against citrus fruit pathogens. Agronmy Sustainable Dev 27:273\u2013277","journal-title":"Agronmy Sustainable Dev"},{"key":"10283_CR24","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.jep.2012.07.017","volume":"143","author":"K Angmo","year":"2012","unstructured":"Angmo K, Adhikari BS, Rawat GS (2012) Changing aspects of traditional healthcare system in Western Ladakh, India. J Ethnopharmacolgy 143:621\u2013630","journal-title":"J Ethnopharmacolgy"},{"issue":"1","key":"10283_CR1","first-page":"98","volume":"12","author":"R Balaji","year":"2019","unstructured":"Balaji R, Duraisamy R, Kumar MP (2019) Complications of diabetes mellitus: a review. Drug Invention Today 12(1):98\u2013103","journal-title":"Drug Invention Today"},{"key":"10283_CR15","first-page":"23","volume":"2","author":"AB Barakat","year":"2010","unstructured":"Barakat AB, Shoman SA, Dina N, Alfarouk OR (2010) Antiviral activity and mode of action of Dianthus caryophyllus L. and Lupinus termes L. seed extracts against in vitro herpes simplex and hepatitis A virus infection. J Microbiolgy Antimicrobials 2:23\u201329","journal-title":"J Microbiolgy Antimicrobials"},{"key":"10283_CR22","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jep.2004.06.007","volume":"94","author":"S Bonjar","year":"2004","unstructured":"Bonjar S (2004) Evaluation of antibacterial properties of some medicinal plants used in Iran. J Ethnopharmacolgy 94:301\u2013305","journal-title":"J Ethnopharmacolgy"},{"key":"10283_CR51","doi-asserted-by":"crossref","unstructured":"Can A\u011fca A, Altay D, Yilmaz Sar\u0131alt\u0131n S, Bahadir Acikara \u00d6, Sever Yilmaz B, Ko\u00e7 M (2023) Chemical compounds isolated from aerial parts of Bolanthus aziz-sancarii, a new species from T\u00fcrkiye. Nat Prod Res 1\u20137","DOI":"10.1080\/14786419.2023.2293146"},{"issue":"4","key":"10283_CR35","doi-asserted-by":"publisher","first-page":"e01474","DOI":"10.1016\/j.heliyon.2019.e01474","volume":"5","author":"V Capella","year":"2019","unstructured":"Capella V, Rivero RE, Liaudat AC, Ibarra LE, Roma DA, Alustiza F, Ma\u00f1as F, Barbero CA, Bosch P, Rivarola CR, Rodriguez N (2019) Cytotoxicity and bioadhesive properties of poly-N-isopropylacrylamide hydrogel. Heliyon 5(4):e01474","journal-title":"Heliyon"},{"issue":"3","key":"10283_CR11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.imr.2015.06.004","volume":"4","author":"S Chandra","year":"2015","unstructured":"Chandra S, Rawat DS (2015) Medicinal plants of the family Caryophyllaceae: a review of ethno-medicinal uses and pharmacological properties. Integr Med Res 4(3):123\u2013131","journal-title":"Integr Med Res"},{"issue":"10085","key":"10283_CR4","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1016\/S0140-6736(17)30058-2","volume":"389","author":"S Chatterjee","year":"2017","unstructured":"Chatterjee S, Khunti K, Davies MJ (2017) Type 2 diabetes. Lancet 389(10085):2239\u20132251","journal-title":"Lancet"},{"key":"10283_CR71","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.lfs.2015.11.028","volume":"144","author":"JW Choi","year":"2016","unstructured":"Choi JW, Lee CW, Lee J, Choi DJ, Sohng JK, Park YI (2016) 7,8-Dihydroxyflavone inhibits adipocyte differentiation via antioxidant activity and induces apoptosis in 3T3-L1 preadipocyte cells. Life Sci 144:103\u2013112","journal-title":"Life Sci"},{"key":"10283_CR16","first-page":"361","volume":"40","author":"GA Cordell","year":"1977","unstructured":"Cordell GA, Lyon RL, Fong HH, Benoit PS, Farnsworth NR (1977) Biological and phytochemical investigations of Dianthus barbatus Cv. China Doll (Caryophyllaceae). Lloydia 40:361\u2013363","journal-title":"Lloydia"},{"issue":"2","key":"10283_CR72","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/med.20078","volume":"27","author":"C Decaestecker","year":"2007","unstructured":"Decaestecker C, Debeir O, Van Ham P, Kiss R (2007) Can anti-migratory drugs be screened in vitro? A review of 2D and 