{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:24:29Z","timestamp":1787495069259,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10735-025-10421-7","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T23:07:51Z","timestamp":1745536071000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["N6-methyladenosine-modified circ_0000517 promotes non-small cell lung cancer metastasis via miR-1233-3p\/CDH6 axis"],"prefix":"10.1007","volume":"56","author":[{"given":"Weixian","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu\u2019an","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qipeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enwu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"10421_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrc.2017.99","volume":"18","author":"E Anastasiadou","year":"2018","unstructured":"Anastasiadou E, Jacob LS, Slack FJ (2018) Non-coding RNA networks in cancer. Nat Rev Cancer 18:5\u201318. https:\/\/doi.org\/10.1038\/nrc.2017.99","journal-title":"Nat Rev Cancer"},{"key":"10421_CR2","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1002\/1878-0261.12947","volume":"15","author":"RA Bartolom\u00e9","year":"2021","unstructured":"Bartolom\u00e9 RA, Robles J, Martin-Regalado \u00c1, Pintado-Berninches L, Burdiel M, Ja\u00e9n M, Aizpur\u00faa C, Imbaud JI, Casal JI (2021) CDH6-activated \u0391IIb\u03b23 crosstalks with \u03912\u03b21 to trigger cellular adhesion and invasion in metastatic ovarian and renal cancers. Mol Oncol 15:1849\u20131865. https:\/\/doi.org\/10.1002\/1878-0261.12947","journal-title":"Mol Oncol"},{"key":"10421_CR3","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1002\/kjm2.12440","volume":"37","author":"ZX Bing","year":"2021","unstructured":"Bing ZX, Zhang JQ, Wang GG, Wang YQ, Wang TG, Li DQ (2021) Silencing of circ_0000517 suppresses proliferation, glycolysis, and glutamine decomposition of non-small cell lung cancer by modulating miR-330-5p\/YY1 signal pathway. Kaohsiung J Med Sci 37:1027\u20131037. https:\/\/doi.org\/10.1002\/kjm2.12440","journal-title":"Kaohsiung J Med Sci"},{"key":"10421_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.canlet.2017.11.018","volume":"415","author":"X Cai","year":"2018","unstructured":"Cai X, Wang X, Cao C, Gao Y, Zhang S, Yang Z, Liu Y, Zhang X, Zhang W, Ye L (2018) HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7&nbsp;g. Cancer Lett 415:11\u201319. https:\/\/doi.org\/10.1016\/j.canlet.2017.11.018","journal-title":"Cancer Lett"},{"key":"10421_CR5","doi-asserted-by":"publisher","first-page":"4695","DOI":"10.1038\/s41467-019-12651-2","volume":"10","author":"RX Chen","year":"2019","unstructured":"Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, Wang F, Ma NF, Guan X, Yun JP, Wang FW, Xu RH, Dan X (2019) N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Nat Commun 10:4695. https:\/\/doi.org\/10.1038\/s41467-019-12651-2","journal-title":"Nat Commun"},{"key":"10421_CR6","doi-asserted-by":"publisher","first-page":"664290","DOI":"10.3389\/fonc.2021.664290","volume":"11","author":"HH Chen","year":"2021","unstructured":"Chen HH, Zhang TN, Wu QJ, Huang XM, Zhao YH (2021) Circular RNAs in lung cancer: recent advances and future perspectives. Front Oncol 11:664290. https:\/\/doi.org\/10.3389\/fonc.2021.664290","journal-title":"Front Oncol"},{"key":"10421_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28160","author":"V Das","year":"2019","unstructured":"Das V, Bhattacharya S, Chikkaputtaiah C, Hazra S, Pal M (2019) The basics of epithelial-mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective. J Cell Physiol. https:\/\/doi.org\/10.1002\/jcp.28160","journal-title":"J Cell