{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:00:24Z","timestamp":1772006424107,"version":"3.50.1"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10735-025-10685-z","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T14:18:25Z","timestamp":1767017905000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sennoside A alleviates sepsis-triggered acute kidney injury via activating SIRT1 signaling pathway"],"prefix":"10.1007","volume":"57","author":[{"given":"Shaohua","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"issue":"7","key":"10685_CR1","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1080\/10715762.2018.1468564","volume":"52","author":"G Aldini","year":"2018","unstructured":"Aldini G et al (2018) N-acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res 52(7):751\u2013762","journal-title":"Free Radic Res"},{"issue":"8","key":"10685_CR2","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.jsps.2020.07.003","volume":"28","author":"AD Al-Ghamdi","year":"2020","unstructured":"Al-Ghamdi AD, Zaheer Z, Aazam ES (2020) Sennoside A drug capped biogenic fabrication of silver nanoparticles and their antibacterial and antifungal activities. Saudi Pharm J 28(8):1035\u20131048","journal-title":"Saudi Pharm J"},{"key":"10685_CR3","first-page":"1030","volume":"23","author":"WH Almalki","year":"2024","unstructured":"Almalki WH, Almujri SS (2024) Oxidative stress and senescence in aging kidneys: the protective role of SIRT1. Excli J 23:1030","journal-title":"Excli J"},{"key":"10685_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133153","author":"DK Alves-Fernandes","year":"2019","unstructured":"Alves-Fernandes DK, Jasiulionis MG (2019) The role of SIRT1 on DNA damage response and epigenetic alterations in cancer. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20133153","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10685_CR5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1097\/ACO.0000000000000958","volume":"34","author":"C Chiu","year":"2021","unstructured":"Chiu C, Legrand M (2021) Epidemiology of sepsis and septic shock. Curr Opin Anaesthesiol 34(2):71\u201376","journal-title":"Curr Opin Anaesthesiol"},{"key":"10685_CR6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.freeradbiomed.2023.04.014","volume":"204","author":"J Fang","year":"2023","unstructured":"Fang J et al (2023) Overexpression of GPX4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury. Free Radic Biol Med 204:68\u201381","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"10685_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113858","volume":"21","author":"ED Gregorio","year":"2020","unstructured":"Gregorio ED et al (2020) Relevance of SIRT1-NF-\u03baB axis as therapeutic target to ameliorate inflammation in liver disease. Int J Mol Sci 21(11):3858","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10685_CR8","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1002\/JLB.1A0422-211R","volume":"112","author":"J Guo","year":"2022","unstructured":"Guo J, Wang R, Min F (2022) Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells. J Leukoc Biol 112(5):1065\u20131077","journal-title":"J Leukoc Biol"},{"key":"10685_CR9","doi-asserted-by":"publisher","DOI":"10.1177\/2050312119835043","volume":"7","author":"B Gyawali","year":"2019","unstructured":"Gyawali B, Ramakrishna K, Dhamoon AS (2019) Sepsis: the evolution in definition, pathophysiology, and management. SAGE Open Med 7:2050312119835043","journal-title":"SAGE Open Med"},{"issue":"6","key":"10685_CR10","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s11064-022-03560-w","volume":"47","author":"L He","year":"2022","unstructured":"He L et al (2022) Mitochondrial sirtuins in Parkinson\u2019s disease. Neurochem Res 47(6):1491\u20131502","journal-title":"Neurochem Res"},{"key":"10685_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126583","author":"K Hosohata","year":"2022","unstructured":"Hosohata K, Harnsirikarn T, Chokesuwattanaskul S (2022) Ferroptosis: a potential therapeutic target in acute kidney injury. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23126583","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10685_CR12","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jgg.2021.11.005","volume":"49","author":"Z Ji","year":"2022","unstructured":"Ji Z, Liu GH, Qu J (2022) Mitochondrial sirtuins, metabolism, and aging. J Genet Genomics 49(4):287\u2013298","journal-title":"J Genet Genomics"},{"issue":"7","key":"10685_CR13","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.2215\/CJN.00850122","volume":"17","author":"S Kuwabara","year":"2022","unstructured":"Kuwabara S, Goggins E, Okusa MD (2022) The pathophysiology of sepsis-associated AKI. Clin J Am Soc Nephrol 17(7):1050\u20131069","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10685_CR14","doi-asserted-by":"publisher","first-page":"12026","DOI":"10.1038\/s41598-017-12285-8","volume":"7","author":"KC