{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:39:10Z","timestamp":1786981150156,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360102"],"award-info":[{"award-number":["82360102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"crossref","award":["20224BAB206017"],"award-info":[{"award-number":["20224BAB206017"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10735-025-10656-4","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T05:14:47Z","timestamp":1763961287000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ALKBH5-mediated RNA N6-methyladenosine demethylation protects against myocardial I\/R-induced injury via FSP1-dependent inhibition of ferroptosis"],"prefix":"10.1007","volume":"57","author":[{"given":"Zehong","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhua","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexiang","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxiang","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"10656_CR1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","volume":"33","author":"M Algoet","year":"2023","unstructured":"Algoet M, Janssens S, Himmelreich U, Gsell W, Pusovnik M, Van den Eynde J, Oosterlinck W (2023) Myocardial ischemia-reperfusion injury and the influence of inflammation. Trends Cardiovasc Med 33:357\u2013366. https:\/\/doi.org\/10.1016\/j.tcm.2022.02.005","journal-title":"Trends Cardiovasc Med"},{"key":"10656_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41392-024-02088-5","volume":"10","author":"F Alves","year":"2025","unstructured":"Alves F, Lane D, Nguyen TPM, Bush AI, Ayton S (2025) In defence of ferroptosis. Signal Transduct Target Ther 10:2. https:\/\/doi.org\/10.1038\/s41392-024-02088-5","journal-title":"Signal Transduct Target Ther"},{"key":"10656_CR3","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s10020-025-01149-x","volume":"31","author":"D Benak","year":"2025","unstructured":"Benak D, Alanova P, Holzerova K, Chalupova M, Opletalova B, Kolar F, Pavlinkova G, Hlavackova M (2025) Epitranscriptomic regulation of HIF-1: bidirectional regulatory pathways. Mol Med 31:105. https:\/\/doi.org\/10.1186\/s10020-025-01149-x","journal-title":"Mol Med"},{"key":"10656_CR4","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","volume":"575","author":"S Doll","year":"2019","unstructured":"Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH et al (2019) FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575:693\u2013698. https:\/\/doi.org\/10.1038\/s41586-019-1707-0","journal-title":"Nature"},{"key":"10656_CR5","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000002373","author":"M Fang","year":"2024","unstructured":"Fang M, Li T, Wu Z (2024) WTAP-mediated m6A modification of KLF6 aggravates hypoxia\/reoxygenation-induced human cardiomyocyte injury. Shock. https:\/\/doi.org\/10.1097\/SHK.0000000000002373","journal-title":"Shock"},{"key":"10656_CR6","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301292R","volume":"37","author":"X Gao","year":"2023","unstructured":"Gao X, Liang X, Liu B, Hong Y, He H, Shen Y, Chen J, Huang X, Hu B, Li W et al (2023) Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction. FASEB J 37:e23294. https:\/\/doi.org\/10.1096\/fj.202301292R","journal-title":"FASEB J"},{"key":"10656_CR7","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1056\/NEJMoa2412392","volume":"392","author":"B Greenberg","year":"2025","unstructured":"Greenberg B, Taylor M, Adler E, Colan S, Ricks D, Yarabe P, Battiprolu P, Shah G, Patel K, Coggins M et al (2025) Phase 1 study of AAV9.LAMP2B gene therapy in Danon disease. N Engl J Med 392:972\u2013983. https:\/\/doi.org\/10.1056\/NEJMoa2412392","journal-title":"N Engl J Med"},{"key":"10656_CR8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.medj.2023.12.007","volume":"5","author":"G Heusch","year":"2024","unstructured":"Heusch G (2024) Myocardial ischemia\/reperfusion: translational pathophysiology of ischemic heart disease. Med 