{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:48:34Z","timestamp":1792000114775,"version":"4.4.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10735-025-10667-1","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:57:33Z","timestamp":1767016653000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Renoprotective effect of polyphenolic-rich extract of Phyllanthus niruri in streptozotocin-induced diabetic nephropathy via moderation of oxidative stress and inhibition of kidney injury"],"prefix":"10.1007","volume":"57","author":[{"given":"Olakunle Bamikole","family":"Afolabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayomide Gabriel","family":"Akinola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha Kanoyinsola","family":"Raji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olabisi Tajudeen","family":"Obafemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwaseun Ruth","family":"Olasehinde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adejoke Oluyemi","family":"Olorunlagba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwafemi Emmanuel","family":"Babatunde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing Ariyo","family":"Obafemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaposi Idowu","family":"Omotuyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omotade Ibidun","family":"Oloyede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sogolo Lucky","family":"Lebelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monde McMillan","family":"Ntwasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"10667_CR2","doi-asserted-by":"publisher","first-page":"154464","DOI":"10.1016\/j.phymed.2022.154464","volume":"107","author":"NA Abd Wahab","year":"2022","unstructured":"Abd Wahab NA, Giribabu N, Kilari EK, Salleh N (2022) Abietic acid ameliorates nephropathy progression via mitigating renal oxidative stress, inflammation, fibrosis and apoptosis in high fat diet and low dose streptozotocin-induced diabetic rats. Phytomedicine 107:154464. https:\/\/doi.org\/10.1016\/j.phymed.2022.154464","journal-title":"Phytomedicine"},{"issue":"3","key":"10667_CR1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1159\/000375305","volume":"24","author":"D Abdali","year":"2015","unstructured":"Abdali D, Samson SE, Grover AK (2015) How effective are antioxidant supplements in obesity and diabetes? Med Princ Pract 24(3):201\u2013215. https:\/\/doi.org\/10.1159\/000375305","journal-title":"Med Princ Pract"},{"key":"10667_CR3","doi-asserted-by":"publisher","first-page":"101023","DOI":"10.1016\/j.fbio.2021.101023","volume":"41","author":"OB Afolabi","year":"2021","unstructured":"Afolabi OB, Oloyede OI, Aluko BT, Johnson JA (2021) Biosynthesis of magnesium hydroxide nanomaterials using Monodora myristica, antioxidative activities and effect on disrupted glucose metabolism in streptozotocin-induced diabetic rat. Food Biosci 41:101023. https:\/\/doi.org\/10.1016\/j.fbio.2021.101023","journal-title":"Food Biosci"},{"key":"10667_CR4","doi-asserted-by":"publisher","first-page":"100557","DOI":"10.1016\/j.obmed.2024.100557","volume":"51","author":"AM Ajayi","year":"2024","unstructured":"Ajayi AM, Akintelu TE, Igari FO, Okubena O, Umukoro S (2024) Sorghum bicolor polyphenol-rich extract improves insulin sensitivity and protect against chronic stress exacerbated diabetic nephropathy through modulation of Nrf2\/NF-\u03baB. Obes Med 51:100557. https:\/\/doi.org\/10.1016\/j.obmed.2024.100557","journal-title":"Obes Med"},{"key":"10667_CR7","doi-asserted-by":"publisher","first-page":"766","DOI":"10.3390\/nu9070766","volume":"9","author":"RH Al Zarzour","year":"2017","unstructured":"Al Zarzour RH, Ahmad M, Asmawi MZ (2017) Phyllanthus Niruri standardized extract alleviates the progression of non-alcoholic fatty liver disease and decreases atherosclerotic risk in Sprague\u2013Dawley