{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:16:30Z","timestamp":1757618190044,"version":"3.44.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10735-025-10454-y","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:02:50Z","timestamp":1749117770000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitigation of cadmium-induced hepatotoxicity by orally administered Xylopia aethiopica synthesized silver nanoparticles in rats"],"prefix":"10.1007","volume":"56","author":[{"given":"Emmanuel Nnaemeka","family":"Uhuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiemeziem Adnma","family":"Obike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parker Elijah","family":"Joshua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prince Ogochukwu","family":"Alaebo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonick Chukwuemeka","family":"Anyanwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"10454_CR1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00580-023-03477-y","volume":"32","author":"OB Adewale","year":"2023","unstructured":"Adewale OB, Anadozie SO, Odomene JC et al (2023) Attenuation of cadmium-induced hepatotoxicity by orally administered Crassocephalum rubens synthesized gold nanoparticles in rats. Comp Clin Pathol 32:691\u2013698","journal-title":"Comp Clin Pathol"},{"key":"10454_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/s0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126. https:\/\/doi.org\/10.1016\/s0076-6879(84)05016-3","journal-title":"Methods Enzymol"},{"key":"10454_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.lfs.2020.118268","volume":"259","author":"PM Aja","year":"2020","unstructured":"Aja PM, Izekwe FI, Famurewa AC, Ekpono EU, Nwite FE, Igwenyi IO, Ale BA (2020) Hesperidin protects against cadmium-induced pancreatitis by modulating insulin secretion, redox imbalance, and iNOS\/NF-\u0138B signaling in rats. Life Sci 259:118\u2013268","journal-title":"Life Sci"},{"key":"10454_CR4","doi-asserted-by":"publisher","unstructured":"Akintola AO, Kehinde BD, Ayoola PB, Adewoyin AG, Adedosu OT, Ajayi JF, Ogunsona SB (2020) Antioxidant properties of silver nanoparticles biosynthesized from methanolic leaf extract of Blighia  sapida. In: IOP conference series: materials science and engineering, vol 805, p 012004. https:\/\/doi.org\/10.1088\/1757-899X\/805\/1\/012004","DOI":"10.1088\/1757-899X\/805\/1\/012004"},{"key":"10454_CR5","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3390\/toxics10120729","volume":"10","author":"AS Alahmari","year":"2022","unstructured":"Alahmari AS, El-Mekkawy HI, Al-Doaiss AA, Alduwish MA (2022) Effect of natural Commiphora myrrha extract against hepatotoxicity induced by alcohol intake in rat model. Toxics 10:729. https:\/\/doi.org\/10.3390\/toxics10120729","journal-title":"Toxics"},{"key":"10454_CR6","first-page":"109","volume":"15","author":"NS Alharbi","year":"2022","unstructured":"Alharbi NS, Alsubhi NS, Felimban AI (2022) Green synthesis of silver nanoparticles using medicinal plants: characterization and application. J Radiat Res Appl Sci 15:109\u2013124","journal-title":"J Radiat Res Appl Sci"},{"issue":"1","key":"10454_CR7","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1515\/biol-2020-0094","volume":"15","author":"A Almatroudi","year":"2020","unstructured":"Almatroudi A (2020) Silver nanoparticles: synthesis, characterization and biomedical applications. Open Life Sci 15(1):819\u2013839. https:\/\/doi.org\/10.1515\/biol-2020-0094","journal-title":"Open Life Sci"},{"issue":"3","key":"10454_CR8","doi-asserted-by":"publisher","first-page":"182","DOI":"10.4103\/JNSM.JNSM_2_20","volume":"3","author":"FA Alshubaily","year":"2020","unstructured":"Alshubaily FA, Jambi EJ, Khojah SM, Balgoon MJ, Al-Zahrani MH, Alkhattabi NA (2020) Studying the effect of silver nanoparticles synthesized by Ulva fasciata aqueous extract against liver toxicity induced by CCl4 in rats. J Nat Sci Med 3(3):182\u2013188. https:\/\/doi.org\/10.4103\/JNSM.JNSM_2_20","journal-title":"J