{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:41:48Z","timestamp":1793324508332,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hainan Provincial Natural Science Foundation of China","award":["820QN405"],"award-info":[{"award-number":["820QN405"]}]},{"name":"Hainan Province Clinical Medical Center"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10735-025-10417-3","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T09:32:01Z","timestamp":1745832721000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["STAT3\/FoxO3a\/Sirt1 pathway inhibition by ginsenoside Rc ameliorates cardiomyocyte damage in septic cardiomyopathy by altering macrophage polarization"],"prefix":"10.1007","volume":"56","author":[{"given":"M. S.","family":"Jinzhong Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Jian Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"issue":"5","key":"10417_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1177\/17534259211034221","volume":"27","author":"DD Chen","year":"2021","unstructured":"Chen DD, Wang HW, Cai XJ (2021a) Long non-coding RNA ZFAS1 alleviates sepsis-induced myocardial injury via target miR-34b-5p\/SIRT1. Innate Immun 27(5):377\u2013387","journal-title":"Innate Immun"},{"key":"10417_CR27","doi-asserted-by":"publisher","first-page":"107791","DOI":"10.1016\/j.intimp.2021.107791","volume":"96","author":"X Chen","year":"2021","unstructured":"Chen X et al (2021b) The roles of macrophage polarization in the host immune response to sepsis. Int Immunopharmacol 96:107791","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"10417_CR18","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1159\/000491651","volume":"47","author":"Y Cheng","year":"2018","unstructured":"Cheng Y et al (2018) N-Propargyl caffeamide skews macrophages towards a resolving M2-Like phenotype against myocardial ischemic injury via activating Nrf2\/HO-1 pathway and inhibiting NF-kB pathway. Cell Physiol Biochem 47(6):2544\u20132557","journal-title":"Cell Physiol Biochem"},{"issue":"8","key":"10417_CR32","doi-asserted-by":"publisher","first-page":"17763","DOI":"10.3390\/ijms160817763","volume":"16","author":"MC Cimolai","year":"2015","unstructured":"Cimolai MC et al (2015) Mitochondrial mechanisms in septic cardiomyopathy. Int J Mol Sci 16(8):17763\u201317778","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10417_CR13","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1089\/ars.2017.7178","volume":"28","author":"N D\u2019Onofrio","year":"2018","unstructured":"D\u2019Onofrio N, Servillo L, Balestrieri ML (2018) SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection. Antioxid Redox Signal 28(8):711\u2013732","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"10417_CR26","first-page":"189","volume":"30","author":"X Fang","year":"2018","unstructured":"Fang X, Wang J (2018) [Role of mitochondrial dysfunction in the pathogenesis of septic cardiomyopathy]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 30(2):189\u2013192","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"issue":"2","key":"10417_CR9","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/cvr\/cvu034","volume":"102","author":"A Haghikia","year":"2014","unstructured":"Haghikia A et al (2014) STAT3, a key regulator of cell-to-cell communication in the heart. Cardiovasc Res 102(2):281\u2013289","journal-title":"Cardiovasc Res"},{"key":"10417_CR41","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.freeradbiomed.2017.10.005","volume":"113","author":"D Han","year":"2017","unstructured":"Han D et al (2017) Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist. Free Radic Biol Med 113:291\u2013303","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10417_CR8","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1021\/jacs.0c10836","volume":"143","author":"Q Huang","year":"2021","unstructured":"Huang Q et al (2021) A SIRT1 activator, ginsenoside Rc, promotes energy metabolism in cardiomyocytes and neurons. J Am