rats. Nutrients 9:766. https:\/\/doi.org\/10.3390\/nu9070766","journal-title":"Nutrients"},{"issue":"9","key":"10667_CR5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s13205-022-03233-z","volume":"12","author":"A Ali","year":"2022","unstructured":"Ali A, Ali A, Ahmad W, Amir M, Ashraf K, Wahab S et al (2022) Nephroprotective effect of polyphenol-rich extract of Costus spicatus in cisplatin-induced nephrotoxicity in Wistar albino rats. 3 Biotech 12(9):189. https:\/\/doi.org\/10.1007\/s13205-022-03233-z","journal-title":"3 Biotech"},{"key":"10667_CR6","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.2215\/CJN.11491116","volume":"12","author":"RZ Alicic","year":"2017","unstructured":"Alicic RZ, Rooney MT, Tuttle KR (2017) Diabetic kidney disease: challenges, progress, and possibilities. Clin J Am Soc Nephrol 12:2032\u20132045. https:\/\/doi.org\/10.2215\/CJN.11491116","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10667_CR8","doi-asserted-by":"publisher","first-page":"515523","DOI":"10.1080\/09712119.2023.2230754","volume":"51","author":"B Aslama","year":"2023","unstructured":"Aslama B, Hussain A, Sindhu Z, Nigar S, Jand I, Alrefaei AF et al (2023) Polyphenols-rich polyherbal mixture attenuates hepatorenal impairment, dyslipidaemia, oxidative stress and inflammation in alloxan-induced diabetic rats. J Appl Anim Res 51(1):515523. https:\/\/doi.org\/10.1080\/09712119.2023.2230754","journal-title":"J Appl Anim Res"},{"issue":"8","key":"10667_CR9","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","volume":"33","author":"AG Atanasov","year":"2015","unstructured":"Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P et al (2015) Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv 33(8):1582\u20131614. https:\/\/doi.org\/10.1016\/j.biotechadv.2015.08.001","journal-title":"Biotechnol Adv"},{"issue":"12","key":"10667_CR10","doi-asserted-by":"publisher","first-page":"3426","DOI":"10.1080\/14786419.2024.2337108","volume":"39","author":"V Bhushan","year":"2025","unstructured":"Bhushan V, Bharti SK, Krishnan S, Kumar A, Kumar A (2025) Antidiabetic effectiveness of Phyllanthus niruri bioactive compounds via targeting DPP-IV. Nat Prod Res 39(12):3426\u20133432. https:\/\/doi.org\/10.1080\/14786419.2024.2337108","journal-title":"Nat Prod Res"},{"key":"10667_CR11","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fendo.2017.00006","volume":"8","author":"A Chaudhury","year":"2017","unstructured":"Chaudhury A, Duvoor C, Reddy Dendi VS, Kraleti S, Chada A, Ravilla R et al (2017) Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management. Front Endocrinol 8:6. https:\/\/doi.org\/10.3389\/fendo.2017.00006","journal-title":"Front Endocrinol"},{"key":"10667_CR12","doi-asserted-by":"publisher","first-page":"6910","DOI":"10.1021\/jf020665f","volume":"50","author":"YF Chu","year":"2002","unstructured":"Chu YF, Sun J, Wu X, Liu RH (2002) Antioxidant and antiproliferative activities of common vegetables. J Agric Food Chem 50:6910\u20136916. https:\/\/doi.org\/10.1021\/jf020665f","journal-title":"J Agric Food Chem"},{"issue":"7","key":"10667_CR13","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41581-022-00559-y","volume":"18","author":"M Cortinovis","year":"2022","unstructured":"Cortinovis M, Perico N, Ruggenenti P, Remuzzi A, Remuzzi G (2022) Glomerular hyperfiltration. Nat Rev Nephrol 18(7):435\u2013451. https:\/\/doi.org\/10.1038\/s41581-022-00559-y","journal-title":"Nat Rev Nephrol"},{"key":"10667_CR14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.31254\/phyto.2019.8106","volume":"8","author":"S Das","year":"2019","unstructured":"Das S, Vasudeva N, Sharma S (2019) Kidney disorders and management through herbs: a review. J Phytopharm 8:21\u201327","journal-title":"J Phytopharm"},{"key":"10667_CR15","doi-asserted-by":"publisher","first-page":"110383","DOI":"10.1016\/j.foodres.2021.110383","volume":"145","author":"D