{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:23:33Z","timestamp":1787235813048,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH288"],"award-info":[{"award-number":["ZR2021MH288"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Province Medical and Health Science and Technology Development Program","award":["2016WS0438"],"award-info":[{"award-number":["2016WS0438"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s10735-024-10331-0","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T22:08:22Z","timestamp":1735337302000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the immune system maternal-fetal interface during palatal development"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9037-0474","authenticated-orcid":false,"given":"Wang","family":"Yongkai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2280-6172","authenticated-orcid":false,"given":"Zhang","family":"Shuhui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-2007","authenticated-orcid":false,"given":"Ma","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"10331_CR1","doi-asserted-by":"publisher","first-page":"575197","DOI":"10.3389\/fimmu.2020.575197","volume":"11","author":"B Abu-Raya","year":"2020","unstructured":"Abu-Raya B, Michalski C, Sadarangani M, Lavoie PM (2020) Maternal immunological adaptation during normal pregnancy. Front Immunol 11:575197. https:\/\/doi.org\/10.3389\/fimmu.2020.575197","journal-title":"Front Immunol"},{"key":"10331_CR2","doi-asserted-by":"publisher","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","volume":"218","author":"GJ Burton","year":"2018","unstructured":"Burton GJ, Jauniaux E (2018) Pathophysiology of placental-derived fetal growth restriction. Am J Obstet Gynecol 218:S745\u2013S761. https:\/\/doi.org\/10.1016\/j.ajog.2017.11.577","journal-title":"Am J Obstet Gynecol"},{"key":"10331_CR3","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1177\/15353702211012288","volume":"246","author":"Y Chen","year":"2021","unstructured":"Chen Y, Liu X, Liu X, Cui L, He Z, Gao Z, Liu L et al (2021) Correlation between TGF-\u03b22\/3 promoter DNA methylation and smad signaling during palatal fusion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Exp Biol Med (Maywood) 246:2019\u20132028. https:\/\/doi.org\/10.1177\/15353702211012288","journal-title":"Exp Biol Med (Maywood)"},{"key":"10331_CR4","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1093\/toxres\/tfac068","volume":"11","author":"Q Chen","year":"2022","unstructured":"Chen Q, Xie Y, Dong X, Zhang X, Zhang Y, Yuan X, Ding X et al (2022) TCDD induces cleft palate through exosomes derived from mesenchymal cells. Toxicol Res (Camb) 11:901\u2013910. https:\/\/doi.org\/10.1093\/toxres\/tfac068","journal-title":"Toxicol Res (Camb)"},{"key":"10331_CR5","doi-asserted-by":"publisher","first-page":"11801","DOI":"10.3390\/ijms222111801","volume":"22","author":"N Dopkins","year":"2021","unstructured":"Dopkins N, Neameh WH, Hall A, Lai Y, Rutkovsky A, Gandy AO, Lu K et al (2021) Effects of Acute 2,3,7,8-Tetrachlorodibenzo-p-Dioxin exposure on the circulating and Cecal Metabolome Profile. Int J Mol Sci 22:11801. https:\/\/doi.org\/10.3390\/ijms222111801","journal-title":"Int J Mol Sci"},{"key":"10331_CR6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1177\/01926233211042270","volume":"50","author":"SA Elmore","year":"2022","unstructured":"Elmore SA, Cochran RZ, Bolon B, Lubeck B, Mahler B, Sabio D, Ward JM (2022) Histology Atlas of the Developing Mouse Placenta. Toxicol Pathol 50:60\u2013117. https:\/\/doi.org\/10.1177\/01926233211042270","journal-title":"Toxicol Pathol"},{"key":"10331_CR7","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/humupd\/dmp004","volume":"15","author":"LR Guerin","year":"2009","unstructured":"Guerin LR, Prins JR, Robertson SA (2009) Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update 15:517\u2013535. https:\/\/doi.org\/10.1093\/humupd\/dmp004","journal-title":"Hum Reprod Update"},{"key":"10331_CR8","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.bcp.2008.10.030","volume":"77","author":"R Ishimura","year":"2009","unstructured":"Ishimura R, Kawakami T, Ohsako S, Tohyama C (2009) Dioxin-induced toxicity on vascular remodeling of the placenta. Biochem Pharmacol 