{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T08:40:01Z","timestamp":1745484001907,"version":"3.40.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Key Research & Development Project of Shaanxi Province","award":["2018KW-042"],"award-info":[{"award-number":["2018KW-042"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s10735-025-10410-w","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T16:32:02Z","timestamp":1743784322000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["L6H21 stabilizing gut barrier improves EtOH-LPS-induced hepatic steatosis and injury in mice"],"prefix":"10.1007","volume":"56","author":[{"given":"Li","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuo","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"10410_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jhep.2020.02.005","volume":"73","author":"JP Arab","year":"2020","unstructured":"Arab JP, Cabrera D, Sehrawat TS, Jalan-Sakrikar N, Verma VK, Simonetto D et al (2020) Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12. J Hepatol 73:149\u2013160","journal-title":"J Hepatol"},{"key":"10410_CR2","doi-asserted-by":"publisher","first-page":"7485","DOI":"10.3390\/ijms22147485","volume":"22","author":"J Calleja-Conde","year":"2021","unstructured":"Calleja-Conde J, Echeverry-Alzate V, B\u00fchler KM, Dur\u00e1n-Gonz\u00e1lez P, Morales-Garc\u00eda J, Segovia-Rodr\u00edguez L et al (2021) The immune system through the lens of alcohol intake and gut microbiota. Int J Mol Sci 22:7485","journal-title":"Int J Mol Sci"},{"key":"10410_CR3","doi-asserted-by":"publisher","first-page":"1916278","DOI":"10.1080\/19490976.2021.1916278","volume":"13","author":"B Caslin","year":"2021","unstructured":"Caslin B, Mohler K, Thiagarajan S, Melamed E (2021) Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome? Gut Microbes 13:1916278","journal-title":"Gut Microbes"},{"key":"10410_CR4","doi-asserted-by":"publisher","first-page":"3735","DOI":"10.3390\/ijms24043735","volume":"24","author":"M Duki\u0107","year":"2023","unstructured":"Duki\u0107 M, Radonji\u0107 T, Jovanovi\u0107 I, Zdravkovi\u0107 M, Todorovi\u0107 Z, Krai\u0161nik N et al (2023) Alcohol, inflammation, and microbiota in alcoholic liver disease. Int J Mol Sci 24:3735","journal-title":"Int J Mol Sci"},{"key":"10410_CR5","doi-asserted-by":"publisher","first-page":"2281014","DOI":"10.1080\/19490976.2023.2281014","volume":"15","author":"JA Eom","year":"2023","unstructured":"Eom JA, Jeong JJ, Han SH, Kwon GH, Lee KJ, Gupta H et al (2023) Gut-microbiota prompt activation of natural killer cell on alcoholic liver disease. Gut Microbes 15:2281014","journal-title":"Gut Microbes"},{"key":"10410_CR6","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","volume":"21","author":"CL Hsu","year":"2023","unstructured":"Hsu CL, Schnabl B (2023) The gut-liver axis and gut microbiota in health and liver disease. Nat Rev Microbiol 21:719\u2013733","journal-title":"Nat Rev Microbiol"},{"key":"10410_CR7","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s12974-019-1529-x","volume":"16","author":"F Ib\u00e1\u00f1ez","year":"2019","unstructured":"Ib\u00e1\u00f1ez F, Montesinos J, Ure\u00f1a-Peralta JR, Guerri C, Pascual M (2019) TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles. J Neuroinflam 16:136","journal-title":"J Neuroinflam"},{"key":"10410_CR8","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1186\/s12871-024-02704-5","volume":"24","author":"W Jiang","year":"2024","unstructured":"Jiang W, Zhang M, Cao R, Wang X, Zuo Y (2024) Different ethanol exposure durations affect cytochrome P450 2E1-mediated Sevoflurane metabolism in rat liver. BMC Anesthesiol 24:321","journal-title":"BMC Anesthesiol"},{"key":"10410_CR10","doi-asserted-by":"publisher","first-page":"9292","DOI":"10.1038\/s41598-017-09045-z","volume":"7","author":"X Kong","year":"2017","unstructured":"Kong X, Yang Y, Ren L, Shao T, Li F, Zhao C et al (2017) Activation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling. Sci Rep 7:9292","journal-title":"Sci Rep"},{"key":"10410_CR9","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1111\/acer.14120","volume":"43","author":"X Kong","year":"2019","unstructured":"Kong X, Wu G, Chen S, Zhang L, Li F, Shao T et al (2019) Chalcone derivative L6H21 reduces EtOH\u2009+\u2009LPS-induced liver injury through Inhibition of nlrp3 inflammasome activation. Alcohol Clin Exp Res 43:1662\u20131671","journal-title":"Alcohol Clin Exp Res"},{"key":"10410_CR11","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jhep.2023.04.037","volume":"79","author":"E Kotsiliti","year":"2023","unstructured":"Kotsiliti E, Leone V, Schuehle S, Govaere O, Li H, Wolf MJ et al (2023) Intestinal B cells license metabolic T-cell activation in NASH microbiota\/ antigen-independently and contribute to fibrosis by IgA-FcR signalling. J Hepatol 79:296\u2013313","journal-title":"J Hepatol"},{"key":"10410_CR12","doi-asserted-by":"publisher","first-page":"134809","DOI":"10.1016\/j.ijbiomac.2024.134809","volume":"278","author":"W Lai","year":"2024","unstructured":"Lai W, Zhang J, Sun J, Min T, Bai Y, He J et al (2024) Oxidative stress in alcoholic liver disease, focusing on proteins, nucleic acids, and lipids: a review. Int J Biol Macromol 278:134809","journal-title":"Int J Biol Macromol"},{"key":"10410_CR13","doi-asserted-by":"publisher","first-page":"e100013","DOI":"10.1136\/egastro-2023-100013","volume":"1","author":"L Maccioni","year":"2023","unstructured":"Maccioni L, Fu Y, Horsmans Y, Leclercq I, St\u00e4rkel P, Kunos G et al (2023) Alcohol-associated bowel disease: new insights into pathogenesis. eGastroenterology 1:","journal-title":"eGastroenterology"},{"key":"10410_CR14","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1186\/s12967-024-05865-6","volume":"22","author":"T Mao","year":"2024","unstructured":"Mao T, Xu X, Liu L, Wu Y, Wu X, Niu W et al (2024) ABL1\u2013YAP1 axis in intestinal stem cell activated by deoxycholic acid contributes to hepatic steatosis. J Transl Med 22:1119","journal-title":"J Transl Med"},{"key":"10410_CR15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.21037\/tgh.2019.09.08","volume":"5","author":"S Mitra","year":"2020","unstructured":"Mitra S, De A, Chowdhury A (2020) Epidemiology of non-alcoholic and alcoholic fatty liver diseases. Transl Gastroenterol Hepatol 5:16","journal-title":"Transl Gastroenterol Hepatol"},{"key":"10410_CR17","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41575-023-00771-6","volume":"20","author":"O Pabst","year":"2023","unstructured":"Pabst O, Hornef MW, Schaap FG, Cerovic V, Clavel T, Bruns T (2023) Gut-liver axis: barriers and functional circuits. Nat Rev Gastroenterol Hepatol 20:447\u2013461","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10410_CR16","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3390\/ijms23010426","volume":"23","author":"JW Park","year":"2021","unstructured":"Park JW, Kim SE, Lee NY, Kim JH, Jung JH, Jang MK et al (2021) Role of microbiota-derived metabolites in alcoholic and non-alcoholic fatty liver diseases. Int J Mol Sci 23:426","journal-title":"Int J Mol Sci"},{"key":"10410_CR18","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41401-023-01179-3","volume":"45","author":"JF Qian","year":"2024","unstructured":"Qian JF, Liang SQ, Wang QY, Xu JC, Luo W, Huang WJ et al (2024) Isoproterenol induces MD2 activation by \u03b2-AR-cAMP-PKA-ROS signalling axis in cardiomyocytes and macrophages drives inflammatory heart failure. Acta Pharmacol Sin 45:531\u2013544","journal-title":"Acta Pharmacol Sin"},{"key":"10410_CR19","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1055\/a-2145-7331","volume":"43","author":"T Ranjbarian","year":"2023","unstructured":"Ranjbarian T, Schnabl B (2023) Gut Microbiome-centered therapies for alcohol-associated liver disease. Semin Liver Dis 43:311\u2013322","journal-title":"Semin