{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:11:06Z","timestamp":1793772666438,"version":"4.6.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10735-025-10451-1","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T05:27:48Z","timestamp":1747805268000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Myoinositol improves sperm parameters in diabetic rats by reducing oxidative stress and regulating apoptosis-related genes"],"prefix":"10.1007","volume":"56","author":[{"given":"Mina","family":"Kiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek Soleimani","family":"Mehranjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ali","family":"Shariatzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"10451_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10561-019-09801-7","volume":"21","author":"M Abdolsamadi","year":"2020","unstructured":"Abdolsamadi M, Mohammadi F, Nashtaei MS, Teimouri M, Sardar R, Dayani M, Zandieh Z (2020) Does myoinositol supplement improve sperm parameters and DNA integrity in patients with oligoasthenoteratozoospermia after the freezing\u2013thawing process? Cell Tissue Banking 21:99\u2013106","journal-title":"Cell Tissue Banking"},{"key":"10451_CR2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00441-017-2660-6","volume":"370","author":"MV Aguirre-Arias","year":"2017","unstructured":"Aguirre-Arias MV, Velarde V, Moreno RD (2017) Effects of ascorbic acid on spermatogenesis and sperm parameters in diabetic rats. Cell Tissue Res 370:305\u2013317","journal-title":"Cell Tissue Res"},{"issue":"1","key":"10451_CR3","first-page":"7945589","volume":"2024","author":"MA Alshehri","year":"2024","unstructured":"Alshehri MA, Ali Seyed M, Alasmari A, Panneerselvam C, Hajad Alboqami H, Ahmed Alkeridis L, Aioub AA (2024) Retama raetam extract for testicular health in type 2 diabetic rats: insight view on the steroidogenesis, antioxidants, and molecular docking scores of bioactive compounds against bax. J Food Biochem 2024(1):7945589","journal-title":"J Food Biochem"},{"issue":"1","key":"10451_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2022.151974","volume":"125","author":"N Andlib","year":"2023","unstructured":"Andlib N, Sajad M, Kumar R, Thakur SC (2023) Abnormalities in sex hormones and sexual dysfunction in males with diabetes mellitus: a mechanistic insight. Acta Histochem 125(1):151974","journal-title":"Acta Histochem"},{"issue":"2","key":"10451_CR5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/09513590.2016.1254179","volume":"33","author":"PG Artini","year":"2017","unstructured":"Artini PG, Casarosa E, Carletti E, Monteleone P, Di Noia A, Di Berardino O (2017) In vitro effect of myo-inositol on sperm motility in normal and oligoasthenospermia patients undergoing in vitro fertilization. Gynecol Endocrinol 33(2):109\u2013112","journal-title":"Gynecol Endocrinol"},{"key":"10451_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13063-020-04561-2","volume":"21","author":"G Asimakopoulos","year":"2020","unstructured":"Asimakopoulos G, Pergialiotis V, Anastasiou E, Antsaklis P, Theodora M, Vogiatzi E, Daskalakis G (2020) Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: study protocol for a randomized controlled trial. Trials 21:1\u201310","journal-title":"Trials"},{"issue":"16","key":"10451_CR7","doi-asserted-by":"publisher","first-page":"8852","DOI":"10.3390\/ijms23168852","volume":"23","author":"VF Avram","year":"2022","unstructured":"Avram VF, Merce AP, H\u00e2ncu IM, B\u0103tr\u00e2n AD, Kennedy G, Rosca MG, Muntean DM (2022) Impairment of mitochondrial respiration in metabolic diseases: an overview. Int J Mol Sci 23(16):8852","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10451_CR8","doi-asserted-by":"publisher","DOI":"10.1111\/and.13313","volume":"51","author":"M Bahmanzadeh","year":"2019","unstructured":"Bahmanzadeh M, Goodarzi MT, Rezaei Farimani A, Fathi N, Alizadeh Z (2019) Resveratrol supplementation improves DNA integrity and sperm parameters in streptozotocin\u2013nicotinamide-induced type 2 diabetic