de Paulo Farias","year":"2021","unstructured":"de Paulo Farias D, de Ara\u00fajo FF, Neri-Numa IA, Pastore GM (2021) Antidiabetic potential of dietary polyphenols: a mechanistic review. Food Res Int 145:110383. https:\/\/doi.org\/10.1016\/j.foodres.2021.110383","journal-title":"Food Res Int"},{"key":"10667_CR16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/s41392-024-01916-y","volume":"9","author":"L Du","year":"2024","unstructured":"Du L, Zong Y, Li H, Wang Q, Xie L, Yang B, Pang Y, Zhang C, Zhong Z, Gao J (2024) Hyperuricemia and its related diseases: mechanisms and advances in therapy. Signal Transduct Target Ther 9:212. https:\/\/doi.org\/10.1038\/s41392-024-01916-y","journal-title":"Signal Transduct Target Ther"},{"issue":"17","key":"10667_CR17","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1089\/ars.2020.8184","volume":"35","author":"T Ebert","year":"2021","unstructured":"Ebert T, Neytchev O, Witasp A, Kublickiene K, Stenvinkel P, Shiels PG et al (2021) Inflammation and oxidative stress in chronic kidney disease and dialysis patients. Antioxid Redox Signal 35(17):1426\u20131448 https:\/\/doi.org\/10.1089\/ars.2020.8184","journal-title":"Antioxid Redox Signal"},{"key":"10667_CR18","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70\u201377. https:\/\/doi.org\/10.1016\/0003-9861(59)90090-6","journal-title":"Arch Biochem Biophys"},{"key":"10667_CR19","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1136\/jcp.13.2.156","volume":"13","author":"JK Fawcett","year":"1960","unstructured":"Fawcett JK, Scott JE (1960) A rapid and precise method for the determination of Urea. J Clin Pathol 13:156\u2013159. https:\/\/doi.org\/10.1136\/jcp.13.2.156","journal-title":"J Clin Pathol"},{"key":"10667_CR21","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.3390\/nu14132675","volume":"14","author":"AK Fotheringham","year":"2022","unstructured":"Fotheringham AK, Gallo LA, Borg DJ, Forbes JM (2022) Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney. Nutrients 14:2675. https:\/\/doi.org\/10.3390\/nu14132675","journal-title":"Nutrients"},{"issue":"4","key":"10667_CR22","doi-asserted-by":"publisher","first-page":"376","DOI":"10.22038\/ijbms.2019.31922.7674","volume":"22","author":"H Ghasemi","year":"2019","unstructured":"Ghasemi H, Einollahi B, Kheiripour N, Hosseini-Zijoud SR, Farhadian Nezhad M (2019) Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated Lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes. Iran J Basic Med Sci 22(4):376\u2013383. https:\/\/doi.org\/10.22038\/ijbms.2019.31922.7674","journal-title":"Iran J Basic Med Sci"},{"issue":"11","key":"10667_CR23","doi-asserted-by":"publisher","first-page":"9352","DOI":"10.3390\/ijms24119352","volume":"24","author":"P Gonz\u00e1lez","year":"2023","unstructured":"Gonz\u00e1lez P, Lozano P, Ros G, Solano F (2023) Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections. Int J Mol Sci 24(11):9352. https:\/\/doi.org\/10.3390\/ijms24119352","journal-title":"Int J Mol Sci"},{"key":"10667_CR24","volume-title":"Renal function tests","author":"V Gounden","year":"2024","unstructured":"Gounden V, Bhatt H, Jialal I (2024) Renal function tests. StatPearls Publishing. Treasure Island"},{"key":"10667_CR25","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.3390\/foods11071060","volume":"11","author":"\u00cd Guerreiro","year":"2022","unstructured":"Guerreiro \u00cd, Ferreira-P\u00eago C, Carregosa D, Santos CN, Menezes R, Fernandes AS et al (2022) Polyphenols and their metabolites in renal diseases: an overview. Foods 11:1060. https:\/\/doi.org\/10.3390\/foods11071060","journal-title":"Foods"},{"key":"10667_CR26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cmet.2014.05.011","volume":"20","author":"EN Gurzov","year":"2014","unstructured":"Gurzov EN, Tran M, Fernandez-Rojo MA (2014) Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2. Cell Metab 20:85\u2013102. https:\/\/doi.org\/10.1016\/j.cmet.2014.05.011","journal-title":"Cell Metab"},{"key":"10667_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00125-018-4711-2","volume":"62","author":"JL Harding","year":"2019","unstructured":"Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW (2019) Global trends in diabetes complications: a review of current evidence. Diabetologia 62:3\u201316. https:\/\/doi.org\/10.1007\/s00125-018-4711-2","journal-title":"Diabetologia"},{"key":"10667_CR28","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.3390\/biomedicines12051098","volume":"12","author":"R Jha","year":"2024","unstructured":"Jha R, Lopez-Trevino S, Kankanamalage HR, Jha JC (2024) Diabetes and renal complications: an overview on pathophysiology, biomarkers and therapeutic interventions. Biomedicines 12:1098. https:\/\/doi.org\/10.3390\/biomedicines12051098","journal-title":"Biomedicines"},{"key":"10667_CR29","doi-asserted-by":"publisher","first-page":"1185317","DOI":"10.3389\/fimmu.2023.1185317","volume":"14","author":"Q Jin","year":"2023","unstructured":"Jin Q, Liu T, Qiao Y, Liu D, Yang L, Mao H et al (2023) Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols. Front Immunol 14:1185317. https:\/\/doi.org\/10.3389\/fimmu.2023.1185317","journal-title":"Front Immunol"},{"key":"10667_CR30","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2835691","author":"R Kasole","year":"2019","unstructured":"Kasole R, Martin HD, Kimiywe J (2019) Traditional medicine and its role in the management of diabetes mellitus: patients and herbalists\u2019 perspectives. Evid Based Compl Alternat Med 2019: 2835691 https:\/\/doi.org\/10.1155\/2019\/2835691","journal-title":"Evid Based Compl Alternat Med"},{"key":"10667_CR31","doi-asserted-by":"publisher","first-page":"172625","DOI":"10.1016\/j.ejphar.2019.172625","volume":"862","author":"R Khursheed","year":"2019","unstructured":"Khursheed R, Singh SK, Wadhwa S (2019) Treatment strategies against diabetes: success so Far and challenges ahead. Eur J Pharmacol 862:172625. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172625","journal-title":"Eur J Pharmacol"},{"key":"10667_CR32","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1055\/s-0032-1306349","volume":"120","author":"NA Kotb","year":"2012","unstructured":"Kotb NA, Gaber R, Salah W, Elhendy A (2012) Relations among glycemic control, Circulating endothelial cells, nitric oxide, and flow mediated dilation in patients with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 120:460\u2013465. https:\/\/doi.org\/10.1055\/s-0032-1306349","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10667_CR33","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1062430","author":"V Kumar","year":"2016","unstructured":"Kumar V, Jain P, Rathore K, Ahmed Z (2016) Biological evaluation of Pupalia Lappacea for antidiabetic, antiadipogenic, and hypolipidemic activity both in vitro and in vivo. Scientifica 2016: 1062430 https:\/\/doi.org\/10.1155\/2016\/1062430","journal-title":"Scientifica"},{"issue":"8","key":"10667_CR34","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/jphp.12565","volume":"68","author":"NY Lee","year":"2016","unstructured":"Lee NY, Khoo WK, Adnan MA, Mahalingam TP, Fernandez AR, Jeevaratnam K (2016) The pharmacological potential of Phyllanthus Niruri. J Pharm Pharmacol 68(8):953\u2013969. https:\/\/doi.org\/10.1111\/jphp.12565","journal-title":"J Pharm Pharmacol"},{"issue":"6","key":"10667_CR35","doi-asserted-by":"publisher","first-page":"F1825","DOI":"10.1152\/ajprenal.90442.2008","volume":"295","author":"A Leelahavanichkul","year":"2008","unstructured":"Leelahavanichkul A, Yasuda H, Doi K, Hu X, Zhou H, Yuen PS, Star RA (2008) Methyl-2-acetamidoacrylate, an Ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice. Am