{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:26:53Z","timestamp":1794259613784,"version":"4.9.0"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]},{"name":"The authors did not receive support from any organization for the submitted work. The authors have no relevant financial or non-financial interests to disclose.","award":["non applicable"],"award-info":[{"award-number":["non applicable"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10735-025-10693-z","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:15:29Z","timestamp":1770210929000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal high-fat diet and its multigenerational impact on hypertension and metabolic alterations in Wistar rat offspring"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7629-4269","authenticated-orcid":false,"given":"Maghawry","family":"Hegazy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Mohamed","family":"Mokhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed G. E.","family":"Elsakka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham A.","family":"El-Mahdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy Y.","family":"Elkhawaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6475-6937","authenticated-orcid":false,"given":"Mohamed A.","family":"Elkady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr Mohamed","family":"Yehia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Aglan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salama Abdo","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamada Ahmed","family":"Mokhlis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham Fathy","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel I.","family":"Abdelaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher Hassan","family":"Gomaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"El-Husseiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Eldeib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Shaaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha M.","family":"Alnefaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5411-4260","authenticated-orcid":false,"given":"Ahmed","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"1","key":"10693_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4067\/S0716-97602004000100010","volume":"37","author":"NM Abd-Allah","year":"2004","unstructured":"Abd-Allah NM et al (2004) Age dependence of the levels of plasma norepinephrine, aldosterone, renin activity and urinary vanillylmandelic acid in normal and essential hypertensives. Biol Res 37(1):95\u2013106","journal-title":"Biol Res"},{"issue":"7","key":"10693_CR2","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1161\/ATVBAHA.107.160192","volume":"28","author":"M Adiels","year":"2008","unstructured":"Adiels M et al (2008) Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol 28(7):1225\u20131236","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10693_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121697","volume":"323","author":"S Allam","year":"2023","unstructured":"Allam S et al (2023) Androgen receptor blockade by flutamide down-regulates renal fibrosis, inflammation, and apoptosis pathways in male rats. Life Sci 323:121697","journal-title":"Life Sci"},{"issue":"23","key":"10693_CR4","doi-asserted-by":"publisher","first-page":"5287","DOI":"10.1111\/bph.14931","volume":"177","author":"I Andreadou","year":"2020","unstructured":"Andreadou I et al (2020) Hyperlipidaemia and cardioprotection: animal models for translational studies. Br J Pharmacol 177(23):5287\u20135311","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10693_CR5","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jjcc.2020.02.003","volume":"76","author":"Y Arima","year":"2020","unstructured":"Arima Y, Fukuoka H (2020) Developmental origins of health and disease theory in cardiology. J Cardiol 76(1):14\u201317","journal-title":"J Cardiol"},{"key":"10693_CR6","volume-title":"Theory and practice of histological techniques","author":"JD Bancroft","year":"2008","unstructured":"Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Elsevier Health Sciences"},{"issue":"1","key":"10693_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1017\/S0007114519002708","volume":"123","author":"CM Barbosa","year":"2020","unstructured":"Barbosa CM et al (2020) Maternal high-fat diet triggers metabolic syndrome disorders that are transferred to first and second offspring generations. Br J Nutr 123(1):59\u201371","journal-title":"Br J Nutr"},{"key":"10693_CR8","first-page":"273","volume-title":"Advances in pharmacology","author":"AA Bodton","year":"1997","unstructured":"Bodton