{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:49:33Z","timestamp":1779324573417,"version":"3.51.4"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2025R381"],"award-info":[{"award-number":["PNURSP2025R381"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10735-025-10487-3","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T04:00:10Z","timestamp":1753934410000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Selenium nanoparticles mitigate chlorpyrifos-induced nephrotoxicity by modulating oxidative stress, inflammation, and the SIRT1\/Nrf2\/HO-1 signaling pathway"],"prefix":"10.1007","volume":"56","author":[{"given":"Alaa A. A.","family":"Mahmoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman M.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Abdel-Moneim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulaiman M.","family":"Alnasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem S.","family":"Alruhaimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad H. M.","family":"Hassanein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanaa M. Abd","family":"El-Twab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"10487_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121281","volume":"313","author":"MS Abduh","year":"2023","unstructured":"Abduh MS, Alruhaimi RS, Alqhtani HA, Hussein OE, Abukhalil MH, Kamel EM, Mahmoud AM (2023) Rosmarinic acid mitigates chlorpyrifos-induced oxidative stress, inflammation, and kidney injury in rats by modulating SIRT1 and Nrf2\/HO-1 signaling. Life Sci 313:121281","journal-title":"Life Sci"},{"issue":"8","key":"10487_CR2","first-page":"838","volume":"13","author":"NG Abraham","year":"1985","unstructured":"Abraham NG, Lutton JD, Levere RD (1985) Heme metabolism and erythropoiesis in abnormal iron states: role of delta-aminolevulinic acid synthase and heme oxygenase. Exp Hematol 13(8):838\u2013843","journal-title":"Exp Hematol"},{"issue":"7","key":"10487_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29128","volume":"10","author":"MF Ahmad","year":"2024","unstructured":"Ahmad MF, Ahmad FA, Alsayegh AA, Zeyaullah M, AlShahrani AM, Muzammil K, Saati AA, Wahab S, Elbendary EY, Kambal N, Abdelrahman MH, Hussain S (2024) Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures. Heliyon 10(7):e29128","journal-title":"Heliyon"},{"issue":"8","key":"10487_CR4","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3390\/biom9080346","volume":"9","author":"SH Aladaileh","year":"2019","unstructured":"Aladaileh SH, Abukhalil MH, Saghir SA, Hanieh H, Alfwuaires MA, Almaiman AA, Bin-Jumah M, Mahmoud AM (2019) Galangin activates Nrf2 signaling and attenuates oxidative damage, inflammation, and apoptosis in a rat model of cyclophosphamide-induced hepatotoxicity. Biomolecules 9(8):346","journal-title":"Biomolecules"},{"issue":"2","key":"10487_CR5","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.foodcont.2013.05.006","volume":"34","author":"M Alamgir Zaman Chowdhury","year":"2013","unstructured":"Alamgir Zaman Chowdhury M, Fakhruddin ANM, Nazrul Islam M, Moniruzzaman M, Gan SH, Khorshed Alam M (2013) Detection of the residues of nineteen pesticides in fresh vegetable samples using gas chromatography\u2013mass spectrometry. Food Control 34(2):457\u2013465","journal-title":"Food Control"},{"issue":"7","key":"10487_CR6","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3390\/biom9070261","volume":"9","author":"G Albasher","year":"2019","unstructured":"Albasher G, Almeer R, Al-Otibi FO, Al-Kubaisi N, Mahmoud AM (2019) Ameliorative effect of beta vulgaris root extract on chlorpyrifos-induced oxidative stress, inflammation and liver injury in rats. Biomolecules 9(7):261","journal-title":"Biomolecules"},{"issue":"1","key":"10487_CR7","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s12011-019-01910-4","volume":"196","author":"MH Al-dossari","year":"2020","unstructured":"Al-dossari MH, Fadda LM, Attia HA, Hasan IH, Mahmoud AM (2020) Curcumin and selenium prevent lipopolysaccharide\/diclofenac-induced