J Physiol Ren Physiol 295(6):F1825\u2013F1835. https:\/\/doi.org\/10.1152\/ajprenal.90442.2008","journal-title":"Am J Physiol Ren Physiol"},{"issue":"1","key":"10667_CR36","doi-asserted-by":"publisher","first-page":"2146512","DOI":"10.1080\/0886022X.2022.2146512","volume":"45","author":"X Ma","year":"2023","unstructured":"Ma X, Ma J, Leng T, Yuan Z, Hu T, Liu Q (2023) Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention. Ren Fail 45(1):2146512. https:\/\/doi.org\/10.1080\/0886022X.2022.2146512","journal-title":"Ren Fail"},{"issue":"2","key":"10667_CR37","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1177\/2042018816638050","volume":"7","author":"M May","year":"2016","unstructured":"May M, Schindler C (2016) Clinically and Pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab 7(2):69\u201383. https:\/\/doi.org\/10.1177\/2042018816638050","journal-title":"Ther Adv Endocrinol Metab"},{"key":"10667_CR39","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","volume":"247","author":"HP Misra","year":"1972","unstructured":"Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170\u20133175","journal-title":"J Biol Chem"},{"key":"10667_CR40","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.cmet.2021.04.004","volume":"33","author":"Y Mori","year":"2021","unstructured":"Mori Y, Ajay AK, Chang JH, Mou S, Zhao H, Kishi S, Li J (2021) KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. Cell Metab 33:1042\u20131061. https:\/\/doi.org\/10.1016\/j.cmet.2021.04.004","journal-title":"Cell Metab"},{"issue":"4","key":"10667_CR41","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.5530\/pj.2021.13.136","volume":"13","author":"WN Mustaffa","year":"2021","unstructured":"Mustaffa WN, Jusof WHW (2021) A review on antioxidant and antidiabetic activities of Nephelium lappaceum L. Pharmacogn J 13(4):1053\u20131057. https:\/\/doi.org\/10.5530\/pj.2021.13.136","journal-title":"Pharmacogn J"},{"key":"10667_CR42","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.bbrc.2017.09.080","volume":"493","author":"M Najari Beidokhti","year":"2017","unstructured":"Najari Beidokhti M, Andersen MV, Eid HM, Sanchez Villavicencio ML, Staerk D, Haddad PS, J\u00e4ger AK (2017) Investigation of antidiabetic potential of Phyllanthus Niruri L. using assays for \u03b1-glucosidase, muscle glucose transport, liver glucose production, and adipogenesis. Biochem Biophys Res Commun 493:869\u2013874. https:\/\/doi.org\/10.1016\/j.bbrc.2017.09.080","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10667_CR43","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1023\/a:1024600905574","volume":"18","author":"N Nakanishi","year":"2003","unstructured":"Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K (2003) Serum uric acid and risk for development of hypertension and impaired fasting glucose or type II diabetes in Japanese male office workers. Eur J Epidemiol 18(6):523\u2013530. https:\/\/doi.org\/10.1023\/a:1024600905574","journal-title":"Eur J Epidemiol"},{"issue":"9","key":"10667_CR44","first-page":"4681","volume":"5","author":"N Narendra","year":"2012","unstructured":"Narendra N, Swathi J, Sowjanya KM, Satya AK (2012) Phyllanthus niruri: a review on its ethnobotanical, phytochemical and Pharmacological profile. J Pharm Res 5(9):4681\u20134691","journal-title":"J Pharm Res"},{"key":"10667_CR45","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6353949","author":"N Nata","year":"2020","unstructured":"Nata N, Rangsin R, Supasyndh O, Satirapoj B (2020) Impaired glomerular filtration rate in type 2 diabetes mellitus subjects: a nationwide cross-sectional study in Thailand. J Diabetes Res 2020 6353949 https:\/\/doi.org\/10.1155\/2020\/6353949","journal-title":"J Diabetes Res"},{"key":"10667_CR46","doi-asserted-by":"publisher","first-page":"411","DOI":"10.4103\/bbrj.bbrj_126_23","volume":"7","author":"OB