3D assays for the quantitative analysis of cell migration. Med Res Rev 27(2):149\u2013176","journal-title":"Med Res Rev"},{"issue":"6","key":"10283_CR25","doi-asserted-by":"publisher","first-page":"e0252707","DOI":"10.1371\/journal.pone.0252707","volume":"16","author":"GE Derici","year":"2021","unstructured":"Derici GE, \u00d6zda\u015f S, Canatar \u0130, Ko\u00e7 M (2021) Antidiabetic activities of Bolanthus Spergulifolius (Caryophyllaceae) extracts on insulin-resistant 3T3-L1 adipocytes. PLoS ONE 16(6):e0252707","journal-title":"PLoS ONE"},{"issue":"2","key":"10283_CR13","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s40200-021-00829-9","volume":"20","author":"SS El-Hawary","year":"2021","unstructured":"El-Hawary SS, Mubarek MM, Lotfy RA, Sleem AA, Okba MM (2021) In vivo antidiabetic potential of standardized Gymnocarpos Decandrus Forssk. Extract. J Diabetes Metab Disord 20(2):1129\u20131135","journal-title":"J Diabetes Metab Disord"},{"issue":"3","key":"10283_CR28","first-page":"105","volume":"9","author":"FS Ercan","year":"2020","unstructured":"Ercan FS, Azarkan SY, Ercan N, Koc M (2020) Sequence variants of CYP345a1 and CYP6a14 gene regions in Tribolium castaneum (Coleoptera: Tenebrionidae) adults treated with the novel character\u0131zed Bolanthus turcicus (Caryophyllaceae) extract. Mol Biol Res Commun 9(3):105\u2013110","journal-title":"Mol Biol Res Commun"},{"issue":"2","key":"10283_CR6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2337\/dc23-0800","volume":"47","author":"D Gallardo-G\u00f3mez","year":"2024","unstructured":"Gallardo-G\u00f3mez D, Salazar-Mart\u00ednez E, Alfonso-Rosa RM, Ramos-Munell J, Del Pozo-Cruz J, Del Pozo Cruz B, \u00c1lvarez-Barbosa F (2024) Optimal dose and type of physical activity to \u0131mprove glycemic control in people diagnosed with type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 47(2):295\u2013303","journal-title":"Diabetes Care"},{"issue":"23","key":"10283_CR10","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1080\/14786419.2017.1294174","volume":"31","author":"L Golea","year":"2017","unstructured":"Golea L, Benkhaled M, Lavaud C, Long C, Haba H (2017) Phytochemical components and biological activities of Silene arenarioides Desf. Nat Prod Res 31(23):2801\u20132805","journal-title":"Nat Prod Res"},{"issue":"6","key":"10283_CR78","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.diabet.2014.01.005","volume":"40","author":"R Govers","year":"2014","unstructured":"Govers R (2014) Molecular mechanisms of GLUT4 regulation in adipocytes. Diabetes Metab 40(6):400\u2013410","journal-title":"Diabetes Metab"},{"issue":"6","key":"10283_CR30","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/S0306-3623(98)00238-9","volume":"32","author":"MA Gyamfi","year":"1999","unstructured":"Gyamfi MA, Yonamine M, Aniya Y (1999) Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally-induced liver injuries. Gen Pharmacol 32(6):661\u2013667","journal-title":"Gen Pharmacol"},{"issue":"5","key":"10283_CR26","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3906\/bot-1612-41","volume":"41","author":"E Hamzao\u011flu","year":"2017","unstructured":"Hamzao\u011flu E, Koc M, B\u00fcy\u00fck \u0130 (2017) Dianthus ucarii (Caryophyllaceae): a new species from the northwest of Turkey. Turkish J Bot 41(5):486\u2013492","journal-title":"Turkish J Bot"},{"issue":"1","key":"10283_CR75","doi-asserted-by":"publisher","first-page":"10492","DOI":"10.1038\/s41598-019-47060-4","volume":"9","author":"R Haselgr\u00fcbler","year":"2019","unstructured":"Haselgr\u00fcbler R, Lanzerstorfer P, R\u00f6hrl C, St\u00fcbl F, Schurr J et al (2019) Hypolipidemic effects of herbal extracts by reduction of adipocyte differentiation, intracellular neutral lipid content, lipolysis, fatty acid exchange and lipid droplet motility. Sci Rep 9(1):10492","journal-title":"Sci Rep"},{"issue":"1","key":"10283_CR19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2174\/1871525717666190227231834","volume":"17","author":"M