{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:13:17Z","timestamp":1785910397657,"version":"3.56.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s10735-025-10374-x","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T03:00:09Z","timestamp":1741143609000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Protective effects of vincamine against ethanol-induced gastric ulcer by attenuation of IL-6, IL-1\u03b2, and TNF-\u03b1 mRNA expression levels in the gastric mucosa of BALB\/c mice"],"prefix":"10.1007","volume":"56","author":[{"given":"Hira","family":"Imam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-830X","authenticated-orcid":false,"given":"Arham","family":"Shabbir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anum","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel Masood","family":"Butt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabinda","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa M.","family":"Haji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan K.","family":"Alswailmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali F.","family":"Almutairy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mujeeb Ur Rehman","family":"Parrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashfaq","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"10374_CR1","doi-asserted-by":"crossref","first-page":"105926","DOI":"10.1016\/j.jff.2023.105926","volume":"112","author":"ER Abdelaleem","year":"2024","unstructured":"Abdelaleem ER, Abdelwahab MF, Abdel-Wahab NM, Abu-Baih DH, Zaher AMA, Altemani FH, Algehainy NA, Abdelmohsen UR, Bakhsh HT, Mokhtar FA (2024) Apple extract protects against indomethacin-induced gastric ulcers in rats by suppressing oxidative stress\u2013the implication of Nrf-2\/HO-1 signaling pathway: in silico and in vivo studies. J Funct Foods 112:105926","journal-title":"J Funct Foods"},{"key":"10374_CR2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1139\/cjpp-2014-0236","volume":"92","author":"A Ahmad","year":"2014","unstructured":"Ahmad A, Sattar MA, Rathore HA, Abdulla MH, Khan SA, Abdullah NA, Kaur G, Johns EJ (2014) Functional contribution of \u03b11D-adrenoceptors in the renal vasculature of left ventricular hypertrophy induced with isoprenaline and caffeine in Wistar-Kyoto rats. Can J Physiol Pharmacol 92:1029\u20131035","journal-title":"Can J Physiol Pharmacol"},{"key":"10374_CR3","first-page":"31","volume":"67","author":"A Ahmad","year":"2016","unstructured":"Ahmad A, Sattar M, Rathore H, Abdulla M, Khan S, Abdullah N, Johns E (2016a) Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated Wistar-Kyoto rats. J Physiol Pharmacol 67:31\u201344","journal-title":"J Physiol Pharmacol"},{"key":"10374_CR4","doi-asserted-by":"crossref","first-page":"e0150137","DOI":"10.1371\/journal.pone.0150137","volume":"11","author":"A Ahmad","year":"2016","unstructured":"Ahmad A, Sattar MA, Rathore HA, Abdulla MH, Khan SA, Azam M, Abdullah NA, Johns EJ (2016b) Up Regulation of cystathione \u03b3 lyase and hydrogen sulphide in the myocardium inhibits the progression of isoproterenol-caffeine induced left ventricular hypertrophy in wistar kyoto rats. PLoS ONE 11:e0150137","journal-title":"PLoS ONE"},{"key":"10374_CR5","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.3390\/molecules24183233","volume":"24","author":"SS Ahmad","year":"2019","unstructured":"Ahmad SS, Khan H, Danish Rizvi SM, Ansari SA, Ullah R, Rastrelli L, Mahmood HM, Siddiqui MH (2019) Computational study of natural compounds for the clearance of amyloid-\u03b2eta: a potential therapeutic management strategy for Alzheimer\u2019s disease. Molecules 24:3233","journal-title":"Molecules"},{"key":"10374_CR6","doi-asserted-by":"crossref","first-page":"8675275","DOI":"10.1155\/2020\/8675275","volume":"2020","author":"T