rats. Andrologia 51(8):e13313","journal-title":"Andrologia"},{"issue":"18","key":"10451_CR9","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1242\/dev.110627","volume":"141","author":"EL Bell","year":"2014","unstructured":"Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, Watson N, Guarente L (2014) SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development 141(18):3495\u20133504","journal-title":"Development"},{"issue":"4","key":"10451_CR10","doi-asserted-by":"publisher","first-page":"311","DOI":"10.2174\/1874467212666190620143303","volume":"12","author":"S Benvenga","year":"2019","unstructured":"Benvenga S, Micali A, Pallio G, Vita R, Malta C, Puzzolo D, Minutoli L (2019) Effects of myo-inositol alone and in combination with seleno-lmethionine on cadmium-induced testicular damage in mice. Curr Mol Pharmacol 12(4):311\u2013323. https:\/\/doi.org\/10.2174\/1874467212666190620143303","journal-title":"Curr Mol Pharmacol"},{"key":"10451_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.662582","volume":"12","author":"S Benvenga","year":"2021","unstructured":"Benvenga S, Nordio M, Lagan\u00e0 AS, Unfer V (2021) The role of inositol in thyroid physiology and in subclinical hypothyroidism management. Front Endocrinol 12:662582","journal-title":"Front Endocrinol"},{"issue":"9","key":"10451_CR12","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.3390\/ani13091483","volume":"13","author":"LG Bezerra","year":"2023","unstructured":"Bezerra LG, Silva AM, Jurema AP, Dantas MR, Pereira AG, Oliveira MF, Silva AR (2023) Changes in sperm morphology, morphometry, and motility from the epididymis to the vas deferens in rheas (Rhea americana Linnaeus,1758). Animals 13(9):1483","journal-title":"Animals"},{"issue":"1","key":"10451_CR13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4103\/0976-9668.82309","volume":"2","author":"Y Bhutia","year":"2011","unstructured":"Bhutia Y, Ghosh A, Sherpa ML, Pal R, Mohanta PK (2011) Serum malondialdehyde level: surrogate stress marker in the Sikkimese diabetics. J Nat Sci Biol Med 2(1):107\u2013112. https:\/\/doi.org\/10.4103\/0976-9668.82309","journal-title":"J Nat Sci Biol Med"},{"issue":"2","key":"10451_CR14","doi-asserted-by":"publisher","first-page":"E237","DOI":"10.1152\/ajpendo.00162.2019","volume":"318","author":"H Cabrera-Cruz","year":"2020","unstructured":"Cabrera-Cruz H, Or\u00f3stica L, Plaza-Parrochia F, Torres-Pinto I, Romero C, Vega M (2020) The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment. Am J Physiol Endocrinol Metab 318(2):E237-e248. https:\/\/doi.org\/10.1152\/ajpendo.00162.2019","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"10451_CR15","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/andr.12025","volume":"3","author":"AE Calogero","year":"2015","unstructured":"Calogero AE, Gullo G, La Vignera S, Condorelli RA, Vaiarelli A (2015) Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: a prospective double-blind randomized placebo-controlled study. Andrology 3(3):491\u2013495. https:\/\/doi.org\/10.1111\/andr.12025","journal-title":"Andrology"},{"issue":"8","key":"10451_CR16","doi-asserted-by":"publisher","first-page":"e14161","DOI":"10.1111\/jfbc.14161","volume":"46","author":"M Cellat","year":"2022","unstructured":"Cellat M, \u0130\u015fler CT, Uyar A, Kuzu M, Ayd\u0131n T, Etyemez M, G\u00fcven\u00e7 M (2022) Protective effect of Smilax excelsa L. pretreatment via antioxidant anti-inflammatory effects and activation of Nrf-2\/HO-1 pathway in testicular torsion model. J Food Biochem 46(8):e14161","journal-title":"J Food Biochem"},{"issue":"2","key":"10451_CR17","first-page":"129","volume":"15","author":"RA Condorelli","year":"2011","unstructured":"Condorelli RA, La Vignera S, Di Bari F, Unfer V, Calogero AE (2011) Effects of myoinositol on sperm mitochondrial function in-vitro. Eur Rev Med Pharmacol Sci 15(2):129\u2013134","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"5","key":"10451_CR18","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/sj.cdd.4402099","volume":"14","author":"A