{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T05:10:09Z","timestamp":1752469809214,"version":"3.41.2"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10735-025-10456-w","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T05:36:37Z","timestamp":1748237797000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biochemical and histopathological changes in ovary, uterus and testicular tissues after acrylamide exposure"],"prefix":"10.1007","volume":"56","author":[{"given":"Hamit","family":"Uslu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-9164","authenticated-orcid":false,"given":"G\u00f6zde","family":"Atila Uslu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha Abdulkadir","family":"\u00c7oban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Sefa","family":"Mendil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Toraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00d6zkaraca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"issue":"7","key":"10456_CR1","doi-asserted-by":"publisher","first-page":"e202400062","DOI":"10.1002\/cbdv.202400062","volume":"21","author":"A Aboul Naser","year":"2024","unstructured":"Aboul Naser A, El-Feky AF, Hamed AM MA (2024) Mitigating effect of Lepidium sativum seeds oil on ovarian oxidative stress, DNA abnormality and hormonal disturbances induced by acrylamide in rats. Chem Biodivers 21(7):e202400062. https:\/\/doi.org\/10.1002\/cbdv.202400062","journal-title":"Chem Biodivers"},{"key":"10456_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/s0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126. https:\/\/doi.org\/10.1016\/s0076-6879(84)05016-3","journal-title":"Methods Enzymol"},{"issue":"1","key":"10456_CR3","doi-asserted-by":"publisher","first-page":"2341537","DOI":"10.1080\/13510002.2024.2341537","volume":"29","author":"AJ Ajibare","year":"2024","unstructured":"Ajibare AJ, Odetayo AF, Akintoye OO, Olayaki LA (2024) Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2\/HO-1\/NfkB and Bax\/Bcl2 signaling pathway. Redox Rep 29(1):2341537. https:\/\/doi.org\/10.1080\/13510002.2024.2341537","journal-title":"Redox Rep"},{"issue":"11","key":"10456_CR4","doi-asserted-by":"publisher","first-page":"5965","DOI":"10.1039\/C8FO00902C","volume":"9","author":"L Bo","year":"2018","unstructured":"Bo L, Liu Y, Jia S, Liu Y, Zhang M, Li S, Zhao X, Sun C (2018) Metabonomics analysis of Quercetin against the nephrotoxicity of acrylamide in rats. Food Funct 9(11):5965\u20135974. https:\/\/doi.org\/10.1039\/C8FO00902C","journal-title":"Food Funct"},{"key":"10456_CR5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00204-005-0011-y","volume":"80","author":"MI Boettcher","year":"2006","unstructured":"Boettcher MI, Bolt HM, Drexler H, Angerer J (2006) Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide. Arch Toxicol 80:55\u201361. https:\/\/doi.org\/10.1007\/s00204-005-0011-y","journal-title":"Arch Toxicol"},{"issue":"1\u20132","key":"10456_CR6","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"M Bradford","year":"1976","unstructured":"Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-Dye binding. Anal Biochem 72(1\u20132):248\u2013254. https:\/\/doi.org\/10.1016\/0003-2697(76)90527-3","journal-title":"Anal Biochem"},{"issue":"1","key":"10456_CR7","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.etap.2013.12.007","volume":"37","author":"H Budak","year":"2014","unstructured":"Budak H, Gonul N, Ceylan H, Kocpina EF (2014) Impact of long term Fe3\u2009+\u2009toxicity on expression of glutathione system in rat liver. Environ Toxicol Pharmacol 37(1):365\u2013370. https:\/\/doi.org\/10.1016\/j.etap.2013.12.007","journal-title":"Environ Toxicol Pharmacol"},{"key":"10456_CR8","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.toxrep.2022.07.015","volume":"9","author":"AM Firouzabadi","year":"2022","unstructured":"Firouzabadi AM, Imani M, Zakizadeh F, Ghaderi N, Zare F, Yadegari M, Pourentezari M, Fesahat F (2022) Evaluating effect of acrylamide and ascorbic acid on oxidative stress and apoptosis in ovarian tissue of Wistar rat. Toxicol Rep 9:1580\u20131585. https:\/\/doi.org\/10.1016\/j.toxrep.2022.07.015","journal-title":"Toxicol Rep"},{"issue":"16","key":"10456_CR9","doi-asserted-by":"publisher","first-page":"4504","DOI":"10.1021\/jf030204+","volume":"51","author":"M Friedman","year":"2003","unstructured":"Friedman M (2003) Chemistry, biochemistry, and