Nat Sci Med"},{"key":"10454_CR9","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.2147\/IJN.S109098","volume":"11","author":"V Asgary","year":"2016","unstructured":"Asgary V, Shoari A, Baghbani-Arani F, Sadat Shandiz SA, Khosravy MS, Janani A et al (2016) Green synthesis and evaluation of silver nanoparticles as adjuvant in rabies veterinary vaccine. Int J Nanomed 11:3597\u20133605","journal-title":"Int J Nanomed"},{"issue":"1","key":"10454_CR10","first-page":"34254","volume":"43","author":"J Bagyalakshmi","year":"2022","unstructured":"Bagyalakshmi J, Priya B, Bavya C (2022) Evaluation of antidiabetic activity of aqueous extract of bark of Pterocarpus marsupium silver nanoparticles against streptozotocin and nicotinamide induced type 2 diabetes in rats. Biomed J Sci Tech Res 43(1):34254\u201334268","journal-title":"Biomed J Sci Tech Res"},{"issue":"9","key":"10454_CR11","doi-asserted-by":"publisher","first-page":"737","DOI":"10.3390\/toxics11090737","volume":"11","author":"M Banaee","year":"2023","unstructured":"Banaee M, Impellitteri F, Multisanti CR, Sureda A, Arfuso F, Piccione G, Faggio C (2023) Evaluating silymarin extract as a potent antioxidant supplement in diazinon- exposed rainbow trout: oxidative stress and biochemical parameter analysis. Toxics 11(9):737. https:\/\/doi.org\/10.3390\/toxics11090737","journal-title":"Toxics"},{"key":"10454_CR12","first-page":"223","volume":"9","author":"R Bhuvaneswari","year":"2014","unstructured":"Bhuvaneswari R, Chidambaranathan N, Jegatheesan K (2014) Hepatoprotective effect of Embilica officinalis and its silver nanoparticles against ccl4 induced hepatotoxicity in wistar albino rats. Dig J Nanomater Biostruct 9:223\u2013235","journal-title":"Dig J Nanomater Biostruct"},{"key":"10454_CR13","doi-asserted-by":"publisher","first-page":"604377","DOI":"10.3389\/fcell.2020.604377","volume":"8","author":"JJV Branca","year":"2020","unstructured":"Branca JJV, Pacini A, Gulisano M, Taddei N, Fiorillo C, Becatti M (2020) Cadmium-induced cytotoxicity: effects on mitochondrial electron transport chain. Front Cell Dev Biol 8:604377. https:\/\/doi.org\/10.3389\/fcell.2020.604377","journal-title":"Front Cell Dev Biol"},{"key":"10454_CR14","first-page":"225","volume-title":"Chapter 15 Methods in enzymology","author":"K Canene-Adams","year":"2013","unstructured":"Canene-Adams K (2013) Preparation of formalin-fixed paraffin-embedded tissue for immunohistochemistry. In: Lorsch J (ed) Chapter 15 Methods in enzymology, vol 533. Academic Press, London, pp 225\u2013233"},{"key":"10454_CR15","doi-asserted-by":"publisher","first-page":"101108","DOI":"10.1016\/j.rechem.2023.101108","volume":"6","author":"A Dhaka","year":"2023","unstructured":"Dhaka A, Mali SC, Sharma S, Trivedi R (2023) A review on biological synthesis of silver nanoparticles and their potential applications. Results Chem 6:101108","journal-title":"Results Chem"},{"issue":"8","key":"10454_CR16","doi-asserted-by":"publisher","first-page":"902","DOI":"10.3390\/catal11080902","volume":"11","author":"PK Dikshit","year":"2021","unstructured":"Dikshit PK, Kumar J, Das AK et al (2021) Green synthesis of metallic nanoparticles: applications and limitations. Catalysts 11(8):902","journal-title":"Catalysts"},{"issue":"1","key":"10454_CR17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.11648\/j.ajqcms.20200402.12","volume":"5","author":"DJ Dingtsen","year":"2021","unstructured":"Dingtsen DJ, Bartholomew O, John SS, Eyitayo E (2021) Evaluation of the anti- nutritional and nutritional composition of five Nigerian spices. Am J Quantum Chem Mol Spectrosc 5(1):22\u201327. https:\/\/doi.org\/10.11648\/j.ajqcms.20200402.12","journal-title":"Am J Quantum Chem Mol Spectrosc"},{"issue":"1","key":"10454_CR18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0009-8981(71)90365-2","volume":"31","author":"BT Doumas","year":"1971","unstructured":"Doumas BT, Watson WA, Biggs HG (1971) Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta 31(1):87\u201396","journal-title":"Clin Chim Acta"},{"key":"10454_CR19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cotox.2019.12.002","volume":"19","author":"D \u0110uki\u0107-\u0106osi\u0107","year":"2020","unstructured":"\u0110uki\u0107-\u0106osi\u0107 D, Barali\u0107 K, Javorac D, Djordjevic AB, Bulat Z (2020) An overview of molecular mechanisms in cadmium toxicity. Curr Opin Toxicol 19:56\u201362","journal-title":"Curr Opin Toxicol"},{"key":"10454_CR20","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.3390\/cimb44070202","volume":"44","author":"MA Elfaky","year":"2022","unstructured":"Elfaky MA, Sirwi A, Ismail SH, Awad HH, Gad SS (2022) Hepatoprotective effect of silver nanoparticles at two different particle sizes: comparative study with and without silymarin. Curr Issues Mol Biol 44:2923\u20132938. https:\/\/doi.org\/10.3390\/cimb44070202","journal-title":"Curr Issues Mol Biol"},{"issue":"2","key":"10454_CR21","first-page":"110","volume":"1","author":"YH Elshiekh","year":"2022","unstructured":"Elshiekh YH, Alnoor GH, Hussein SE, Abdalrhman MI, Rahmtalla HA (2022) Preliminary phytochemical screening, antimicrobial, and antioxidant activities of Xylopia aethiopica (Dunal) A. Rich fruits. Napata Sci J 1(2):110\u2013126","journal-title":"Napata Sci J"},{"key":"10454_CR22","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1007\/s13204-021-01945-x","volume":"13","author":"A Eswaran","year":"2023","unstructured":"Eswaran A, Muthukrishnan S, Mathaiyan M et al (2023) Green synthesis, characterization and hepatoprotective activity of silver nanoparticles synthesized from pre-formulated Liv-Pro-08 poly-herbal formulation. Appl Nanosci 13:2315\u20132327. https:\/\/doi.org\/10.1007\/s13204-021-01945-x","journal-title":"Appl Nanosci"},{"key":"10454_CR23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.mrfmmm.2011.09.002","volume":"733","author":"M Filipic","year":"2012","unstructured":"Filipic M (2012) Mechanisms of cadmium induced genomic instability. Mut Res 733:69\u201377","journal-title":"Mut Res"},{"issue":"5","key":"10454_CR24","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.22092\/ari.2021.355622.1705","volume":"76","author":"Z Gattea Al-Rikabi","year":"2021","unstructured":"Gattea Al-Rikabi Z, Abbas AH, Kadhum Oudah H, Sajer Nassir H, Ali SA (2021) Histopathological study of liver and kidney tissues in C57 mice via chronic exposure to cadmium and Zinc. Arch Razi Inst 76(5):1501\u20131508. https:\/\/doi.org\/10.22092\/ari.2021.355622.1705","journal-title":"Arch Razi Inst"},{"issue":"11","key":"10454_CR25","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.3390\/ijerph17113782","volume":"17","author":"G Genchi","year":"2020","unstructured":"Genchi G, Sinicropi MS, Lauria G, Carocci A, Catalano A (2020) The effects of cadmium toxicity. Int J Environ Res Public Health 17(11):3782. https:\/\/doi.org\/10.3390\/ijerph17113782","journal-title":"Int J Environ Res Public Health"},{"issue":"24","key":"10454_CR26","doi-asserted-by":"publisher","first-page":"481","DOI":"10.21037\/atm.2016.12.27","volume":"4","author":"N Gjin","year":"2016","unstructured":"Gjin N, Adnan K (2016) Gamma-glutamyl transferase and cardiovascular disease. Ann Transl Med 4(24):481","journal-title":"Ann Transl Med"},{"key":"10454_CR27","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/toxsci\/kfv149","volume":"147","author":"YM Go","year":"2015","unstructured":"Go YM, Sutliff RL, Chandler JD, Khalidur R, Kang BY, Anania FA, Orr M, Hao L, FowlerBA JDP (2015) Low-dose cadmium causes metabolic and genetic dysregulation associated with fatty liver disease in mice. Toxicol Sci off J Soc Toxicol 147:524\u2013534","journal-title":"Toxicol Sci off J Soc Toxicol"},{"key":"10454_CR28","volume-title":"Fundamentals of clinical chemistry","author":"GH Grant","year":"1987","unstructured":"Grant GH, Silverman LM, Christenson RH (1987) Amino acids and proteins. In: Tietz NW (ed) Fundamentals of clinical chemistry, 3rd edn. WB Saunders