{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:24:17Z","timestamp":1787167457671,"version":"build-2736575974"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Innovation Platform for Academicians of Hainan Province and its specific research fund","award":["YSPTZX202319"],"award-info":[{"award-number":["YSPTZX202319"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10735-025-10675-1","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T02:19:09Z","timestamp":1767752349000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["APMAP regulated by YY1 transcription mediates ferroptosis and metastasis in non-small cell lung cancer through the PI3K\/AKT\/mTOR pathway"],"prefix":"10.1007","volume":"57","author":[{"given":"Xiaohong","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-sheng","family":"zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-ru","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"10675_CR1","doi-asserted-by":"publisher","first-page":"154885","DOI":"10.1016\/j.prp.2023.154885","volume":"251","author":"N Chandnani","year":"2023","unstructured":"Chandnani N, Gupta I, Thakkar V, Sarkar K (2023) Epigenetic regulation of enhancer of Zeste homolog 2 (EZH2) -Yin Yang 1 (YY1) axis in cancer. Pathol Res Pract 251:154885. https:\/\/doi.org\/10.1016\/j.prp.2023.154885","journal-title":"Pathol Res Pract"},{"issue":"1","key":"10675_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12943-023-01888-7","volume":"22","author":"Y Cui","year":"2023","unstructured":"Cui Y, Wu X, Jin J, Man W, Li J, Li X, Wang Y (2023) CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis. Mol Cancer 22(1):179. https:\/\/doi.org\/10.1186\/s12943-023-01888-7","journal-title":"Mol Cancer"},{"key":"10675_CR3","doi-asserted-by":"publisher","first-page":"116345","DOI":"10.1016\/j.bcp.2024.116345","volume":"226","author":"R Fu","year":"2024","unstructured":"Fu R, You Y, Wang Y, Wang J, Lu Y, Gao R, Wang H (2024) Sanggenol L induces ferroptosis in non-small cell lung cancer cells via regulating the miR-26a-1-3p\/MDM2\/p53 signaling pathway. Biochem Pharmacol 226:116345. https:\/\/doi.org\/10.1016\/j.bcp.2024.116345","journal-title":"Biochem Pharmacol"},{"issue":"7\u20138","key":"10675_CR4","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1007\/s10495-024-01966-1","volume":"29","author":"R Gao","year":"2024","unstructured":"Gao R, Wang J, Huang J, Wang T, Guo L, Liu W, Pan H (2024) FSP1-mediated ferroptosis in cancer: from mechanisms to therapeutic applications. Apoptosis 29(7\u20138):1019\u20131037. https:\/\/doi.org\/10.1007\/s10495-024-01966-1","journal-title":"Apoptosis"},{"issue":"1","key":"10675_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40478-019-0660-3","volume":"7","author":"H Gerber","year":"2019","unstructured":"Gerber H, Mosser S, Boury-Jamot B, Stumpe M, Piersigilli A, Goepfert C, Fraering PC (2019) The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in alzheimer\u2019s disease. Acta Neuropathol Commun 7(1):13. https:\/\/doi.org\/10.1186\/s40478-019-0660-3","journal-title":"Acta Neuropathol Commun"},{"issue":"12","key":"10675_CR6","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.7150\/ijbs.85883","volume":"19","author":"Q Guan","year":"2023","unstructured":"Guan Q, Wang Z, Hu K, Cao J, Dong Y, Chen Y (2023) Melatonin ameliorates hepatic ferroptosis in NAFLD by inhibiting ER stress via the MT2\/cAMP\/PKA\/IRE1 signaling pathway. Int J Biol Sci 19(12):3937\u20133950. https:\/\/doi.org\/10.7150\/ijbs.85883","journal-title":"Int J Biol Sci"},{"key":"10675_CR7","doi-asserted-by":"publisher","first-page":"102250","DOI":"10.1016\/j.pupt.2023.102250","volume":"83","author":"H