5:10\u201331. https:\/\/doi.org\/10.1016\/j.medj.2023.12.007","journal-title":"Med"},{"key":"10656_CR9","doi-asserted-by":"publisher","first-page":"2454892","DOI":"10.1080\/13510002.2025.2454892","volume":"30","author":"Q Jiang","year":"2025","unstructured":"Jiang Q, Chen X, Gong K, Xu Z, Chen L, Zhang F (2025) M6a demethylase FTO regulates the oxidative stress, mitochondrial biogenesis of cardiomyocytes and PGC-1a stability in myocardial ischemia-reperfusion injury. Redox Rep 30:2454892. https:\/\/doi.org\/10.1080\/13510002.2025.2454892","journal-title":"Redox Rep"},{"key":"10656_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12929-023-00927-1","volume":"30","author":"J Ju","year":"2023","unstructured":"Ju J, Li XM, Zhao XM, Li FH, Wang SC, Wang K, Li RF, Zhou LY, Liang L, Wang Y et al (2023) Circular RNA feacr inhibits ferroptosis and alleviates myocardial ischemia\/reperfusion injury by interacting with NAMPT. J Biomed Sci 30:45. https:\/\/doi.org\/10.1186\/s12929-023-00927-1","journal-title":"J Biomed Sci"},{"key":"10656_CR11","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1161\/CIRCULATIONAHA.123.064719","volume":"150","author":"M Katoh","year":"2024","unstructured":"Katoh M, Nomura S, Yamada S, Ito M, Hayashi H, Katagiri M, Heryed T, Fujiwara T, Takeda N, Nishida M et al (2024) Vaccine therapy for heart failure targeting the inflammatory cytokine Igfbp7. Circulation 150:374\u2013389. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.123.064719","journal-title":"Circulation"},{"key":"10656_CR12","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1038\/s41467-022-29905-1","volume":"13","author":"P Koppula","year":"2022","unstructured":"Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M et al (2022) A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun 13:2206. https:\/\/doi.org\/10.1038\/s41467-022-29905-1","journal-title":"Nat Commun"},{"key":"10656_CR13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/FJC.0000000000001515","volume":"83","author":"D Li","year":"2024","unstructured":"Li D, Li L, Dong S, Yu Y, Zhang L, Jiang S (2024a) Alkylation repair homolog 5 regulates N(6)-methyladenosine (m6A) methylation of Mitsugumin 53 to attenuate myocardial infarction by inhibiting apoptosis and oxidative stress. J Cardiovasc Pharmacol 83:183\u2013192. https:\/\/doi.org\/10.1097\/FJC.0000000000001515","journal-title":"J Cardiovasc Pharmacol"},{"key":"10656_CR14","doi-asserted-by":"publisher","first-page":"4760","DOI":"10.1038\/s41467-024-49202-3","volume":"15","author":"R Li","year":"2024","unstructured":"Li R, Yan X, Xiao C, Wang T, Li X, Hu Z, Liang J, Zhang J, Cai J, Sui X et al (2024b) FTO deficiency in older livers exacerbates ferroptosis during ischaemia\/reperfusion injury by upregulating ACSL4 and TFRC. Nat Commun 15:4760. https:\/\/doi.org\/10.1038\/s41467-024-49202-3","journal-title":"Nat Commun"},{"key":"10656_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2023.104565","volume":"149","author":"Y Liu","year":"2023","unstructured":"Liu Y, Li L, Wang Z, Zhang J, Zhou Z (2023) Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention. Microvasc Res 149:104565. https:\/\/doi.org\/10.1016\/j.mvr.2023.104565","journal-title":"Microvasc Res"},{"key":"10656_CR16","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.ymthe.2024.01.037","volume":"32","author":"ZY Liu","year":"2024","unstructured":"Liu ZY, Lin LC, Liu ZY, Yang JJ, Tao H (2024a) M6A epitranscriptomic and epigenetic crosstalk in cardiac fibrosis. Mol Ther 32:878\u2013889. https:\/\/doi.org\/10.1016\/j.ymthe.2024.01.037","journal-title":"Mol Ther"},{"key":"10656_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103176","volume":"73","author":"N Liu","year":"2024","unstructured":"Liu N, Wu WL, Wan XR, Wang J, Huang JN, Jiang YY, Sheng YC, Wu JC, Liang ZQ, Qin ZH, Wang Y (2024b) Regulation of FSP1 myristoylation by NADPH: a novel mechanism for ferroptosis inhibition. Redox Biol 73:103176. https:\/\/doi.org\/10.1016\/j.redox.2024.103176","journal-title":"Redox