Akhtar","year":"2020","unstructured":"Akhtar T, Ali G, Sheikh N (2020) Immunosuppressant-induced oxidative stress and iron: a paradigm shift from systemic to intrahepatic abnormalities. Oxid Med Cell Longev 2020:8675275","journal-title":"Oxid Med Cell Longev"},{"key":"10374_CR7","doi-asserted-by":"crossref","first-page":"19572","DOI":"10.1038\/s41598-024-69729-1","volume":"14","author":"R Alaaeldin","year":"2024","unstructured":"Alaaeldin R, Mohyeldin RH, Sharata EE, Attya ME, Fathy M (2024) Vincamine exerts hepato-protective activity during colon ligation puncture-induced sepsis by modulating oxidative stress, apoptosis, and TNF\u03b1\/Nrf-2\/Keap-1 signaling pathways. Sci Rep 14:19572","journal-title":"Sci Rep"},{"key":"10374_CR8","doi-asserted-by":"crossref","first-page":"118617","DOI":"10.1016\/j.jep.2024.118617","volume":"335","author":"DE Ali","year":"2024","unstructured":"Ali DE, El-Shiekh RA, el Sawy MA, Khalifa AA, Elblehi SS, Elsokkary NH, Ali MA (2024a) In vivo anti-gastric ulcer activity of 7-O-methyl aromadendrin and sakuranetin via mitigating inflammatory and oxidative stress trails. J Ethnopharmacol 335:118617","journal-title":"J Ethnopharmacol"},{"key":"10374_CR9","doi-asserted-by":"crossref","first-page":"117115","DOI":"10.1016\/j.jep.2023.117115","volume":"30","author":"NB Ali","year":"2024","unstructured":"Ali NB, Ibrahim SS, Alsherbiny MA, Sheta E, El-Shiekh RA, Ashour RM, El-Gazar AA, Ragab GM, El-Gayed SH, Li CG, Abdel-Sattar E (2024b) Gastroprotective potential of red onion (Allium cepa L.) peel in ethanol-induced gastric injury in rats: involvement of Nrf2\/HO-1 and HMGB-1\/NF-\u03baB trajectories. J Ethnopharmacol 30:117115","journal-title":"J Ethnopharmacol"},{"key":"10374_CR10","doi-asserted-by":"crossref","first-page":"3643824","DOI":"10.1155\/2016\/3643824","volume":"2016","author":"SB Almasaudi","year":"2016","unstructured":"Almasaudi SB, El-Shitany NA, Abbas AT, Abdel-dayem UA, Ali SS, Al Jaouni SK, Harakeh S (2016) Antioxidant, anti-inflammatory, and antiulcer potential of manuka honey against gastric ulcer in rats. Oxid Med Cell Longev 2016:3643824","journal-title":"Oxid Med Cell Longev"},{"key":"10374_CR11","doi-asserted-by":"crossref","first-page":"104626","DOI":"10.1016\/j.bioorg.2021.104626","volume":"107","author":"S Al-Rashed","year":"2021","unstructured":"Al-Rashed S, Baker A, Ahmad SS, Syed A, Bahkali AH, Elgorban AM, Khan MS (2021) Vincamine, a safe natural alkaloid, represents a novel anticancer agent. Bioorg Chem 107:104626\u2013104637","journal-title":"Bioorg Chem"},{"key":"10374_CR12","doi-asserted-by":"crossref","first-page":"e0122417","DOI":"10.1371\/journal.pone.0122417","volume":"10","author":"HH Arab","year":"2015","unstructured":"Arab HH, Salama SA, Omar HA, Arafa E-SA, Maghrabi IA (2015) Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions. PLoS ONE 10:e0122417","journal-title":"PLoS ONE"},{"key":"10374_CR13","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jscs.2011.02.008","volume":"16","author":"S-EN Ayyad","year":"2012","unstructured":"Ayyad S-EN, Basaif SA, Al-Saggaf AT, Alarif WM (2012) Vincamine and 14-epi-vincamine indole alkaloids from Ambelania occidentalis. J Saudi Chem Soc 16:419\u2013422","journal-title":"J Saudi Chem Soc"},{"key":"10374_CR14","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.biopha.2018.12.002","volume":"110","author":"RS Aziz","year":"2019","unstructured":"Aziz RS, Siddiqua A, Shahzad M, Shabbir A, Naseem N (2019) Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-\u03b1, NF-\u0138B, and COX-2 levels, and upregulation of TFF-2 levels. Biomed Pharmacother 110:554\u2013560","journal-title":"Biomed