Chem Soc 143(3):1416\u20131427","journal-title":"J Am Chem Soc"},{"key":"10417_CR10","doi-asserted-by":"publisher","first-page":"790612","DOI":"10.3389\/fcvm.2021.790612","volume":"8","author":"T Jiang","year":"2021","unstructured":"Jiang T et al (2021a) IL-6\/STAT3 signaling promotes cardiac dysfunction by upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic reticulum membranes formation in sepsis mice. Front Cardiovasc Med 8:790612","journal-title":"Front Cardiovasc Med"},{"key":"10417_CR16","doi-asserted-by":"publisher","first-page":"p2989974","DOI":"10.1155\/2021\/2989974","volume":"2021","author":"X Jiang","year":"2021","unstructured":"Jiang X et al (2021b) Irisin attenuates oxidative stress, mitochondrial dysfunction, and apoptosis in the H9C2 cellular model of septic cardiomyopathy through augmenting Fundc1-Dependent mitophagy. Oxid Med Cell Longev 2021:p2989974","journal-title":"Oxid Med Cell Longev"},{"key":"10417_CR30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40560-016-0148-1","volume":"4","author":"Y Kakihana","year":"2016","unstructured":"Kakihana Y et al (2016) Sepsis-induced myocardial dysfunction: pathophysiology and management. J Intensive Care 4:22","journal-title":"J Intensive Care"},{"issue":"6","key":"10417_CR5","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s12272-013-0223-2","volume":"37","author":"DH Kim","year":"2014","unstructured":"Kim DH et al (2014) Ginsenoside Rc modulates Akt\/FoxO1 pathways and suppresses oxidative stress. Arch Pharm Res 37(6):813\u2013820","journal-title":"Arch Pharm Res"},{"issue":"11","key":"10417_CR40","doi-asserted-by":"publisher","first-page":"7796","DOI":"10.1111\/jcmm.14656","volume":"23","author":"Z Li","year":"2019","unstructured":"Li Z et al (2019) GSK-3beta Inhibition protects the rat heart from the lipopolysaccharide-induced inflammation injury via suppressing FOXO3A activity. J Cell Mol Med 23(11):7796\u20137809","journal-title":"J Cell Mol Med"},{"key":"10417_CR12","doi-asserted-by":"publisher","first-page":"109716","DOI":"10.1016\/j.cellsig.2020.109716","volume":"74","author":"Z Li","year":"2020","unstructured":"Li Z et al (2020) miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A. Cell Signal 74:109716","journal-title":"Cell Signal"},{"issue":"2","key":"10417_CR23","doi-asserted-by":"publisher","first-page":"e12962","DOI":"10.1111\/cpr.12962","volume":"54","author":"Z Li","year":"2021","unstructured":"Li Z et al (2021) Kcnh2 mediates FAK\/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction. Cell Prolif 54(2):e12962","journal-title":"Cell Prolif"},{"issue":"5","key":"10417_CR29","doi-asserted-by":"publisher","first-page":"520","DOI":"10.7150\/ijbs.8879","volume":"10","author":"YC Liu","year":"2014","unstructured":"Liu YC et al (2014) Macrophage polarization in inflammatory diseases. Int J Biol Sci 10(5):520\u2013529","journal-title":"Int J Biol Sci"},{"key":"10417_CR19","doi-asserted-by":"publisher","first-page":"644225","DOI":"10.3389\/fphar.2021.644225","volume":"12","author":"L Liu","year":"2021","unstructured":"Liu L et al (2021) Adiponectin attenuates Lipopolysaccharide-induced apoptosis by regulating the Cx43\/PI3K\/AKT pathway. Front Pharmacol 12:644225","journal-title":"Front Pharmacol"},{"key":"10417_CR20","doi-asserted-by":"crossref","unstructured":"Long X et al (2021) Upregulation of miR\u2013335 exerts protective effects against sepsis\u2013induced myocardial injury. Mol Med Rep, 24(5)","DOI":"10.3892\/mmr.2021.12446"},{"issue":"1","key":"10417_CR28","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s11655-019-3064-0","volume":"26","author":"TT Luo","year":"2020","unstructured":"Luo TT et al (2020) Network Pharmacology in research of Chinese medicine formula: methodology, application and prospective. Chin J Integr Med 26(1):72\u201380","journal-title":"Chin J Integr Med"},{"issue":"Pt A","key":"10417_CR33","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.fct.2017.07.019","volume":"107","author":"C