Biol"},{"key":"10656_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122368","volume":"303","author":"Q Luo","year":"2023","unstructured":"Luo Q, Sun W, Li Z, Sun J, Xiao Y, Zhang J, Zhu C, Liu B, Ding J (2023) Biomaterials-mediated targeted therapeutics of myocardial ischemia-reperfusion injury. Biomaterials 303:122368. https:\/\/doi.org\/10.1016\/j.biomaterials.2023.122368","journal-title":"Biomaterials"},{"key":"10656_CR19","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0291","author":"P Pang","year":"2023","unstructured":"Pang P, Si W, Wu H, Ju J, Liu K, Wang C, Jia Y, Diao H, Zeng L, Jiang W et al (2023) YTHDF2 promotes cardiac ferroptosis via degradation of SLC7A11 in cardiac ischemia-reperfusion injury. Antioxid Redox Signal. https:\/\/doi.org\/10.1089\/ars.2023.0291","journal-title":"Antioxid Redox Signal"},{"key":"10656_CR20","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1161\/CIRCRESAHA.123.322640","volume":"133","author":"J Rhee","year":"2023","unstructured":"Rhee J, Freeman R, Roh K, Lyons M, Xiao C, Zlotoff D, Yeri A, Li H, Guerra J, Guseh JS et al (2023) Cardioprotective and anti-inflammatory effects of FAM3D in myocardial ischemia-reperfusion injury. Circ Res 133:651\u2013653. https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.322640","journal-title":"Circ Res"},{"key":"10656_CR21","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1080\/15548627.2024.2370751","volume":"20","author":"Y Shao","year":"2024","unstructured":"Shao Y, Zhang Y, Zou S, Wang J, Li X, Qin M, Sun L, Yin W, Chang X, Wang S et al (2024) (-)-Epigallocatechin 3-gallate protects pancreatic beta-cell against excessive autophagy-induced injury through promoting FTO degradation. Autophagy 20:2460\u20132477. https:\/\/doi.org\/10.1080\/15548627.2024.2370751","journal-title":"Autophagy"},{"key":"10656_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103157","volume":"72","author":"L Wu","year":"2024","unstructured":"Wu L, Du Y, Wang L, Zhang Y, Ren J (2024) Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis. Redox Biol 72:103157. https:\/\/doi.org\/10.1016\/j.redox.2024.103157","journal-title":"Redox Biol"},{"key":"10656_CR23","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1161\/CIRCULATIONAHA.123.066628","volume":"150","author":"GA Wyant","year":"2024","unstructured":"Wyant GA, Jiang Q, Singh M, Qayyum S, Levrero C, Maron BA, Kaelin WG Jr (2024) Induction of DEPP1 by HIF mediates multiple hallmarks of ischemic cardiomyopathy. Circulation 150:770\u2013786. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.123.066628","journal-title":"Circulation"},{"key":"10656_CR24","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.tem.2023.10.010","volume":"35","author":"Q Xiang","year":"2024","unstructured":"Xiang Q, Yi X, Zhu XH, Wei X, Jiang DS (2024) Regulated cell death in myocardial ischemia-reperfusion injury. Trends Endocrinol Metab 35:219\u2013234. https:\/\/doi.org\/10.1016\/j.tem.2023.10.010","journal-title":"Trends Endocrinol Metab"},{"key":"10656_CR25","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s41590-024-02047-w","volume":"26","author":"B Xiang","year":"2025","unstructured":"Xiang B, Zhang M, Li K, Zhang Z, Liu Y, Gao M, Wang X, Xiao X, Sun Y, He C et al (2025) The epitranscriptional factor PCIF1 orchestrates CD8(+) T cell ferroptosis and activation to control antitumor immunity. Nat Immunol 26:252\u2013264. https:\/\/doi.org\/10.1038\/s41590-024-02047-w","journal-title":"Nat Immunol"},{"key":"10656_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116112","volume":"171","author":"X Xu","year":"2024","unstructured":"Xu X, Xu XD, Ma MQ, Liang Y, Cai YB, Zhu ZX, Xu T, Zhu L, Ren K (2024a) The mechanisms of ferroptosis and its role in atherosclerosis. Biomed Pharmacother 171:116112. https:\/\/doi.org\/10.1016\/j.biopha.2023.116112","journal-title":"Biomed Pharmacother"},{"key":"10656_CR27","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-024-01044-2","author":"GE Xu","year":"2024","unstructured":"Xu GE, Yu P, Hu Y, Wan W, Shen K, Cui X, Wang J, Wang