Odeghe","year":"2023","unstructured":"Odeghe OB, Orororo CO, Egbune EO, Onobrudu DA, Nwiloh BA, Bassey UE (2023) Phytochemical analysis, antioxidant capability, and inhibition studies of the aqueous extract of Phyllanthus discoideus root. Biomed Biotechnol Res J 7:411\u2013419. https:\/\/doi.org\/10.4103\/bbrj.bbrj_126_23","journal-title":"Biomed Biotechnol Res J"},{"key":"10667_CR47","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"10667_CR48","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s00580-022-03399-1","volume":"31","author":"OI Oloyede","year":"2022","unstructured":"Oloyede OI, Afolabi OB, Babatunde OE, Adegboro AG, Ogunkorode DO (2022) Cytoprotective potential of the aqueous extract from Bridelia ferruginea stem bark against experimental cadmium-induced hepato-renal toxicity in Wistar rat. Comp Clin Pathol 31:967\u2013978. https:\/\/doi.org\/10.1007\/s00580-022-03399-1","journal-title":"Comp Clin Pathol"},{"issue":"2","key":"10667_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/dmrr.2841","volume":"33","author":"N Papadopoulou-Marketou","year":"2017","unstructured":"Papadopoulou-Marketou N, Chrousos GP, Kanaka-Gantenbein C (2017) Diabetic nephropathy in type 1 diabetes: a review of early natural history, pathogenesis, and diagnosis. Diabetes Metab Res Rev 33(2):1\u20139. https:\/\/doi.org\/10.1002\/dmrr.2841","journal-title":"Diabetes Metab Res Rev"},{"key":"10667_CR50","doi-asserted-by":"publisher","unstructured":"Paramitha D, Ulum MF, Purnama A (2017) Monitoring degradation products and metal ions in vivo. In: Monitoring and evaluation of biomaterials and their performance in vivo. Woodhead Publishing 2017: 19\u201344. https:\/\/doi.org\/10.1016\/B978-0-08-100603-0.00002-X","DOI":"10.1016\/B978-0-08-100603-0.00002-X"},{"key":"10667_CR51","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.3390\/antiox12091772","volume":"12","author":"N Piko","year":"2023","unstructured":"Piko N, Bevc S, Hojs R, Ekart R (2023) The role of oxidative stress in kidney injury. Antioxidants 12:1772. https:\/\/doi.org\/10.3390\/antiox12091772","journal-title":"Antioxidants"},{"key":"10667_CR52","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1681\/ASN.2021010044","volume":"32","author":"GZ Quinn","year":"2021","unstructured":"Quinn GZ, Abedini A, Liu H, Ma Z, Cucchiara A, Havasi A, Hill J, Palmer MB, Susztak K (2021) Renal histologic analysis provides complementary information to kidney function measurement for patients with early diabetic or hypertensive disease. J Am Soc Nephrol 32:2863\u20132876. https:\/\/doi.org\/10.1681\/ASN.2021010044","journal-title":"J Am Soc Nephrol"},{"key":"10667_CR53","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6144967","author":"A Radajewska","year":"2023","unstructured":"Radajewska A, Szyller J, Niewiadomska J, Noszczyk-Nowak A, Bil-Lula I (2023) Punica granatum L. polyphenolic extract as an antioxidant to prevent kidney injury in metabolic syndrome rats. Oxid Med Cell Longev 2023:6144967 https:\/\/doi.org\/10.1155\/2023\/6144967","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10667_CR54","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3390\/metabo13010130","volume":"13","author":"AH Rahmani","year":"2023","unstructured":"Rahmani AH, Alsahli MA, Khan AA, Almatroodi SA (2023) Quercetin, a plant flavonol attenuates diabetic complications, renal tissue damage, renal oxidative stress and inflammation in streptozotocin-induced diabetic rats. Metabolites 13(1):130. https:\/\/doi.org\/10.3390\/metabo13010130","journal-title":"Metabolites"},{"issue":"6","key":"10667_CR55","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.3390\/plants12061217","volume":"12","author":"NB Rathod","year":"2023","unstructured":"Rathod NB, Elabed N, Punia S, Ozogul F, Kim SK, Rocha JM (2023) Recent developments in polyphenol applications on