Guo","year":"2023","unstructured":"Guo H, Ren H, Han K, Li J, Dong Y, Zhao X, Li C (2023) Knockdown of HDAC10 inhibits POLE2-mediated DNA damage repair in NSCLC cells by increasing SP1 acetylation levels. Pulm Pharmacol Ther 83:102250. https:\/\/doi.org\/10.1016\/j.pupt.2023.102250","journal-title":"Pulm Pharmacol Ther"},{"issue":"7","key":"10675_CR8","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00432-024-05862-8","volume":"150","author":"L He","year":"2024","unstructured":"He L, Chen H, Ruan B, He L, Luo M, Fu Y, Zou R (2024) UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K\/AKT pathway. J Cancer Res Clin Oncol 150(7):335. https:\/\/doi.org\/10.1007\/s00432-024-05862-8","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"10675_CR9","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1042\/bj20080503","volume":"414","author":"A Ilhan","year":"2008","unstructured":"Ilhan A, Gartner W, Nabokikh A, Daneva T, Majdic O, Cohen G, Wagner L (2008) Localization and characterization of the novel protein encoded by C20orf3. Biochem J 414(3):485\u2013495. https:\/\/doi.org\/10.1042\/bj20080503","journal-title":"Biochem J"},{"issue":"5","key":"10675_CR10","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1007\/s12094-024-03754-4","volume":"27","author":"R Jawed","year":"2025","unstructured":"Jawed R, Bhatti H, Khan A (2025) Genetic profile of ferroptosis in non-small cell lung carcinoma and pharmaceutical options for ferroptosis induction. Clin Transl Oncol 27(5):1867\u20131886. https:\/\/doi.org\/10.1007\/s12094-024-03754-4","journal-title":"Clin Transl Oncol"},{"key":"10675_CR11","doi-asserted-by":"publisher","first-page":"102315","DOI":"10.1016\/j.arr.2024.102315","volume":"97","author":"SK Jha","year":"2024","unstructured":"Jha SK, De Rubis G, Devkota SR, Zhang Y, Adhikari R, Jha LA, Paudel KR (2024) Cellular senescence in lung cancer: molecular mechanisms and therapeutic interventions. Ageing Res Rev 97:102315. https:\/\/doi.org\/10.1016\/j.arr.2024.102315","journal-title":"Ageing Res Rev"},{"issue":"12","key":"10675_CR12","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1158\/0008-5472.Can-18-3295","volume":"79","author":"S Jiang","year":"2019","unstructured":"Jiang S, Wang X, Song D, Liu X, Gu Y, Xu Z, Gao S (2019) Cholesterol induces Epithelial-to-Mesenchymal transition of prostate cancer cells by suppressing degradation of EGFR through APMAP. Cancer Res 79(12):3063\u20133075. https:\/\/doi.org\/10.1158\/0008-5472.Can-18-3295","journal-title":"Cancer Res"},{"key":"10675_CR13","doi-asserted-by":"publisher","first-page":"102289","DOI":"10.1016\/j.tranon.2025.102289","volume":"53","author":"Z Jiang","year":"2025","unstructured":"Jiang Z, Sun X, Li Y, Wang J, Wang C, Pan Z, Yang Y (2025) Anlotinib induced ferroptosis through the p53\/xCT\/GPX4 pathway in non-small cell lung cancer. Transl Oncol 53:102289. https:\/\/doi.org\/10.1016\/j.tranon.2025.102289","journal-title":"Transl Oncol"},{"issue":"7877","key":"10675_CR14","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/s41586-021-03879-4","volume":"597","author":"RA Kamber","year":"2021","unstructured":"Kamber RA, Nishiga Y, Morton B, Banuelos AM, Barkal AA, Vences-Catal\u00e1n F, Bassik MC (2021) Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis. Nature 597(7877):549\u2013554. https:\/\/doi.org\/10.1038\/s41586-021-03879-4","journal-title":"Nature"},{"issue":"3","key":"10675_CR15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2174\/0118744710254730231114181358","volume":"17","author":"AG Kavak","year":"2024","unstructured":"Kavak AG, Karslioglu I, Saracaloglu A, Demiry\u00fcrek S, Demiry\u00fcrek AT (2024) Impact of radiation therapy on serum humanin