{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:55:15Z","timestamp":1787968515967,"version":"build-2784847793"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10735-025-10459-7","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T22:33:19Z","timestamp":1748385199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of TIGIT, PVRIG, CD112 and CD155 expression in early and late onset preeclampsia"],"prefix":"10.1007","volume":"56","author":[{"given":"H\u00fclya","family":"\u00c7etin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lknur","family":"Lafc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeliz","family":"Arman Karakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buket","family":"Er Urganc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Ko\u015far Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"issue":"3","key":"10459_CR1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/eji.200839116","volume":"39","author":"KS Boles","year":"2009","unstructured":"Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M (2009) A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Eur J Immunol 39(3):695\u2013703. https:\/\/doi.org\/10.1002\/eji.200839116","journal-title":"Eur J Immunol"},{"issue":"1","key":"10459_CR2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","volume":"72","author":"MA Brown","year":"2018","unstructured":"Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, Hall DR, Warren CE, Adoyi G, Ishaku S, International Society for the Study of Hypertension in Pregnancy (ISSHP) (2018) Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for \u0131nternational practice. Hypertension (Dallas, Tex: 1979) 72(1):24\u201343. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.117.10803","journal-title":"Hypertension (Dallas, Tex: 1979)"},{"key":"10459_CR3","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.placenta.2021.08.060","volume":"114","author":"S Dong","year":"2021","unstructured":"Dong S, Shah NK, He J, Han S, Xie M, Wang Y, Cheng T, Liu Z, Shu C (2021) The abnormal expression of Tim-3 is involved in the regulation of myeloid-derived suppressor cells and its correlation with preeclampsia. Placenta 114:108\u2013114. https:\/\/doi.org\/10.1016\/j.placenta.2021.08.060","journal-title":"Placenta"},{"issue":"1","key":"10459_CR4","doi-asserted-by":"publisher","first-page":"e22073","DOI":"10.1096\/fj.202101306R","volume":"36","author":"XH Hu","year":"2022","unstructured":"Hu XH, Li ZH, Muyayalo KP, Wang LL, Liu CY, Mor G, Liao AH (2022) A newly intervention strategy in preeclampsia: targeting PD-1\/Tim-3 signaling pathways to modulate the polarization of decidual macrophages. FASEB J off Publ Fed Am Soc Exp Biol 36(1):e22073. https:\/\/doi.org\/10.1096\/fj.202101306R","journal-title":"FASEB J off Publ Fed Am Soc Exp Biol"},{"key":"10459_CR5","doi-asserted-by":"publisher","first-page":"8570882","DOI":"10.1155\/2022\/8570882","volume":"2022","author":"X Huo","year":"2022","unstructured":"Huo X, Zhang X, Li S, Wang S, Sun H, Yang M (2022) Identification of novel \u0131mmunologic checkpoint gene prognostic markers for ovarian cancer. J Oncol 2022:8570882. https:\/\/doi.org\/10.1155\/2022\/8570882","journal-title":"J Oncol"},{"key":"10459_CR6","doi-asserted-by":"publisher","first-page":"111381","DOI":"10.1016\/j.intimp.2023.111381","volume":"127","author":"F Jiang","year":"2024","unstructured":"Jiang F, Mao M, Jiang S, Jiao Y, Cao D, Xiang Y (2024) PD-1 and TIGIT coexpressing CD8 + CD103 + tissue-resident memory cells in endometrial cancer as potential targets for immunotherapy. Int Immunopharmacol 127:111381. https:\/\/doi.org\/10.1016\/j.intimp.2023.111381","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"10459_CR7","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1080\/08820139.2021.1904976","volume":"51","author":"A Kamrani","year":"2022","unstructured":"Kamrani A, Soltani-Zangbar MS, Shiri S, Yousefzadeh Y, Pourakbari R, Aghebati-Maleki L, Mehdizadeh A, Danaii S, Jadidi-Niaragh F, Yousefi B, Kafil HS, Hojjat-Farsangi M, Motavalli R, Zolfaghari M, Haji-Fatahaliha M, Mahmoodpoor A, Ahmadian Heris J, Emdadi A, Yousefi M (2022) TIGIT and CD155 as Immune-modulator receptor and ligand on CD4+ T cells in preeclampsia patients. Immunol Invest 51(4):1023\u20131038. https:\/\/doi.org\/10.1080\/08820139.2021.1904976","journal-title":"Immunol Invest"},{"issue":"7","key":"10459_CR8","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/nm0798-844","volume":"4","author":"J Kononen","year":"1998","unstructured":"Kononen J, Bubendorf L, Kallioniemi A, B\u00e4rlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 4(7):844\u2013847. https:\/\/doi.org\/10.1038\/nm0798-844","journal-title":"Nat