T, Cui C, Chatterjee E et al (2024b) Exercise training decreases lactylation and prevents myocardial ischemia-reperfusion injury by inhibiting YTHDF2. Basic Res Cardiol. https:\/\/doi.org\/10.1007\/s00395-024-01044-2","journal-title":"Basic Res Cardiol"},{"key":"10656_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.09.004","author":"K Yang","year":"2023","unstructured":"Yang K, Zhao Y, Hu J, Gao R, Shi J, Wei X, Chen J, Hu K, Sun A, Ge J (2023) ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction. J Adv Res. https:\/\/doi.org\/10.1016\/j.jare.2023.09.004","journal-title":"J Adv Res"},{"key":"10656_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103067","volume":"70","author":"Y Yang","year":"2024","unstructured":"Yang Y, Ren J, Zhang J, Shi H, Wang J, Yan Y (2024) FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53\u2013P21\/Nrf2 activation in a HuR-dependent m6A manner. Redox Biol 70:103067. https:\/\/doi.org\/10.1016\/j.redox.2024.103067","journal-title":"Redox Biol"},{"key":"10656_CR30","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1161\/CIRCRESAHA.123.322620","volume":"133","author":"L Yao","year":"2023","unstructured":"Yao L, He F, Zhao Q, Li D, Fu S, Zhang M, Zhang X, Zhou B, Wang L (2023) Spatial multiplexed protein profiling of cardiac ischemia-reperfusion injury. Circ Res 133:86\u2013103. https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.322620","journal-title":"Circ Res"},{"key":"10656_CR31","doi-asserted-by":"publisher","first-page":"5779","DOI":"10.1093\/nar\/gkab415","volume":"49","author":"F Yu","year":"2021","unstructured":"Yu F, Wei J, Cui X, Yu C, Ni W, Bungert J, Wu L, He C, Qian Z (2021) Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response. Nucleic Acids Res 49:5779\u20135797. https:\/\/doi.org\/10.1093\/nar\/gkab415","journal-title":"Nucleic Acids Res"},{"key":"10656_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115765","volume":"168","author":"K Zhang","year":"2023","unstructured":"Zhang K, Tian XM, Li W, Hao LY (2023a) Ferroptosis in cardiac hypertrophy and heart failure. Biomed Pharmacother 168:115765. https:\/\/doi.org\/10.1016\/j.biopha.2023.115765","journal-title":"Biomed Pharmacother"},{"key":"10656_CR33","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s13578-023-01169-2","volume":"13","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Luo Y, Peng L, Rong X, Liu Y, Li J, Luo J (2023b) Ferroptosis in cardiovascular diseases: role and mechanism. Cell Biosci 13:226. https:\/\/doi.org\/10.1186\/s13578-023-01169-2","journal-title":"Cell Biosci"},{"key":"10656_CR34","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s12951-024-02583-5","volume":"22","author":"X Zhu","year":"2024","unstructured":"Zhu X, Li W, Lu M, Shang J, Zhou J, Lin L, Liu Y, Xing J, Zhang M, Zhao S et al (2024) M(6)a demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p\/FOXO1 axis. J Nanobiotechnology 22:367. https:\/\/doi.org\/10.1186\/s12951-024-02583-5","journal-title":"J Nanobiotechnology"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10656-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10656-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10656-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:25:20Z","timestamp":1772000720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10656-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10656"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10656-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.173372242.25727947\/v1","asserted-by":"object"}]},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"26 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental protocols involving animals in this study were approved by the Laboratory Animal Research Committee of The First Affiliated Hospital of Nanchang University (CDYFY-IACUC-202304QR027).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All the authors have consented to the publication of this research.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"5"}}