Lan","year":"2017","unstructured":"Lan KC et al (2017) Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-\u03baB and HMGB1 pathways through the upregulation of SIRT1. Sci Rep 7(1):12026","journal-title":"Sci Rep"},{"issue":"2","key":"10685_CR15","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.bbrc.2018.04.108","volume":"500","author":"J Le","year":"2018","unstructured":"Le J, Jia W, Sun Y (2018) Sennoside A protects mitochondrial structure and function to improve high-fat diet-induced hepatic steatosis by targeting VDAC1. Biochem Biophys Res Commun 500(2):484\u2013489","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10685_CR16","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.apsb.2019.01.014","volume":"9","author":"J Le","year":"2019","unstructured":"Le J et al (2019) Regulation of microbiota-GLP1 axis by sennoside A in diet-induced obese mice. Acta Pharm Sin B 9(4):758\u2013768","journal-title":"Acta Pharm Sin B"},{"key":"10685_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.714586","volume":"12","author":"J Le","year":"2021","unstructured":"Le J et al (2021) Pharmacology, toxicology, and metabolism of sennoside A, a medicinal plant-derived natural compound. Front Pharmacol 12:714586","journal-title":"Front Pharmacol"},{"issue":"3","key":"10685_CR18","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.bbadis.2018.10.041","volume":"1865","author":"YM Li","year":"2019","unstructured":"Li YM et al (2019) Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-\u03bab pathway. Biochim Et Biophys Acta (BBA) 1865(3):558\u2013569","journal-title":"Biochim Et Biophys Acta (BBA)"},{"issue":"1","key":"10685_CR19","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1080\/0886022X.2021.1942915","volume":"43","author":"L Li","year":"2021","unstructured":"Li L et al (2021a) Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway. Ren Fail 43(1):1028\u20131040","journal-title":"Ren Fail"},{"key":"10685_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.796724","volume":"8","author":"C Li","year":"2021","unstructured":"Li C et al (2021b) The programmed cell death of macrophages, endothelial cells, and tubular epithelial cells in Sepsis-AKI. Front Med Lausanne 8:796724","journal-title":"Front Med Lausanne"},{"key":"10685_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/cells11203261","author":"X Li","year":"2022","unstructured":"Li X et al (2022) Gut-kidney impairment process of adenine combined with Folium sennae-induced diarrhea: association with interactions between Lactobacillus intestinalis, Bacteroides acidifaciens and acetic acid, inflammation, and kidney function. Cells. https:\/\/doi.org\/10.3390\/cells11203261","journal-title":"Cells"},{"key":"10685_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110290","volume":"120","author":"X Li","year":"2023","unstructured":"Li X et al (2023) Sennoside A restrains TRAF6 level to modulate ferroptosis, inflammation and cognitive impairment in aging mice with Alzheimer\u2019s disease. Int Immunopharmacol 120:110290","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"10685_CR23","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.bbrc.2020.03.117","volume":"526","author":"L Ma","year":"2020","unstructured":"Ma L et al (2020) Sennoside A restores colonic barrier function through protecting colon enterocytes from ROS-induced mitochondrial damage in diet-induced obese mice. Biochem Biophys Res Commun 526(2):519\u2013524","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10685_CR24","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ccc.2020.11.010","volume":"37","author":"CL Manrique-Caballero","year":"2021","unstructured":"Manrique-Caballero CL, Del Rio-Pertuz G, Gomez H (2021a) Sepsis-associated acute kidney injury. Crit Care Clin 37(2):279\u2013301","journal-title":"Crit Care Clin"},{"issue":"2","key":"10685_CR25","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ccc.2020.11.010","volume":"37","author":"CL Manrique-Caballero","year":"2021","unstructured":"Manrique-Caballero CL, Del Rio-Pertuz G, Gomez H (2021b) Sepsis-associated acute kidney injury. Crit Care Clin 37(2):279\u2013301","journal-title":"Crit Care Clin"},{"issue":"5","key":"10685_CR26","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3390\/biom11050705","volume":"11","author":"AK Mishra","year":"2021","unstructured":"Mishra AK, Baek K-H (2021) Salicylic acid biosynthesis and metabolism: a divergent pathway for plants and bacteria. Biomolecules 11(5):705","journal-title":"Biomolecules"},{"issue":"5","key":"10685_CR27","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.kint.2019.05.026","volume":"96","author":"S Peerapornratana","year":"2019","unstructured":"Peerapornratana S et al (2019) Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int 96(5):1083\u20131099","journal-title":"Kidney