and MOTS-c levels in patients with lung or breast cancer. Curr Radiopharm 17(3):229\u2013237. https:\/\/doi.org\/10.2174\/0118744710254730231114181358","journal-title":"Curr Radiopharm"},{"key":"10675_CR16","doi-asserted-by":"publisher","first-page":"115891","DOI":"10.1016\/j.biopha.2023.115891","volume":"169","author":"Y Li","year":"2023","unstructured":"Li Y, Yan B, He S (2023) Advances and challenges in the treatment of lung cancer. Biomed Pharmacother 169:115891. https:\/\/doi.org\/10.1016\/j.biopha.2023.115891","journal-title":"Biomed Pharmacother"},{"key":"10675_CR17","doi-asserted-by":"publisher","unstructured":"Liu J, Sauer MA, Hussein SG, Yang J, Tenen DG, Chai L (2021) SALL4 and microrna: the role of Let-7. Genes (Basel) 12(9). https:\/\/doi.org\/10.3390\/genes12091301","DOI":"10.3390\/genes12091301"},{"key":"10675_CR18","doi-asserted-by":"publisher","first-page":"101154","DOI":"10.1016\/j.drup.2024.101154","volume":"77","author":"Z Liu","year":"2024","unstructured":"Liu Z, Liu C, Fan C, Li R, Zhang S, Liu J, Shen Y (2024) E3 ubiquitin ligase DTX2 fosters ferroptosis resistance via suppressing NCOA4-mediated ferritinophagy in non-small cell lung cancer. Drug Resist Updat 77:101154. https:\/\/doi.org\/10.1016\/j.drup.2024.101154","journal-title":"Drug Resist Updat"},{"key":"10675_CR20","doi-asserted-by":"publisher","unstructured":"Luo L, Xu G (2022) Fascaplysin induces apoptosis and ferroptosis, and enhances Anti-PD-1 immunotherapy in Non-Small cell lung cancer (NSCLC) by promoting PD-L1 expression. Int J Mol Sci 23(22). https:\/\/doi.org\/10.3390\/ijms232213774","DOI":"10.3390\/ijms232213774"},{"key":"10675_CR19","doi-asserted-by":"publisher","unstructured":"Luo G, Hong T, Yu L, Ren Z (2023) FTO regulated intramuscular fat by targeting APMAP gene via an m(6)A-YTHDF2-dependent manner in Rex rabbits. Cells 12(3). https:\/\/doi.org\/10.3390\/cells12030369","DOI":"10.3390\/cells12030369"},{"key":"10675_CR21","doi-asserted-by":"publisher","first-page":"529240","DOI":"10.3389\/pore.2021.529240","volume":"27","author":"J Ma","year":"2021","unstructured":"Ma J, Du R, Huang Y, Zhong W, Gui H, Mao C, Lu J (2021) Expression, prognosis and gene regulation network of NFAT transcription factors in Non-Small cell lung cancer. Pathol Oncol Res 27:529240. https:\/\/doi.org\/10.3389\/pore.2021.529240","journal-title":"Pathol Oncol Res"},{"key":"10675_CR22","doi-asserted-by":"publisher","first-page":"104349","DOI":"10.1016\/j.critrevonc.2024.104349","volume":"197","author":"Q Pang","year":"2024","unstructured":"Pang Q, Tang Z, Luo L (2024) The crosstalk between oncogenic signaling and ferroptosis in cancer. Crit Rev Oncol Hematol 197:104349. https:\/\/doi.org\/10.1016\/j.critrevonc.2024.104349","journal-title":"Crit Rev Oncol Hematol"},{"issue":"7","key":"10675_CR23","doi-asserted-by":"publisher","first-page":"500","DOI":"10.20892\/j.issn.2095-3941.2023.0108","volume":"20","author":"R Rosell","year":"2023","unstructured":"Rosell R, Jain A, Codony-Servat J, Jantus-Lewintre E, Morrison B, Ginesta JB, Gonz\u00e1lez-Cao M (2023) Biological insights in non-small cell lung cancer. Cancer Biol Med 20(7):500\u2013518. https:\/\/doi.org\/10.20892\/j.issn.2095-3941.2023.0108","journal-title":"Cancer Biol Med"},{"key":"10675_CR24","doi-asserted-by":"publisher","first-page":"4539932","DOI":"10.1155\/2022\/4539932","volume":"2022","author":"C Sun","year":"2022","unstructured":"Sun C, Peng F, Li J, Cui X, Qiao X, Zhu W (2022) Ferroptosis-Specific inhibitor Ferrostatin-1 relieves H(2)O(2)-Induced redox imbalance in primary cardiomyocytes through the Nrf2\/ARE pathway. Dis Markers 2022:4539932. https:\/\/doi.org\/10.1155\/2022\/4539932","journal-title":"Dis