Hebi","year":"2019","unstructured":"Hebi M, Eddouks M (2019) Hypolipidemic and antioxidant activities of Corrigiola telephiifolia in diabetic rats. Cardiovasc Hematol Agents Medcinal Chem 17(1):47\u201351","journal-title":"Cardiovasc Hematol Agents Medcinal Chem"},{"issue":"5","key":"10283_CR67","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1021\/jf062912b","volume":"55","author":"CL Hsu","year":"2007","unstructured":"Hsu CL, Yen GC (2007) Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells. J Agric Food Chem 55(5):1730\u20131736","journal-title":"J Agric Food Chem"},{"issue":"4","key":"10283_CR70","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/10284150290032012","volume":"5","author":"R Jackson","year":"2002","unstructured":"Jackson R, McNeil B, Taylor C, Holl G, Ruff D, Gwebu ET (2002) Effect of aged garlic extract on caspase-3 activity, in vitro. Nutr Neurosci 5(4):287\u2013290","journal-title":"Nutr Neurosci"},{"key":"10283_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2840-4-5","volume":"4","author":"JS Johansen","year":"2005","unstructured":"Johansen JS, Harris AK, Rychly DJ, Ergul A (2005) Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol 4:1\u201311","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"10283_CR42","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1038\/s41467-023-38591-6","volume":"14","author":"S Kalgudde Gopal","year":"2023","unstructured":"Kalgudde Gopal S, Dai R, Stefanska AM, Ansari M (2023) Wound infiltrating adipocytes are not myofibroblasts. Nat Commun 14(1):3020","journal-title":"Nat Commun"},{"key":"10283_CR17","first-page":"305","volume":"5","author":"R Karamian","year":"2013","unstructured":"Karamian R, Ghasemlou F (2013) Screening of total phenol and flavonoid content, antioxidant, and antibacterial activities of the methanolic extracts of three Silene species from Iran. Int J Agric Crop Sci 5:305\u2013312","journal-title":"Int J Agric Crop Sci"},{"key":"10283_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11670-010-0087-7","volume":"22","author":"MA Khan","year":"2010","unstructured":"Khan MA, Tania M, Zhang DZ, Chen HC (2010) Antioxidant enzymes and cancer. Chin J Cancer Res 22:87\u201392","journal-title":"Chin J Cancer Res"},{"issue":"4","key":"10283_CR9","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3906\/bot-1401-40","volume":"38","author":"M Ko\u00e7","year":"2014","unstructured":"Ko\u00e7 M, Hamzao\u011flu E (2014) HernCaucasicacasica (Caryophyllaceae), Cypriusyprius (Polygonaceae), and Potentilla multifida (Rosaceae); 3 new records for Turkey. Turkish J Bot 38(4):819\u2013825","journal-title":"Turkish J Bot"},{"key":"10283_CR27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3897\/phytokeys.52.4479","volume":"52","author":"M Ko\u00e7","year":"2015","unstructured":"Ko\u00e7 M, Hamzao\u011flu E (2015) Bolanthus turcicus (Caryophyllaceae), a new species from Turkey. PhytoKeys 52:81","journal-title":"PhytoKeys"},{"key":"10283_CR41","doi-asserted-by":"crossref","unstructured":"Komakech R, Yim NH, Shim KS, Jung H, Byun JE et al (2022) Root extract of a micropropagated Prunus africana Medicinal plant \u0131nduced apoptosis in human prostate cancer cells (PC-3) via Caspase-3 aactivation. Evid Based Complement Alternat Med 8232851.","DOI":"10.1155\/2022\/8232851"},{"key":"10283_CR76","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/gtc.12747","volume":"25","author":"H Kunitomi","year":"2020","unstructured":"Kunitomi H, Oki Y, Onishi N, Kano K, Banno K, Aoki D et al (2020) The insulin-PI3K-Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics. Genes Cells 25:165\u2013174","journal-title":"Genes Cells"},{"issue":"4","key":"10283_CR48","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.3390\/app13042135","volume":"13","author":"IL Lawag","year":"2023","unstructured":"Lawag IL, Nolden ES, Schaper AAM, Lim LY, Locher C (2023) A