Pharmacother"},{"key":"10374_CR15","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1136\/bmj.323.7319.980","volume":"323","author":"J Calam","year":"2001","unstructured":"Calam J, Baron J (2001) Pathophysiology of duodenal and gastric ulcer and gastric cancer. BMJ 323:980\u2013982","journal-title":"BMJ"},{"key":"10374_CR16","doi-asserted-by":"crossref","unstructured":"CHAI, J. 2011. Gastric ulcer healing-Role of serum response factor. Peptic Ulcer Disease. Rijeka, Croatia: InTech, 143\u201364.","DOI":"10.5772\/17410"},{"key":"10374_CR17","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.ijbiomac.2020.05.163","volume":"159","author":"W Chen","year":"2020","unstructured":"Chen W, Wu D, Jin Y, Li Q, Liu Y, Qiao X, Zhang J, Dong G, Li Z, Li T (2020) Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats. Int J Biol Macromol 159:948\u2013956","journal-title":"Int J Biol Macromol"},{"key":"10374_CR18","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.3748\/wjg.v19.i39.6529","volume":"19","author":"M Cicala","year":"2013","unstructured":"Cicala M, Emerenziani S, Guarino MPL, Ribolsi M (2013) Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease. World J Gastroenterol: WJG 19:6529","journal-title":"World J Gastroenterol: WJG"},{"key":"10374_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e38893","author":"AZ Darkazally","year":"2024","unstructured":"Darkazally AZ, Alnour A, Homsi S (2024) Troxerutin effect on gastric ulcers induced by ketorolac in rats: relation with oxidative stress. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e38893","journal-title":"Heliyon"},{"key":"10374_CR20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/JOE-18-0432","volume":"240","author":"T Du","year":"2019","unstructured":"Du T, Yang L, Xu X, Shi X, Xu X, Lu J, Lv J, Huang X, Chen J, Wang H (2019) Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice. J Endocrinol 240:195\u2013214","journal-title":"J Endocrinol"},{"key":"10374_CR21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lfs.2018.04.002","volume":"202","author":"AM El-Dessouki","year":"2018","unstructured":"El-Dessouki AM, el Fattah MA, Awad AS, Zaki HF (2018) Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: role of the JNK\/ERK pathway. Life Sci 202:78\u201388","journal-title":"Life Sci"},{"key":"10374_CR22","doi-asserted-by":"crossref","first-page":"119224","DOI":"10.1016\/j.lfs.2021.119224","volume":"272","author":"RM El-Sayed","year":"2021","unstructured":"El-Sayed RM, el Gheit REA, Badawi GA (2021a) Vincamine protects against cisplatin induced nephrotoxicity via activation of Nrf2\/HO-1 and hindering TLR4\/IFN-\u03b3\/CD44 cells inflammatory cascade. Life Sci 272:119224\u2013119234","journal-title":"Life Sci"},{"key":"10374_CR23","doi-asserted-by":"crossref","first-page":"119224","DOI":"10.1016\/j.lfs.2021.119224","volume":"272","author":"RM El-Sayed","year":"2021","unstructured":"El-Sayed RM, el Gheit REA, Badawi GA (2021b) Vincamine protects against cisplatin induced nephrotoxicity via activation of Nrf2\/HO-1 and hindering TLR4\/IFN-\u03b3\/CD44 cells inflammatory cascade. Life Sci 272:119224","journal-title":"Life Sci"},{"key":"10374_CR24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000119288","volume":"34","author":"PK Fischhof","year":"1996","unstructured":"Fischhof PK, M\u00f6slinger-Gehmayr R, Herrmann WM, Friedmann A, Ru\u03b2mann DL (1996) Therapeutic efficacy of vincamine in dementia. Neuropsychobiology 34:29\u201335","journal-title":"Neuropsychobiology"},{"key":"10374_CR25","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1007\/s12011-023-03817-7","volume":"202","author":"A\u00c7 G\u00fcndo\u011fdu","year":"2024","unstructured":"G\u00fcndo\u011fdu A\u00c7, \u00d6zbayer C, Kar F (2024) Boric acid alleviates gastric ulcer by regulating oxidative stress and