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All the methods\/studies were conducted in accordance with the Declaration of Helsinki. All animal experimental protocols were approved by the Animal Experiment Ethics Committee of Kunming Medical University (kmmu2020198), and the animal procedures adhered to the ARRIVE guidelines 2.0.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethical approval and consent to participate"}}],"article-number":"172"}}