{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:24:16Z","timestamp":1787243056487,"version":"build-2736575974"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10735-025-10511-6","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T14:48:47Z","timestamp":1752590927000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does Moringa oleifera leaf extract protect the brain against 3-acetylpyridine-induced cerebellar ataxia in rat?"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7451-5021","authenticated-orcid":false,"given":"Doaa Mohamad","family":"Hassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourhan Tharwat","family":"Sabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha Eid","family":"Farghaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Yahia","family":"Sedeak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"issue":"34","key":"10511_CR1","doi-asserted-by":"publisher","first-page":"43028","DOI":"10.1007\/s11356-020-10161-z","volume":"27","author":"ME Abdel","year":"2020","unstructured":"Abdel ME, Fattah HM, Sobhy AR, Abdelrazek HMA (2020) Hepatoprotective effect of Moringa oleifera leaves aquatic extract against lead acetate\u2013induced liver injury in male Wistar rats. Environ Sci Pollut 27(34):43028\u201343043. https:\/\/doi.org\/10.1007\/s11356-020-10161-z","journal-title":"Environ Sci Pollut"},{"key":"10511_CR2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.biopha.2016.11.074","volume":"85","author":"AI Abushouk","year":"2017","unstructured":"Abushouk AI, Negida A, Ahmed H, Abdel-Daim MM (2017) Neuroprotective mechanisms of plant extracts against MPTP induced neurotoxicity: future applications in Parkinson\u2019s disease. Biomed Pharmacother 85:635\u2013645. https:\/\/doi.org\/10.1016\/j.biopha.2016.11.074","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10511_CR3","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1096\/fasebj.29.1_supplement.lb508","volume":"29","author":"B Adewale","year":"2016","unstructured":"Adewale B, Norazah B, Ravikanth V, Satyajit S, Olusegun A, Olumayokun O (2016) Moringa oleifera inhibit neuroinflammation in LPS activated BV2 microglia. FASEB J 29(1):634\u2013700. https:\/\/doi.org\/10.1096\/fasebj.29.1_supplement.lb508","journal-title":"FASEB J"},{"issue":"1","key":"10511_CR4","doi-asserted-by":"publisher","first-page":"e13579","DOI":"10.1111\/jfbc.13579","volume":"45","author":"WS Alqahtani","year":"2021","unstructured":"Alqahtani WS, Albasher G (2021) Moringa oleifera Lam. extract rescues lead-induced oxidative stress, inflammation, and apoptosis in the rat cerebral cortex. J Food Biochem 45(1):e13579. https:\/\/doi.org\/10.1111\/jfbc.13579","journal-title":"J Food Biochem"},{"issue":"1","key":"10511_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2005.07.008","volume":"27","author":"GF Ameenah","year":"2005","unstructured":"Ameenah GF (2005) Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med 27(1):1\u201393. https:\/\/doi.org\/10.1016\/j.mam.2005.07.008","journal-title":"Mol Aspects Med"},{"issue":"13","key":"10511_CR6","doi-asserted-by":"publisher","first-page":"1035220","DOI":"10.3389\/fphar.2022.1035220","volume":"5","author":"UK Azlan","year":"2022","unstructured":"Azlan UK, Annuar NAK, Mediani A, Aizat WM, Damanhuri HA, Tong X, Yanagisawa D, Tooyama I, Ngah WZW, Jantan I, Hamezah HS (2022) An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera. Front Pharmacol 5(13):1035220. https:\/\/doi.org\/10.3389\/fphar.2022.1035220","journal-title":"Front Pharmacol"},{"issue":"3","key":"10511_CR7","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.jep.2013.08.006","volume":"149","author":"AG Bakre","year":"2013","unstructured":"Bakre AG, Aderibigbe AO, Ademowo OG (2013) Studies on neuropharmacological profile of ethanol extract of Moringa oleifera leaves in mice. J Ethnopharmacol 149(3):783\u2013789. https:\/\/doi.org\/10.1016\/j.jep.2013.08.006","journal-title":"J Ethnopharmacol"},{"issue":"1985","key":"10511_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0165-0173(85)90017-7","volume":"356","author":"CD Balaban","year":"1985","unstructured":"Balaban CD (1985) Central neurotoxic effects of intraperitoneally administered 3-acetylpyridine, harmaline and niacinamide in Sprague-Dawley and Long-Evans rats: a critical review of central 3-acetylpyridine neurotoxicity. Brain Res 356(1985):21\u201342. https:\/\/doi.org\/10.1016\/0165-0173(85)90017-7","journal-title":"Brain Res"},{"key":"10511_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1017\/cbo9780511529771.018","volume-title":"The cerebellum and adaptive control","author":"JB Barlow","year":"2002","unstructured":"Barlow JB (2002) The cerebellum and adaptive control. Cambridge University Press, New York, pp 273\u2013292. https:\/\/doi.org\/10.1017\/cbo9780511529771.018"},{"key":"10511_CR10","doi-asserted-by":"publisher","first-page":"40","DOI":"10.15406\/mojfpt.2016.02.00030","volume":"22","author":"AM Basuny","year":"2016","unstructured":"Basuny AM, Al-Marzouq MA (2016) Biochemical studies on Moringa oleifera seed oil. MOJFPT. 