Liver Dis"},{"key":"10410_CR20","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.jhep.2018.05.021","volume":"69","author":"T Shao","year":"2018","unstructured":"Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L et al (2018) Intestinal HIF-1\u03b1 deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction. J Hepatol 69:886\u2013895","journal-title":"J Hepatol"},{"key":"10410_CR21","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/j.chom.2024.06.008","volume":"32","author":"H Shen","year":"2024","unstructured":"Shen H, Zhou L, Zhang H, Yang Y, Jiang L, Wu D et al (2024) Dietary fiber alleviates alcoholic liver injury via bacteroides acidifaciens and subsequent ammonia detoxification. Cell Host Microbe 32:1331\u20131346","journal-title":"Cell Host Microbe"},{"key":"10410_CR22","doi-asserted-by":"publisher","first-page":"1054265","DOI":"10.3389\/fnut.2022.1054265","volume":"9","author":"Q Wang","year":"2022","unstructured":"Wang Q, Shi J, Zhao M, Ruan G, Dai Z, Xue Y et al (2022) Microbial treatment of alcoholic liver disease: a systematic review and meta-analysis. Front Nutr 9:1054265","journal-title":"Front Nutr"},{"issue":"3","key":"10410_CR23","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.ajpath.2024.12.006","volume":"195","author":"Z Wang","year":"2025","unstructured":"Wang Z, Liang G, Peng J, Gu Y, Zhang X, Ding C et al (2025) Sirtuin 7 promotes alcohol-associated liver injury via modulating myeloid cell chemokine (C-C Motif) ligand 2 secretion through the NF-\u03baB signaling pathway. Am J Pathol 195(3):575\u2013588","journal-title":"Am J Pathol"},{"key":"10410_CR24","doi-asserted-by":"publisher","first-page":"e21377","DOI":"10.1096\/fj.202001202R","volume":"35","author":"DR Warner","year":"2021","unstructured":"Warner DR, Warner JB, Hardesty JE, Song YL, Chen CY, Chen Z et al (2021) Beneficial effects of an endogenous enrichment in n3-PUFAs on Wnt signaling are associated with Attenuation of alcohol-mediated liver disease in mice. FASEB J 35:e21377","journal-title":"FASEB J"},{"key":"10410_CR25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jnutbio.2019.04.003","volume":"70","author":"S Xu","year":"2019","unstructured":"Xu S, Luo W, Xu X, Qian Y, Xu Z, Yu W et al (2019) MD2 Blockade prevents oxLDL-induced renal epithelial cell injury and protects against high-fat-diet-induced kidney dysfunction. J Nutr Biochem 70:47\u201355","journal-title":"J Nutr Biochem"},{"key":"10410_CR26","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12967-023-04166-8","volume":"21","author":"C Yan","year":"2023","unstructured":"Yan C, Hu W, Tu J, Li J, Liang Q, Han S (2023) Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease. J Transl Med 21:300","journal-title":"J Transl Med"},{"key":"10410_CR27","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1111\/jcmm.13395","volume":"22","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Wu B, Zhang H, Ge X, Ying S, Hu M et al (2018) Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease. J Cell Mol Med 22:936\u2013947","journal-title":"J Cell Mol Med"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10410-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10410-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10410-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T08:07:09Z","timestamp":1745482029000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10410-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10410"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10410-w","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"type":"print","value":"1567-2379"},{"type":"electronic","value":"1567-2387"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"6 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal studies were approved by the Institutional Animal Care and Use Committee of University of Louisville IACUC (#18378).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"127"}}