Company, Philadelphia","edition":"3"},{"key":"10454_CR29","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s13337-021-00682-7","volume":"32","author":"p Adegbola","year":"2021","unstructured":"Ifeoluwa P, Banjo A, Olumide S, Fadahunsi S (2021) Molecular docking and ADMET studies of Allium cepa, Azadirachta indica and Xylopia aethiopica isolates as potential anti-viral drugs for Covid-19. VirusDisease 32:85\u201397","journal-title":"VirusDisease"},{"issue":"5","key":"10454_CR30","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1002\/fsn3.4010","volume":"12","author":"HM Jaffar","year":"2024","unstructured":"Jaffar HM, Al-Asmari F, Khan FA, Rahim MA, Zongo E (2024) Silymarin: unveiling its pharmacological spectrum and therapeutic potential in liver diseases\u2014a comprehensive narrative review. Food Sci Nutr 12(5):3097\u20133111","journal-title":"Food Sci Nutr"},{"issue":"1","key":"10454_CR31","doi-asserted-by":"publisher","first-page":"22109","DOI":"10.1038\/s41598-022-24818-x","volume":"12","author":"D Jini","year":"2022","unstructured":"Jini D, Sharmila S, Anitha A, Pandian M, Rajapaksha RMH (2022) In vitro and in silico studies of silver nanoparticles (AgNPs) from Allium sativum against diabetes. Sci Rep 12(1):22109","journal-title":"Sci Rep"},{"key":"10454_CR32","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.3390\/ijms20082027","volume":"20","author":"S Joardar","year":"2019","unstructured":"Joardar S, Dewanjee S, Bhowmick S, Dua TK, Das S, Saha A, De Feo V (2019) Rosmarinic acid attenuates cadmium-induced nephrotoxicity via inhibition of oxidative stress, apoptosis, inflammation and fibrosis. Int J Mol Sci 20:2027","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10454_CR33","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","volume":"98","author":"K Jomova","year":"2024","unstructured":"Jomova K, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M (2024) Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants. Arch Toxicol 98(5):1323\u20131367","journal-title":"Arch Toxicol"},{"issue":"1","key":"10454_CR34","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12951-022-01477-8","volume":"20","author":"N Joudeh","year":"2022","unstructured":"Joudeh N, Linke D (2022) Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists. J Nanobiotechnol 20(1):262","journal-title":"J Nanobiotechnol"},{"issue":"9","key":"10454_CR35","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s11051-014-2605-x","volume":"16","author":"A Kaler","year":"2014","unstructured":"Kaler A, Mittal AK, Katariya M, Harde H, Agrawal AK, Jain S et al (2014) An investigation of in vivo wound healing activity of biologically synthesized silver nanoparticles\u2019. J Nanoparticle Res 16(9):99. https:\/\/doi.org\/10.1007\/s11051-014-2605-x","journal-title":"J Nanoparticle Res"},{"issue":"12","key":"10454_CR36","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.3390\/ph17121711","volume":"17","author":"A Karnwal","year":"2024","unstructured":"Karnwal A, Jassim AY, Mohammed AA, Sharma V, Al-Tawaha ARMS, Sivanesan I (2024) Nanotechnology for healthcare: plant-derived nanoparticles in disease treatment and regenerative medicine. Pharmaceuticals (Basel, Switzerland) 17(12):1711. https:\/\/doi.org\/10.3390\/ph17121711","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"key":"10454_CR37","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1007\/s00210-020-01900-7","volume":"393","author":"G Kaur","year":"2020","unstructured":"Kaur G, Shivanandappa TB, Kumar M, Kushwah AS (2020) Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-infammatory action and aid in recast the liver function. Naunyn-Schmiedeb Arch Pharmacol 393:1911\u20131920","journal-title":"Naunyn-Schmiedeb Arch Pharmacol"},{"key":"10454_CR38","doi-asserted-by":"publisher","first-page":"275","DOI":"10.2147\/IJN.S233789","volume":"15","author":"KX Lee","year":"2020","unstructured":"Lee KX, Shameli K, Yew YP, Teow SY, Jahangirian H, RafieeMoghaddam R, Webster TJ (2020) Recent developments in the facile bio-synthesis of gold