Criollo","year":"2007","unstructured":"Criollo A, Maiuri MC, Tasdemir E, Vitale I, Fiebig AA, Andrews D, Kroemer G (2007) Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ 14(5):1029\u20131039. https:\/\/doi.org\/10.1038\/sj.cdd.4402099","journal-title":"Cell Death Differ"},{"issue":"12","key":"10451_CR19","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1017\/s000711451500121x","volume":"113","author":"ML Croze","year":"2015","unstructured":"Croze ML, G\u00e9lo\u00ebn A, Soulage CO (2015) Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation. Br J Nutr 113(12):1862\u20131875. https:\/\/doi.org\/10.1017\/s000711451500121x","journal-title":"Br J Nutr"},{"key":"10451_CR20","doi-asserted-by":"crossref","unstructured":"DiNicolantonio, J. J., & O'Keefe, J. H. (2022). Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes (Vol. 9, pp. e001989): Archives of Disease in childhood.","DOI":"10.1136\/openhrt-2022-001989"},{"issue":"4","key":"10451_CR21","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1177\/0192623311436182","volume":"40","author":"D Dutta","year":"2012","unstructured":"Dutta D, Park I, Mills NC (2012) Fixation temperature affects DNA integrity in the testis as measured by the TUNEL assay. Toxicol Pathol 40(4):667\u2013674","journal-title":"Toxicol Pathol"},{"issue":"1","key":"10451_CR22","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1080\/13510002.2018.1540675","volume":"23","author":"AP Ebokaiwe","year":"2018","unstructured":"Ebokaiwe AP, Ijomone OM, Osawe SO, Chukwu CJ, Ejike CE, Zhang G, Wang F (2018) Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus. Redox Rep 23(1):194\u2013205","journal-title":"Redox Rep"},{"issue":"1","key":"10451_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/01485018408987498","volume":"13","author":"H Ekwall","year":"1984","unstructured":"Ekwall H, Jansson \u00c5, Sj\u00f6berg P, Pl\u00f6en L (1984) Differentiation of the rat testis between 20 and 120 days of age. Arch Androl 13(1):27\u201336","journal-title":"Arch Androl"},{"issue":"1","key":"10451_CR24","first-page":"2","volume":"96","author":"MJ Freitas","year":"2017","unstructured":"Freitas MJ, Vijayaraghavan S, Fardilha M (2017) Signaling mechanisms in mammalian sperm motility. Biol Reprod 96(1):2\u201312","journal-title":"Biol Reprod"},{"issue":"2","key":"10451_CR25","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.psj.2019.10.014","volume":"99","author":"F Gonzalez-Uarquin","year":"2020","unstructured":"Gonzalez-Uarquin F, Rodehutscord M, Huber K (2020) Myo-inositol: its metabolism and potential implications for poultry nutrition-a review. Poult Sci 99(2):893\u2013905. https:\/\/doi.org\/10.1016\/j.psj.2019.10.014","journal-title":"Poult Sci"},{"key":"10451_CR26","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.biopha.2018.12.012","volume":"110","author":"X-X Han","year":"2019","unstructured":"Han X-X, Jiang Y-P, Liu N, Wu J, Yang J-M, Li Y-X, Yu J-Q (2019) Protective effects of astragalin on spermatogenesis in streptozotocin-induced diabetes in male mice by improving antioxidant activity and inhibiting inflammation. Biomed Pharmacother 110:561\u2013570","journal-title":"Biomed Pharmacother"},{"key":"10451_CR27","doi-asserted-by":"publisher","first-page":"1284988","DOI":"10.3389\/fcell.2024.1284988","volume":"12","author":"JY Hwang","year":"2024","unstructured":"Hwang JY (2024) Analysis of Ca(2+)-mediated sperm motility to evaluate the functional normality of the sperm-specific Ca(2+) channel. CatSper Front Cell Dev Biol 12:1284988. https:\/\/doi.org\/10.3389\/fcell.2024.1284988","journal-title":"CatSper Front Cell Dev Biol"},{"key":"10451_CR28","doi-asserted-by":"publisher","first-page":"1150984","DOI":"10.3389\/fvets.2023.1150984","volume":"10","author":"A Jawad","year":"2023","unstructured":"Jawad A, Oh D, Choi H, Kim M, Cai L, Lee J, Hyun S-H (2023) Myo-inositol improves the viability of boar sperm during liquid storage. Front Veterinary Sci 10:1150984","journal-title":"Front Veterinary Sci"},{"issue":"1","key":"10451_CR29","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41598-024-51224-2","volume":"14","author":"Z