77:660\u2013669. https:\/\/doi.org\/10.1016\/j.bcp.2008.10.030","journal-title":"Biochem Pharmacol"},{"key":"10331_CR9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.toxrep.2021.12.011","volume":"9","author":"H Kakutani","year":"2022","unstructured":"Kakutani H, Yuzuriha T, Nakao T, Ohta S (2022) Long-term orally exposure of dioxins affects antigen-specific antibody production in mice. Toxicol Rep 9:53\u201357. https:\/\/doi.org\/10.1016\/j.toxrep.2021.12.011","journal-title":"Toxicol Rep"},{"key":"10331_CR10","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/SAP.0b013e318295dcb8","volume":"74","author":"L Ma","year":"2015","unstructured":"Ma L, Shi B, Zheng Q (2015) Targeted mutations of genes reveal important roles in palatal development in mice. Ann Plast Surg 74:263\u2013268. https:\/\/doi.org\/10.1097\/SAP.0b013e318295dcb8","journal-title":"Ann Plast Surg"},{"key":"10331_CR11","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/SCS.0000000000004055","volume":"29","author":"L Ma","year":"2018","unstructured":"Ma L, Shi B, Zheng Q (2018) Cell polarity and PAR complex likely to be involved in Dexamethasone-Induced Cleft Palate. J Craniofac Surg 29:260\u2013263. https:\/\/doi.org\/10.1097\/SCS.0000000000004055","journal-title":"J Craniofac Surg"},{"key":"10331_CR12","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1749-6632.2010.05938.x","volume":"1221","author":"G Mor","year":"2011","unstructured":"Mor G, Cardenas I, Abrahams V, Guller S (2011) Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci 1221:80\u201387. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05938.x","journal-title":"Ann N Y Acad Sci"},{"key":"10331_CR13","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3390\/cells11030568","volume":"11","author":"MA Ortega","year":"2022","unstructured":"Ortega MA, Fraile-Mart\u00ednez O, Garc\u00eda-Montero C, S\u00e1ez MA, \u00c1lvarez-Mon MA, Torres-Carranza D, \u00c1lvarez-Mon M et al (2022) The pivotal role of the Placenta in Normal and pathological pregnancies: a focus on Preeclampsia, fetal growth restriction, and maternal chronic venous disease. Cells 11:568. https:\/\/doi.org\/10.3390\/cells11030568","journal-title":"Cells"},{"key":"10331_CR15","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1016\/j.jcms.2018.09.016","volume":"46","author":"C Sakuma","year":"2018","unstructured":"Sakuma C, Imura H, Yamada T, Sugahara T, Hirata A, Ikeda Y, Natsume N (2018) Cleft palate formation after palatal fusion occurs due to the rupture of epithelial basement membranes. J Craniomaxillofac Surg 46:2027\u20132031. https:\/\/doi.org\/10.1016\/j.jcms.2018.09.016","journal-title":"J Craniomaxillofac Surg"},{"key":"10331_CR14","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.3390\/ijms23042069","volume":"23","author":"C Sakuma","year":"2022","unstructured":"Sakuma C, Imura H, Yamada T, Hirata A, Ikeda Y, Ito M, Natsume N (2022) Histological and Immunohistochemical Studies to determine the mechanism of cleft palate induction after Palatal Fusion in mice exposed to TCDD. Int J Mol Sci 23:2069. https:\/\/doi.org\/10.3390\/ijms23042069","journal-title":"Int J Mol Sci"},{"key":"10331_CR16","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1242\/dev.020099","volume":"135","author":"DG Simmons","year":"2008","unstructured":"Simmons DG, Natale DR, Begay V, Hughes M, Leutz A, Cross JC (2008) Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. Development 135:2083\u20132091. https:\/\/doi.org\/10.1242\/dev.020099","journal-title":"Development"},{"key":"10331_CR17","doi-asserted-by":"publisher","unstructured":"Sykes L, MacIntyre DA, Yap XJ, Ponnampalam S, Teoh TG, Bennett PR (2012) Changes in the Th1: Th2 cytokine Bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-\u2206(12,14)-prostaglandin J2. Mediators Inflamm 2012(416739). https:\/\/doi.org\/10.1155\/2012\/416739","DOI":"10.1155\/2012\/416739"},{"key":"10331_CR18","doi-asserted-by":"publisher","first-page":"152444","DOI":"10.1016\/j.tox.2020.152444","volume":"438","author":"Y Tao","year":"2020","unstructured":"Tao Y, Liu X, Cui L, Liu X, Chen Y, He Z, Ji M et al (2020) Oct4 plays a role in 2, 3, 7, 8\u2014Tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation. Toxicology 438:152444. https:\/\/doi.org\/10.1016\/j.tox.2020.152444","journal-title":"Toxicology"},{"key":"10331_CR19","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.3389\/fimmu.2020.02025","volume":"11","author":"W