safety of acrylamide. A review. J Agric Food Chem 51(16):4504\u20134526. https:\/\/doi.org\/10.1021\/jf030204+","journal-title":"J Agric Food Chem"},{"issue":"4","key":"10456_CR10","doi-asserted-by":"publisher","first-page":"e13194","DOI":"10.1590\/1678-4162-13194","volume":"76","author":"NM Ibrahim","year":"2024","unstructured":"Ibrahim NM, Kandil AM, Ali RS, Hesham R, El-Ashram S, Alquraishi MI, Abdel-Gaber R, Dkhil M, Elhemiely AA (2024) Zeolite abrogates cadmium-induced testicular damage in rats: implication of NF-\u03baB\/TNF-\u03b1\/IL-1\u03b2 pathway. Arq Bras Med Vet Zootec 76(4):e13194. https:\/\/doi.org\/10.1590\/1678-4162-13194","journal-title":"Arq Bras Med Vet Zootec"},{"key":"10456_CR11","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.freeradbiomed.2022.02.004","volume":"181","author":"M Jaganjac","year":"2022","unstructured":"Jaganjac M, Milkovic L, Zarkovic N, Zarkovic K (2022) Oxidative stress and regeneration. Free Radic Biol Med 181:154\u2013165. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.02.004","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"10456_CR12","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s10661-017-6288-5","volume":"189","author":"AL Khandare","year":"2017","unstructured":"Khandare AL, Gourineni SR, Validandi V (2017) Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride-affected hilly areas of Doda district, Jammu and Kashmir, India. Environ Monit Assess 189(11):579. https:\/\/doi.org\/10.1007\/s10661-017-6288-5","journal-title":"Environ Monit Assess"},{"key":"10456_CR13","doi-asserted-by":"publisher","first-page":"118301","DOI":"10.1016\/j.lfs.2020.118301","volume":"261","author":"S Kucukler","year":"2020","unstructured":"Kucukler S, Caglayan C, Darendelio\u011flu E, Kandemir FM (2020) Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-\u03baB, Bax\/Bcl-2 and PI3K\/Akt\/mTOR signaling pathways. Life Sci 261:118301. https:\/\/doi.org\/10.1016\/j.lfs.2020.118301","journal-title":"Life Sci"},{"issue":"11","key":"10456_CR14","doi-asserted-by":"publisher","first-page":"5074","DOI":"10.1002\/tox.24390","volume":"39","author":"YC Liu","year":"2024","unstructured":"Liu YC, Li RC, Wang WK, Chen YZ, He QK, Xu ZR, Yang YF, Cheng SY, Wang HL, Qi ZQ, Xu CL, Liu Y (2024) Acrylamide exposure impairs ovarian Tricarboxylic acid cycle and reduces oocyte quality in mouse. Environ Toxicol 39(11):5074\u20135085. https:\/\/doi.org\/10.1002\/tox.24390","journal-title":"Environ Toxicol"},{"doi-asserted-by":"publisher","unstructured":"Nasr NN, Elbatanony MM, Hamed MA (2024) GC\/MS analysis and compounds isolation of Lycium Shawii petroleum ether seeds extract for regulating Nrf2\/OH-1 pathway, oxidative stress, and inflammation in Acrylamide\u2010Induced infertility in female rats. Chem Biodivers 2024:e202401102. https:\/\/doi.org\/10.1002\/cbdv.202401102","key":"10456_CR15","DOI":"10.1002\/cbdv.202401102"},{"key":"10456_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.abb.2015.11.017","volume":"595","author":"E Niki","year":"2016","unstructured":"Niki E (2016) Oxidative stress and antioxidants: distress or eustress? Arch Biochem 595:19\u201324. https:\/\/doi.org\/10.1016\/j.abb.2015.11.017","journal-title":"Arch Biochem"},{"issue":"2","key":"10456_CR17","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"issue":"12","key":"10456_CR18","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1002\/mnfr.200900447","volume":"53","author":"R Pernice","year":"2009","unstructured":"Pernice R, Hauder J, Koehler P, Vitaglione P, Fogliano V, Somoza V (2009) Effect of Sulforaphane on glutathione-adduct formation and on glutathione_S_transferase\u2010dependent detoxification of acrylamide in Caco\u20102 cells. Mol Nutr Food Res 53(12):1540\u20131550. https:\/\/doi.org\/10.1002\/mnfr.200900447","journal-title":"Mol Nutr Food Res"},{"issue":"8","key":"10456_CR19","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.22038\/ijbms.2021.55009.12331","volume":"24","author":"MG Rahbardar","year":"2021","unstructured":"Rahbardar MG, Farmad HC, Hosseinzadeh H, Mehri S (2021) Protective effects of selenium on acrylamide-induced neurotoxicity and hepatotoxicity in rats. IJBMS 24(8):1041. https:\/\/doi.org\/10.22038\/ijbms.2021.55009.12331","journal-title":"IJBMS"},{"issue":"10","key":"10456_CR20","doi-asserted-by":"publisher","first-page":"7122","DOI":"10.4049\/jimmunol.177.10.7122","volume":"177","author":"A