Physiol"},{"key":"10421_CR8","doi-asserted-by":"publisher","first-page":"e1592","DOI":"10.1002\/wrna.1592","volume":"11","author":"R Drula","year":"2020","unstructured":"Drula R, Braicu C, Harangus A, Nabavi SM, Trif M, Slaby O, Ionescu C, Irimie A, Berindan-Neagoe I (2020) Critical function of circular RNAs in lung cancer. Wiley Interdiscip Rev RNA 11:e1592. https:\/\/doi.org\/10.1002\/wrna.1592","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"10421_CR9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12943-022-01575-z","volume":"21","author":"A Du","year":"2022","unstructured":"Du A, Li S, Zhou Y, Disoma C, Liao Y, Zhang Y, Chen Z, Yang Q, Liu P, Liu S, Dong Z, Razzaq A, Tao S, Chen X, Liu Y, Xu L, Zhang Q, Li S, Peng J, Xia Z (2022) M6A-mediated upregulation of circmdk promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma. Mol Cancer 21:109. https:\/\/doi.org\/10.1186\/s12943-022-01575-z","journal-title":"Mol Cancer"},{"key":"10421_CR10","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.mayocp.2019.01.013","volume":"94","author":"N Duma","year":"2019","unstructured":"Duma N, Santana-Davila R, Molina JR (2019) Non-Small cell lung cancer: epidemiology, screening, diagnosis, and treatment. Mayo Clin Proc 94:1623\u20131640. https:\/\/doi.org\/10.1016\/j.mayocp.2019.01.013","journal-title":"Mayo Clin Proc"},{"key":"10421_CR11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12943-022-01521-z","volume":"21","author":"HN Fan","year":"2022","unstructured":"Fan HN, Chen ZY, Chen XY, Chen M, Yi YC, Zhu JS, Zhang J (2022) METTL14-mediated m(6)A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p\/AKT1S1 axis. Mol Cancer 21:51. https:\/\/doi.org\/10.1186\/s12943-022-01521-z","journal-title":"Mol Cancer"},{"key":"10421_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133154","author":"G Fontemaggi","year":"2021","unstructured":"Fontemaggi G, Turco C, Esposito G, Di Agostino S (2021) New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers13133154","journal-title":"Cancers (Basel)"},{"key":"10421_CR13","doi-asserted-by":"publisher","first-page":"229","DOI":"10.21873\/cgp.20128","volume":"16","author":"C Goebel","year":"2019","unstructured":"Goebel C, Louden CL, McKenna R Jr., Onugha O, Wachtel A, Long T (2019) Diagnosis of Non-small cell lung cancer for early stage asymptomatic patients. Cancer Genomics Proteom 16:229\u2013244. https:\/\/doi.org\/10.21873\/cgp.20128","journal-title":"Cancer Genomics Proteom"},{"key":"10421_CR14","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/onc.2016.237","volume":"36","author":"M Gugnoni","year":"2017","unstructured":"Gugnoni M, Sancisi V, Gandolfi G, Manzotti G, Ragazzi M, Giordano D, Tamagnini I, Tigano M, Frasoldati A, Piana S, Ciarrocchi A (2017) Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy. Oncogene 36:667\u2013677. https:\/\/doi.org\/10.1038\/onc.2016.237","journal-title":"Oncogene"},{"key":"10421_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12935-024-03250-3","volume":"24","author":"X Ji","year":"2024","unstructured":"Ji X, Wan X, Sun H, Deng Q, Meng S, Xie B, Zhou S (2024) METTL14 enhances the m6A modification level of LncRNA MSTRG.292666.16 to promote the progression of non-small cell lung cancer. Cancer Cell Int 24:61. https:\/\/doi.org\/10.1186\/s12935-024-03250-3","journal-title":"Cancer Cell Int"},{"key":"10421_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207624","author":"I Kaszak","year":"2020","unstructured":"Kaszak I, Witkowska-Pi\u0142aszewicz O, Niewiadomska Z, Dworecka-Kaszak B, Ngosa Toka F, Jurka P (2020) Role of Cadherins in Cancer-A Review. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21207624","journal-title":"Int J Mol Sci"},{"key":"10421_CR17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.tig.2019.12.007","volume":"36","author":"Y Lee","year":"2020","unstructured":"Lee Y, Choe J, Park OH, Kim YK (2020) Molecular mechanisms driving mRNA degradation by m(6)A modification. Trends Genet 36:177\u2013188. https:\/\/doi.org\/10.1016\/j.tig.2019.12.007","journal-title":"Trends Genet"},{"key":"10421_CR18","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1002\/1878-0261.12852","volume":"15","author":"X Li","year":"2021","unstructured":"Li X, Feng Y, Yang B, Xiao T, Ren H, Yu X, Li L, Li M, Zhang W (2021) A novel circular RNA, Hsa_circ_0030998 suppresses lung cancer tumorigenesis and taxol resistance by sponging miR-558. Mol Oncol 15:2235\u20132248. https:\/\/doi.org\/10.1002\/1878-0261.12852","journal-title":"Mol Oncol"},{"key":"10421_CR19","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/s13046-022-02462-7","volume":"41","author":"L Liang","year":"2022","unstructured":"Liang L, Zhu Y, Li J, Zeng J, Wu L (2022) ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription. J Exp Clin Cancer Res 41:261. https:\/\/doi.org\/10.1186\/s13046-022-02462-7","journal-title":"J Exp Clin Cancer Res"},{"key":"10421_CR20","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12943-021-01398-4","volume":"20","author":"Z Liu","year":"2021","unstructured":"Liu Z, Wang T, She Y, Wu K, Gu S, Li L, Dong C, Chen C, Zhou Y (2021) N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer 20:105. https:\/\/doi.org\/10.1186\/s12943-021-01398-4","journal-title":"Mol Cancer"},{"key":"10421_CR21","doi-asserted-by":"publisher","first-page":"6291","DOI":"10.7150\/thno.71456","volume":"12","author":"P Liu","year":"2022","unstructured":"Liu P, Fan B, Othmane B, Hu J, Li H, Cui Y, Ou Z, Chen J, Zu X (2022) m(6)A-induced LncDBET promotes the malignant progression of bladder cancer through FABP5-mediated lipid metabolism. Theranostics 12:6291\u20136307. https:\/\/doi.org\/10.7150\/thno.71456","journal-title":"Theranostics"},{"key":"10421_CR22","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.bbrc.2020.03.084","volume":"526","author":"M Lu","year":"2020","unstructured":"Lu M, Wu Y, Zeng B, Sun J, Li Y, Luo J, Wang L, Yi Z, Li H, Ren G (2020) CircEHMT1 inhibits metastatic potential of breast cancer cells by modulating miR-1233-3p\/KLF4\/MMP2 axis. Biochem Biophys Res Commun 526:306\u2013313. https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.084","journal-title":"Biochem Biophys Res Commun"},{"key":"10421_CR23","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s40618-020-01317-2","volume":"44","author":"W Ma","year":"2021","unstructured":"Ma W, Zhao P, Zang L, Zhang K, Liao H, Hu Z (2021) CircTP53 promotes the proliferation of thyroid cancer via targeting miR-1233-3p\/MDM2 axis. J Endocrinol Invest 44:353\u2013362. https:\/\/doi.org\/10.1007\/s40618-020-01317-2","journal-title":"J Endocrinol Invest"},{"key":"10421_CR24","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","author":"S Memczak","year":"2013","unstructured":"Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N (2013) Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495:333\u2013338. https:\/\/doi.org\/10.1038\/nature11928","journal-title":"Nature"},{"key":"10421_CR25","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s41586-018-0040-3","volume":"556","author":"I Pastushenko","year":"2018","unstructured":"Pastushenko I, Brisebarre A, Sifrim A, Fioramonti M, Revenco T, Boumahdi S, Van Keymeulen A, Brown D, Moers V, Lemaire S, De Clercq S, Minguij\u00f3n E, Balsat C, Sokolow Y, Dubois C, De Cock F, Scozzaro S, Sopena F, Lanas A, D\u2019Haene N, Salmon I, Marine JC, Voet T, Sotiropoulou