Int"},{"issue":"2","key":"10685_CR28","doi-asserted-by":"publisher","first-page":"339","DOI":"10.2215\/CJN.07310717","volume":"13","author":"J Prowle","year":"2018","unstructured":"Prowle J (2018) Sepsis-associated AKI. Clin J Am Soc Nephrol 13(2):339\u2013342","journal-title":"Clin J Am Soc Nephrol"},{"issue":"6","key":"10685_CR29","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10735-023-10156-3","volume":"54","author":"S Qiao","year":"2023","unstructured":"Qiao S et al (2023) Sennoside A induces autophagic death of prostate cancer via inactivation of PI3K\/AKT\/mTOR axis. J Mol Histol 54(6):645\u2013654","journal-title":"J Mol Histol"},{"key":"10685_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.857067","volume":"13","author":"Z Qiongyue","year":"2022","unstructured":"Qiongyue Z et al (2022) Post-treatment with Irisin attenuates acute kidney injury in sepsis mice through anti-ferroptosis via the SIRT1\/Nrf2 pathway. Front Pharmacol 13:857067","journal-title":"Front Pharmacol"},{"issue":"8","key":"10685_CR31","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s10157-021-02057-0","volume":"25","author":"A Raji-Amirhasani","year":"2021","unstructured":"Raji-Amirhasani A et al (2021) Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI)(effect of SIRT1 activators on acute kidney injury). Clin Exp Nephrol 25(8):807\u2013821","journal-title":"Clin Exp Nephrol"},{"key":"10685_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109772","volume":"122","author":"Q Ren","year":"2020","unstructured":"Ren Q et al (2020) Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-\u03baB p65 and MAPK signaling pathways in septic AKI mice. Biomed Pharmacother 122:109772","journal-title":"Biomed Pharmacother"},{"issue":"10212","key":"10685_CR33","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1016\/S0140-6736(19)32563-2","volume":"394","author":"C Ronco","year":"2019","unstructured":"Ronco C, Bellomo R, Kellum JA (2019) Acute kidney injury. Lancet 394(10212):1949\u20131964","journal-title":"Lancet"},{"key":"10685_CR34","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9707292","volume":"2016","author":"Y Shang","year":"2016","unstructured":"Shang Y et al (2016) Downregulation of glutathione biosynthesis contributes to oxidative stress and liver dysfunction in acute kidney injury. Oxid Med Cell Longev 2016:9707292","journal-title":"Oxid Med Cell Longev"},{"key":"10685_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118648","volume":"335","author":"G Shu","year":"2024","unstructured":"Shu G et al (2024) Water extract of earthworms mitigates kidney injury triggered by oxidative stress via activating intrarenal Sirt1\/Nrf2 cascade and ameliorating mitochondrial damage. J Ethnopharmacol 335:118648","journal-title":"J Ethnopharmacol"},{"key":"10685_CR36","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.3389\/fphar.2019.01030","volume":"10","author":"S Song","year":"2019","unstructured":"Song S et al (2019) Protective effects of Dioscin against doxorubicin-induced hepatotoxicity via regulation of Sirt1\/FOXO1\/NF-\u03bab signal. Front Pharmacol 10:1030","journal-title":"Front Pharmacol"},{"key":"10685_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsisyn.2025.100627","volume":"11","author":"A Sonoda","year":"2025","unstructured":"Sonoda A et al (2025) Perls\u2019 Prussian blue staining and chemistry of Prussian blue and Turnbull blue. Forensic Sci Int Synergy 11:100627","journal-title":"Forensic Sci Int Synergy"},{"key":"10685_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106361","volume":"183","author":"YK Sun","year":"2022","unstructured":"Sun YK et al (2022) Progress in the treatment of drug-induced liver injury with natural products. Pharmacol Res 183:106361","journal-title":"Pharmacol Res"},{"issue":"4","key":"10685_CR39","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s11655-021-2881-0","volume":"28","author":"Y Tan","year":"2022","unstructured":"Tan Y et al (2022) Lingbao Huxin Pill alleviates apoptosis and inflammation at infarct border zone through SIRT1-mediated FOXO1 and NF-\u03ba B pathways in rat model of acute myocardial infarction. Chin J Integr Med 28(4):330\u2013338","journal-title":"Chin J Integr Med"},{"key":"10685_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114286","volume":"159","author":"Z Tan","year":"2023","unstructured":"Tan Z et al (2023) Pectolinarigenin alleviated septic acute kidney injury via inhibiting Jak2\/Stat3 signaling and mitochondria dysfunction. Biomed Pharmacother 159:114286","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10685_CR41","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1002\/kjm2.12442","volume":"38","author":"L Wang","year":"2022","unstructured":"Wang L, Cao QM (2022) Long non-coding RNA XIST alleviates sepsis-induced acute kidney injury through inhibiting inflammation and cell apoptosis via regulating miR-155-5p\/WWC1 axis. Kaohsiung J Med Sci 