Riccioli","year":"2006","unstructured":"Riccioli A, Starace D, Galli R, Fuso A, Scarpa S, Palombi F, De Cesaris P, Ziparo E, Filippini A (2006) Sertoli cells initiate testicular innate immune responses through TLR activation. J Immun 177(10):7122\u20137130. https:\/\/doi.org\/10.4049\/jimmunol.177.10.7122","journal-title":"J Immun"},{"issue":"2","key":"10456_CR21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1177\/1091581820902405","volume":"39","author":"L Rifai","year":"2020","unstructured":"Rifai L, Saleh FA (2020) A review on acrylamide in food: occurrence, toxicity, and mitigation strategies. IJT 39(2):93\u2013102. https:\/\/doi.org\/10.1177\/1091581820902405","journal-title":"IJT"},{"issue":"1","key":"10456_CR22","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1038\/s41598-024-52259-1","volume":"14","author":"DO Saleh","year":"2024","unstructured":"Saleh DO, Baraka SM, Jaleel GAA, Hassan A, Ahmed-Farid OA (2024) Eugenol alleviates acrylamide-induced rat testicular toxicity by modulating AMPK\/p-AKT\/mTOR signaling pathway and blood\u2013testis barrier remodeling. Scie Rep 14(1):1910. https:\/\/doi.org\/10.1038\/s41598-024-52259-1","journal-title":"Scie Rep"},{"issue":"8","key":"10456_CR23","doi-asserted-by":"publisher","first-page":"4332","DOI":"10.3390\/ijerph18084332","volume":"18","author":"C Sarion","year":"2021","unstructured":"Sarion C, Codin\u0103 GG, Dabija A (2021) Acrylamide in bakery products: a review on health risks, legal regulations and strategies to reduce its formation. IJERPH 18(8):4332. https:\/\/doi.org\/10.3390\/ijerph18084332","journal-title":"IJERPH"},{"key":"10456_CR24","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal Biochem 25:192\u2013205. https:\/\/doi.org\/10.1016\/0003-2697(68)90092-4","journal-title":"Anal Biochem"},{"key":"10456_CR25","doi-asserted-by":"publisher","first-page":"108586","DOI":"10.1016\/j.reprotox.2024.108586","volume":"126","author":"AME Shipa","year":"2024","unstructured":"Shipa AME, Kahilo KA, Elshazly SA, Taher ES, Nasr NE, Alotaibi BS, Almadaly EA, Assas M, Abdo W, Abouzed TK, Salem AE, Kirci D, El-Seedi HR, Refaey MS, Rizk NI, Shukry M, Dorghamm DA (2024) Protective effect of Petroselinum crispum methanolic extract against acrylamide-induced reproductive toxicity in male rats through NF-\u0138B, Kinesin, steroidogenesis pathways. Reprod Toxicol 126:108586. https:\/\/doi.org\/10.1016\/j.reprotox.2024.108586","journal-title":"Reprod Toxicol"},{"issue":"6906","key":"10456_CR26","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/419449a","volume":"419","author":"RH Stadler","year":"2002","unstructured":"Stadler RH, Blank I, Varga N, Robert F, Hau J, Guy PA, Robert MC, Riediker S (2002) Acrylamide from Maillard reaction products. Nature 419(6906):449\u2013450. https:\/\/doi.org\/10.1038\/419449a","journal-title":"Nature"},{"key":"10456_CR27","doi-asserted-by":"publisher","first-page":"105105","DOI":"10.3389\/fnut.2022.859189","volume":"72","author":"D Triningsih","year":"2021","unstructured":"Triningsih D, Yang JH, Sim KH, Lee C, Lee YJ (2021) Acrylamide and its metabolite induce neurotoxicity via modulation of protein kinase C and AMP-activated protein kinase pathways. Toxicol Vitro 72:105105. https:\/\/doi.org\/10.3389\/fnut.2022.859189","journal-title":"Toxicol Vitro"},{"issue":"2","key":"10456_CR28","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s00210-023-02638-8","volume":"397","author":"MM \u00dcremi\u015f","year":"2024","unstructured":"\u00dcremi\u015f MM, G\u00fcltekin S, \u00dcremi\u015f N, \u015eafak T, \u00c7i\u011fremi\u015f Y, G\u00fcl M, Aydin M, Zayman E, T\u00fcrk\u00f6z Y (2024) Protective role of vitamin E against acrylamide-induced testicular toxicity from pregnancy to adulthood: insights into oxidative stress and aromatase regulation. Naunyn Schmiedebergs Arch Pharmacol 397(2):829\u2013841. https:\/\/doi.org\/10.1007\/s00210-023-02638-8","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10456_CR29","doi-asserted-by":"publisher","first-page":"113253","DOI":"10.1016\/j.fct.2022.113253","volume":"167","author":"A Wang","year":"2022","unstructured":"Wang A, Chen X, Wang L, Jia W, Wan X, Jiao J, Yao W, Zhang Y (2022) Catechins protect against acrylamide-and glycidamide-induced cellular toxicity via rescuing cellular apoptosis and DNA damage. FCT 