Mancuso","year":"2017","unstructured":"Mancuso C, Santangelo R (2017) Panax ginseng and Panax quinquefolius: from Pharmacology to toxicology. Food Chem Toxicol 107(Pt A):362\u2013372","journal-title":"Food Chem Toxicol"},{"issue":"12","key":"10417_CR15","doi-asserted-by":"publisher","first-page":"949","DOI":"10.2174\/1568026618666180330141351","volume":"18","author":"J Muhammad","year":"2018","unstructured":"Muhammad J et al (2018) Network pharmacology: exploring the resources and methodologies. Curr Top Med Chem 18(12):949\u2013964","journal-title":"Curr Top Med Chem"},{"issue":"3","key":"10417_CR11","doi-asserted-by":"publisher","first-page":"346","DOI":"10.4331\/wjbc.v5.i3.346","volume":"5","author":"RS Nho","year":"2014","unstructured":"Nho RS, Hergert P (2014) FoxO3a and disease progression. World J Biol Chem 5(3):346\u2013354","journal-title":"World J Biol Chem"},{"issue":"1","key":"10417_CR22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1186\/s12967-021-03022-x","volume":"19","author":"J Pan","year":"2021","unstructured":"Pan J et al (2021) microRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3\/HMGB1 axis. J Transl Med 19(1):386","journal-title":"J Transl Med"},{"issue":"3","key":"10417_CR25","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2174\/157340311798220494","volume":"7","author":"FJ Romero-Bermejo","year":"2011","unstructured":"Romero-Bermejo FJ et al (2011) Sepsis-induced cardiomyopathy. Curr Cardiol Rev 7(3):163\u2013183","journal-title":"Curr Cardiol Rev"},{"issue":"1","key":"10417_CR21","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1080\/13880209.2022.2072518","volume":"60","author":"L Shi","year":"2022","unstructured":"Shi L et al (2022) Ginsenoside Rc attenuates myocardial ischaemic injury through antioxidative and anti-inflammatory effects. Pharm Biol 60(1):1038\u20131046","journal-title":"Pharm Biol"},{"issue":"18","key":"10417_CR31","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.2174\/1381612825666190708155400","volume":"25","author":"Y Tan","year":"2019","unstructured":"Tan Y et al (2019) Mitochondrial injury and targeted intervention in septic cardiomyopathy. Curr Pharm Des 25(18):2060\u20132070","journal-title":"Curr Pharm Des"},{"issue":"3","key":"10417_CR4","first-page":"177","volume":"69","author":"J Vincelj","year":"2015","unstructured":"Vincelj J (2015) [Septic cardiomyopathy]. Acta Med Croatica 69(3):177\u2013182","journal-title":"Acta Med Croatica"},{"key":"10417_CR1","doi-asserted-by":"publisher","first-page":"107160","DOI":"10.1016\/j.intimp.2020.107160","volume":"90","author":"W Wang","year":"2021","unstructured":"Wang W et al (2021a) The role of the cholinergic anti-inflammatory pathway in septic cardiomyopathy. Int Immunopharmacol 90:107160","journal-title":"Int Immunopharmacol"},{"key":"10417_CR2","doi-asserted-by":"publisher","first-page":"p6616270","DOI":"10.1155\/2021\/6616270","volume":"2021","author":"L Wang","year":"2021","unstructured":"Wang L et al (2021b) Lipocalin 10 as a new prognostic biomarker in Sepsis-Induced myocardial dysfunction and mortality: A pilot study. Mediators Inflamm 2021:p6616270","journal-title":"Mediators Inflamm"},{"key":"10417_CR6","doi-asserted-by":"publisher","first-page":"620524","DOI":"10.3389\/fphar.2021.620524","volume":"12","author":"Y Wang","year":"2021","unstructured":"Wang Y et al (2021c) Ginsenoside Rc ameliorates endothelial insulin resistance via upregulation of Angiotensin-Converting enzyme 2. Front Pharmacol 12:620524","journal-title":"Front Pharmacol"},{"issue":"1","key":"10417_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/jcp.30527","volume":"237","author":"R Wang","year":"2022","unstructured":"Wang R et al (2022) Pathogenetic mechanisms of septic cardiomyopathy. J Cell Physiol 237(1):49\u201358","journal-title":"J Cell Physiol"},{"key":"10417_CR37","doi-asserted-by":"publisher","first-page":"990476","DOI":"10.3389\/fphar.2022.990476","volume":"13","author":"B Xie","year":"2022","unstructured":"Xie