nanoparticles (AuNPs) and their biomedical applications. Int J Nanomed 15:275\u2013300","journal-title":"Int J Nanomed"},{"key":"10454_CR39","doi-asserted-by":"publisher","first-page":"111454","DOI":"10.1016\/j.jinorgbio.2021.111454","volume":"219","author":"L Mao","year":"2021","unstructured":"Mao L, Chen Z, Wang Y, Chen C (2021) Design and application of nanoparticlesas vaccine adjuvants against human corona virus infection. J Inorg Biochem 219:111454. https:\/\/doi.org\/10.1016\/j.jinorgbio.2021.111454","journal-title":"J Inorg Biochem"},{"key":"10454_CR40","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1177\/0960327119895564","volume":"39","author":"HR Momeni","year":"2020","unstructured":"Momeni HR, Eskandari N (2020) Curcumin protects the testis against cadmium-induced histopathological damages and oxidative stress in mice. Hum Exp Toxicol 39:653\u2013661","journal-title":"Hum Exp Toxicol"},{"issue":"2","key":"10454_CR41","first-page":"4595","volume":"8","author":"CN Nwolisa","year":"2020","unstructured":"Nwolisa CN, Iheukwumere IH, Chude CO, Department (2020) Fungistatic potential of aqueous extract from Xylopia aethiopica against Aspergillus niger isolated from stored onions (Allium cepa). Glob Sci J 8(2):4595\u20134606","journal-title":"Glob Sci J"},{"issue":"2","key":"10454_CR42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4314\/bajopas.v12i2.19","volume":"12","author":"AF Obajuluwa","year":"2019","unstructured":"Obajuluwa AF, Durowaiye MT (2019) Comparative study off antibacterial activities of fruits of Xylopia aethiopica (Dunal) A. Rich and bulb of Crinum Jagus (Thompson) Dandy. Bayero J Pure Appl Sci 12(2):135\u2013140","journal-title":"Bayero J Pure Appl Sci"},{"issue":"2","key":"10454_CR43","first-page":"58","volume":"11","author":"AA Obiloma","year":"2020","unstructured":"Obiloma AA, Madu WC, Osuji GO, Ogbonna PC, Maduforo AN, Ogbu CC (2020) Nutrients, phytochemicals, and terpene composition of spice made from Xylopia aethiopica. J Dietit Assoc Niger 11(2):58\u201364","journal-title":"J Dietit Assoc Niger"},{"key":"10454_CR44","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00580-023-03477-y","volume":"32","author":"BA Olusola","year":"2023","unstructured":"Olusola BA, Scholastica OA, Justice CO, Oluwatobiloba A, Funmilayo DA, Olajumoke TI, Oyindamola AO, Joseph OA, Olukemi AO (2023) Attenuation of cadmium-induced hepatotoxicity by orally administered Crassocephalum rubens synthesized gold nanoparticles in rats. Comp Clin Pathol 32:691\u2013698","journal-title":"Comp Clin Pathol"},{"key":"10454_CR45","first-page":"95","volume":"26","author":"HO Otamere","year":"2023","unstructured":"Otamere HO, Akpamu U, Adisa WA, Shelu OJ, Imhantabhunu ES (2023) Oxidative stress in testis of rats exposed to cadmium. Afr J Biomed Res 26:95\u201399","journal-title":"Afr J Biomed Res"},{"issue":"1","key":"10454_CR46","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/biom13010036","volume":"13","author":"M Peana","year":"2022","unstructured":"Peana M, Pelucelli A, Chasapis CT, Perlepes SP, Bekiari V, Medici S, Zoroddu MA (2022) Biological effects of human exposure to environmental cadmium. Biomolecules 13(1):36. https:\/\/doi.org\/10.3390\/biom13010036","journal-title":"Biomolecules"},{"key":"10454_CR47","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40816-020-00181-0","volume":"6","author":"M Poosa","year":"2020","unstructured":"Poosa M, Vanapatla SR (2020) Protective effect of Antigonon leptopus (Hook et. Arn) in cadmium induced hepatotoxicity and nephrotoxicity in rats. Clin Phytosci 6:32","journal-title":"Clin Phytosci"},{"key":"10454_CR48","doi-asserted-by":"publisher","first-page":"135","DOI":"10.22088\/cjim.8.3.135","volume":"3","author":"M Rafati Rahimzadeh","year":"2017","unstructured":"Rafati Rahimzadeh M, Rafati Rahimzadeh M, Kazemi S, Moghadamnia AA (2017) Cadmium toxicity and treatment: an update. Caspian J Intern Med 3:135\u2013145. https:\/\/doi.org\/10.22088\/cjim.8.3.135","journal-title":"Caspian J Intern