inflammation-related multiple signaling pathways. Biol Trace Elem Res 202:2124\u20132132","journal-title":"Biol Trace Elem Res"},{"key":"10374_CR26","doi-asserted-by":"crossref","first-page":"117739","DOI":"10.1016\/j.jep.2024.117739","volume":"325","author":"Y Guo","year":"2024","unstructured":"Guo Y, Wu Y, Huang T, Huang D, Zeng Q, Wang Z, Hu Y, Liang P, Chen H, Zheng Z, Liang T, Zhai D, Jiang C, Liu L, Zhu H, Liu Q (2024) Licorice flavonoid ameliorates ethanol-induced gastric ulcer in rats by suppressing apoptosis via PI3K\/AKT signaling pathway. J Ethnopharmacol 325:117739","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"10374_CR27","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/bcpt.13023","volume":"123","author":"PF Haastrup","year":"2018","unstructured":"Haastrup PF, Thompson W, S\u00f8ndergaard J, Jarb\u00f8l DE (2018) Side effects of long-term proton pump inhibitor use: a review. Basic Clin Pharm Toxicol 123(2):114\u2013121","journal-title":"Basic Clin Pharm Toxicol"},{"key":"10374_CR28","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3390\/biom11101549","volume":"11","author":"SF Hashmi","year":"2021","unstructured":"Hashmi SF, Rathore HA, Sattar MA, Johns EJ, Gan C-Y, Chia TY, Ahmad A (2021) Hydrogen sulphide treatment prevents renal ischemia-reperfusion injury by inhibiting the expression of ICAM-1 and NF-kB concentration in normotensive and hypertensive rats. Biomolecules 11:1549","journal-title":"Biomolecules"},{"issue":"7","key":"10374_CR29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1089\/jmf.2024.k.0015","volume":"27","author":"CF Hsuan","year":"2024","unstructured":"Hsuan CF, Tsai IT, Fang LW, Chang TH, Chen YL, Houng HY, Chang CC, Houng JY (2024) Aibika flower flavonoid extract exhibits antiulcer activity in a murine model of ethanol-induced acute gastric injury. J Med Food 27(7):615\u2013626","journal-title":"J Med Food"},{"key":"10374_CR30","first-page":"1","volume":"8","author":"SA Hussein","year":"2016","unstructured":"Hussein SA, Karousa MM, Amin A, Awadalla MA (2016) Evaluation of gastroprotective effect and anti-inflammatory role of resveratrol against gastric mucosal alterations in experimental model of gastritis in rats. Dig Syst Dis 8:1\u201312","journal-title":"Dig Syst Dis"},{"key":"10374_CR31","first-page":"294","volume":"3","author":"OE Ifeanyi","year":"2014","unstructured":"Ifeanyi OE, Sunday AG (2014) Some haematological and biochemical parameters in peptic ulcer patients in Umudike, Abia state, Nigeria. World J Pharm Pharm Sci 3:294\u2013302","journal-title":"World J Pharm Pharm Sci"},{"key":"10374_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/1734752","volume":"2021","author":"H Izhar","year":"2021","unstructured":"Izhar H, Shabbir A, Shahzad M, Mobashar A, Ahmed SS (2021) Phyllanthus reticulatus prevents ethanol-induced gastric ulcer via downregulation of IL-8 and TNF-\u03b1 levels. Evid Based Complement Altern Med 2021:1\u20138","journal-title":"Evid Based Complement Altern Med"},{"key":"10374_CR33","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.3390\/ijms22052719","volume":"22","author":"D-I Jang","year":"2021","unstructured":"Jang D-I, Lee A-H, Shin H-Y, Song H-R, Park J-H, Kang T-B, Lee S-R, Yang S-H (2021) The role of tumor necrosis factor alpha (TNF-\u03b1) in autoimmune disease and current TNF-\u03b1 inhibitors in therapeutics. Int J Mol Sci 22:2719\u20132735","journal-title":"Int J Mol Sci"},{"key":"10374_CR34","doi-asserted-by":"crossref","first-page":"117438","DOI":"10.1016\/j.seppur.2020.117438","volume":"252","author":"M Koel","year":"2020","unstructured":"Koel M, Kuhtinskaja M, Vaher M (2020) Extraction of bioactive compounds from Catharanthus roseus and Vinca minor. Sep Purif Technol 252:117438","journal-title":"Sep