AA, Eisenhofer G (1997) Catecholamine metabolism: from molecular understanding to clinical diagnosis and treatment. In: Goldstein DS, Eisenhofer G, McCarty R (eds) Advances in pharmacology. Academic Press, pp 273\u2013292"},{"issue":"3","key":"10693_CR9","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/mpo.2950200306","volume":"20","author":"M Candito","year":"1992","unstructured":"Candito M et al (1992) Methylated catecholamine metabolites for diagnosis of neuroblastoma. Med Pediatr Oncol 20(3):215\u2013220","journal-title":"Med Pediatr Oncol"},{"issue":"12","key":"10693_CR10","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1002\/oby.20374","volume":"21","author":"J Carlin","year":"2013","unstructured":"Carlin J et al (2013) Reversal of dopamine system dysfunction in response to high-fat diet. Obesity (Silver Spring) 21(12):2513\u20132521","journal-title":"Obesity (Silver Spring)"},{"issue":"4","key":"10693_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800970","volume":"63","author":"F Ciccarone","year":"2019","unstructured":"Ciccarone F et al (2019) High dietary fat intake affects DNA methylation\/hydroxymethylation in mouse heart: epigenetic hints for obesity-related cardiac dysfunction. Mol Nutr Food Res 63(4):e1800970","journal-title":"Mol Nutr Food Res"},{"issue":"15","key":"10693_CR12","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.2174\/092986711795656081","volume":"18","author":"M Costa","year":"2011","unstructured":"Costa M et al (2011) Contribution of catecholamine reactive intermediates and oxidative stress to the pathologic features of heart diseases. Curr Med Chem 18(15):2272\u20132314","journal-title":"Curr Med Chem"},{"issue":"3","key":"10693_CR13","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.ajog.2014.03.025","volume":"211","author":"M Desai","year":"2014","unstructured":"Desai M et al (2014) Maternal obesity and high-fat diet program offspring metabolic syndrome. Am J Obstet Gynecol 211(3):237","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10693_CR14","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.2337\/db11-1314","volume":"61","author":"GL Ding","year":"2012","unstructured":"Ding GL et al (2012) Transgenerational glucose intolerance with Igf2\/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes 61(5):1133\u20131142","journal-title":"Diabetes"},{"key":"10693_CR15","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.yjmcc.2012.08.023","volume":"55","author":"M Dong","year":"2013","unstructured":"Dong M et al (2013) Maternal obesity, lipotoxicity and cardiovascular diseases in offspring. J Mol Cell Cardiol 55:111\u2013116","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"10693_CR16","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1124\/pr.56.3.1","volume":"56","author":"G Eisenhofer","year":"2004","unstructured":"Eisenhofer G, Kopin IJ, Goldstein DS (2004) Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol Rev 56(3):331\u2013349","journal-title":"Pharmacol Rev"},{"issue":"4","key":"10693_CR17","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1017\/S000711450820749X","volume":"102","author":"MM Elahi","year":"2009","unstructured":"Elahi MM et al (2009) Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. Br J Nutr 102(4):514\u2013519","journal-title":"Br J Nutr"},{"key":"10693_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117628","volume":"251","author":"EGE Elsakka","year":"2020","unstructured":"Elsakka EGE et al (2020) Androgen\/androgen receptor affects gentamicin-induced nephrotoxicity through regulation of megalin expression. Life Sci 251:117628","journal-title":"Life Sci"},{"issue":"1","key":"10693_CR19","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.trsl.2014.06.007","volume":"165","author":"S Friso","year":"2015","unstructured":"Friso S et al (2015) Epigenetics and arterial hypertension: the challenge of emerging evidence. Transl Res 165(1):154\u2013165","journal-title":"Transl Res"},{"issue":"1","key":"10693_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.cardiores.2004.06.011","volume":"64","author":"T Fujii","year":"2004","unstructured":"Fujii T et al (2004) Extraneuronal enzymatic degradation of myocardial interstitial norepinephrine in the ischemic region. Cardiovasc Res 64(1):125\u2013131","journal-title":"Cardiovasc Res"},{"issue":"6","key":"10693_CR21","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/nutrit\/nuaa020","volume":"79","author":"K Gawlinska","year":"2021","unstructured":"Gawlinska K et al (2021) Relationship of maternal high-fat diet during pregnancy and lactation to offspring health. Nutr Rev 79(6):709\u2013725","journal-title":"Nutr