Wang","year":"2020","unstructured":"Wang W, Sung N, Gilman-Sachs A, Kwak-Kim J (2020) T helper (th) cell profiles in pregnancy and recurrent pregnancy losses: Th1\/Th2\/Th9\/Th17\/Th22\/Tfh cells. Front Immunol 11:2025. https:\/\/doi.org\/10.3389\/fimmu.2020.02025","journal-title":"Front Immunol"},{"key":"10331_CR20","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.3892\/etm.2019.8354","volume":"19","author":"WL Xiao","year":"2020","unstructured":"Xiao WL, Yu G, Zhao N (2020) Development and gene expression of C57BL\/6 mouse embryo palate shelves in rotary organ culture. Exp Ther Med 19:1235\u20131242. https:\/\/doi.org\/10.3892\/etm.2019.8354","journal-title":"Exp Ther Med"},{"key":"10331_CR22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1741-4520.2006.00097.x","volume":"46","author":"T Yamada","year":"2006","unstructured":"Yamada T, Mishima K, Fujiwara K, Imura H, Sugahara T (2006) Cleft lip and palate in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: a morphological in vivo study. Congenit Anom (Kyoto) 46:21\u201325. https:\/\/doi.org\/10.1111\/j.1741-4520.2006.00097.x","journal-title":"Congenit Anom (Kyoto)"},{"key":"10331_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcms.2013.01.024","volume":"42","author":"T Yamada","year":"2014","unstructured":"Yamada T, Hirata A, Sasabe E, Yoshimura T, Ohno S, Kitamura N, Yamamoto T (2014) TCDD disrupts posterior palatogenesis and causes cleft palate. J Craniomaxillofac Surg 42:1\u20136. https:\/\/doi.org\/10.1016\/j.jcms.2013.01.024","journal-title":"J Craniomaxillofac Surg"},{"key":"10331_CR23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12940-018-0365-2","volume":"17","author":"M Ye","year":"2018","unstructured":"Ye M, Warner M, Mocarelli P, Brambilla P, Eskenazi B (2018) Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study. Environ Health 17:22. https:\/\/doi.org\/10.1186\/s12940-018-0365-2","journal-title":"Environ Health"},{"key":"10331_CR25","doi-asserted-by":"publisher","first-page":"5396","DOI":"10.3892\/mmr.2018.8521","volume":"17","author":"W Zhang","year":"2018","unstructured":"Zhang W, Zhou S, Gao Y, Song H, Jiao X, Wang X, Li Y (2018) Alterations in DNA methyltransferases and methyl-CpG binding domain proteins during cleft palate formation as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice. Mol Med Rep 17:5396\u20135401. https:\/\/doi.org\/10.3892\/mmr.2018.8521","journal-title":"Mol Med Rep"},{"key":"10331_CR24","doi-asserted-by":"publisher","first-page":"826053","DOI":"10.3389\/fcell.2022.826053","volume":"10","author":"S Zhang","year":"2022","unstructured":"Zhang S, Ding J, Zhang Y, Liu S, Yang J, Yin T (2022) Regulation and function of chemokines at the maternal\u2013fetal interface. Front Cell Dev Biol 10:826053. https:\/\/doi.org\/10.3389\/fcell.2022.826053","journal-title":"Front Cell Dev Biol"},{"key":"10331_CR26","doi-asserted-by":"publisher","first-page":"108731","DOI":"10.1016\/j.reprotox.2024.108731","volume":"130","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Xu D, Song S, Wang G, Su H, Wu Y, Zhang Y et al (2023) AKT\/mTOR-mediated autophagic signaling is associated with TCDD-induced cleft palate. Reprod Toxicol 130:108731. https:\/\/doi.org\/10.1016\/j.reprotox.2024.108731","journal-title":"Reprod Toxicol"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-024-10331-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-024-10331-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-024-10331-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T21:28:15Z","timestamp":1738790895000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-024-10331-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10331"],"URL":"https:\/\/doi.org\/10.1007\/s10735-024-10331-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5190161\/v1","asserted-by":"object"}]},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"2 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All mice experimental operations were approved by the Shandong Provincial Hospital Affiliated to Shandong First Medical University Laboratory Animal Ethics Review Committee (No.2019\u2009\u2212\u2009299).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"60"}}