PA, Blanpain C (2018) Identification of the tumour transition States occurring during EMT. Nature 556:463\u2013468. https:\/\/doi.org\/10.1038\/s41586-018-0040-3","journal-title":"Nature"},{"key":"10421_CR26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.gde.2017.11.007","volume":"48","author":"IL Patop","year":"2018","unstructured":"Patop IL, Kadener S (2018) CircRNAs in cancer. Curr Opin Genet Dev 48:121\u2013127. https:\/\/doi.org\/10.1016\/j.gde.2017.11.007","journal-title":"Curr Opin Genet Dev"},{"key":"10421_CR27","doi-asserted-by":"publisher","first-page":"109463","DOI":"10.1016\/j.cellsig.2019.109463","volume":"65","author":"P Sarode","year":"2020","unstructured":"Sarode P, Mansouri S, Karger A, Schaefer MB, Grimminger F, Seeger W, Savai R (2020) Epithelial cell plasticity defines heterogeneity in lung cancer. Cell Signal 65:109463. https:\/\/doi.org\/10.1016\/j.cellsig.2019.109463","journal-title":"Cell Signal"},{"key":"10421_CR28","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s12943-019-1071-6","volume":"18","author":"BQ Shang","year":"2019","unstructured":"Shang BQ, Li ML, Quan HY, Hou PF, Li ZW, Chu SF, Zheng JN, Bai J (2019) Functional roles of circular RNAs during epithelial-to-mesenchymal transition. Mol Cancer 18:138. https:\/\/doi.org\/10.1186\/s12943-019-1071-6","journal-title":"Mol Cancer"},{"key":"10421_CR29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"10421_CR30","doi-asserted-by":"publisher","first-page":"552","DOI":"10.22074\/cellj.2021.7913","volume":"23","author":"Q Tan","year":"2021","unstructured":"Tan Q, Liu C, Shen Y, Huang T (2021) Circular RNA circ_0000517 facilitates the growth and metastasis of Non-Small cell lung cancer by sponging miR-326\/miR-330-5p. Cell J 23:552\u2013561. https:\/\/doi.org\/10.22074\/cellj.2021.7913","journal-title":"Cell J"},{"key":"10421_CR31","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature12986","volume":"505","author":"Y Tay","year":"2014","unstructured":"Tay Y, Rinn J, Pandolfi PP (2014) The multilayered complexity of CeRNA crosstalk and competition. Nature 505:344\u2013352. https:\/\/doi.org\/10.1038\/nature12986","journal-title":"Nature"},{"key":"10421_CR32","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12943-018-0889-7","volume":"17","author":"L Wang","year":"2018","unstructured":"Wang L, Tong X, Zhou Z, Wang S, Lei Z, Zhang T, Liu Z, Zeng Y, Li C, Zhao J, Su Z, Zhang C, Liu X, Xu G, Zhang HT (2018) Circular RNA Hsa_circ_0008305 (circPTK2) inhibits TGF-\u03b2-induced epithelial-mesenchymal transition and metastasis by controlling TIF1\u03b3 in non-small cell lung cancer. Mol Cancer 17:140. https:\/\/doi.org\/10.1186\/s12943-018-0889-7","journal-title":"Mol Cancer"},{"key":"10421_CR33","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3389\/fonc.2019.01105","volume":"9","author":"X Wang","year":"2019","unstructured":"Wang X, Wang X, Li W, Zhang Q, Chen J, Chen T (2019) Up-Regulation of Hsa_circ_0000517 predicts adverse prognosis of hepatocellular carcinoma. Front Oncol 9:1105. https:\/\/doi.org\/10.3389\/fonc.2019.01105","journal-title":"Front Oncol"},{"key":"10421_CR34","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.cmet.2020.12.010","volume":"33","author":"K Wang","year":"2021","unstructured":"Wang K, Huang W, Chen R, Lin P, Zhang T, Ni YF, Li H, Wu J, Sun XX, Geng JJ, Zhu YM, Nan G, Zhang W, Chen X, Zhu P, Bian H, Chen ZN (2021) Di-methylation of CD147-K234 promotes the progression of NSCLC by enhancing lactate export. Cell Metab 33:160\u2013173e6. https:\/\/doi.org\/10.1016\/j.cmet.2020.12.010","journal-title":"Cell Metab"},{"key":"10421_CR35","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.7150\/ijms.46261","volume":"17","author":"W