liver injury by suppressing inflammation and oxidative stress. Biol Trace Elem Res 196(1):173\u2013183","journal-title":"Biol Trace Elem Res"},{"key":"10487_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2024.114788","volume":"190","author":"RS Alruhaimi","year":"2024","unstructured":"Alruhaimi RS, Alotaibi MF, Alnasser SM, Alzoghaibi MA, Germoush MO, Alotaibi M, Hassanein EHM, Mahmoud AM (2024) Farnesol prevents chlorpyrifos nephrotoxicity by modulating inflammatory mediators, Nrf2 and FXR and attenuating oxidative stress. Food Chem Toxicol 190:114788","journal-title":"Food Chem Toxicol"},{"key":"10487_CR9","doi-asserted-by":"publisher","first-page":"104542","DOI":"10.1016\/j.etap.2024.104542","volume":"110","author":"RS Alruhaimi","year":"2024","unstructured":"Alruhaimi RS, Ahmeda AF, Hussein OE, Alotaibi MF, Germoush MO, Elgebaly HA, Hassanein EHM, Mahmoud AM (2024) Galangin attenuates chlorpyrifos-induced kidney injury by mitigating oxidative stress and inflammation and upregulating Nrf2 and farnesoid-X-receptor in rats. Environ Toxicol Pharmacol 110:104542","journal-title":"Environ Toxicol Pharmacol"},{"issue":"1","key":"10487_CR10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s12011-016-0748-6","volume":"175","author":"KA Amin","year":"2017","unstructured":"Amin KA, Hashem KS, Alshehri FS, Awad ST, Hassan MS (2017) Antioxidant and hepatoprotective efficiency of selenium nanoparticles against acetaminophen-induced hepatic damage. Biol Trace Elem Res 175(1):136\u2013145","journal-title":"Biol Trace Elem Res"},{"key":"10487_CR11","doi-asserted-by":"publisher","first-page":"120260","DOI":"10.1016\/j.lfs.2021.120260","volume":"291","author":"SA Antar","year":"2022","unstructured":"Antar SA, Abdo W, Taha RS, Farage AE, El-Moselhy LE, Amer ME, Abdel Monsef AS, Abdel Hamid AM, Kamel EM, Ahmeda AF, Mahmoud AM (2022) Telmisartan attenuates diabetic nephropathy by mitigating oxidative stress and inflammation, and upregulating Nrf2\/HO-1 signaling in diabetic rats. Life Sci 291:120260","journal-title":"Life Sci"},{"issue":"2","key":"10487_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1203\/PDR.0b013e3181a9eafb","volume":"66","author":"RL Auten","year":"2009","unstructured":"Auten RL, Davis JM (2009) Oxygen toxicity and reactive oxygen species: the devil is in the details. Pediatr Res 66(2):121\u2013127","journal-title":"Pediatr Res"},{"key":"10487_CR13","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2020.6057","author":"EFS Authority","year":"2020","unstructured":"Authority EFS, Medina-Pastor P, Triacchini G (2020) The 2018 European Union report on pesticide residues in food. EFSA J. https:\/\/doi.org\/10.2903\/j.efsa.2020.6057","journal-title":"EFSA J"},{"key":"10487_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/bs.vh.2022.09.002","volume":"121","author":"DA Averill-Bates","year":"2023","unstructured":"Averill-Bates DA (2023) The antioxidant glutathione. Vitam Horm 121:109\u2013141","journal-title":"Vitam Horm"},{"issue":"Suppl 2","key":"10487_CR15","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/jnc.14077","volume":"142 Suppl 2","author":"RD Burke","year":"2017","unstructured":"Burke RD et al (2017) Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms. J Neurochem 142 Suppl 2(Suppl 2):162\u2013177","journal-title":"J Neurochem"},{"issue":"1","key":"10487_CR16","first-page":"15","volume":"1","author":"Z Cai","year":"2013","unstructured":"Cai Z, Yan L-J (2013) Protein oxidative modifications: beneficial roles in disease and health. J Biochem Pharmacol Res 1(1):15","journal-title":"J Biochem Pharmacol Res"},{"issue":"1","key":"10487_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.powtec.2004.09.014","volume":"148","author":"LC Damonte","year":"2004","unstructured":"Damonte LC, Mendoza Z\u00e9lis LA, Mar\u00ed Soucase B, Hern\u00e1ndez Fenollosa MA (2004) Nanoparticles of ZnO obtained by mechanical milling. Powder Technol 148(1):15\u201319","journal-title":"Powder