Rev"},{"issue":"6","key":"10693_CR22","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/nutrit\/nuaa020","volume":"79","author":"K Gawli\u0144ska","year":"2021","unstructured":"Gawli\u0144ska K et al (2021) Relationship of maternal high-fat diet during pregnancy and lactation to offspring health. Nutr Rev 79(6):709\u2013725","journal-title":"Nutr Rev"},{"key":"10693_CR23","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328350a274","author":"LV Ghimire","year":"2012","unstructured":"Ghimire LV et al (2012) Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise. Pharmacogenet Genomics. https:\/\/doi.org\/10.1097\/FPC.0b013e328350a274","journal-title":"Pharmacogenet Genomics"},{"issue":"6","key":"10693_CR24","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10286-010-0065-7","volume":"20","author":"DS Goldstein","year":"2010","unstructured":"Goldstein DS (2010) Catecholamines 101. Clin Auton Res 20(6):331\u2013352","journal-title":"Clin Auton Res"},{"issue":"4","key":"10693_CR25","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/0888-7543(92)90316-K","volume":"12","author":"MH Grossman","year":"1992","unstructured":"Grossman MH, Emanuel BS, Budarf ML (1992) Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1\u2013q11.2. Genomics 12(4):822\u2013825","journal-title":"Genomics"},{"key":"10693_CR26","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.tifs.2020.04.021","volume":"100","author":"T Guo","year":"2020","unstructured":"Guo T, Luo F, Lin Q (2020) You are affected by what your parents eat: diet, epigenetics, transgeneration and intergeneration. Trends Food Sci Technol 100:248\u2013261","journal-title":"Trends Food Sci Technol"},{"issue":"24","key":"10693_CR27","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014986","volume":"8","author":"KT Hall","year":"2019","unstructured":"Hall KT et al (2019) Catechol-O-methyltransferase and cardiovascular disease: MESA. J Am Heart Assoc 8(24):e014986","journal-title":"J Am Heart Assoc"},{"key":"10693_CR28","doi-asserted-by":"publisher","first-page":"1158089","DOI":"10.3389\/fgene.2023.1158089","volume":"14","author":"B Harmancioglu","year":"2023","unstructured":"Harmancioglu B, Kabaran S (2023) Maternal high fat diets: impacts on offspring obesity and epigenetic hypothalamic programming. Front Genet 14:1158089","journal-title":"Front Genet"},{"issue":"13","key":"10693_CR29","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1038\/sj.npp.1301543","volume":"33","author":"PJ Harrison","year":"2008","unstructured":"Harrison PJ, Tunbridge EM (2008) Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology 33(13):3037\u20133045","journal-title":"Neuropsychopharmacology"},{"key":"10693_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173383","volume":"885","author":"M Hegazy","year":"2020","unstructured":"Hegazy M et al (2020) Pioglitazone ameliorates high fat diet-induced hypertension and induces catechol o-methyl transferase expression in rats. Eur J Pharmacol 885:173383","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"10693_CR31","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/obr.12303","volume":"16","author":"A Horstmann","year":"2015","unstructured":"Horstmann A, Fenske WK, Hankir MK (2015) Argument for a non-linear relationship between severity of human obesity and dopaminergic tone. Obes Rev 16(10):821\u2013830","journal-title":"Obes Rev"},{"issue":"5","key":"10693_CR32","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/j.1365-2796.2007.01776.x","volume":"261","author":"S Johansson","year":"2007","unstructured":"Johansson S et al (2007) Increased catecholamines and heart rate in children with low birth weight: perinatal contributions to sympathoadrenal overactivity. J Intern Med 261(5):480\u2013487","journal-title":"J Intern Med"},{"key":"10693_CR33","volume-title":"Biochemistry, catecholamine degradation","author":"S Kamal","year":"2022","unstructured":"Kamal S, Lappin SL (2022) Biochemistry, catecholamine degradation. StatPearls Publishing, Treasure Island (FL)"},{"key":"10693_CR34","doi-asserted-by":"publisher","first-page":"7927","DOI":"10.1038\/s41598-017-08513-w","volume":"7","author":"M Kanasaki","year":"2017","unstructured":"Kanasaki M et al (2017) Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice. Sci Rep 7:7927","journal-title":"Sci Rep"},{"key":"10693_CR35","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s00335-020-09839-z","volume":"31","author":"D Kaspar","year":"2020","unstructured":"Kaspar D et al (2020) Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations. Mamm Genome 31:119\u2013133","journal-title":"Mamm