Jin","year":"2024","unstructured":"Jin Z, Cao Y, Wen Q, Zhang H, Fang Z, Zhao Q, Zhang Z (2024) Dapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis. Sci Rep 14(1):641","journal-title":"Sci Rep"},{"key":"10451_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108684","volume":"112","author":"A Johnson","year":"2019","unstructured":"Johnson A, Cheng S-C, Tsou D, Kong Z-L (2019) Attenuation of reproductive dysfunction in diabetic male rats with timber cultured Antrodia cinnamomea ethanol extract. Biomed Pharmacother 112:108684","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10451_CR31","first-page":"47","volume":"140","author":"V Katalinic","year":"2005","unstructured":"Katalinic V, Modun D, Music I, Boban M (2005) Gender differences in antioxidant capacity of rat tissues determined by 2, 2\u2032-azinobis (3-ethylbenzothiazoline 6-sulfonate; ABTS) and ferric reducing antioxidant power (FRAP) assays. Comp Biochem Physiol C: Toxicol Pharmacol 140(1):47\u201352","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"key":"10451_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116135","volume":"223","author":"M Kiani","year":"2024","unstructured":"Kiani M, Mehranjani MS, Shariatzadeh MA (2024) Empagliflozin reduces the adverse effects of diabetes mellitus on testicular tissue in type 2 diabetic Rats: A stereological and biochemical study. Biochem Pharmacol 223:116135","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10451_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2024.100971","volume":"25","author":"M Kiani","year":"2025","unstructured":"Kiani M, Mehranjani MS, Shariatzadeh MA (2025) Empagliflozin improves sperm quality in diabetic rats by lowering oxidative stress and reducing apoptosis-related genes expression. Reprod Biol 25(1):100971","journal-title":"Reprod Biol"},{"key":"10451_CR34","doi-asserted-by":"crossref","unstructured":"Lei, X., Huo, P., Wang, Y., Xie, Y., Shi, Q., Tu, H.,... Zhang, S. (2020). Lycium barbarum polysaccharides improve testicular spermatogenic function in streptozotocin-induced diabetic rats. Frontiers in Endocrinology, 11, 164.","DOI":"10.3389\/fendo.2020.00164"},{"issue":"4","key":"10451_CR35","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/and.12454","volume":"48","author":"CY Liu","year":"2016","unstructured":"Liu CY, Hsu YJ, Chien YW, Cha TL, Tsao CW (2016) Dietary resistant maltodextrin ameliorates testicular function and spermatogenesis in streptozotocin\u2013nicotinamide-induced diabetic rats. Andrologia 48(4):363\u2013373","journal-title":"Andrologia"},{"issue":"6","key":"10451_CR36","doi-asserted-by":"publisher","first-page":"523","DOI":"10.4314\/ejhs.v26i6.4","volume":"26","author":"M Madi","year":"2016","unstructured":"Madi M, Babu S, Kumari S, Shetty S, Achalli S, Madiyal A, Bhat M (2016) Status of serum and salivary levels of superoxide dismutase in type 2 diabetes mellitus with oral manifestations: a case control study. Ethiop J Health Sci 26(6):523\u2013532","journal-title":"Ethiop J Health Sci"},{"key":"10451_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.651286","volume":"8","author":"C-F Mao","year":"2021","unstructured":"Mao C-F, Sudirman S, Lee C-C, Tsou D, Kong Z-L (2021) Echinacea purpurea ethanol extract improves male reproductive dysfunction with streptozotocin\u2013nicotinamide-induced diabetic rats. Frontiers in Veterinary Science 8:651286","journal-title":"Frontiers in Veterinary Science"},{"issue":"5","key":"10451_CR38","first-page":"343","volume":"12","author":"M Mardani","year":"2014","unstructured":"Mardani M, Vaez A, Razavi S (2014) Effect of saffron on rat sperm chromatin integrity. Iran J Reprod Med 12(5):343","journal-title":"Iran J Reprod Med"},{"issue":"3","key":"10451_CR39","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47(3):469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"Eur J Biochem"},{"key":"10451_CR40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.biochi.2023.11.004","volume":"219","author":"S