Technol"},{"key":"10487_CR18","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.colsurfb.2014.06.062","volume":"122","author":"H Estevez","year":"2014","unstructured":"Estevez H, Garcia-Lidon JC, Luque-Garcia JL, Camara C (2014) Effects of chitosan-stabilized selenium nanoparticles on cell proliferation, apoptosis and cell cycle pattern in HepG2 cells: comparison with other selenospecies. Colloids Surf B Biointerfaces 122:184\u2013193","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"3","key":"10487_CR19","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1753-4887.2006.tb00198.x","volume":"64","author":"JW Finley","year":"2006","unstructured":"Finley JW (2006) Bioavailability of selenium from foods. Nutr Rev 64(3):146\u2013151","journal-title":"Nutr Rev"},{"key":"10487_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.171711","volume":"928","author":"H Fu","year":"2024","unstructured":"Fu H, Ge Y, Liu X, Deng S, Li J, Tan P, Yang Y, Wu Z (2024) Exposure to the environmental pollutant chlorpyrifos induces hepatic toxicity through activation of the JAK\/STAT and MAPK pathways. Sci Total Environ 928:171711","journal-title":"Sci Total Environ"},{"issue":"21","key":"10487_CR21","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1101\/gad.1467506","volume":"20","author":"MC Haigis","year":"2006","unstructured":"Haigis MC, Guarente LP (2006) Mammalian sirtuins\u2014emerging roles in physiology, aging, and calorie restriction. Genes Dev 20(21):2913\u20132921","journal-title":"Genes Dev"},{"key":"10487_CR22","doi-asserted-by":"publisher","first-page":"122445","DOI":"10.1016\/j.lfs.2024.122445","volume":"340","author":"IH Hasan","year":"2024","unstructured":"Hasan IH, Shaheen SY, Alhusaini AM, Mahmoud AM (2024) Simvastatin mitigates diabetic nephropathy by upregulating farnesoid X receptor and Nrf2\/HO-1 signaling and attenuating oxidative stress and inflammation in rats. Life Sci 340:122445","journal-title":"Life Sci"},{"key":"10487_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.115274","volume":"408","author":"HF Hozyen","year":"2020","unstructured":"Hozyen HF, Khalil HMA, Ghandour RA, Al-Mokaddem AK, Amer MS, Azouz RA (2020) Nano selenium protects against deltamethrin-induced reproductive toxicity in male rats. Toxicol Appl Pharmacol 408:115274","journal-title":"Toxicol Appl Pharmacol"},{"key":"10487_CR24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.bmt.2023.12.001","volume":"6","author":"KK Karthik","year":"2024","unstructured":"Karthik KK, Cheriyan BV, Rajeshkumar S, Gopalakrishnan M (2024) A review on selenium nanoparticles and their biomedical applications. Biomed Technol 6:61\u201374","journal-title":"Biomed Technol"},{"issue":"8","key":"10487_CR25","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/tox.23156","volume":"36","author":"S K\u00fc\u00e7\u00fckler","year":"2021","unstructured":"K\u00fc\u00e7\u00fckler S, \u00c7omakl\u0131 S, \u00d6zdemir S, \u00c7a\u011flayan C, Kandemir FM (2021) Hesperidin protects against the chlorpyrifos-induced chronic hepato-renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up-regulation of PARP-1\/VEGF. Environ Toxicol 36(8):1600\u20131617","journal-title":"Environ Toxicol"},{"issue":"6","key":"10487_CR26","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"T Lawrence","year":"2009","unstructured":"Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1(6):a001651","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10487_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2022.105483","volume":"86","author":"J-W Lin","year":"2023","unstructured":"Lin J-W, Fu S-C, Liu J-M, Liu S-H, Lee K-I, Fang K-M, Hsu R-J, Huang C-F, Liu K-M, Chang K-C, Su C-C, Chen Y-W (2023) Chlorpyrifos induces neuronal cell death via both oxidative stress and Akt activation downstream-regulated CHOP-triggered apoptotic pathways. Toxicol in Vitro 86:105483","journal-title":"Toxicol in Vitro"},{"issue":"4","key":"10487_CR28","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2011","unstructured":"Livak KJ, Schmittgen TD (2011) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"issue":"1Pt A","key":"10487_CR29","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1016\/j.bbagen.2016.08.013","volume":"1861","author":"AM Mahmoud","year":"2017","unstructured":"Mahmoud AM, Wilkinson FL, Jones AM, Wilkinson JA, Romero M, Duarte J, Alexander MY (2017) A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: Involvement of Akt\/eNOS and Nrf2\/ARE signaling. Biochim Biophys Acta Gen Subj 1861(1Pt A):3311\u20133322","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"10487_CR30","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.freeradbiomed.2020.07.037","volume":"160","author":"T Mohan","year":"2020","unstructured":"Mohan T, Narasimhan KKS, Ravi DB, Velusamy P, Chandrasekar N, Chakrapani LN, Srinivasan A, Karthikeyan P, Kannan P, Tamilarasan B, Johnson T, Kalaiselvan P, Periandavan K (2020) Role of Nrf2 dysfunction in the pathogenesis of diabetic nephropathy: therapeutic prospect of epigallocatechin-3-gallate. Free Radical Biol Med 160:227\u2013238","journal-title":"Free Radical Biol Med"},{"issue":"1","key":"10487_CR31","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1152\/physrev.00029.2006","volume":"87","author":"P Pacher","year":"2007","unstructured":"Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87(1):315\u2013424","journal-title":"Physiol Rev"},{"issue":"1","key":"10487_CR32","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4110\/in.2009.9.1.12","volume":"9","author":"HO Pae","year":"2009","unstructured":"Pae HO, Chung HT (2009) Heme oxygenase-1: its therapeutic roles in inflammatory diseases. Immune Netw 9(1):12\u201319","journal-title":"Immune Netw"},{"issue":"5","key":"10487_CR33","doi-asserted-by":"publisher","first-page":"749","DOI":"10.3390\/foods11050749","volume":"11","author":"Y Qiu","year":"2022","unstructured":"Qiu Y, Chen X, Chen Z, Zeng X, Yue T, Yuan Y (2022) Effects of selenium nanoparticles on preventing patulin-induced liver kidney and gastrointestinal damage. Foods 11(5):749","journal-title":"Foods"},{"issue":"8","key":"10487_CR34","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1016\/j.arabjc.2015.10.014","volume":"12","author":"NR Rodrigues","year":"2019","unstructured":"Rodrigues NR et al (2019) Activation of p38MAPK and NRF2 signaling pathways in the toxicity induced by chlorpyrifos in Drosophila melanogaster: protective effects of Psidium guajava pom\u00edfera L. (Myrtaceae) hydroalcoholic extract. Arab J Chem 12(8):3490\u20133502","journal-title":"Arab J Chem"},{"issue":"4","key":"10487_CR35","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3390\/molecules29040801","volume":"29","author":"S Sampath","year":"2024","unstructured":"Sampath S, Sunderam V, Manjusha M, Dlamini Z, Lawrance AV (2024) Selenium nanoparticles: a comprehensive examination of synthesis techniques and their diverse applications in medical research and toxicology studies. Molecules 29(4):801","journal-title":"Molecules"},{"key":"10487_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.618582","volume":"12","author":"M Saoudi","year":"2021","unstructured":"Saoudi M, Badraoui R, Rahmouni F, Jamoussi K, El Feki A (2021) Antioxidant and protective effects of Artemisia campestris essential oil against chlorpyrifos-induced kidney and liver injuries in rats. Front Physiol 12:618582","journal-title":"Front Physiol"},{"key":"10487_CR37","doi-asserted-by":"publisher","first-page":"9237263","DOI":"10.1155\/2017\/9237263","volume":"2017","author":"S Satta","year":"2017","unstructured":"Satta S, Mahmoud AM, Wilkinson FL, Yvonne Alexander M, White SJ (2017) The role of Nrf2 in cardiovascular function and disease. Oxid Med Cell Longev 2017:9237263","journal-title":"Oxid Med Cell Longev"},{"key":"10487_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118173","volume":"259","author":"AM Sayed","year":"2020","unstructured":"Sayed AM, Hassanein EHM, Salem SH, Hussein OE, Mahmoud AM (2020) Flavonoids-mediated SIRT1 signaling activation in hepatic disorders. Life Sci 