Med"},{"key":"10454_CR49","first-page":"1","volume":"5","author":"HM Rafie","year":"2014","unstructured":"Rafie HM, Hamed MA (2014) Antioxidant and anti-inflammatory activities of silver nanoparticles biosynthesized from aqueous leaves extracts of four Terminalia species. Adv Nat Sci Nanosci Nanotechnol 5:1\u201311","journal-title":"Adv Nat Sci Nanosci Nanotechnol"},{"key":"10454_CR50","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"S Reitman","year":"1957","unstructured":"Reitman S, Frankel S (1957) A colorimetric method for the determination of serum glutamate oxaloacetate and pyruvate transaminase. Am J Clin Pathol 28:56\u201363","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"10454_CR51","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s12011-020-02138-3","volume":"199","author":"SS Salem","year":"2021","unstructured":"Salem SS, Fouda A (2021) Green synthesis of metallic nanoparticles and their prospective biotechnological applications: an overview. Biol Trace Elem Res 199(1):344\u2013370. https:\/\/doi.org\/10.1007\/s12011-020-02138-3","journal-title":"Biol Trace Elem Res"},{"key":"10454_CR52","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s10876-017-1179-z","volume":"28","author":"GD Saratale","year":"2017","unstructured":"Saratale GD, Saratale RG, Benelli G, Kumar G, Pugazhendhi A, Kim D-S et al (2017) Anti- diabetic potential of silver nanoparticles synthesized with Argyreia nervosa leaf extract high synergistic antibacterial activity with standard antibiotics against foodborne bacteria. J Clust Sci 28:1709\u20131727","journal-title":"J Clust Sci"},{"key":"10454_CR53","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1177\/004051755902901003","volume":"29","author":"L Segal","year":"1959","unstructured":"Segal L, Creely JJ, Martin AE, Conrad CM (1959) An empirical method for estimating the degree of crystallinity of native cellulose using X-ray diffractometer. Text Res J 29:786\u2013794. https:\/\/doi.org\/10.1177\/004051755902901003","journal-title":"Text Res J"},{"issue":"5","key":"10454_CR54","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.3390\/nu11051155","volume":"11","author":"GA Soliman","year":"2019","unstructured":"Soliman GA (2019) Dietary fiber, atherosclerosis, and cardiovascular disease. Nutrients 11(5):1155. https:\/\/doi.org\/10.3390\/nu11051155","journal-title":"Nutrients"},{"key":"10454_CR55","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s13204-014-0293-6","volume":"5","author":"MK Swamy","year":"2014","unstructured":"Swamy MK, Sudipta KM, Jayanta K, Balasubramanya S (2014) The green synthesis, characterization, and evaluation of the biological activities of silver nanoparticles synthesized from Leptadenia reticulata leaf extract. Appl Nanosci 5:73\u201381","journal-title":"Appl Nanosci"},{"issue":"5","key":"10454_CR56","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.3390\/nano11051343","volume":"11","author":"C Tyavambiza","year":"2021","unstructured":"Tyavambiza C, Elbagory AM, Madiehe AM, Meyer M, Meyer S (2021) The antimicrobial and anti-inflammatory effects of silver nanoparticles synthesised from Cotyledon orbiculata aqueous extract. Nanomaterials (Basel) 11(5):1343. https:\/\/doi.org\/10.3390\/nano11051343","journal-title":"Nanomaterials (Basel)"},{"key":"10454_CR57","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1080\/09553009014552121","volume":"58","author":"R Varshney","year":"1990","unstructured":"Varshney R, Kale RK (1990) Effect of calmodulin antagonist on radiation induced lipid peroxidation in microsome. Int J Rad Biol 58:733\u2013743","journal-title":"Int J Rad Biol"},{"issue":"7","key":"10454_CR58","first-page":"664","volume":"5","author":"T Varthini","year":"2018","unstructured":"Varthini T, Bai GCV, Mani RJ (2018) Green synthesis of silver nanoparticles using seed extract of Moringa oleifera medicinal plant. Int J Emerg Technol Innov Res 5(7):664\u2013666","journal-title":"Int J Emerg Technol Innov