167:113253. https:\/\/doi.org\/10.1016\/j.fct.2022.113253","journal-title":"FCT"},{"issue":"4","key":"10456_CR30","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.reprotox.2004.10.006","volume":"19","author":"HJ Yang","year":"2005","unstructured":"Yang HJ, Lee SH, Jin Y, Choi JH, Han DU, Chae C, Lee MH, Han CH (2005) Toxicological effects of acrylamide on rat testicular gene expression profile. Reprod Toxicol 19(4):527\u2013534. https:\/\/doi.org\/10.1016\/j.reprotox.2004.10.006","journal-title":"Reprod Toxicol"},{"issue":"2\u20133","key":"10456_CR31","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.ejphar.2011.08.029","volume":"674","author":"R Yang","year":"2012","unstructured":"Yang R, Yang L, Shen X, Cheng W, Zhao B, Ali KH, Qian Z, Ji H (2012) Suppression of NF-\u03baB pathway by Crocetin contributes to Attenuation of lipopolysaccharide-induced acute lung injury in mice. Eur J Pharmacol 674(2\u20133):391\u2013396. https:\/\/doi.org\/10.1016\/j.ejphar.2011.08.029","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"10456_CR32","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1177\/0960327116686818","volume":"36","author":"BO Yilmaz","year":"2017","unstructured":"Yilmaz BO, Yildizbayrak N, Aydin Y, Erkan M (2017) Evidence of acrylamide-and glycidamide-induced oxidative stress and apoptosis in Leydig and Sertoli cells. HET 36(12):1225\u20131235. https:\/\/doi.org\/10.1177\/0960327116686818","journal-title":"HET"},{"key":"10456_CR33","doi-asserted-by":"publisher","first-page":"112766","DOI":"10.1016\/j.fct.2021.112766","volume":"159","author":"D Yu","year":"2022","unstructured":"Yu D, Jiang X, Ge W, Qiao B, Zhang D, Liu H, Kuang H (2022) Gestational exposure to acrylamide suppresses luteal endocrine function through dysregulation of ovarian angiogenesis, oxidative stress and apoptosis in mice. FCT 159:112766. https:\/\/doi.org\/10.1016\/j.fct.2021.112766","journal-title":"FCT"},{"key":"10456_CR34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.toxlet.2022.08.007","volume":"368","author":"Y Yuan","year":"2022","unstructured":"Yuan Y, Yucai L, Lu L, Hui L, Yong P, Haiyang Y (2022) Acrylamide induces ferroptosis in HSC-T6 cells by causing antioxidant imbalance of the XCT-GSH-GPX4 signaling and mitochondrial dysfunction. Toxicol Lett 368:24\u201332. https:\/\/doi.org\/10.1016\/j.toxlet.2022.08.007","journal-title":"Toxicol Lett"},{"key":"10456_CR35","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.toxlet.2021.12.004","volume":"356","author":"T Zhao","year":"2022","unstructured":"Zhao T, Guo Y, Ji H, Mao G, Feng W, Chen Y, Wu X, Yang L (2022) Short-term exposure to acrylamide exacerbated metabolic disorders and increased metabolic toxicity susceptibility on adult male mice with diabetes. Toxicol Lett 356:41\u201353. https:\/\/doi.org\/10.1016\/j.toxlet.2021.12.004","journal-title":"Toxicol Lett"},{"key":"10456_CR36","doi-asserted-by":"publisher","first-page":"116395","DOI":"10.1016\/j.envpol.2020.116395","volume":"271","author":"F Zhu","year":"2021","unstructured":"Zhu F, Wang J, Jiao J, Zhang Y (2021) Exposure to acrylamide induces skeletal developmental toxicity in zebrafish and rat embryos. Environ Pollut 271:116395. https:\/\/doi.org\/10.1016\/j.envpol.2020.116395","journal-title":"Environ Pollut"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10456-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10456-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10456-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T04:41:38Z","timestamp":1752468098000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10456-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10456"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10456-w","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"type":"print","value":"1567-2379"},{"type":"electronic","value":"1567-2387"}],"subject":[],"published":{"date-parts":[[2025,5,26]]},"assertion":[{"value":"18 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Declerations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All operations involving experimental animals were carried out in accordance with national and international rules. The required authorizations for these experimental methods were given by Erzincan Binali Y\u0131ld\u0131r\u0131m University\u2019s local ethics committee for animal studies (protocol number 2024\/41).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"171"}}