22:40\u201346. https:\/\/doi.org\/10.15406\/mojfpt.2016.02.00030","journal-title":"MOJFPT."},{"issue":"14","key":"10511_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fnins.2020.00187","volume":"20","author":"C Bei-Bei","year":"2020","unstructured":"Bei-Bei C, Xiao-Xian Z, Chen-Yu D, Zhan L, Yi-Hua Q, Yu-Ping P (2020) TGF-\u03b21 provides neuroprotection via inhibition of microglial activation in 3-acetylpyridine-induced cerebellar ataxia model rats. Front Neurosci 20(14):187. https:\/\/doi.org\/10.3389\/fnins.2020.00187","journal-title":"Front Neurosci"},{"issue":"2","key":"10511_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bcp.2009.09.014","volume":"79","author":"A Buffo","year":"2010","unstructured":"Buffo A, Rolando C, Ceruti S (2010) Astrocytes in the damaged brain: Molecular and cellular insights into their reactive response and healing potential. Biochem Pharmacol 79(2):77\u201389. https:\/\/doi.org\/10.1016\/j.bcp.2009.09.014","journal-title":"Biochem Pharmacol"},{"issue":"19","key":"10511_CR13","doi-asserted-by":"publisher","first-page":"4510","DOI":"10.1523\/JNEUROSCI.4530-03.2004","volume":"24","author":"NL Cerminara","year":"2004","unstructured":"Cerminara NL, Rawson JA (2004) Evidence that climbing fibers control an intrinsic spike generator in cerebellar Purkinje cells. J Neurosci 24(19):4510\u20134517. https:\/\/doi.org\/10.1523\/JNEUROSCI.4530-03.2004","journal-title":"J Neurosci"},{"issue":"4","key":"10511_CR14","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/acn3.54","volume":"1","author":"C Chang","year":"2014","unstructured":"Chang C, Cho S, Wang J (2014) (-) Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways. Ann Clin Transl Neurol 1(4):258\u2013271. https:\/\/doi.org\/10.1002\/acn3.54","journal-title":"Ann Clin Transl Neurol"},{"issue":"1","key":"10511_CR15","doi-asserted-by":"publisher","first-page":"14945","DOI":"10.1038\/s41598-020-71966-z","volume":"10","author":"PS Chong","year":"2020","unstructured":"Chong PS, Khairuddin S, Tse ACK, Hiew LF, Lau CL, Tipoe GL, Fung ML, Wong KH, Lim LW (2020) Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia. Sci Rep 10(1):14945. https:\/\/doi.org\/10.1038\/s41598-020-71966-z","journal-title":"Sci Rep"},{"key":"10511_CR16","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.3791\/2609","volume":"75","author":"RMJ Deacon","year":"2013","unstructured":"Deacon RMJ (2013) Measuring motor coordination in mice. J vis Exp 75:2609. https:\/\/doi.org\/10.3791\/2609","journal-title":"J vis Exp"},{"key":"10511_CR17","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1080\/07315724.2019.1649218","volume":"39","author":"CO Edeogu","year":"2020","unstructured":"Edeogu CO, Kalu ME, Famurewa AC, Asogwa NT, Onyeji GN, Ikpemo KO (2020) Nephroprotective effect of Moringa oleifera seed oil on gentamicin-induced nephrotoxicity in rats: biochemical evaluation of antioxidant, anti-inflammatory, and Antiapoptotic pathways. J Am Coll Nutr 39:307\u2013315. https:\/\/doi.org\/10.1080\/07315724.2019.1649218","journal-title":"J Am Coll Nutr"},{"issue":"4","key":"10511_CR18","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4):495\u2013516. https:\/\/doi.org\/10.1080\/01926230701320337","journal-title":"Toxicol Pathol"},{"issue":"1","key":"10511_CR19","doi-asserted-by":"publisher","first-page":"e178","DOI":"10.1371\/journal.pone.0000178","volume":"2","author":"HA El-Shemy","year":"2007","unstructured":"El-Shemy HA, Aboul-Enein AM, Aboul-Enein KM, Fujita K (2007) Willow leaves\u2019 extracts contain anti-tumor agents effective againstthree cell types. PLoS ONE 2(1):e178. https:\/\/doi.org\/10.1371\/journal.pone.0000178","journal-title":"PLoS ONE"},{"issue":"1","key":"10511_CR20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/s0031-9422(00)00316-2","volume":"56","author":"JW Fahey","year":"2001","unstructured":"Fahey JW, Zakmann AT, Talalay P (2001) The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 56(1):5\u201351. https:\/\/doi.org\/10.1016\/s0031-9422(00)00316-2","journal-title":"Phytochemistry"},{"issue":"3","key":"10511_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12748","volume":"43","author":"AC Famurewa","year":"2019","unstructured":"Famurewa