Modified Folin-Ciocalteu assay for the determination of total phenolics content in honey. Appl Sci 13(4):2135","journal-title":"Appl Sci"},{"issue":"7","key":"10283_CR69","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.7150\/jca.26380","volume":"10","author":"J Lee","year":"2019","unstructured":"Lee J, Hong EM, Kim JH, Jung JH, Park SW, Koh DH et al (2019) Metformin \u0131nduces apoptosis and \u0131nhibits proliferation through the AMP-Activated protein kinase and \u0131nsulin-like growth factor 1 receptor pathways in the bile duct cancer cells. J Cancer 10(7):1734\u20131744","journal-title":"J Cancer"},{"issue":"2","key":"10283_CR39","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nprot.2007.30","volume":"2","author":"CC Liang","year":"2007","unstructured":"Liang CC, Park AY, Guan JL (2007) In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2(2):329\u2013333","journal-title":"Nat Protoc"},{"issue":"4","key":"10283_CR45","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"key":"10283_CR62","doi-asserted-by":"publisher","first-page":"111423","DOI":"10.1016\/j.indcrop.2019.05.072","volume":"138","author":"YH Lu","year":"2019","unstructured":"Lu YH, Tian CR, Gao CY, Wang XY, Yang X, Chen YX, Liu ZZ (2019) Phenolic profile, antioxidant and enzyme inhibitory activities of Ottelia Acuminata, an endemic plant from southwestern China. Ind Crop Prod 138:111423","journal-title":"Ind Crop Prod"},{"issue":"12","key":"10283_CR52","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.1096\/fj.15-277731","volume":"29","author":"M Magnone","year":"2015","unstructured":"Magnone M, Ameri P, Salis A, Andraghetti G, Emionite L et al (2015) Microgram amounts of abscisic acid in fruit extracts improve glucose tolerance and reduce insulinemia in rats and in humans. FASEB J 29(12):4783\u20134793","journal-title":"FASEB J"},{"issue":"24","key":"10283_CR12","doi-asserted-by":"publisher","first-page":"8781","DOI":"10.3390\/molecules27248781","volume":"27","author":"MM Makhmudova","year":"2022","unstructured":"Makhmudova MM, Bacher M, Zengin G, Rosenau T, Youssef FS, Almasri DM, Elhady SS, Mamadalieva NZ (2022) Silviridoside: a new triterpene glycoside from Silene Viridiflora with promising antioxidant and enzyme \u0131nhibitory potential. Molecules 27(24):8781","journal-title":"Molecules"},{"issue":"17","key":"10283_CR7","doi-asserted-by":"publisher","first-page":"354","DOI":"10.4239\/wjd.v7.i17.354","volume":"7","author":"JJ Mar\u00edn-Pe\u00f1alver","year":"2016","unstructured":"Mar\u00edn-Pe\u00f1alver JJ, Mart\u00edn-Tim\u00f3n I, Sevillano-Collantes C, del Ca\u00f1izo-G\u00f3mez FJ (2016) Update on the treatment of type 2 diabetes mellitus. World J Diabetes 7(17):354","journal-title":"World J Diabetes"},{"key":"10283_CR77","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.1002\/jcp.27157","volume":"234","author":"L Mor-Yossef Moldovan","year":"2019","unstructured":"Mor-Yossef Moldovan L, Lustig M, Naftaly A, Mardamshina M, Geiger T, Gefen A et al (2019) Cell shape alteration during adipogenesis is associated with coordinated matrix cues. J Cell Physiol 234:3850\u20133863","journal-title":"J Cell Physiol"},{"issue":"7","key":"10283_CR81","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.2337\/db16-0221","volume":"65","author":"PM Moraes-Vieira","year":"2016","unstructured":"Moraes-Vieira PM, Saghatelian A, Kahn BB (2016) GLUT4 expression in adipocytes regulates de novo lipogenesis and levels of a novel class of lipids with antidiabetic and anti-inflammatory effects. Diabetes 65(7):1808\u20131815","journal-title":"Diabetes"},{"issue":"3","key":"10283_CR65","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/oby.21377","volume":"24","author":"LA Muir","year":"2016","unstructured":"Muir LA, Neeley CK, Meyer KA, Baker NA, Brosius AM et al (2016) Adipose tissue fibrosis, hypertrophy, and hyperplasia: correlations with diabetes in human obesity. Obes (Silver Spring) 