259:118173","journal-title":"Life Sci"},{"issue":"1","key":"10487_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40064-016-3004-9","volume":"5","author":"S Sharma","year":"2016","unstructured":"Sharma S, Chadha P (2016) Induction of neurotoxicity by organophosphate pesticide chlorpyrifos and modulating role of cow urine. Springerplus 5(1):1\u20137","journal-title":"Springerplus"},{"issue":"2","key":"10487_CR40","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.semnephrol.2018.12.010","volume":"39","author":"H Shen","year":"2019","unstructured":"Shen H, Scialis RJ, Lehman-McKeeman L (2019) Xenobiotic transporters in the kidney: function and role in toxicity. Semin Nephrol 39(2):159\u2013175","journal-title":"Semin Nephrol"},{"key":"10487_CR41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s12011-016-0863-4","volume":"177","author":"L-H Sun","year":"2017","unstructured":"Sun L-H, Pi D-A, Zhao L, Wang X-Y, Zhu L-Y, Qi D-S, Liu Y-L (2017) Response of selenium and selenogenome in immune tissues to LPS-induced inflammatory reactions in pigs. Biol Trace Elem Res 177:90\u201396","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"10487_CR42","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1515\/reveh-2014-0072","volume":"30","author":"S Suratman","year":"2015","unstructured":"Suratman S, Edwards JW, Babina K (2015) Organophosphate pesticides exposure among farmworkers: pathways and risk of adverse health effects. Rev Environ Health 30(1):65\u201379","journal-title":"Rev Environ Health"},{"issue":"5","key":"10487_CR43","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1016\/j.apsb.2023.02.018","volume":"13","author":"Y Teng","year":"2023","unstructured":"Teng Y, Huang Y, Yu H, Wu C, Yan Q, Wang Y, Yang M, Xie H, Wu T, Yang H, Zou J (2023) Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling. Acta Pharmaceutica Sinica B 13(5):2269\u20132280","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"10487_CR44","doi-asserted-by":"publisher","first-page":"142649","DOI":"10.1016\/j.scitotenv.2020.142649","volume":"755","author":"HU ur Rahman","year":"2021","unstructured":"ur Rahman HU, Asghar W, Nazir W, Sandhu MA, Ahmed A, Khalid N (2021) A comprehensive review on chlorpyrifos toxicity with special reference to endocrine disruption: evidence of mechanisms, exposures and mitigation strategies. Sci Total Environ 755:142649","journal-title":"Sci Total Environ"},{"issue":"6","key":"10487_CR45","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/j.fct.2010.03.051","volume":"48","author":"FG Uzun","year":"2010","unstructured":"Uzun FG, Demir F, Kalender S, Bas H, Kalender Y (2010) Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats. Food Chem Toxicol 48(6):1714\u20131720","journal-title":"Food Chem Toxicol"},{"issue":"9","key":"10487_CR46","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.3390\/ma14092257","volume":"14","author":"SI Vicas","year":"2021","unstructured":"Vicas SI, Laslo V, Timar AV, Balta C, Herman H, Ciceu A, Gharbia S, Rosu M, Mladin B, Chiana L, Prokisch J, Puschita M, Miutescu E, Cavalu S, Cotoraci C, Hermenean A (2021) Nano selenium-enriched probiotics as functional food products against cadmium liver toxicity. Materials (Basel) 14(9):2257","journal-title":"Materials (Basel)"},{"key":"10487_CR47","doi-asserted-by":"publisher","first-page":"7478523","DOI":"10.1155\/2017\/7478523","volume":"2017","author":"N Wang","year":"2017","unstructured":"Wang N, Tan HY, Li S, Xu Y, Guo W, Feng Y (2017) Supplementation of micronutrient selenium in metabolic diseases: its role as an antioxidant. Oxid Med Cell Longev 2017:7478523","journal-title":"Oxid Med Cell Longev"},{"issue":"8","key":"10487_CR48","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.7150\/thno.70830","volume":"12","author":"S Wang","year":"2022","unstructured":"Wang S, Chen Y, Han S, Liu Y, Gao J, Huang Y, Sun W, Wang J, Wang C, Zhao J (2022) Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1\/NLRP3\/Caspase-1 pathway. Theranostics 