AC, Aja PM, Nwankwo OE, Awoke JN, Maduagwuna EK, Aloke C (2019) Moringa oleifera seed oil or virgin coconut oil supplementation abrogates cerebral neurotoxicity induced by antineoplastic agent methotrexate by suppression of oxidative stress and neuroinflammation in rats. J Food Biochem 43(3):e12748. https:\/\/doi.org\/10.1111\/jfbc.12748","journal-title":"J Food Biochem"},{"issue":"1","key":"10511_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.pathophys.2017.12.003","volume":"25","author":"OO Gabriel","year":"2018","unstructured":"Gabriel OO, Ismail TG, Olayemi JO, Shakirat ODH, Tolulope TA, Emmanuel OY (2018) Moringa oleifera phytochemicals protect the brain against experimental nicotine-induced neurobehavioral disturbances and cerebellar degeneration. Pathophysiology 25(1):57\u201362. https:\/\/doi.org\/10.1016\/j.pathophys.2017.12.003","journal-title":"Pathophysiology"},{"issue":"12","key":"10511_CR23","doi-asserted-by":"publisher","first-page":"10351","DOI":"10.1039\/d0fo02438d","volume":"11","author":"A Garate-carrillo","year":"2020","unstructured":"Garate-carrillo A, Rodriguez A, Ceballos G, Calzada-mendoza C, Hogan MC, Villarreal F et al (2020) Effects of (-)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice. Food Funct 11(12):10351\u201310361. https:\/\/doi.org\/10.1039\/d0fo02438d","journal-title":"Food Funct"},{"issue":"4","key":"10511_CR24","doi-asserted-by":"publisher","first-page":"538","DOI":"10.5115\/acb.23.101","volume":"56","author":"NO Ghada","year":"2023","unstructured":"Ghada NO, Doaa MH (2023) A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats. Anat Cell Biol 56(4):538\u2013551. https:\/\/doi.org\/10.5115\/acb.23.101","journal-title":"Anat Cell Biol"},{"key":"10511_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2021.09.005","author":"D Gonz\u00e1lez-Tapia","year":"2021","unstructured":"Gonz\u00e1lez-Tapia D, V\u00e1zquez-Hern\u00e1ndez N, Urmeneta-Ortiz F, Navidad-Hernandez N, Lazo-Yepez M, Tejeda-Mart\u00ednez A, Flores-Soto M, Gonz\u00e1lez-Burgos I (2021) 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. https:\/\/doi.org\/10.1016\/j.nrl.2021.09.005","journal-title":"Neurologia"},{"issue":"1","key":"10511_CR26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12974-016-0650-3","volume":"13","author":"M Gupta","year":"2016","unstructured":"Gupta M, Gurcharan K (2016) Aqueous extract from the Withania somnifera leaves as a potential antineuro inflammatory agent: a mechanistic study. J Inflammation. 13(1):193. https:\/\/doi.org\/10.1186\/s12974-016-0650-3","journal-title":"J Inflammation."},{"issue":"2","key":"10511_CR27","first-page":"183","volume":"31","author":"OO Igado","year":"2017","unstructured":"Igado OO, Olopade JO (2017) A review on the possible neuroprotective effects of Moringa oleifera leaf extract. Niger J Physiol Sci 31(2):183\u2013187","journal-title":"Niger J Physiol Sci"},{"key":"10511_CR28","doi-asserted-by":"crossref","unstructured":"Jacksson P, Blythe D (2013) Immunohistochemical techniques. In: Suvarna SK, Layton C, Bancroft JD (eds). Theory & Practice of histelegical techniques, 7th edn, Churchill Livingstone of El Sevier. Philadelphia, pp 381\u2013434","DOI":"10.1016\/B978-0-7020-4226-3.00018-4"},{"issue":"1","key":"10511_CR29","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.bbr.2004.11.018","volume":"160","author":"T Jana","year":"2005","unstructured":"Jana T, Hana K, Pavel M (2005) Postnatal caffeine exposure: effects on motor skills and locomotor activity during ontogenesis. Comparative study. Behav Brain Res 160(1):99\u2013106. https:\/\/doi.org\/10.1016\/j.bbr.2004.11.018","journal-title":"Behav Brain Res"},{"issue":"3","key":"10511_CR30","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.neuro.2009.02.014","volume":"30","author":"M Janahmadi","year":"2009","unstructured":"Janahmadi M, Goudarzi I, Kaffashian MR, Behzadi G, Fathollahi Y, Hajizadeh S (2009) Co-treatment with riluzole, a neuroprotective drug, ameliorates the 3-acetylpyridine-induced neurotoxicity in cerebellar Purkinje neurones of rats: behavioural and electrophysiological evidence. Neurotoxicology 30(3):393\u2013402. https:\/\/doi.org\/10.1016\/j.neuro.2009.02.014","journal-title":"Neurotoxicology"},{"issue":"6","key":"10511_CR31","doi-asserted-by":"publisher","first-page":"4174","DOI":"10.1074\/jbc.M112.436022","volume":"288","author":"LL Jessica","year":"2013","unstructured":"Jessica LL, Viktor B, Yongkang Z, Randal AS (2013) Endothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium. J Biol Chem 288(6):4174\u20134193. https:\/\/doi.org\/10.1074\/jbc.M112.436022","journal-title":"J Biol