Purif Technol"},{"key":"10374_CR35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5567\/pharmacologia.2013.243.248","volume":"4","author":"V Lakshmi","year":"2013","unstructured":"Lakshmi V, Agarwal S, Mahdi A, Mishra V, Pandey H, Palit G (2013) Vincamine and vindoline from Catharanthus roseus linn. protects the gastric mucosa of gastric ulcer in rats. Pharmacologia 4:243\u2013248","journal-title":"Pharmacologia"},{"key":"10374_CR36","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/abbs\/gmy002","volume":"50","author":"Q Li","year":"2018","unstructured":"Li Q, Hu X, Xuan Y, Ying J, Fei Y, Rong J, Zhang Y, Zhang J, Liu C, Liu Z (2018) Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO. Acta Biochim Biophys Sin 50:246\u2013253","journal-title":"Acta Biochim Biophys Sin"},{"key":"10374_CR37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cbi.2018.01.014","volume":"283","author":"J Liang","year":"2018","unstructured":"Liang J, Dou Y, Wu X, Li H, Wu J, Huang Q, Luo D, Yi T, Liu Y, Su Z (2018) Prophylactic efficacy of patchoulene epoxide against ethanol-induced gastric ulcer in rats: influence on oxidative stress, inflammation and apoptosis. Chem Biol Interact 283:30\u201337","journal-title":"Chem Biol Interact"},{"key":"10374_CR38","doi-asserted-by":"crossref","first-page":"117845","DOI":"10.1016\/j.jep.2024.117845","volume":"10","author":"H Liu","year":"2024","unstructured":"Liu H, Chen Y, Hu Y, Zhang W, Zhang H, Su T, Wang J, Yin Z, Zhao X, Zhou X, Li L (2024a) Protective effects of an alcoholic extract of Kaempferia galanga L. rhizome on ethanol-induced gastric ulcer in mice. J Ethnopharmacol 10:117845","journal-title":"J Ethnopharmacol"},{"key":"10374_CR39","first-page":"2562","volume":"5","author":"AA Mahmood","year":"2011","unstructured":"Mahmood AA, Al-Bayaty FH, Salmah I, Nor Syuhada AB, Harita H, Mughrabi FF (2011) Enhancement of gastric ulcer by Areca catechu nut in ethanol-induced gastric mucosal injuries in rats. J Med Plant Res 5:2562\u20132569","journal-title":"J Med Plant Res"},{"key":"10374_CR40","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.biopha.2018.10.118","volume":"1","author":"YI Mahmoud","year":"2019","unstructured":"Mahmoud YI, Abd El-Ghffar EA (2019) Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. Biomed Pharmacother 1:314\u2013321","journal-title":"Biomed Pharmacother"},{"key":"10374_CR41","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0140-6736(09)60938-7","volume":"374","author":"P Malfertheiner","year":"2009","unstructured":"Malfertheiner P, Chan FK, McColl KE (2009) Peptic ulcer disease. Lancet 374:1449\u20131461","journal-title":"Lancet"},{"key":"10374_CR42","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/ptr.2502","volume":"22","author":"MA Morsy","year":"2008","unstructured":"Morsy MA, Fouad AA (2008) Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. Phytother Res: Int J Devot Pharmacol Toxicol Eval Nat Prod Deriv 22:1361\u20131366","journal-title":"Phytother Res: Int J Devot Pharmacol Toxicol Eval Nat Prod Deriv"},{"key":"10374_CR43","first-page":"40","volume":"14","author":"M Mustafa","year":"2015","unstructured":"Mustafa M, Menon J, Muiandy R, Fredie R, Sein M, Fariz A (2015) Risk factors, diagnosis, and management of peptic ulcer disease. J Dent Med Sci 14:40\u201346","journal-title":"J Dent Med Sci"},{"key":"10374_CR44","first-page":"3122","volume":"5","author":"F Nabavizadeh","year":"2011","unstructured":"Nabavizadeh F, Alizadeh AM, Sadroleslami Z, Adeli S (2011) Gastroprotective effects of amygdalin on experimental gastric ulcer: role of NO and TNF-\u03b1. J Med Plants Res 5:3122\u20133127","journal-title":"J Med Plants Res"},{"key":"10374_CR45","doi-asserted-by":"crossref","first-page":"117970","DOI":"10.1016\/j.jep.2024.117970","volume":"327","author":"G