human health: a review with current Knowledge. Plants 12(6):1217 https:\/\/doi.org\/10.3390\/plants12061217","journal-title":"Plants"},{"key":"10667_CR56","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3390\/antiox10071143","volume":"10","author":"M Sakashita","year":"2021","unstructured":"Sakashita M, Tanaka T, Inagi R (2021) Metabolic changes and oxidative stress in diabetic kidney disease. Antioxidants 10:1143. https:\/\/doi.org\/10.3390\/antiox10071143","journal-title":"Antioxidants"},{"key":"10667_CR57","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1497449","author":"N Samsu","year":"2021","unstructured":"Samsu N (2021) Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. Biomed Res Int. 2021:1497449 https:\/\/doi.org\/10.1155\/2021\/1497449","journal-title":"Biomed Res Int"},{"issue":"1","key":"10667_CR59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/dom.14007","volume":"22","author":"NM Selby","year":"2020","unstructured":"Selby NM, Taal MW (2020) An updated overview of diabetic nephropathy: diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab 22(1):3\u201315. https:\/\/doi.org\/10.1111\/dom.14007","journal-title":"Diabetes Obes Metab"},{"key":"10667_CR60","first-page":"10","volume":"3","author":"S Shafi","year":"2012","unstructured":"Shafi S, Tabassum N, Ahmad F (2012) Diabetic nephropathy and herbal medicines. Int J Phytopharmacol 3:10\u201317","journal-title":"Int J Phytopharmacol"},{"key":"10667_CR61","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","volume":"47","author":"AK Sinha","year":"1972","unstructured":"Sinha AK (1972) Colorimetric assay of catalase. Anal Biochem 47:389\u2013394. https:\/\/doi.org\/10.1016\/0003-2697(72)90132-7","journal-title":"Anal Biochem"},{"key":"10667_CR62","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jep.2016.07.005","volume":"192","author":"J Soelberg","year":"2016","unstructured":"Soelberg J, Davis O, J\u00e4ger AK (2016) Historical versus contemporary medicinal plant uses in the US Virgin Islands. J Ethnopharmacol 192:74\u201389. https:\/\/doi.org\/10.1016\/j.jep.2016.07.005","journal-title":"J Ethnopharmacol"},{"key":"10667_CR64","doi-asserted-by":"publisher","first-page":"105803","DOI":"10.1016\/j.fitote.2023.105803","volume":"173","author":"D Swargiary","year":"2024","unstructured":"Swargiary D, Kashyap B, Sarma P, Ahmed SA, Gurumayum S, Barge SR et al (2024) Free radical scavenging polyphenols isolated from Phyllanthus Niruri L. ameliorates hyperglycemia via SIRT1 induction and GLUT4 translocation in in vitro and in vivo models. Fitoterapia 173:105803. https:\/\/doi.org\/10.1016\/j.fitote.2023.105803","journal-title":"Fitoterapia"},{"key":"10667_CR65","unstructured":"Tietz NW (1995) Clinical guide to laboratory tests. Clin Biochem 1995: 1096"},{"issue":"7","key":"10667_CR66","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/s0026-0495(03)00101-x","volume":"52","author":"F Tosi","year":"2003","unstructured":"Tosi F, Muggeo M, Brun E, Spiazzi G, Perobelli L, Zanolin E et al (2003) Combination treatment with Metformin and Glibenclamide versus single-drug therapies in type 2 diabetes mellitus: a randomized, double-blind, comparative study. Metabolism 52(7):862\u2013867. https:\/\/doi.org\/10.1016\/s0026-0495(03)00101-x","journal-title":"Metabolism"},{"key":"10667_CR67","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jep.2016.03.060","volume":"186","author":"BT Trinh","year":"2016","unstructured":"Trinh BT, Staerk D, J\u00e4ger AK (2016) Screening for potential \u03b1-glucosidase and \u03b1-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes. J Ethnopharmacol 186:189\u2013195. https:\/\/doi.org\/10.1016\/j.jep.2016.03.060","journal-title":"J Ethnopharmacol"},{"key":"10667_CR71","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.toxlet.2013.10.005","volume":"224","author":"X