Xu","year":"2020","unstructured":"Xu W, Zhou B, Wu J, Jiang P, Chen H, Yan F (2020) Circular RNA hsa-circ-0007766 modulates the progression of gastric carcinoma via miR-1233-3p\/GDF15 axis. Int J Med Sci 17:1569\u20131583. https:\/\/doi.org\/10.7150\/ijms.46261","journal-title":"Int J Med Sci"},{"key":"10421_CR36","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/s41419-021-03601-2","volume":"12","author":"Z Yu","year":"2021","unstructured":"Yu Z, Zhu X, Li Y, Liang M, Liu M, Liu Z, Qin L, Wu X, Du K, Liu L, Wang Y, Zheng Y (2021) Circ-HMGA2 (hsa_circ_0027446) promotes the metastasis and epithelial-mesenchymal transition of lung adenocarcinoma cells through the miR-1236-3p\/ZEB1 axis. Cell Death Dis 12:313. https:\/\/doi.org\/10.1038\/s41419-021-03601-2","journal-title":"Cell Death Dis"},{"key":"10421_CR37","doi-asserted-by":"publisher","first-page":"3457","DOI":"10.2147\/cmar.S244024","volume":"12","author":"H Zang","year":"2020","unstructured":"Zang H, Li Y, Zhang X, Huang G (2020) Circ_0000517 contributes to hepatocellular carcinoma progression by upregulating TXNDC5 via sponging miR-1296-5p. Cancer Manag Res 12:3457\u20133468. https:\/\/doi.org\/10.2147\/cmar.S244024","journal-title":"Cancer Manag Res"},{"key":"10421_CR38","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.7150\/thno.49345","volume":"11","author":"L Zhang","year":"2021","unstructured":"Zhang L, Wan Y, Zhang Z, Jiang Y, Gu Z, Ma X, Nie S, Yang J, Lang J, Cheng W, Zhu L (2021) IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression. Theranostics 11:1100\u20131114. https:\/\/doi.org\/10.7150\/thno.49345","journal-title":"Theranostics"},{"key":"10421_CR39","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1186\/s12935-021-02071-y","volume":"21","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Li S, Li S, Wang J, Lin H, Fu W (2021) High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. Cancer Cell Int 21:493. https:\/\/doi.org\/10.1186\/s12935-021-02071-y","journal-title":"Cancer Cell Int"},{"key":"10421_CR40","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s13046-018-0901-5","volume":"37","author":"H Zheng","year":"2018","unstructured":"Zheng H, Zhan Y, Liu S, Lu J, Luo J, Feng J, Fan S (2018) The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications. J Exp Clin Cancer Res 37:226. https:\/\/doi.org\/10.1186\/s13046-018-0901-5","journal-title":"J Exp Clin Cancer Res"},{"key":"10421_CR41","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.7150\/ijbs.77133","volume":"19","author":"C Zhong","year":"2023","unstructured":"Zhong C, Long Z, Yang T, Wang S, Zhong W, Hu F, Teoh JY, Lu J, Mao X (2023) M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy. Int J Biol Sci 19:1543\u20131563. https:\/\/doi.org\/10.7150\/ijbs.77133","journal-title":"Int J Biol Sci"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10421-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10421-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10421-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T17:02:25Z","timestamp":1752512545000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10421-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10421"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10421-7","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"20 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of General Hospital of Southern Theater Command, PLA (NZLL KZ2024024). All participants were provided with written informed consent at the time of recruitment, and all experiments involving human tissue specimens comply with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"139"}}