Nabil","year":"2024","unstructured":"Nabil G, Ahmed YH, Ahmed O, Milad SS, Hisham M, Rafat M, Atia M, Shokry AA (2024) Argel\u2019s stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways. J Ethnopharmacol 327:117970","journal-title":"J Ethnopharmacol"},{"key":"10374_CR46","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejphar.2018.11.034","volume":"843","author":"H Nandini","year":"2019","unstructured":"Nandini H, Naik PR (2019) Antidiabetic, antihyperlipidemic and antioxidant effect of Vincamine, in streptozotocin-induced diabetic rats. Eur J Pharmacol 843:233\u2013239","journal-title":"Eur J Pharmacol"},{"key":"10374_CR47","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1038\/s41598-024-56647-5","volume":"14","author":"N Parham","year":"2024","unstructured":"Parham N, Rahimi K, Ghotbeddin Z, Tabandeh MR (2024) Fish oil ameliorates ethanol-induced gastric injury in rat by modulating gene related to apoptosis. Sci Rep 14:6193","journal-title":"Sci Rep"},{"key":"10374_CR48","doi-asserted-by":"crossref","first-page":"111500","DOI":"10.1016\/j.jfoodeng.2023.111500","volume":"350","author":"S Park","year":"2023","unstructured":"Park S, Yang M, Yim DG, Jo C, Kim G (2023) VIS\/NIR hyperspectral imaging with artificial neural networks to evaluate the content of thiobarbituric acid reactive substances in beef muscle. J Food Eng 350:111500","journal-title":"J Food Eng"},{"key":"10374_CR49","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainresrev.2008.12.020","volume":"60","author":"K Ren","year":"2009","unstructured":"Ren K, Torres R (2009) Role of interleukin-1\u03b2 during pain and inflammation. Brain Res Rev 60:57\u201364","journal-title":"Brain Res Rev"},{"key":"10374_CR50","doi-asserted-by":"crossref","first-page":"108773","DOI":"10.1016\/j.intimp.2022.108773","volume":"108","author":"AP Renushe","year":"2022","unstructured":"Renushe AP, Banothu AK, Bharani KK, Mekala L, Kumar JM, Neeradi D, Hanuman DDV, Gadige A, Khurana A (2022) Vincamine, an active constituent of Vinca rosea ameliorates experimentally induced acute lung injury in Swiss albino mice through modulation of Nrf-2\/NF-\u03baB signaling cascade. Int Immunopharmacol 108:108773","journal-title":"Int Immunopharmacol"},{"key":"10374_CR51","doi-asserted-by":"crossref","first-page":"19171","DOI":"10.1038\/s41598-024-69431-2","volume":"14","author":"RR Rofaeil","year":"2024","unstructured":"Rofaeil RR, Mohyeldin RH, Sharata EE, Attya ME, Essawy H, Ibrahim OA, Abdelzaher WY (2024) The protective effect of vinpocetine against Estradiol-benzoate induced cervical hyperkeratosis in female rats via modulation of SIRT1\/Nrf2, and NLRP3 inflammasome. Sci Rep 14:19171","journal-title":"Sci Rep"},{"key":"10374_CR52","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/abbs\/gmz140","volume":"52","author":"K Saremi","year":"2020","unstructured":"Saremi K, Rad SK, Khalilzadeh M, Hussaini J, Majid NA (2020) In vivo acute toxicity and anti-gastric evaluation of a novel dichloro Schiff base: Bax and HSP70 alteration. Acta Biochim Biophys Sin 52:26\u201337","journal-title":"Acta Biochim Biophys Sin"},{"key":"10374_CR53","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00204-019-02429-2","volume":"93","author":"YM Shalaby","year":"2019","unstructured":"Shalaby YM, Menze ET, Azab SS, Awad AS (2019) Involvement of Nrf2\/HO-1 antioxidant signaling and NF-\u03baB inflammatory response in the potential protective effects of vincamine against methotrexate-induced nephrotoxicity in rats: cross talk between nephrotoxicity and neurotoxicity. Arch Toxicol 93:1417\u20131431","journal-title":"Arch Toxicol"},{"issue":"2","key":"10374_CR54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ame2.12060","volume":"2","author":"S