Markers"},{"issue":"10299","key":"10675_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/s0140-6736(21)00312-3","volume":"398","author":"AA Thai","year":"2021","unstructured":"Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS (2021) Lung cancer. Lancet 398(10299):535\u2013554. https:\/\/doi.org\/10.1016\/s0140-6736(21)00312-3","journal-title":"Lancet"},{"issue":"8","key":"10675_CR26","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/s41591-021-01450-2","volume":"27","author":"M Wang","year":"2021","unstructured":"Wang M, Herbst RS, Boshoff C (2021) Toward personalized treatment approaches for non-small-cell lung cancer. Nat Med 27(8):1345\u20131356. https:\/\/doi.org\/10.1038\/s41591-021-01450-2","journal-title":"Nat Med"},{"key":"10675_CR28","doi-asserted-by":"publisher","first-page":"100916","DOI":"10.1016\/j.drup.2022.100916","volume":"66","author":"Y Wang","year":"2023","unstructured":"Wang Y, Wu X, Ren Z, Li Y, Zou W, Chen J, Wang H (2023) Overcoming cancer chemotherapy resistance by the induction of ferroptosis. Drug Resist Updat 66:100916. https:\/\/doi.org\/10.1016\/j.drup.2022.100916","journal-title":"Drug Resist Updat"},{"issue":"5","key":"10675_CR27","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1080\/1120009x.2023.2281759","volume":"36","author":"X Wang","year":"2024","unstructured":"Wang X, Liu C, Wang J, Tian Z (2024) Resveratrol suppresses NSCLC cell growth, invasion and migration by mediating Wnt\/\u03b2-catenin pathway via downregulating SIX4 and SPHK2. J Chemother 36(5):411\u2013421. https:\/\/doi.org\/10.1080\/1120009x.2023.2281759","journal-title":"J Chemother"},{"issue":"9","key":"10675_CR29","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.2174\/1570180820666230914104206","volume":"21","author":"Y-Z Wei","year":"2024","unstructured":"Wei Y-Z, Yang M-Z, Yuan W (2024) Network Pharmacological study of the active ingredient of Panax Notoginseng saponins for the treatment of lung cancer by inhibiting AKR1C3. Lett Drug Des Discovery 21(9):1546\u20131554","journal-title":"Lett Drug Des Discovery"},{"issue":"1","key":"10675_CR30","doi-asserted-by":"publisher","first-page":"2346543","DOI":"10.1080\/07853890.2024.2346543","volume":"56","author":"Q Wu","year":"2024","unstructured":"Wu Q, Huang F (2024) Targeting ferroptosis as a prospective therapeutic approach for diabetic nephropathy. Ann Med 56(1):2346543. https:\/\/doi.org\/10.1080\/07853890.2024.2346543","journal-title":"Ann Med"},{"issue":"1","key":"10675_CR31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12943-025-02245-6","volume":"24","author":"Z Xi","year":"2025","unstructured":"Xi Z, Dai R, Ze Y, Jiang X, Liu M, Xu H (2025) Traditional Chinese medicine in lung cancer treatment. Mol Cancer 24(1):57. https:\/\/doi.org\/10.1186\/s12943-025-02245-6","journal-title":"Mol Cancer"},{"issue":"4","key":"10675_CR32","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41419-020-2452-x","volume":"11","author":"Y Xia","year":"2020","unstructured":"Xia Y, Wei K, Yang FM, Hu LQ, Pan CF, Pan XL, Chen L (2020) Correction: miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC. Cell Death Dis 11(4):261. https:\/\/doi.org\/10.1038\/s41419-020-2452-x","journal-title":"Cell Death Dis"},{"issue":"10","key":"10675_CR33","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/s41419-020-03027-2","volume":"11","author":"L Yang","year":"2020","unstructured":"Yang L, Liu G, Li X, Xia Z, Wang Y, Lin W, Li X (2020) Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Cell Death Dis 11(10):827. https:\/\/doi.org\/10.1038\/s41419-020-03027-2","journal-title":"Cell Death