Wang","year":"2014","unstructured":"Wang X, Zhang W, Chen H (2014) High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS. Toxicol Lett 224:16\u201323. https:\/\/doi.org\/10.1016\/j.toxlet.2013.10.005","journal-title":"Toxicol Lett"},{"key":"10667_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13063-018-2749-6","volume":"19","author":"X Wang","year":"2018","unstructured":"Wang X, Wang Z, Zhou J (2018) Effects of traditional Chinese herbal medicine in patients with diabetic kidney disease: study protocol for a randomized controlled trial. Trials 19:1\u20139. https:\/\/doi.org\/10.1186\/s13063-018-2749-6","journal-title":"Trials"},{"key":"10667_CR69","doi-asserted-by":"publisher","first-page":"536213","DOI":"10.3389\/fendo.2020.536213","volume":"11","author":"J Wang","year":"2020","unstructured":"Wang J, Yue X, Meng C, Wang Z, Jin X, Cui X, Yang J, Shan C, Gao Z, Yang Y, Li J, Chang B, Chang B (2020) Acute hyperglycemia May induce renal tubular injury through mitophagy Inhibition. Front Endocrinol (Lausanne) 11:536213. https:\/\/doi.org\/10.3389\/fendo.2020.536213","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"10667_CR68","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3390\/antiox14020130","volume":"14","author":"CY Wang","year":"2025","unstructured":"Wang CY, Wu DL, Yu MH, Wang CY, Liang HW, Lee HJ (2025) Apple polyphenol mitigates diabetic nephropathy via attenuating renal dysfunction with antioxidation in Streptozotocin-Induced diabetic rats. Antioxidants 14(2):130. https:\/\/doi.org\/10.3390\/antiox14020130","journal-title":"Antioxidants"},{"key":"10667_CR72","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.jff.2013.01.027","volume":"5","author":"Y Yang","year":"2013","unstructured":"Yang Y, Huang C, Wang C, Lee Y, Chen M, Peng C (2013a) Polyphenols of Hibiscus Sabdariffa improved diabetic nephropathy via regulating the pathogenic markers and kidney function s of type 2 diabetic rats. J Funct Foods 5:810\u2013819. https:\/\/doi.org\/10.1016\/j.jff.2013.01.027","journal-title":"J Funct Foods"},{"issue":"31","key":"10667_CR73","doi-asserted-by":"publisher","first-page":"7545","DOI":"10.1021\/jf4020735","volume":"61","author":"YS Yang","year":"2013","unstructured":"Yang YS, Wang CJ, Huang CN, Chen ML, Chen MJ, Peng CH (2013b) Polyphenols of hibiscus Sabdariffa improved diabetic nephropathy via attenuating renal epithelial mesenchymal transition. J Agric Food Chem 61(31):7545\u20137551. https:\/\/doi.org\/10.1021\/jf4020735","journal-title":"J Agric Food Chem"},{"issue":"8","key":"10667_CR74","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3390\/antiox13080922","volume":"13","author":"M Zahra","year":"2024","unstructured":"Zahra M, Abrahamse H, George BP (2024) Flavonoids: antioxidant powerhouses and their role in nanomedicine. Antioxidants 13(8):922. https:\/\/doi.org\/10.3390\/antiox13080922","journal-title":"Antioxidants"},{"issue":"2","key":"10667_CR75","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Ley SH, Hu FB (2018) Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 14(2):88\u201398. https:\/\/doi.org\/10.1038\/nrendo.2017.151","journal-title":"Nat Rev Endocrinol"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10667-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10667-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10667-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:24:44Z","timestamp":1772000684000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10667-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10667"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10667-1","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"19 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experiments were performed according to the ethical guidelines of the institutional animal committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"13"}}