24(3):597\u2013605","journal-title":"Obes (Silver Spring)"},{"issue":"7","key":"10283_CR55","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.3390\/ijms22073380","volume":"22","author":"IG Munteanu","year":"2021","unstructured":"Munteanu IG, Apetrei C (2021) Analytical methods used in determining antioxidant activity: a review. Int J Mol Sci 22(7):3380","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10283_CR68","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1172\/JCI1235","volume":"101","author":"A Okuno","year":"1998","unstructured":"Okuno A, Tamemoto H, Tobe K, Ueki K, Mori Y et al (1998) Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 101(6):1354\u20131361","journal-title":"J Clin Invest"},{"issue":"10397","key":"10283_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","volume":"402","author":"KL Ong","year":"2023","unstructured":"Ong KL, Stafford LK, McLaughlin SA, Boyko EJ, Vollset SE, Smith AE et al (2023) Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of Disease Study 2021. Lancet 402(10397):203\u2013234","journal-title":"Lancet"},{"key":"10283_CR59","doi-asserted-by":"publisher","first-page":"44","DOI":"10.4103\/japtr.JAPTR_98_19","volume":"11","author":"S Patra","year":"2020","unstructured":"Patra S, Bhattacharya S, Bala A, Haldar P (2020) Antidiabetic effect of Drymaria cordata leaf against streptozotocin\u2013nicotinamide-induced diabetic albino rats. J Adv Pharm Tech Res 11:44\u201352","journal-title":"J Adv Pharm Tech Res"},{"issue":"3","key":"10283_CR40","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/molecules24030524","volume":"24","author":"MJ Predebon","year":"2019","unstructured":"Predebon MJ, Bond DR, Brzozowski J, Jankowski H, Deane F et al (2019) The Bispidinone derivative 3,7-Bis-[2-(S)-amino-3-(1H-indol-3-yl)-propionyl]-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one dihydrochloride \u0131nduces an apoptosis-mediated cytotoxic effect on pancreatic cancer cells \u0131n vitro. Molecules 24(3):524","journal-title":"Molecules"},{"issue":"12","key":"10283_CR58","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1080\/10408398.2020.1862755","volume":"62","author":"C Proen\u00e7a","year":"2022","unstructured":"Proen\u00e7a C, Ribeiro D, Freitas M, Fernandes E (2022) Flavonoids as potential agents in the management of type 2 diabetes through the modulation of \u03b1-amylase and \u03b1-glucosidase activity: a review. Crit Rev Food Sci Nutr 62(12):3137\u20133207","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10283_CR63","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/1472-6882-12-145","volume":"12","author":"N Rani","year":"2012","unstructured":"Rani N, Vasudeva N, Sharma SK (2012) Quality assessment and anti-obesity activity of Stellaria media (Linn.) Vill. BMC Complement Altern Med 12:145","journal-title":"BMC Complement Altern Med"},{"key":"10283_CR44","doi-asserted-by":"crossref","unstructured":"Rio DC, Ares M Jr, Hannon GJ, Nilsen TW (2010) Purification of RNA using TRIzol (TRI reagent). Cold Spring Harb Protoc (6):pdbprot5439","DOI":"10.1101\/pdb.prot5439"},{"issue":"2","key":"10283_CR36","first-page":"127","volume":"5","author":"H Sadeghi-Aliabadi","year":"2011","unstructured":"Sadeghi-Aliabadi H, Minaiyan M, Dabestan A (2011) Cytotoxic evaluation of doxorubicin in combination with simvastatin against human cancer cells. Res Pharm Sci 5(2):127\u2013133","journal-title":"Res Pharm Sci"},{"key":"10283_CR37","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/mrd.22489","volume":"82","author":"J Schindelin","year":"2015","unstructured":"Schindelin J, Rueden C, Hiner M, Eliceiri K (2015) The ImageJ ecosystem: an open platform for biomedical image analysis. Mol Reprod Dev 82:518\u2013529","journal-title":"Mol Reprod Dev"},{"key":"10283_CR61","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.sajb.2018.02.001","volume":"120","author":"V Sekar","year":"2019","unstructured":"Sekar V, Chakraborty S, Mani