Genome"},{"key":"10693_CR100","doi-asserted-by":"crossref","unstructured":"Khalil WKB, Booles HF, Hafiz N, El-Bassyouni G (2018) Ameliorative effects of Brachidontes variabilis calcium carbonate against bone loss in ovariectomized rats. Int J Pharm 14:477\u2013487","DOI":"10.3923\/ijp.2018.477.487"},{"issue":"11","key":"10693_CR36","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1038\/ijo.2013.12","volume":"37","author":"A Khalyfa","year":"2013","unstructured":"Khalyfa A et al (2013) Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring. Int J Obes (Lond) 37(11):1481\u20131489","journal-title":"Int J Obes (Lond)"},{"issue":"1","key":"10693_CR37","doi-asserted-by":"publisher","first-page":"R127","DOI":"10.1152\/ajpregu.00354.2004","volume":"288","author":"IY Khan","year":"2005","unstructured":"Khan IY et al (2005) A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol 288(1):R127\u2013R133","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"10693_CR38","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/MED.0000000000000305","volume":"24","author":"S Kitsiou-Tzeli","year":"2017","unstructured":"Kitsiou-Tzeli S, Tzetis M (2017) Maternal epigenetics and fetal and neonatal growth. Curr Opin Endocrinol Diabetes Obes 24(1):43\u201346","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10693_CR39","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.3390\/nu5041218","volume":"5","author":"B Klop","year":"2013","unstructured":"Klop B, Elte JWF, Cabezas MC (2013) Dyslipidemia in obesity: mechanisms and potential targets. Nutrients 5:1218\u20131240. https:\/\/doi.org\/10.3390\/nu5041218","journal-title":"Nutrients"},{"key":"10693_CR40","doi-asserted-by":"publisher","first-page":"261878","DOI":"10.1155\/2014\/261878","volume":"2014","author":"J Knopfholz","year":"2014","unstructured":"Knopfholz J et al (2014) Validation of the friedewald formula in patients with metabolic syndrome. Cholesterol 2014:261878","journal-title":"Cholesterol"},{"issue":"9","key":"10693_CR41","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1194\/jlr.M034538","volume":"54","author":"DM Kusters","year":"2013","unstructured":"Kusters DM et al (2013) Inheritance pattern of familial hypercholesterolemia and markers of cardiovascular risk. J Lipid Res 54(9):2543\u20132549","journal-title":"J Lipid Res"},{"issue":"4","key":"10693_CR42","doi-asserted-by":"publisher","first-page":"G453","DOI":"10.1152\/ajpgi.00103.2019","volume":"317","author":"X Li","year":"2019","unstructured":"Li X et al (2019) High-fat diet promotes experimental colitis by inducing oxidative stress in the colon. Am J Physiol Gastroint Liver Physiol 317(4):G453\u2013G462","journal-title":"Am J Physiol Gastroint Liver Physiol"},{"issue":"1","key":"10693_CR43","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/s41598-020-79604-4","volume":"11","author":"X-H Lin","year":"2021","unstructured":"Lin X-H et al (2021) Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring. Sci Rep 11(1):316","journal-title":"Sci Rep"},{"issue":"10","key":"10693_CR44","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1002\/mnfr.201600116","volume":"60","author":"J Liu","year":"2016","unstructured":"Liu J et al (2016) Influence of maternal hypercholesterolemia and phytosterol intervention during gestation and lactation on dyslipidemia and hepatic lipid metabolism in offspring of Syrian golden hamsters. Mol Nutr Food Res 60(10):2151\u20132160","journal-title":"Mol Nutr Food Res"},{"issue":"13","key":"10693_CR45","doi-asserted-by":"publisher","first-page":"4202","DOI":"10.1021\/bi00013a008","volume":"34","author":"T Lotta","year":"1995","unstructured":"Lotta T et al (1995) Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34(13):4202\u20134210","journal-title":"Biochemistry"},{"issue":"4","key":"10693_CR46","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0031-6997(24)01423-6","volume":"51","author":"PT M\u00e4nnist\u00f6","year":"1999","unstructured":"M\u00e4nnist\u00f6 PT, Kaakkola S (1999) Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 51(4):593\u2013628","journal-title":"Pharmacol Rev"},{"issue":"6","key":"10693_CR47","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1399-5448.2012.00860.x","volume":"13","author":"ML Marcovecchio","year":"2012","unstructured":"Marcovecchio ML et al (2012) An independent effect of parental lipids on the offspring lipid levels in a cohort of adolescents with type 1 diabetes. Pediatr Diabetes 13(6):463\u2013469","journal-title":"Pediatr Diabetes"},{"issue":"8","key":"10693_CR48","doi-asserted-by":"publisher","first-page":"693","DOI":"10.2174\/138920010794233477","volume":"11","author":"DE Masood","year":"2010","unstructured":"Masood