38(1):6\u201317","journal-title":"Kaohsiung J Med Sci"},{"key":"10685_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.952938","volume":"13","author":"XH Wang","year":"2022","unstructured":"Wang XH et al (2022a) Traditional Chinese medicine: a promising strategy to regulate inflammation, intestinal disorders and impaired immune function due to sepsis. Front Pharmacol 13:952938","journal-title":"Front Pharmacol"},{"issue":"4","key":"10685_CR43","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41419-022-04794-w","volume":"13","author":"B Wang","year":"2022","unstructured":"Wang B et al (2022b) Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis. Cell Death Dis 13(4):333","journal-title":"Cell Death Dis"},{"key":"10685_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102310","volume":"52","author":"AJ Wang","year":"2022","unstructured":"Wang AJ et al (2022c) Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2. Redox Biol 52:102310","journal-title":"Redox Biol"},{"issue":"1","key":"10685_CR45","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s11255-024-04162-x","volume":"57","author":"W Wang","year":"2025","unstructured":"Wang W et al (2025) The role of SIRT1 in kidney diseases. Int Urol Nephrol 57(1):147\u2013158","journal-title":"Int Urol Nephrol"},{"issue":"1","key":"10685_CR46","doi-asserted-by":"publisher","first-page":"F20","DOI":"10.1152\/ajprenal.00119.2018","volume":"316","author":"S Wei","year":"2019","unstructured":"Wei S et al (2019) SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury. Am J Physiol Renal Physiol 316(1):F20-f31","journal-title":"Am J Physiol Renal Physiol"},{"issue":"19","key":"10685_CR47","doi-asserted-by":"publisher","first-page":"9782","DOI":"10.1039\/D2FO01730J","volume":"13","author":"J Wu","year":"2022","unstructured":"Wu J et al (2022) Sennoside A is a novel inhibitor targeting caspase-1. Food Funct 13(19):9782\u20139795","journal-title":"Food Funct"},{"issue":"1","key":"10685_CR48","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/jpp\/rgab142","volume":"74","author":"Z-H Xu","year":"2022","unstructured":"Xu Z-H et al (2022) Ganoderma lucidum polysaccharides protect against sepsis-induced cardiac dysfunction by activating SIRT1. J Pharm Pharmacol 74(1):124\u2013130","journal-title":"J Pharm Pharmacol"},{"key":"10685_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.831168","volume":"13","author":"Y Yang","year":"2022","unstructured":"Yang Y et al (2022) Regulation of SIRT1 and its roles in inflammation. Front Immunol 13:831168","journal-title":"Front Immunol"},{"issue":"5","key":"10685_CR50","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3892\/mmr.2025.13502","volume":"31","author":"X Zhang","year":"2025","unstructured":"Zhang X et al (2025) Salidroside ameliorates lipopolysaccharide-induced ferroptosis in chondrocytes via regulation of the sirt1\/foxo1 axis. Mol Med Rep 31(5):138","journal-title":"Mol Med Rep"},{"key":"10685_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105926","volume":"174","author":"H Zhu","year":"2021","unstructured":"Zhu H et al (2021a) Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl4-induced liver fibrosis. Pharmacol Res 174:105926","journal-title":"Pharmacol Res"},{"key":"10685_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105926","volume":"174","author":"H Zhu","year":"2021","unstructured":"Zhu H et al (2021b) Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl(4)-induced liver fibrosis. Pharmacol Res 174:105926","journal-title":"Pharmacol Res"},{"issue":"1","key":"10685_CR53","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1080\/13510002.2022.2036507","volume":"27","author":"S Zhu","year":"2022","unstructured":"Zhu S et al (2022) Lycium Barbarum polysaccharide protects HaCaT cells from PM2.5-induced apoptosis via inhibiting oxidative stress, ER stress and autophagy. Redox Rep 27(1):32\u201344","journal-title":"Redox Rep"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10685-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10685-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10685-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:04:25Z","timestamp":1772003065000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10685-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10685"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10685-z","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"12 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. All procedures performed in studies involving animals were in accordance with the ethical standards of the ethics committee of the Chibi People\u2019s Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Informed consent was obtained from all individual participants included in the study. The patients participating in the study all agree to publish the research results.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"15"}}