Dis"},{"issue":"7","key":"10675_CR34","doi-asserted-by":"publisher","first-page":"e1007914","DOI":"10.1371\/journal.ppat.1007914","volume":"15","author":"X Ye","year":"2019","unstructured":"Ye X, Gui X, Freed DC, Ku Z, Li L, Chen Y, An Z (2019) Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection. PLoS Pathog 15(7):e1007914. https:\/\/doi.org\/10.1371\/journal.ppat.1007914","journal-title":"PLoS Pathog"},{"issue":"1","key":"10675_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00210-021-02178-z","volume":"395","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Guo R, Li J, Zhu L (2022) Research progress on the occurrence and therapeutic mechanism of ferroptosis in NSCLC. Naunyn Schmiedebergs Arch Pharmacol 395(1):1\u201312. https:\/\/doi.org\/10.1007\/s00210-021-02178-z","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"8","key":"10675_CR36","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1007\/s11010-023-04823-y","volume":"479","author":"K Zhang","year":"2024","unstructured":"Zhang K, Lin G, Nie Z, Jin S, Bing X, Li Z, Li M (2024a) TRIM38 suppresses migration, invasion, metastasis, and proliferation in non-small cell lung cancer (NSCLC) via regulating the AMPK\/NF-\u03baB\/NLRP3 pathway. Mol Cell Biochem 479(8):2069\u20132079. https:\/\/doi.org\/10.1007\/s11010-023-04823-y","journal-title":"Mol Cell Biochem"},{"issue":"7","key":"10675_CR38","doi-asserted-by":"publisher","first-page":"167447","DOI":"10.1016\/j.bbadis.2024.167447","volume":"1870","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Qian J, Fu Y, Wang Z, Hu W, Zhang J, Zuo Z (2024b) Inhibition of DDR1 promotes ferroptosis and overcomes gefitinib resistance in non-small cell lung cancer. Biochim Biophys Acta Mol Basis Dis 1870(7):167447. https:\/\/doi.org\/10.1016\/j.bbadis.2024.167447","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"16","key":"10675_CR35","doi-asserted-by":"publisher","first-page":"e2415814","DOI":"10.1002\/advs.202415814","volume":"12","author":"F Zhang","year":"2025","unstructured":"Zhang F, Huang B, Xu Y, Cao G, Shen M, Liu C, Luo J (2025) MISP suppresses ferroptosis via MST1\/2 kinases to facilitate YAP activation in Non-Small cell lung cancer. Adv Sci (Weinh) 12(16):e2415814. https:\/\/doi.org\/10.1002\/advs.202415814","journal-title":"Adv Sci (Weinh)"},{"issue":"12","key":"10675_CR39","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/s41419-019-2127-7","volume":"10","author":"J Zhou","year":"2019","unstructured":"Zhou J, Zhang S, Chen Z, He Z, Xu Y, Li Z (2019) CircRNA-ENO1 promoted Glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1. Cell Death Dis 10(12):885. https:\/\/doi.org\/10.1038\/s41419-019-2127-7","journal-title":"Cell Death Dis"},{"issue":"20","key":"10675_CR40","doi-asserted-by":"publisher","first-page":"6265","DOI":"10.7150\/jca.59595","volume":"12","author":"X Zhu","year":"2021","unstructured":"Zhu X, Xiang Z, Zou L, Chen X, Peng X, Xu D (2021) APMAP promotes Epithelial-Mesenchymal transition and metastasis of cervical cancer cells by activating the Wnt\/\u03b2-catenin pathway. J Cancer 12(20):6265\u20136273. https:\/\/doi.org\/10.7150\/jca.59595","journal-title":"J Cancer"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10675-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10675-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10675-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:25:23Z","timestamp":1772000723000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10675-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10675"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10675-1","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"assertion":[{"value":"14 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"27"}}