S, SaliV, Vasanthi H (2019) Mangiferin from Mangifera indica fruits reduces post-prandial glucose level by inhibiting \u03b1-glucosidase and \u03b1-amylase activity. South Afr J Bot 120:129\u2013134","journal-title":"South Afr J Bot"},{"issue":"4","key":"10283_CR8","first-page":"59","volume":"4","author":"AK Shakya","year":"2016","unstructured":"Shakya AK (2016) Medicinal plants: future source of new drugs. Int J Herb Med 4(4):59\u201364","journal-title":"Int J Herb Med"},{"issue":"3","key":"10283_CR33","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jep.2009.05.006","volume":"124","author":"XS Shu","year":"2009","unstructured":"Shu XS, Lv JH, Tao J, Li GM, Li HD, Ma N (2009) Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan-induced diabetic rats. J Ethnopharmacol 124(3):539\u2013543","journal-title":"J Ethnopharmacol"},{"key":"10283_CR29","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","volume":"299","author":"VL Singleton","year":"1999","unstructured":"Singleton VL, Orthofer R, Lamuela-Raventos RM (1999) Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299:152\u2013178","journal-title":"Methods Enzymol"},{"issue":"2","key":"10283_CR50","doi-asserted-by":"publisher","first-page":"425","DOI":"10.36899\/JAPS.2023.2.0634","volume":"33","author":"GD S\u00f6nmez","year":"2023","unstructured":"S\u00f6nmez GD (2023) Evaluat\u0131on of the phytochem\u0131cal propert\u0131es and DNA protect\u0131ve act\u0131v\u0131ty of Bolanthus orteg\u0131o\u0131des (f\u0131sch. And c.a. Mey.) madhan\u0131 and rabeler. J Anim Plant Sci 33(2):425\u2013433","journal-title":"J Anim Plant Sci"},{"issue":"11","key":"10283_CR60","doi-asserted-by":"publisher","first-page":"e48589","DOI":"10.1371\/journal.pone.0048589","volume":"7","author":"PM Souza","year":"2012","unstructured":"Souza PM, Elias ST, Simeoni LA, de Paula JE, Gomes SM, Guerra ENS (2012) Plants from Brazilian cerrado with potent tyrosinase inhibitory activity. PLoS ONE 7(11):e48589","journal-title":"PLoS ONE"},{"issue":"18","key":"10283_CR64","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.1002\/jssc.200700261","volume":"30","author":"CD Stalikas","year":"2007","unstructured":"Stalikas CD (2007) Extraction, separation, and detection methods for phenolic acids and flavonoids. J Sep Sci 30(18):3268\u20133295","journal-title":"J Sep Sci"},{"issue":"7","key":"10283_CR43","doi-asserted-by":"publisher","first-page":"e0232565","DOI":"10.1371\/journal.pone.0232565","volume":"15","author":"A Suarez-Arnedo","year":"2020","unstructured":"Suarez-Arnedo A, Torres Figueroa F, Clavijo C, Arbel\u00e1ez P, Cruz JC et al (2020) An image J plugin for the high throughput image analysis of in vitro scratch wound healing assays. PLoS ONE 15(7):e0232565","journal-title":"PLoS ONE"},{"issue":"4\u20135","key":"10283_CR49","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jfca.2011.01.020","volume":"24","author":"SF Sulaiman","year":"2011","unstructured":"Sulaiman SF, Sajak AAB, Supriatno KLO, Seow EM (2011) Effect of solvents in extracting polyphenols and antioxidants of selected raw vegetables. J Food Compos Anal 24(4\u20135):506\u2013515","journal-title":"J Food Compos Anal"},{"issue":"1","key":"10283_CR74","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1073\/pnas.0137044100","volume":"100","author":"QQ Tang","year":"2003","unstructured":"Tang QQ, Otto TC, Lane MD (2003) Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci USA 100(1):44\u201349","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10283_CR46","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12033-013-9672-6","volume":"55","author":"SC Taylor","year":"2013","unstructured":"Taylor SC, Berkelman T, Yadav G, Hammond M (2013) A defined methodology for reliable quantification of Western blot data. Mol Biotechnol 55(3):217\u2013226","journal-title":"Mol Biotechnol"},{"key":"10283_CR57","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.fct.2018.01.049","volume":"113","author":"S