B et al (2022) Ginsenoside Rc ameliorated atherosclerosis via regulating gut microbiota and fecal metabolites. Front Pharmacol 13:990476","journal-title":"Front Pharmacol"},{"issue":"7","key":"10417_CR35","doi-asserted-by":"publisher","first-page":"3252","DOI":"10.1111\/1750-3841.15757","volume":"86","author":"Y Xue","year":"2021","unstructured":"Xue Y et al (2021) Protective effects of ginsenoside Rc against acute cold exposure-induced myocardial injury in rats. J Food Sci 86(7):3252\u20133264","journal-title":"J Food Sci"},{"issue":"3","key":"10417_CR36","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1021\/acs.jafc.2c06926","volume":"71","author":"Y Xue","year":"2023","unstructured":"Xue Y et al (2023) Ginsenoside Rc alleviates myocardial Ischemia-Reperfusion injury by reducing mitochondrial oxidative stress and apoptosis: role of SIRT1 activation. J Agric Food Chem 71(3):1547\u20131561","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10417_CR34","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.3390\/molecules20011293","volume":"20","author":"JW Yang","year":"2015","unstructured":"Yang JW, Kim SS (2015) Ginsenoside Rc promotes anti-adipogenic activity on 3T3-L1 adipocytes by down-regulating C\/EBPalpha and PPARgamma. Molecules 20(1):1293\u20131303","journal-title":"Molecules"},{"issue":"3","key":"10417_CR17","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1142\/S0192415X16500336","volume":"44","author":"T Yu","year":"2016","unstructured":"Yu T et al (2016) Ginsenoside Rc from Korean red ginseng (Panax ginseng C.A. Meyer) attenuates inflammatory symptoms of gastritis, hepatitis and arthritis. Am J Chin Med 44(3):595\u2013615","journal-title":"Am J Chin Med"},{"issue":"2","key":"10417_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jgr.2016.02.001","volume":"41","author":"T Yu","year":"2017","unstructured":"Yu T et al (2017) Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1\/interferon regulatory factor-3 and p38\/ATF-2. J Ginseng Res 41(2):127\u2013133","journal-title":"J Ginseng Res"},{"issue":"2","key":"10417_CR38","doi-asserted-by":"publisher","first-page":"112842","DOI":"10.1016\/j.yexcr.2021.112842","volume":"409","author":"Y Yu","year":"2021","unstructured":"Yu Y et al (2021) MiR-125b enhances autophagic flux to improve septic cardiomyopathy via targeting STAT3\/HMGB1. Exp Cell Res 409(2):112842","journal-title":"Exp Cell Res"},{"issue":"4","key":"10417_CR39","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.3892\/mmr.2013.1315","volume":"7","author":"M Zhang","year":"2013","unstructured":"Zhang M et al (2013) Oxymatrine protects against myocardial injury via Inhibition of JAK2\/STAT3 signaling in rat septic shock. Mol Med Rep 7(4):1293\u20131299","journal-title":"Mol Med Rep"},{"key":"10417_CR24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.lfs.2018.11.055","volume":"217","author":"WX Zhang","year":"2019","unstructured":"Zhang WX et al (2019) Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice. Life Sci 217:8\u201315","journal-title":"Life Sci"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10417-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10417-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10417-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T12:25:15Z","timestamp":1757161515000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10417-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10417"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10417-3","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"assertion":[{"value":"22 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All animal experiments involved in this manuscript were authorized by the animal experimentation ethical committee of the Second Affiliated Hospital of Hainan Medical University and were conducted in strict accordance with the Institute for Animal Protection and Ethics guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"148"}}