Med"},{"issue":"7","key":"10459_CR9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-s","volume":"11","author":"HG Ljunggren","year":"1990","unstructured":"Ljunggren HG, K\u00e4rre K (1990) In search of the \u201cmissing self\u201d: MHC molecules and NK cell recognition. Immunol Today 11(7):237\u2013244. https:\/\/doi.org\/10.1016\/0167-5699(90)90097-s","journal-title":"Immunol Today"},{"issue":"8\u20139","key":"10459_CR10","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.humimm.2022.07.004","volume":"83","author":"S Madadi","year":"2022","unstructured":"Madadi S, Mohammadinejad S, Alizadegan A, Hojjat-Farsangi M, Dolati S, Samadi Kafil H, Jadidi-Niaragh F, Soltani-Zangbar MS, Motavalli R, Etemadi J, Eghbal-Fard S, Aghebati-Maleki L, Danaii S, Taghavi S, Yousefi M (2022) Expression level of immune checkpoint inhibitory factors in preeclampsia. Hum Immunol 83(8\u20139):628\u2013636. https:\/\/doi.org\/10.1016\/j.humimm.2022.07.004","journal-title":"Hum Immunol"},{"key":"10459_CR11","doi-asserted-by":"publisher","first-page":"103949","DOI":"10.1016\/j.jri.2023.103949","volume":"157","author":"J Mittelberger","year":"2023","unstructured":"Mittelberger J, Seefried M, L\u00f6b S, Kuhn C, Franitza M, Garrido F, Wild CM, Ditsch N, Jeschke U, Dannecker C (2023) The programmed cell death protein 1 (PD1) and the programmed cell death ligand 1 (PD-L1) are significantly downregulated on macrophages and Hofbauer cells in the placenta of preeclampsia patients. J Reprod Immunol 157:103949. https:\/\/doi.org\/10.1016\/j.jri.2023.103949","journal-title":"J Reprod Immunol"},{"issue":"10","key":"10459_CR12","doi-asserted-by":"publisher","first-page":"e13263","DOI":"10.1371\/journal.pone.0013263","volume":"5","author":"RW Powers","year":"2010","unstructured":"Powers RW, Jeyabalan A, Clifton RG, Van Dorsten P, Hauth JC, Klebanoff MA, Lindheimer MD, Sibai B, Landon M, Miodovnik M, Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network (2010) Soluble fms-like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies. PLoS ONE 5(10):e13263. https:\/\/doi.org\/10.1371\/journal.pone.0013263","journal-title":"PLoS ONE"},{"issue":"8","key":"10459_CR13","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/OGX.0b013e3182331028","volume":"66","author":"D Raymond","year":"2011","unstructured":"Raymond D, Peterson E (2011) A critical review of early-onset and late-onset preeclampsia. Obstet Gynecol Surv 66(8):497\u2013506. https:\/\/doi.org\/10.1097\/OGX.0b013e3182331028","journal-title":"Obstet Gynecol Surv"},{"issue":"6382","key":"10459_CR14","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1126\/science.aar4060","volume":"359","author":"A Ribas","year":"2018","unstructured":"Ribas A, Wolchok JD (2018) Cancer immunotherapy using checkpoint blockade. Science (New York, N.y.) 359(6382):1350\u20131355. https:\/\/doi.org\/10.1126\/science.aar4060","journal-title":"Science (New York, N.y.)"},{"key":"10459_CR15","unstructured":"Ross, M. H., & Pawl\u0131na, W. (2014). H\u0131stology: Atext And Atlas 6\/E (B. Baykal, Ed.; 6th Ed.). L\u0131pp\u0131ncott W\u0131ll\u0131ams Andw\u0131lk\u0131ns\/Wolters Kluwer Health Inc"},{"issue":"6","key":"10459_CR16","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3390\/cancers11060877","volume":"11","author":"B Sanchez-Correa","year":"2019","unstructured":"Sanchez-Correa B, Valhondo I, Hassouneh F, Lopez-Sejas N, Pera A, Bergua JM, Arcos MJ, Ba\u00f1as H, Casas-Avil\u00e9s I, Dur\u00e1n E, Alonso C, Solana R, Tarazona R (2019) DNAM-1 and the TIGIT\/PVRIG\/TACTILE Axis: novel immune checkpoints for natural killer cell-based cancer immunotherapy. Cancers 11(6):877. https:\/\/doi.org\/10.3390\/cancers11060877","journal-title":"Cancers"},{"issue":"42","key":"10459_CR17","doi-asserted-by":"publisher","first-page":"17858","DOI":"10.1073\/pnas.0903474106","volume":"106","author":"N Stanietsky","year":"2009","unstructured":"Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O (2009) The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci USA 106(42):17858\u201317863. https:\/\/doi.org\/10.1073\/pnas.0903474106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9741","key":"10459_CR18","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","volume":"376","author":"EA Steegers","year":"2010","unstructured":"Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R (2010) Pre-eclampsia. Lancet (London, England) 376(9741):631\u2013644. https:\/\/doi.org\/10.1016\/S0140-6736(10)60279-6","journal-title":"Lancet (London, England)"},{"issue":"1","key":"10459_CR19","doi-asserted-by":"publisher","first-page":"e0147186","DOI":"10.1371\/journal.pone.0147186","volume":"11","author":"J Sun","year":"2016","unstructured":"Sun J, Yang M, Ban Y, Gao W, Song B, Wang Y, Zhang Y, Shao Q, Kong B, Qu X (2016) Tim-3 Is upregulated in NK cells