Chem"},{"issue":"1","key":"10511_CR32","doi-asserted-by":"publisher","first-page":"100503","DOI":"10.1016\/j.jaim.2021.07.019","volume":"13","author":"B Kalgi","year":"2022","unstructured":"Kalgi B, Sri PC, Abhinav K, Aayush M, Rutu R, Aniket R, Raghavendra UKS, Chaitali P, Vaibhav S, Divya KP, Suhani S, Yogendra N, Nitesh K (2022) Effect of Moringa oleifera leaf extract on exercise and dexamethasone-induced functional impairment in skeletal muscles. J Ayurveda Integr Med 13(1):100503. https:\/\/doi.org\/10.1016\/j.jaim.2021.07.019","journal-title":"J Ayurveda Integr Med"},{"issue":"2004","key":"10511_CR33","doi-asserted-by":"publisher","first-page":"18183","DOI":"10.1073\/pnas.0407900101","volume":"101","author":"VB Kazantsev","year":"2004","unstructured":"Kazantsev VB, Nekorkin VI, Makarenko VI, Llin\u00e1s R (2004) Self-referential phase reset based on inferior olive oscillator dynamics. Proc Natl Acad Sci USA 101(2004):18183\u201318188. https:\/\/doi.org\/10.1073\/pnas.0407900101","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10511_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163433","volume":"11","author":"JJ Kim","year":"2016","unstructured":"Kim JJ, Kang YJ, Shin SA, Bak DH, Lee JW, Lee KB et al (2016) Phlorofucofuroeckol improves glutamate-induced neurotoxicity through modulation of oxidative stress-mediated mitochondrial dysfunction in PC12 cells. PLoS ONE 11(9):e0163433. https:\/\/doi.org\/10.1371\/journal.pone.0163433","journal-title":"PLoS ONE"},{"issue":"9","key":"10511_CR35","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.3844\/ajassp.2012.1457.1463","volume":"9","author":"W Kirisattayakul","year":"2012","unstructured":"Kirisattayakul W, Wattanathorn J, Tong-Un T, Muchimapura S, Wannanon P (2012) Moringa oleifera lam mitigates oxidative damage and brain infarct volume in focal cerebral ischemia. Am J Appl Sci 9(9):1457\u20131463. https:\/\/doi.org\/10.3844\/ajassp.2012.1457.1463","journal-title":"Am J Appl Sci"},{"key":"10511_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/951415","volume":"2013","author":"W Kirisattayakul","year":"2013","unstructured":"Kirisattayakul W, Wattanathorn J, Tong-Un T, Muchimapura S, Wannanon P, Jittiwat J (2013) Cerebroprotective effect of Moringa oleifera against focal ischemic stroke induced by middle cerebral artery occlusion. Oxidative Med Cell Longev 2013:951415. https:\/\/doi.org\/10.1155\/2013\/951415","journal-title":"Oxidative Med Cell Longev"},{"key":"10511_CR37","doi-asserted-by":"publisher","unstructured":"Kuo SH, Ataxia C (2019) (Minneap Minn), 25 (2019), pp. 1036\u20131054, https:\/\/doi.org\/10.1212\/CON.0000000000000753.","DOI":"10.1212\/CON.0000000000000753"},{"key":"10511_CR38","first-page":"51","volume":"5","author":"ML Letournel-Boulland","year":"1994","unstructured":"Letournel-Boulland ML, Fages C, Rolland B, Tardy M (1994) Lipopolysaccharides (LPS), up-regulate the IL-1-mRNA and down-regulate the glial fibrillary acidic protein (GFAP) and glutamine synthetase (GS)-mRNAs in astroglial primary cultures. Eur Cytokine Netw 5:51\u201356","journal-title":"Eur Cytokine Netw"},{"key":"10511_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035122","volume":"7","author":"Y Li","year":"2012","unstructured":"Li Y, Paonessa JD, Zhang Y (2012) Mechanism of chemical activation of Nrf2. PLoS ONE 7:e35122. https:\/\/doi.org\/10.1371\/journal.pone.0035122","journal-title":"PLoS ONE"},{"issue":"10","key":"10511_CR40","doi-asserted-by":"publisher","first-page":"19056","DOI":"10.3390\/ijms151019056","volume":"15","author":"CF Luc\u00eda","year":"2014","unstructured":"Luc\u00eda CF, Rafael GG, Diana R, Antonio SH, Adriano JE, Juan JD, Mar\u00eda JC, Mar\u00eda TM, Eulalia B (2014) Neuroprotective role of liver growth factor \u201cLGF\u201d in an experimental model of cerebellar ataxia. Int J Mol Sci 15(10):19056\u201319073. https:\/\/doi.org\/10.3390\/ijms151019056","journal-title":"Int J Mol Sci"},{"key":"10511_CR41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.fitote.2014.06.012","volume":"98","author":"JA Lutz","year":"2014","unstructured":"Lutz JA, Kulshrestha M, Rogers DT, Littleton JM (2014) A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia. Fitoterapia 98:11\u201321. https:\/\/doi.org\/10.1016\/j.fitote.2014.06.012","journal-title":"Fitoterapia"},{"key":"10511_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2019.101706","volume":"102","author":"M Mahmoudi","year":"2019","unstructured":"Mahmoudi M, Bayat AH, Boroujeni ME, Abdollahifar MA, Ebrahimi V, Danyali S, Heidari MH, Aliaghaei A (2019) Curcumin protects Purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP. J