Sim\u00f5es","year":"2019","unstructured":"Sim\u00f5es S, Lopes R, Campos MC, Marruz MJ, da Cruz ME, Corvo L (2019) Animal models of acute gastric mucosal injury: macroscopic and microscopic evaluation. Animal Models Exp Med 2(2):121\u2013126","journal-title":"Animal Models Exp Med"},{"issue":"3","key":"10374_CR55","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/medicina55030064","volume":"55","author":"N Sistani Karampour","year":"2019","unstructured":"Sistani Karampour N, Arzi A, Rezaie A, Pashmforoosh M, Kordi F (2019) Gastroprotective effect of zingerone on ethanol-induced gastric ulcers in rats. Medicina 55(3):64","journal-title":"Medicina"},{"key":"10374_CR56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00365528709090946","volume":"22","author":"S SZABO","year":"1987","unstructured":"SZABO S (1987) Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scand J Gastroenterol 22:21\u201328","journal-title":"Scand J Gastroenterol"},{"key":"10374_CR57","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.3390\/cells10081964","volume":"10","author":"AS Tarnawski","year":"2021","unstructured":"Tarnawski AS, Ahluwalia A (2021a) The critical role of growth factors in gastric ulcer healing: the cellular and molecular mechanisms and potential clinical implications. Cells 10:1964\u20131983","journal-title":"Cells"},{"key":"10374_CR58","unstructured":"VEMULA, S., MYLARAM, J., YADALA, R., ALLA, G., BANOTHU, A. & VEERA, H. D. D. 2024. Protective Effects of Naringenin on 5-Fluorouracil Induced Pulmonary Toxicity Via Modulation of NF-? B and Nrf2 Pathway. Pakistan Veterinary Journal, 44."},{"issue":"3","key":"10374_CR100","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/gast.2000.16510","volume":"119","author":"JL Wallace","year":"2000","unstructured":"Wallace JL, McKnight W, Reuter BK, Vergnolle N  (2000) NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 119(3):706\u201314","journal-title":"Gastroenterology"},{"key":"10374_CR59","doi-asserted-by":"crossref","first-page":"1308995","DOI":"10.3389\/fphar.2023.1308995","volume":"14","author":"X Wang","year":"2024","unstructured":"Wang X, Chen L, Chang L, He Y, He T, Wang R, Wei S, Jing M, Zhou X, Li H (2024) Mechanism of Wuzhuyu decoction on alcohol-induced gastric ulcers using integrated network analysis and metabolomics. Front Pharmacol 14:1308995","journal-title":"Front Pharmacol"},{"key":"10374_CR60","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4236\/jsea.2014.75039","volume":"7","author":"J-Y Yeh","year":"2014","unstructured":"Yeh J-Y, Wu T-H, Tsai W-J (2014) Bleeding and ulcer detection using wireless capsule endoscopy images. J Softw Eng Appl 7:422\u2013432","journal-title":"J Softw Eng Appl"},{"key":"10374_CR61","doi-asserted-by":"crossref","first-page":"155700","DOI":"10.1016\/j.cej.2024.155700","volume":"498","author":"R Zhao","year":"2024","unstructured":"Zhao R, Hu S, Yang Z, Chen T, Chi X, Wu D, Wang W, Liu D, Zhu B, Hu J (2024) Targeted quercetin delivery nanoplatform via folic acid-functionalized metal-organic framework for alleviating ethanol-induced gastric ulcer. Chem Eng J 498:155700","journal-title":"Chem Eng J"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10374-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10374-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10374-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T08:08:38Z","timestamp":1745482118000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10374-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10374"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10374-x","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,5]]},"assertion":[{"value":"9 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"100"}}