during early pregnancy and inhibits NK cytotoxicity toward trophoblast in galectin-9 dependent pathway. PLoS ONE 11(1):e0147186. https:\/\/doi.org\/10.1371\/journal.pone.0147186","journal-title":"PLoS ONE"},{"issue":"11","key":"10459_CR20","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.3390\/biomedicines9111608","volume":"9","author":"L Szereday","year":"2021","unstructured":"Szereday L, Nagy DU, Csiszar B, Kevey D, Feik T, Meggyes M (2021) Examination of the TIGIT, CD226, CD112, and CD155 immune checkpoint molecules in peripheral blood mononuclear cells in women diagnosed with early-onset preeclampsia. Biomedicines 9(11):1608. https:\/\/doi.org\/10.3390\/biomedicines9111608","journal-title":"Biomedicines"},{"issue":"15","key":"10459_CR21","doi-asserted-by":"publisher","first-page":"8378","DOI":"10.3390\/ijms25158378","volume":"25","author":"L Szereday","year":"2024","unstructured":"Szereday L, Nagy DU, Vastag F, Mezosi L, Meggyes M (2024) Immunological profiling of CD8+ and CD8- NK cell subpopulations and immune checkpoint alterations in early-onset preeclampsia and healthy pregnancy. Int J Mol Sci 25(15):8378. https:\/\/doi.org\/10.3390\/ijms25158378","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10459_CR22","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/hr.2016.126","volume":"40","author":"M Umesawa","year":"2017","unstructured":"Umesawa M, Kobashi G (2017) Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis. Hypertens Res off J Jpn Soc Hypertens 40(3):213\u2013220. https:\/\/doi.org\/10.1038\/hr.2016.126","journal-title":"Hypertens Res off J Jpn Soc Hypertens"},{"issue":"1\u20132","key":"10459_CR23","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s11010-018-3453-2","volume":"454","author":"J Wang","year":"2019","unstructured":"Wang J, Liu X, Hao C, Lu Y, Duan X, Liang R, Gao G, Zhang T (2019) MEG3 modulates TIGIT expression and CD4 + T cell activation through absorbing miR-23a. Mol Cell Biochem 454(1\u20132):67\u201376. https:\/\/doi.org\/10.1007\/s11010-018-3453-2","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"10459_CR24","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1158\/2326-6066.CIR-18-0442","volume":"7","author":"S Whelan","year":"2019","unstructured":"Whelan S, Ophir E, Kotturi MF, Levy O, Ganguly S, Leung L, Vaknin I, Kumar S, Dassa L, Hansen K, Bernados D, Murter B, Soni A, Taube JM, Fader AN, Wang TL, Shih IM, White M, Pardoll DM, Liang SC (2019) PVRIG and PVRL2 are induced in cancer and inhibit CD8+ T-cell function. Cancer Immunol Res 7(2):257\u2013268. https:\/\/doi.org\/10.1158\/2326-6066.CIR-18-0442","journal-title":"Cancer Immunol Res"},{"issue":"10","key":"10459_CR25","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s00262-017-2031-x","volume":"66","author":"F Xu","year":"2017","unstructured":"Xu F, Sunderland A, Zhou Y, Schulick RD, Edil BH, Zhu Y (2017) Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions. Cancer Immunol Immunother CII 66(10):1367\u20131375. https:\/\/doi.org\/10.1007\/s00262-017-2031-x","journal-title":"Cancer Immunol Immunother CII"},{"issue":"1","key":"10459_CR26","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/ni.1674","volume":"10","author":"X Yu","year":"2009","unstructured":"Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 10(1):48\u201357. https:\/\/doi.org\/10.1038\/ni.1674","journal-title":"Nat Immunol"},{"issue":"2","key":"10459_CR27","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/eji.201948382","volume":"50","author":"YH Zhang","year":"2020","unstructured":"Zhang YH, Sun HX (2020) Immune checkpoint molecules in pregnancy: focus on regulatory T cells. Eur J Immunol 50(2):160\u2013169. https:\/\/doi.org\/10.1002\/eji.201948382","journal-title":"Eur J Immunol"},{"issue":"2","key":"10459_CR28","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1084\/jem.20150785","volume":"213","author":"Y Zhu","year":"2016","unstructured":"Zhu Y, Paniccia A, Schulick AC, Chen W, Koenig MR, Byers JT, Yao S, Bevers S, Edil BH (2016) Identification of CD112R as a novel checkpoint for human T cells. J Exp Med 213(2):167\u2013176. https:\/\/doi.org\/10.1084\/jem.20150785","journal-title":"J Exp Med"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10459-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10459-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10459-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T04:41:04Z","timestamp":1752468064000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10459-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10459"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10459-7","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]},"assertion":[{"value":"13 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"178"}}