Mondal","year":"2024","unstructured":"Mondal S, Bandyopadhyay A (2024) Glucose transporters (GLUTs): underreported yet crucial molecules in unraveling testicular toxicity. Biochimie 219:55\u201362","journal-title":"Biochimie"},{"issue":"1","key":"10451_CR41","first-page":"1674950","volume":"2016","author":"M Montanino Oliva","year":"2016","unstructured":"Montanino Oliva M, Minutolo E, Lippa A, Iaconianni P, Vaiarelli A (2016) Effect of myoinositol and antioxidants on sperm quality in men with metabolic syndrome. International Journal of Endocrinology 2016(1):1674950","journal-title":"International Journal of Endocrinology"},{"issue":"1","key":"10451_CR42","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s42826-024-00188-5","volume":"40","author":"KB Okesina","year":"2024","unstructured":"Okesina KB, Odetayo AF, Adeyemi WJ, Ajibare AJ, Okesina AA, Olayaki LA (2024) Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase\/uric acid signaling and maintaining redox balance. Lab Animal Res 40(1):5","journal-title":"Lab Animal Res"},{"key":"10451_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155501","volume":"142","author":"KS Olaniyi","year":"2021","unstructured":"Olaniyi KS, Amusa OA, Akinnagbe NT, Ajadi IO, Ajadi MB, Agunbiade TB, Michael OS (2021) Acetate ameliorates nephrotoxicity in streptozotocin-nicotinamide-induced diabetic rats: Involvement of xanthine oxidase activity. Cytokine 142:155501","journal-title":"Cytokine"},{"key":"10451_CR44","doi-asserted-by":"crossref","unstructured":"Olszewska-S\u0142onina, D. M., M\u0105tewski, D., Czajkowski, R., Olszewski, K. J., Wo\u0178niak, A., Odrow\u0105\u017c-Sypniewska, G.,... Kowaliszyn, B. (2011). The concentration of thiobarbituric acid reactive substances (TBARS) and paraoxonase activity in blood of patients with osteoarthrosis after endoprosthesis implantation. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 17(9), CR498.","DOI":"10.12659\/MSM.881936"},{"issue":"1","key":"10451_CR45","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1530\/rep-09-0377","volume":"139","author":"PJ O'Shaughnessy","year":"2010","unstructured":"O\u2019Shaughnessy PJ, Monteiro A, Verhoeven G, De Gendt K, Abel MH (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction 139(1):177\u2013184. https:\/\/doi.org\/10.1530\/rep-09-0377","journal-title":"Reproduction"},{"issue":"9","key":"10451_CR46","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.3390\/antiox12091673","volume":"12","author":"R Osman","year":"2023","unstructured":"Osman R, Lee S, Almubarak A, Han J-I, Yu I-J, Jeon Y (2023) Antioxidant effects of myo-inositol improve the function and fertility of cryopreserved boar semen. Antioxidants 12(9):1673","journal-title":"Antioxidants"},{"issue":"3","key":"10451_CR47","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/febs.14186","volume":"285","author":"A Pe\u00f1a-Blanco","year":"2018","unstructured":"Pe\u00f1a-Blanco A, Garc\u00eda-S\u00e1ez AJ (2018) Bax, Bak and beyond\u2014mitochondrial performance in apoptosis. FEBS J 285(3):416\u2013431","journal-title":"FEBS J"},{"key":"10451_CR48","doi-asserted-by":"publisher","first-page":"9132052","DOI":"10.1155\/2016\/9132052","volume":"2016","author":"B Pintaudi","year":"2016","unstructured":"Pintaudi B, Di Vieste G, Bonomo M (2016) The effectiveness of myo-inositol and D-Chiro inositol treatment in type 2 diabetes. Int J Endocrinol 2016:9132052. https:\/\/doi.org\/10.1155\/2016\/9132052","journal-title":"Int J Endocrinol"},{"issue":"5","key":"10451_CR49","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1093\/jpp\/rgad099","volume":"76","author":"M Raeeszadeh","year":"2024","unstructured":"Raeeszadeh M, Shokrollahi B, Akbari A, Masumi S, Amiri AA (2024) Thyme extract could overcome diabetes-induced reproductive dysfunction by inhibiting oxidative damage and increasing the expression of insulin receptor substrate and pyruvate kinase in the rat sperm. J Pharm Pharmacol 76(5):534\u2013544","journal-title":"J Pharm