Chem Neuroanat 102:101706. https:\/\/doi.org\/10.1016\/j.jchemneu.2019.101706","journal-title":"J Chem Neuroanat"},{"issue":"3","key":"10511_CR43","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.neuro.2009.02.014","volume":"30","author":"J Mahyar","year":"2009","unstructured":"Mahyar J, Iran G, Mohammad RK, Gila B, Yaqub F, Sohrab H (2009) Co-treatment with riluzole, a neuroprotective drug, ameliorates the 3-acetylpyridine-induced neurotoxicity in cerebellar Purkinje neurons of rats: behavioral and electrophysiological evidence. Neurotoxicology 30(3):393\u2013402. https:\/\/doi.org\/10.1016\/j.neuro.2009.02.014","journal-title":"Neurotoxicology"},{"issue":"2","key":"10511_CR44","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1089\/ars.2012.4600","volume":"17","author":"S Malireddy","year":"2012","unstructured":"Malireddy S, Kotha SR, Secor JD, Gurney TO, Abbott JL, Maulik G, Maddipati KR, Parinandi NL (2012) Phytochemical antioxidants modulate mammalian cellular epigenome: implications in health and disease. Antioxid Redox Signal 17(2):327\u2013339. https:\/\/doi.org\/10.1089\/ars.2012.4600","journal-title":"Antioxid Redox Signal"},{"issue":"7","key":"10511_CR45","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.3390\/ijms22073356","volume":"22","author":"L Manon","year":"2021","unstructured":"Manon L, St\u00e9phanie D, Fr\u00e9d\u00e9ric C (2021) Can natural products exert neuroprotection without crossing the blood-brain barrier? Int J Mol Sci 22(7):3356. https:\/\/doi.org\/10.3390\/ijms22073356","journal-title":"Int J Mol Sci"},{"key":"10511_CR46","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12311-009-0127-3","volume":"8","author":"M Manto","year":"2009","unstructured":"Manto M, Marmolino D (2009) Animal models of human cerebellar ataxias: a cornerstone for the therapies of the twenty-first century. Cerebellum 8:137\u2013154. https:\/\/doi.org\/10.1007\/s12311-009-0127-3","journal-title":"Cerebellum"},{"issue":"12","key":"10511_CR47","doi-asserted-by":"publisher","first-page":"e14451","DOI":"10.1111\/jfbc.14451","volume":"46","author":"M Maroti","year":"2022","unstructured":"Maroti M, Anjali B, Divya S, Puneet K (2022) Neuroprotective potential of Moringa oleifera mediated by NF-kB\/Nrf2\/HO-1 signaling pathway. J Food Biochem 46(12):e14451. https:\/\/doi.org\/10.1111\/jfbc.14451","journal-title":"J Food Biochem"},{"issue":"Suppl 4","key":"10511_CR48","doi-asserted-by":"publisher","first-page":"S556","DOI":"10.4103\/0973-1296.172961","volume":"11","author":"TF Masoumeh","year":"2015","unstructured":"Masoumeh TF, Palanisamy A, Govindarajan K, Siti KA, Sharida F (2015) Bioactive extract from Moringa oleifera inhibits the pro-inflammatory mediators in lipopolysaccharide stimulated macrophages. Pharmacogn Mag 11(Suppl 4):S556\u2013S563. https:\/\/doi.org\/10.4103\/0973-1296.172961","journal-title":"Pharmacogn Mag"},{"issue":"3","key":"10511_CR49","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1017\/S002966511000162X","volume":"69","author":"S Mauro","year":"2010","unstructured":"Mauro S, Ilaria P, Anna R (2010) Flavonoids as anti-inflammatory agents. Proc Nutr Soc 69(3):273\u2013278. https:\/\/doi.org\/10.1017\/S002966511000162X","journal-title":"Proc Nutr Soc"},{"issue":"3","key":"10511_CR50","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fphar.2012.00024","volume":"1","author":"M Mbikay","year":"2012","unstructured":"Mbikay M (2012) Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: a review. Front Pharmacol 1(3):24. https:\/\/doi.org\/10.3389\/fphar.2012.00024","journal-title":"Front Pharmacol"},{"issue":"1","key":"10511_CR51","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1440-1789.2009.01042.x","volume":"30","author":"M Mittelbronn","year":"2010","unstructured":"Mittelbronn M, Schittenhelm J, Bakos G, de Vos RA, Wehrmann M, Meyermann R, Burk K (2010) CD8(+)\/perforin\/granzyme B(+) effector cells infiltrating cerebellum and inferior olives in gluten ataxia. Neuropathology 30(1):92\u201396. https:\/\/doi.org\/10.1111\/j.1440-1789.2009.01042.x","journal-title":"Neuropathology"},{"key":"10511_CR52","doi-asserted-by":"publisher","DOI":"10.1177\/1934578x1801300126","author":"A Mohammed","year":"2018","unstructured":"Mohammed A, Mohammed A, Aishwarya R, Abderrahim N, Badreldin HA (2018) Motor and behavioral effects of Moringa oleifera Leaf extract. Communications. https:\/\/doi.org\/10.1177\/1934578x1801300126","journal-title":"Communications"},{"issue":"5","key":"10511_CR53","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1007\/s11011-017-0011-7","volume":"32","author":"BE Moses","year":"2017","unstructured":"Moses