12(8):3882\u20133895","journal-title":"Theranostics"},{"key":"10487_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.130417","volume":"278","author":"GCC Weis","year":"2021","unstructured":"Weis GCC, Assmann CE, Mostardeiro VB, Alves AO, da Rosa JR, Pillat MM, de Andrade CM, Schetinger MRC, Morsch VMM, da Cruz IBM, Costabeber IH (2021) Chlorpyrifos pesticide promotes oxidative stress and increases inflammatory states in BV-2 microglial cells: a role in neuroinflammation. Chemosphere 278:130417","journal-title":"Chemosphere"},{"key":"10487_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.831168","volume":"13","author":"Y Yang","year":"2022","unstructured":"Yang Y, Liu Y, Wang Y, Chao Y, Zhang J, Jia Y, Tie J, Hu D (2022) Regulation of SIRT1 and its roles in inflammation. Front Immunol 13:831168","journal-title":"Front Immunol"},{"issue":"11","key":"10487_CR51","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.3390\/antiox12111973","volume":"12","author":"XQ Ye","year":"2023","unstructured":"Ye XQ, Zhu YR, Yang YY, Qiu SJ, Liu WC (2023) Biogenic selenium nanoparticles synthesized with alginate oligosaccharides alleviate heat stress-induced oxidative damage to organs in broilers through activating Nrf2-mediated anti-oxidation and anti-ferroptosis pathways. Antioxidants (Basel) 12(11):1973","journal-title":"Antioxidants (Basel)"},{"key":"10487_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155533","volume":"128","author":"Y Zeng","year":"2024","unstructured":"Zeng Y, He Y, Wang L, Xu H, Zhang Q, Wang Y, Zhang J, Wang L (2024) Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1\/p53 axis. Phytomedicine 128:155533","journal-title":"Phytomedicine"},{"key":"10487_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117274","volume":"287","author":"M Zhang","year":"2024","unstructured":"Zhang M, Gao J, Kulyar MF, Luo W, Zhang G, Yang X, Zhang T, Gao H, Peng Y, Zhang J, Altaf M, Algharib SA, Zhou D, He J (2024) Antioxidant and renal protective effects of nano-selenium on adenine-induced acute renal failure in canines. Ecotoxicol Environ Saf 287:117274","journal-title":"Ecotoxicol Environ Saf"},{"issue":"6","key":"10487_CR54","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/tox.22736","volume":"34","author":"MW Zhao","year":"2019","unstructured":"Zhao MW, Yang P, Zhao LL (2019) Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress-induced toxicity by miR-181\/SIRT1\/PGC-1\u03b1\/Nrf2 signaling pathway in human neuroblastoma SH-SY5Y cells. Environ Toxicol 34(6):699\u2013707","journal-title":"Environ Toxicol"},{"key":"10487_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.826204","volume":"10","author":"J Zhou","year":"2022","unstructured":"Zhou J, Zheng Q, Chen Z (2022) The Nrf2 pathway in liver diseases. Front Cell Dev Biol 10:826204","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"10487_CR56","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1186\/s12964-024-01751-2","volume":"22","author":"Z Zuo","year":"2024","unstructured":"Zuo Z, Luo M, Liu Z, Liu T, Wang X, Huang X, Li S, Wu H, Pan Q, Chen T, Yang L, Liu H-F (2024) Selenium nanoparticles alleviate renal ischemia\/reperfusion injury by inhibiting ferritinophagy via the XBP1\/NCOA4 pathway. Cell Commun Signal 22(1):376","journal-title":"Cell Commun Signal"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10487-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10487-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10487-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T08:23:47Z","timestamp":1757319827000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10487-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10487"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10487-3","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"14 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The experimental protocol was approved by the Institutional Animal Ethics Committee of Beni-Suef University (Egypt) (Approval no. 021-130).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"249"}}