Pharmacol"},{"key":"10451_CR50","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s40618-019-01136-0","volume":"43","author":"A Ranjan","year":"2020","unstructured":"Ranjan A, Choubey M, Yada T, Krishna A (2020) Nesfatin-1 ameliorates type-2 diabetes-associated reproductive dysfunction in male mice. J Endocrinol Invest 43:515\u2013528","journal-title":"J Endocrinol Invest"},{"key":"10451_CR51","doi-asserted-by":"publisher","first-page":"112034","DOI":"10.1016\/j.mce.2023.112034","volume":"576","author":"SP Rossi","year":"2023","unstructured":"Rossi SP, Matzkin ME, Riviere E, Martinez G, Ponzio R, Levalle O, Frungieri MB (2023) Melatonin improves oxidative state and lactate metabolism in rodent Sertoli cells. Mol Cell Endocrinol 576:112034","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"10451_CR52","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1002\/fsn3.3842","volume":"12","author":"S Rostami","year":"2024","unstructured":"Rostami S, Arefhosseini S, Tutunchi H, Khoshbaten M, Ebrahimi-Mameghani M (2024) Does myo-inositol supplementation influence oxidative stress biomarkers in patients with non-alcoholic fatty liver disease? Food Sci Nutr 12(2):1279\u20131289. https:\/\/doi.org\/10.1002\/fsn3.3842","journal-title":"Food Sci Nutr"},{"key":"10451_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12917-016-0792-7","volume":"12","author":"CP Rubio","year":"2016","unstructured":"Rubio CP, Hern\u00e1ndez-Ruiz J, Martinez-Subiela S, Tvarijonaviciute A, Ceron JJ (2016) Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: an update. BMC Vet Res 12:1\u20137","journal-title":"BMC Vet Res"},{"issue":"10","key":"10451_CR54","doi-asserted-by":"publisher","first-page":"17312","DOI":"10.1002\/jcb.28995","volume":"120","author":"E Sajadi","year":"2019","unstructured":"Sajadi E, Dadras S, Bayat M, Abdi S, Nazarian H, Ziaeipour S, Valizadeh A (2019) Impaired spermatogenesis associated with changes in spatial arrangement of sertoli and spermatogonial cells following induced diabetes. J Cell Biochem 120(10):17312\u201317325","journal-title":"J Cell Biochem"},{"issue":"2","key":"10451_CR55","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/and.12429","volume":"48","author":"S Sar\u0131\u00f6zkan","year":"2016","unstructured":"Sar\u0131\u00f6zkan S, T\u00fcrk G, \u00c7\u0131kla-S\u00fczg\u00fcn P, G\u00fcven\u00e7 M, Y\u00fcce A, Yay A, K\u00fc\u00e7\u00fckg\u00fczel \u015e (2016) Effect of etodolac hydrazone, a new compound synthesised from etodolac, on spermatozoon quality, testicular lipid peroxidation, apoptosis and spermatozoon DNA integrity. Andrologia 48(2):177\u2013188","journal-title":"Andrologia"},{"issue":"9","key":"10451_CR56","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/sj.cdd.4400889","volume":"8","author":"SS Smaili","year":"2001","unstructured":"Smaili SS, Hsu YT, Sanders KM, Russell JT, Youle RJ (2001) Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential. Cell Death Differ 8(9):909\u2013920. https:\/\/doi.org\/10.1038\/sj.cdd.4400889","journal-title":"Cell Death Differ"},{"key":"10451_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.149254","volume":"690","author":"O Soetan","year":"2024","unstructured":"Soetan O, Ajao F, Ajayi A (2024) Erythritol attenuates testicular dysfunction in diabetic rat via suppression of oxidative stress, inflammation and apoptosis. Biochem Biophys Res Commun 690:149254","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10451_CR58","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1177\/0748233713499600","volume":"32","author":"G T\u00fcrk","year":"2016","unstructured":"T\u00fcrk G, \u00c7eriba\u015f\u0131 S, S\u00f6nmez M, \u00c7ift\u00e7i M, Y\u00fcce A, G\u00fcven\u00e7 M, Aksakal M (2016) Ameliorating effect of pomegranate juice consumption on carbon tetrachloride-induced sperm damages, lipid peroxidation, and testicular apoptosis. Toxicol Indus Health 32(1):126\u2013137","journal-title":"Toxicol Indus Health"},{"issue":"4","key":"10451_CR59","doi-asserted-by":"publisher","first-page":"e12976","DOI":"10.1111\/and.12976","volume":"50","author":"G