Res"},{"key":"10454_CR59","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.colsurfb.2014.02.052","volume":"117","author":"K Vasanth","year":"2014","unstructured":"Vasanth K, Ilango K, Mohan Kumar R, Agrawal A, Dubey GP (2014) Anticancer activity of Moringa oleifera mediated silver nanoparticles on human cervical carcinoma cells by apoptosis induction. Colloids Surf B 117:354\u2013359","journal-title":"Colloids Surf B"},{"key":"10454_CR60","first-page":"8","volume":"179","author":"JS Xin","year":"1991","unstructured":"Xin JS, Guo JC, Zhu HQ, Song XX (1991) An assay for superoxide dismutase in mammalian tissue homogenates. Anal Biochem 179:8\u201318","journal-title":"Anal Biochem"},{"issue":"20","key":"10454_CR61","doi-asserted-by":"publisher","first-page":"8996","DOI":"10.7150\/thno.45413","volume":"10","author":"L Xu","year":"2020","unstructured":"Xu L, Wang YY, Huang J, Chen CY, Wang ZX, Xie H (2020) Silver nanoparticles: synthesis, medical applications and biosafety. Theranostics 10(20):8996\u20139031. https:\/\/doi.org\/10.7150\/thno.45413","journal-title":"Theranostics"},{"issue":"9","key":"10454_CR62","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.3390\/molecules25092193","volume":"25","author":"AA Yetisgin","year":"2020","unstructured":"Yetisgin AA, Cetinel S, Zuvin M, Kosar A, Kutlu O (2020) Therapeutic nanoparticles and their targeted delivery applications. Molecules (Basel, Switzerland) 25(9):2193. https:\/\/doi.org\/10.3390\/molecules25092193","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10454_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24101979","author":"X Yin","year":"2019","unstructured":"Yin X, Ch\u00e1vez Le\u00f3n MA, Osae R, Linus LO, Qi LW et al (2019) Xylopia aethiopica seeds from two countries in West Africa exhibit differences in proteomes, mineral content and bioactive phytochemical composition. Molecules; Basel. https:\/\/doi.org\/10.3390\/molecules24101979","journal-title":"Molecules; Basel"},{"key":"10454_CR64","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.2147\/IJN.S198895","volume":"14","author":"H Zhang","year":"2019","unstructured":"Zhang H, Jacob JA, Jiang Z, Xu S, Sun K, Zhong Z, Shanmugam A (2019) Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata. Int J Nanomed 14:3517\u20133524","journal-title":"Int J Nanomed"},{"key":"10454_CR65","doi-asserted-by":"publisher","first-page":"152611","DOI":"10.1016\/j.tox.2020.152611","volume":"446","author":"J Zheng","year":"2020","unstructured":"Zheng J, Zhuo L, Ran D, Ma Y, Luo T, Zhao H, Song R, Zou H, Zhu J, Gu J, Bian J, Yuan Y, Liu Z (2020) Cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts. Toxicology 446:152611","journal-title":"Toxicology"},{"issue":"7","key":"10454_CR66","doi-asserted-by":"publisher","first-page":"940","DOI":"10.3390\/pharmaceutics13070940","volume":"13","author":"C Zhu","year":"2021","unstructured":"Zhu C, Ji Z, Ma J, Ding Z, Shen J, Wang Q (2021) Recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems for cancer treatment. Pharmaceutics 13(7):940","journal-title":"Pharmaceutics"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10454-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10454-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10454-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T18:05:13Z","timestamp":1757181913000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10454-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10454"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10454-y","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"type":"print","value":"1567-2379"},{"type":"electronic","value":"1567-2387"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"10 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental protocols were approved (MOUAU\/BCH\/EC\/2023\/4) by the Animal Ethics Committee, College of Natural Science, Michael Okpara University of Agriculture, Abia State, according to the Guide for the Care and Use of Laboratory Animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"187"}}