Uysal","year":"2018","unstructured":"Uysal S, Aktumsek A, Picot-Allain CMN, Unuvar H, Mollica A, Georgiev MI, Zengin G, Mahomoodally MF (2018) Biological, chemical and in silico fingerprints of Dianthus Calocephalus Boiss.: a novel source for rutin. Food Chem Toxicol 113:179\u2013186","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"10283_CR47","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/ptr.5528","volume":"30","author":"R Vinayagam","year":"2016","unstructured":"Vinayagam R, Jayachandran M, Xu B (2016) Antidiabetic effects of simple phenolic acids: a Comprehensive Review. Phytother Res 30(2):184\u2013199","journal-title":"Phytother Res"},{"issue":"4","key":"10283_CR56","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3390\/molecules23040879","volume":"23","author":"XJ Yang","year":"2018","unstructured":"Yang XJ, Dang B, Fan MT (2018) Free and bound phenolic compound content and antioxidant activity of different cultivated blue highland barley varieties from the Qinghai-Tibet Plateau. Molecules 23(4):879","journal-title":"Molecules"},{"issue":"3","key":"10283_CR20","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3390\/nu11030553","volume":"11","author":"JJ Yoon","year":"2019","unstructured":"Yoon JJ, Park JH, Kim HJ, Jin HG, Kim HY, Ahn YM et al (2019) Dianthus superbus \u0131mproves glomerular fibrosis and renal dysfunction in diabetic nephromodel Model. Nutrients 11(3):553","journal-title":"Nutrients"},{"issue":"1","key":"10283_CR34","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ab.2012.03.005","volume":"425","author":"K Zebisch","year":"2012","unstructured":"Zebisch K, Voigt V, Wabitsch M, Brandsch M (2012) Protocol for effective differentiation of 3T3-L1 cells to adipocytes. Anal Biochem 425(1):88\u201390","journal-title":"Anal Biochem"},{"key":"10283_CR18","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.compbiolchem.2018.10.005","volume":"77","author":"G Zengin","year":"2018","unstructured":"Zengin G, Rodrigues MJ, Abdallah HH, Custodio L, Stefanucci A, Aumeeruddy MZ, Mollica A, Rengasamy KRR, Mahomoodally MF (2018) Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene Salsuginea from Turkey. Comput Biol Chem 77:178\u2013186","journal-title":"Comput Biol Chem"},{"key":"10283_CR31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.foodchem.2016.03.079","volume":"208","author":"L Zhang","year":"2016","unstructured":"Zhang L, Tu ZC, Yuan T, Wang H, Xie X, Fu ZF (2016) Antioxidants and \u03b1-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships. Food Chem 208:61\u201367","journal-title":"Food Chem"},{"issue":"2","key":"10283_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Ley SH, Hu FB (2018) Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Reviews Endocrinol 14(2):88\u201398","journal-title":"Nat Reviews Endocrinol"},{"key":"10283_CR3","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3389\/fphar.2019.00586","volume":"10","author":"W Zhu","year":"2019","unstructured":"Zhu W, Huang W, Xu Z, Cao M, Hu Q, Pan C et al (2019) Analysis of patents issued in China for antihyperglycemic therapies for type 2 diabetes mellitus. Front Pharmacol 10:586","journal-title":"Front Pharmacol"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-024-10283-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-024-10283-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-024-10283-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T02:59:26Z","timestamp":1738810766000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-024-10283-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10283"],"URL":"https:\/\/doi.org\/10.1007\/s10735-024-10283-5","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]},"assertion":[{"value":"19 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human or animal rights statement"}},{"value":"The authors have no relevant interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"59"}}