T\u00fcrk","year":"2018","unstructured":"T\u00fcrk G, Ri\u015fvanl\u0131 A, \u00c7eriba\u015f\u0131 A, S\u00f6nmez M, Y\u00fcce A, G\u00fcven\u00e7 M, Yaman M (2018) Effect of gestational diabetes mellitus on testis and pancreatic tissues of male offspring. Andrologia 50(4):e12976","journal-title":"Andrologia"},{"issue":"2","key":"10451_CR60","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/andr.12718","volume":"8","author":"M Vazquez-Levin","year":"2020","unstructured":"Vazquez-Levin M, Ver\u00f3n GL (2020) Myo-inositol in health and disease: its impact on semen parameters and male fertility. Andrology 8(2):277\u2013298","journal-title":"Andrology"},{"issue":"3","key":"10451_CR61","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s10695-020-00766-z","volume":"46","author":"C Wang","year":"2020","unstructured":"Wang C, Lu S, Li J, Wang L, Jiang H, Liu Y, Yin J (2020) Effects of dietary myo-inositol on growth, antioxidative capacity, and nonspecific immunity in skin mucus of taimen Hucho taimen fry. Fish Physiol Biochem 46(3):1011\u20131018. https:\/\/doi.org\/10.1007\/s10695-020-00766-z","journal-title":"Fish Physiol Biochem"},{"issue":"04","key":"10451_CR62","first-page":"71","volume":"7","author":"Y Xue-ping","year":"2018","unstructured":"Xue-ping Y, Fei-fei G, Xiangrong S, Luo X (2018) The effects of Myo-inositol on glucose metabolic in diabetes rats. Int J Sci 7(04):71\u201376","journal-title":"Int J Sci"},{"issue":"4","key":"10451_CR63","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1002\/open.202100013","volume":"10","author":"Y Yao","year":"2021","unstructured":"Yao Y, Chen S, Li H (2021) An improved system to evaluate superoxide-scavenging effects of bioflavonoids. ChemistryOpen 10(4):503\u2013514","journal-title":"ChemistryOpen"},{"issue":"1\u20132","key":"10451_CR64","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.toxlet.2010.11.001","volume":"200","author":"Y Zhao","year":"2011","unstructured":"Zhao Y, Tan Y, Dai J, Li B, Guo L, Cui J, Cai L (2011) Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice. Toxicol Lett 200(1\u20132):100\u2013106. https:\/\/doi.org\/10.1016\/j.toxlet.2010.11.001","journal-title":"Toxicol Lett"},{"key":"10451_CR65","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.2147\/TCRM.S141738","volume":"13","author":"L Zhao","year":"2017","unstructured":"Zhao L, Gu Q, Xiang L, Dong X, Li H, Ni J, Chen G (2017) Curcumin inhibits apoptosis by modulating Bax\/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats. Therapeutics Clin Risk Manag 13:1099\u20131105","journal-title":"Therapeutics Clin Risk Manag"},{"issue":"1","key":"10451_CR66","first-page":"8712492","volume":"2019","author":"X Zhu","year":"2019","unstructured":"Zhu X, Guo F, Tang H, Huang C, Xie G, Huang T, Chen B (2019) Islet transplantation attenuating testicular injury in type 1 diabetic rats is associated with suppression of oxidative stress and inflammation via Nrf-2\/HO-1 and NF-\u03baB pathways. J Diabetes Res 2019(1):8712492","journal-title":"J Diabetes Res"},{"issue":"1","key":"10451_CR67","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1080\/13880209.2016.1255978","volume":"55","author":"N Ziamajidi","year":"2017","unstructured":"Ziamajidi N, Nasiri A, Abbasalipourkabir R, Sadeghi Moheb S (2017) Effects of garlic extract on TNF-\u03b1 expression and oxidative stress status in the kidneys of rats with STZ+ nicotinamide-induced diabetes. Pharm Biol 55(1):526\u2013531","journal-title":"Pharm Biol"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10451-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10451-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10451-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T15:10:40Z","timestamp":1757171440000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10451-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10451"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10451-1","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]},"assertion":[{"value":"8 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"165"}}