BE, Mfon ME, Edet OA, Dennis UN (2017) Neuroprotective effect of Moringa oleifera leaf extract on aluminium-induced temporal cortical degeneration. Metab Brain Dis 32(5):1437\u20131447. https:\/\/doi.org\/10.1007\/s11011-017-0011-7","journal-title":"Metab Brain Dis"},{"issue":"31","key":"10511_CR54","doi-asserted-by":"publisher","first-page":"32488","DOI":"10.1007\/s11356-019-06368-4","volume":"26","author":"AA Mousa","year":"2019","unstructured":"Mousa AA, El-Gansh HAI, Eldaim MAA, Mohamed MAE, Morsi AH, El Sabagh HS (2019) Protective effect of Moringa oleifera leaves Ethanolic extract against Thioacetamide-induced hepatotoxicity in rats via modulation of cellular antioxidant, apoptotic and inflammatory markers. Environ Sci Pollut Res Int 26(31):32488\u201332504. https:\/\/doi.org\/10.1007\/s11356-019-06368-4","journal-title":"Environ Sci Pollut Res Int"},{"key":"10511_CR55","first-page":"514","volume":"4","author":"NM Olatosin","year":"2014","unstructured":"Olatosin NM, Akinduko DS, Uche CZ (2014) Antioxidant capacity of Moringa oleifera seed oil against CCl4-induced hepatocellular lipid peroxidation in Wistar albino rats. Eur J Exp Biol. 4:514\u2013518","journal-title":"Eur J Exp Biol."},{"issue":"9","key":"10511_CR56","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.ibror.2020.07.004","volume":"12","author":"OI Olumayowa","year":"2009","unstructured":"Olumayowa OI, Anna A, Idris AA, Francesco G, Mariella E, Oluwasanmi OA, Jan G, Ulrike H, Marina B, James OO (2009) The ameliorative effects of a phenolic derivative of Moringa oleifera leave against vanadium-induced neurotoxicity in mice. IBRO Rep 12(9):164\u2013182. https:\/\/doi.org\/10.1016\/j.ibror.2020.07.004","journal-title":"IBRO Rep"},{"key":"10511_CR57","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijn.2019.034","author":"DO Olusegun","year":"2019","unstructured":"Olusegun DO et al (2019) Neuroprotective properties of Moringa oleifera in cadmium and herbal alcoholic beverage induced frontal cortex damage in Wistar Rats. IP Indian J Neurosci. https:\/\/doi.org\/10.18231\/j.ijn.2019.034","journal-title":"IP Indian J Neurosci"},{"key":"10511_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.17352\/jbm.000005","volume":"3","author":"OD Omotoso","year":"2019","unstructured":"Omotoso OD, Adelakun SA, Idomeh IJ, Ogbonna E (2019) Histomorphological characterization of Moringa-Oleifera oil and walnut oil on cadmium induced lateral geniculate body damage in adult Wistar rats (Rattus Novergiccus). J Biol Med 3:1\u20137. https:\/\/doi.org\/10.17352\/jbm.000005","journal-title":"J Biol Med"},{"issue":"2","key":"10511_CR59","first-page":"53","volume":"3","author":"J Owolabi","year":"2014","unstructured":"Owolabi J, William F, Olanrewaju J, Etibor T, Fabiyi O (2014) Histomorphological evidence of Moringa oleifera\u2019s ameliorative effects against lead toxicity in cerebral cortex. World J Life Sci Med Res 3(2):53\u201358","journal-title":"World J Life Sci Med Res"},{"key":"10511_CR60","doi-asserted-by":"publisher","DOI":"10.4103\/2221-1691.254604","author":"A Palanisamy","year":"2019","unstructured":"Palanisamy A, Dong-Kug C, Gothai S, Palanivel G, Katyakyini M, Shin-Young P, Duk-Yeon C, Joon-So K (2019) Attenuation of lipopolysaccharide-induced neuroinflammatory events in BV-2 microglial cells by Moringa oleifera leaf extract. Asian Pac J Trop Biomed. https:\/\/doi.org\/10.4103\/2221-1691.254604","journal-title":"Asian Pac J Trop Biomed"},{"issue":"Pt A","key":"10511_CR61","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.expneurol.2017.08.009","volume":"298","author":"BM Pallavi","year":"2017","unstructured":"Pallavi BM, Li-Ping L, Brian JD, Manisha P (2017) Scavenging reactive oxygen species inhibits status epilepticus-induced neuroinflammation. Exp Neurol 298(Pt A):13\u201322. https:\/\/doi.org\/10.1016\/j.expneurol.2017.08.009","journal-title":"Exp Neurol"},{"key":"10511_CR62","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.bmcl.2012.12.060","volume":"23","author":"S Panda","year":"2013","unstructured":"Panda S, Kar A, Sharma P, Sharma A (2013) Cardioprotective potential of N,alpha-l-rhamnopyranosyl vincosamide, an indole alkaloid, isolatedfrom the leaves of Moringa oleifera in isoproterenol induced cardiotoxic rats: in vivo and in vitro studies. Bioorg Med ChemLett 23:959\u2013962. https:\/\/doi.org\/10.1016\/j.bmcl.2012.12.060","journal-title":"Bioorg Med ChemLett"},{"key":"10511_CR63","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1006\/exnr.1994.1114","volume":"128","author":"I Riva-Depaty","year":"1994","unstructured":"Riva-Depaty I, Fardeau C, Mariani J, Bouchaud C, Delhaye-Bouchaud N (1994) Contribution of peripheral macrophages and microglia to the cellular reaction after mechanical or neurotoxin-induced lesions of the rat brain. Exp Neurol 128:77\u201387. https:\/\/doi.org\/10.1006\/exnr.1994.1114","journal-title":"Exp Neurol"},{"key":"10511_CR64","first-page":"61","volume":"3","author":"JL Rockwood","year":"2013","unstructured":"Rockwood JL, Anderson BG, Casamatta DA (2013) Potential uses of Moringa oleifera and an examination of antibiotic efficacy conferred by M. oleifera seed and leaf extracts using crude extraction techniques available to underserved indigenous populations. Int JPhytotherapy Res 3:61\u201371","journal-title":"Int JPhytotherapy Res"},{"issue":"5","key":"10511_CR65","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1523\/JNEUROSCI.19-05-01663.1999","volume":"19","author":"IM Roman","year":"1999","unstructured":"Roman IM, Bean BP (1999) Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. J Neurosci 19(5):1663\u20131674. https:\/\/doi.org\/10.1523\/JNEUROSCI.19-05-01663.1999","journal-title":"J Neurosci"},{"issue":"7","key":"10511_CR66","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s12031-020-01522-x","volume":"70","author":"S Sara","year":"2020","unstructured":"Sara S, Samira E, Aysan K, Fakhroddin A, Reza S, Mohammad AA, Ali J, Abbas A (2020) Effect of sertoli cell transplantation on reducing neuroinflammation-induced necroptosis and improving motor coordination in the rat model of cerebellar ataxia induced by 3-acetylpyridine. J Mol Neurosci 70(7):1153\u20131163. https:\/\/doi.org\/10.1007\/s12031-020-01522-x","journal-title":"J Mol Neurosci"},{"issue":"48","key":"10511_CR67","doi-asserted-by":"publisher","first-page":"14358","DOI":"10.1021\/acs.jafc.1c04581","volume":"69","author":"G Saurav","year":"2021","unstructured":"Saurav G, Lalita S, Namrata A, Bhakta PG (2021) Moringa oleifera: a tree of life as a promising medicinal plant for neurodegenerative diseases. J Agric Food Chem 69(48):14358\u201314371. https:\/\/doi.org\/10.1021\/acs.jafc.1c04581","journal-title":"J Agric Food Chem"},{"key":"10511_CR68","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1177\/0748233711401264","volume":"28","author":"J Shi","year":"2012","unstructured":"Shi J, Ma Y, Zheng M, Ruan Z, Liu J, Tian S, Zhang D, He X, Li G (2012) Effect of sub-acute exposure to acrylamide on GABAergic neurons and astrocytes in weaning rat cerebellum. Toxicol Ind Health 28:10\u201320. https:\/\/doi.org\/10.1177\/0748233711401264","journal-title":"Toxicol Ind Health"},{"issue":"1984","key":"10511_CR69","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/0168-0102(84)90040-3","volume":"1","author":"M Shimada","year":"1984","unstructured":"Shimada M, Ozaki HS, Murakami TH, Imahayashi T (1984) Effects of 3-acetylpyridine on local cerebral glucose utilization. Neurosci Res 1(1984):357\u2013362. https:\/\/doi.org\/10.1016\/0168-0102(84)90040-3","journal-title":"Neurosci Res"},{"issue":"8","key":"10511_CR70","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1021\/jf020444+","volume":"51","author":"P Siddhuraju","year":"2003","unstructured":"Siddhuraju P, Becker K (2003) Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. J Agric Food Chem 51(8):2144\u20132155. https:\/\/doi.org\/10.1021\/jf020444+","journal-title":"J Agric Food Chem"},{"key":"10511_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijep.2016.02.001","author":"I Suvarna","year":"2016","unstructured":"Suvarna I, Foram G (2016) Effect of aqueous extract of Moringa oleifera leaves on pharmacological models of epilepsy and anxiety in mice. J Epilepsy. https:\/\/doi.org\/10.1016\/j.ijep.2016.02.001","journal-title":"J Epilepsy"},{"issue":"7","key":"10511_CR72","doi-asserted-by":"publisher","first-page":"6089","DOI":"10.3390\/ijms24076089","volume":"24","author":"CCh Sze","year":"2023","unstructured":"Sze CCh, Pit SC, Hongkai J, Ka CT, Sharafuddin K, Anna CKT, Sze YL, George LT, Chi WL, Man-Lung F, Kah HW, Lee WL (2023) Hericium erinaceus promotes anti-inflammatory effects and regulation of metabolites in an animal model of cerebellar ataxia. Int J Mol Sci 24(7):6089. https:\/\/doi.org\/10.3390\/ijms24076089","journal-title":"Int J Mol Sci"},{"key":"10511_CR73","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0304-3940(85)90098-9","volume":"53","author":"Y Tatsuoka","year":"1985","unstructured":"Tatsuoka Y, Kato Y, Imura H (1985) Effect of DN-1417, a synthetic thyrotropin-releasing hormone analogue, on [3H] GABA binding in the cerebellum of ataxic rats. Neurosci Lett 53:63\u201368. https:\/\/doi.org\/10.1016\/0304-3940(85)90098-9","journal-title":"Neurosci Lett"},{"key":"10511_CR74","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1002\/ejlt.200900005","volume":"111","author":"DK Vessela","year":"2009","unstructured":"Vessela DK (2009) Phenolic antioxidants\u2014radical-scavenging and chain-breaking activity: a comparative study. Eur J Lipid Sci Technol 111:1072\u20131089. https:\/\/doi.org\/10.1002\/ejlt.200900005","journal-title":"Eur J Lipid Sci Technol"},{"key":"10511_CR75","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neuro.2016.11.010","volume":"58","author":"L Wecker","year":"2017","unstructured":"Wecker L, Marrero-Rosado B, Engberg ME, Johns BE, Philpot RM (2017) 3-Acetylpyridine neurotoxicity in mice. Neurotoxicology 58:143\u2013152. https:\/\/doi.org\/10.1016\/j.neuro.2016.11.010","journal-title":"Neurotoxicology"},{"issue":"5","key":"10511_CR76","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.14336\/AD.2019.1125","volume":"11","author":"KY Wong","year":"2020","unstructured":"Wong KY, Roy J, Fung ML, Heng BC, Zhang C, Lim LW (2020) Relationships between mitochondrial dysfunction and neurotransmission failure in Alzheimer\u2019s disease. Aging Dis 11(5):1291\u20131316. https:\/\/doi.org\/10.14336\/AD.2019.1125","journal-title":"Aging Dis"},{"key":"10511_CR77","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/951415","volume":"2013","author":"K Woranan","year":"2013","unstructured":"Woranan K, Jintanaporn W, Terdthai T, Supaporn M, Panakaporn W, Jinatta J (2013) Cerebroprotective effect of Moringa oleifera against focal ischemic stroke induced by middle cerebral artery occlusion. Oxid Med Cell Longev 2013:951415. https:\/\/doi.org\/10.1155\/2013\/951415","journal-title":"Oxid Med Cell Longev"},{"issue":"2024","key":"10511_CR78","doi-asserted-by":"publisher","first-page":"7694516","DOI":"10.1155\/2024\/7694516","volume":"24","author":"B Worku","year":"2024","unstructured":"Worku B, Tolossa N (2024) A review on the neuroprotective effect of Moringa oleifera. Oxid Med Cell Longev 24(2024):7694516. https:\/\/doi.org\/10.1155\/2024\/7694516","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"10511_CR79","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1021\/nn800511k","volume":"2","author":"T Xia","year":"2008","unstructured":"Xia T, Kovochich M, Liong M, M\u00e4dler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE (2008) Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2(10):2121\u20132134. https:\/\/doi.org\/10.1021\/nn800511k","journal-title":"ACS Nano"},{"issue":"3","key":"10511_CR80","first-page":"246","volume":"36","author":"J Yong-Ying","year":"2015","unstructured":"Yong-Ying J, Bei-Bei C, Xiao-Qin W, Yu-Ping P, Yi-Hua Q (2015) Cerebellar ataxia induced by 3-AP affects immunological function. Neuro Endocrinol Lett 36(3):246\u2013256","journal-title":"Neuro Endocrinol Lett"},{"key":"10511_CR81","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.2147\/IJN.S28647","volume":"7","author":"KC Yoo","year":"2012","unstructured":"Yoo KC, Yoon CH, Kwon D, Hyun KH, Woo SJ, Kim RK, Lim EJ, Suh Y, Kim MJ, Yoon TH, Lee SJ (2012) Titanium dioxide induces apoptotic cell death through reactive oxygen speciesmediated Fas upregulation and Bax activation. Int J Nanomed 7:1203\u20131214. https:\/\/doi.org\/10.2147\/IJN.S28647","journal-title":"Int J Nanomed"},{"issue":"1","key":"10511_CR82","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12974-017-1036-x","volume":"14","author":"F Zheng","year":"2017","unstructured":"Zheng F, Liang ZG, Yang H, Pan YT, Zheng Y, Wang XM (2017) Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia. J Neuroinflammation 14(1):256. https:\/\/doi.org\/10.1186\/s12974-017-1036-x","journal-title":"J Neuroinflammation"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10511-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10511-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10511-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T01:31:39Z","timestamp":1755739899000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10511-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10511"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10511-6","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"27 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors confirmed no potential conflicts of interest with respect to the research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experiment received granted approval from the Beni-Suef University Institutional Animal Care and Use Committee and adhered to all ethical standards for utilizing animals in research (NO. 022-523).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"227"}}