DE et al (2010) Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease. Curr Drug Metab 11(8):693\u2013714","journal-title":"Curr Drug Metab"},{"issue":"9587","key":"10693_CR49","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S0140-6736(07)61299-9","volume":"370","author":"FH Messerli","year":"2007","unstructured":"Messerli FH, Williams B, Ritz E (2007) Essential hypertension. Lancet 370(9587):591\u2013603","journal-title":"Lancet"},{"key":"10693_CR50","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/B978-0-12-804572-5.00058-6","volume-title":"Principles of nutrigenetics and nutrigenomics","author":"FI Milagro","year":"2020","unstructured":"Milagro FI, Moreno-Aliaga MJ, Mart\u00ednez JA (2020) Nutrients, obesity and gene expression. Principles of nutrigenetics and nutrigenomics. Elsevier, pp 431\u2013440"},{"issue":"4","key":"10693_CR51","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","volume":"16","author":"KT Mills","year":"2020","unstructured":"Mills KT, Stefanescu A, He J (2020) The global epidemiology of hypertension. Nat Rev Nephrol 16(4):223\u2013237","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"10693_CR52","first-page":"8061389","volume":"2018","author":"L Montalvo-Martinez","year":"2018","unstructured":"Montalvo-Martinez L et al (2018) Maternal overnutrition programs central inflammation and addiction-like behavior in offspring. Biomed Res Int 2018(1):8061389","journal-title":"Biomed Res Int"},{"issue":"1","key":"10693_CR53","doi-asserted-by":"publisher","first-page":"9073859","DOI":"10.1155\/2021\/9073859","volume":"2021","author":"RQ Moraes-Souza","year":"2021","unstructured":"Moraes-Souza RQ et al (2021) Oxidative stress profile of mothers and their offspring after maternal consumption of high-fat diet in rodents: a systematic review and meta-analysis. Oxid Med Cell Longev 2021(1):9073859","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10693_CR54","doi-asserted-by":"publisher","first-page":"5542342","DOI":"10.1155\/2021\/5542342","volume":"2021","author":"Y Nie","year":"2021","unstructured":"Nie Y, Luo F (2021) Dietary fiber: an opportunity for a global control of hyperlipidemia. Oxid Med Cell Longev 2021(1):5542342","journal-title":"Oxid Med Cell Longev"},{"key":"10693_CR55","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/B978-0-12-381326-8.00005-3","volume":"95","author":"E Nissinen","year":"2010","unstructured":"Nissinen E, M\u00e4nnist\u00f6 PT (2010) Biochemistry and pharmacology of catechol-O-methyltransferase inhibitors. Int Rev Neurobiol 95:73\u2013118","journal-title":"Int Rev Neurobiol"},{"issue":"10060","key":"10693_CR56","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1016\/S0140-6736(16)31134-5","volume":"388","author":"MH Olsen","year":"2016","unstructured":"Olsen MH et al (2016) A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension. Lancet 388(10060):2665\u20132712","journal-title":"Lancet"},{"key":"10693_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.14","volume":"4","author":"S Oparil","year":"2018","unstructured":"Oparil S et al (2018) Hypertension. Nat Rev Dis Primers 4:18014","journal-title":"Nat Rev Dis Primers"},{"key":"10693_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.676239","volume":"12","author":"M Ostadkarampour","year":"2021","unstructured":"Ostadkarampour M, Putnins EE (2021) Monoamine oxidase inhibitors: a review of their anti-inflammatory therapeutic potential and mechanisms of action. Front Pharmacol 12:676239","journal-title":"Front Pharmacol"},{"issue":"11","key":"10693_CR59","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1096\/fj.02-0226rev","volume":"16","author":"W Palinski","year":"2002","unstructured":"Palinski W, Napoli C (2002) The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis. FASEB J 16(11):1348\u20131360","journal-title":"FASEB J"},{"issue":"19","key":"10693_CR60","doi-asserted-by":"publisher","first-page":"483","DOI":"10.4239\/wjd.v7.i19.483","volume":"7","author":"JA Paniagua","year":"2016","unstructured":"Paniagua JA (2016) Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome. World J Diabetes 7(19):483","journal-title":"World J Diabetes"},{"issue":"2","key":"10693_CR61","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ajog.2011.03.044","volume":"205","author":"O Quehenberger","year":"2011","unstructured":"Quehenberger O et al (2011) Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids. Am J Obstet Gynecol 205(2):156","journal-title":"Am J Obstet Gynecol"},{"key":"10693_CR62","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cofs.2020.09.006","volume":"37","author":"S Ramos","year":"2021","unstructured":"Ramos S, Mart\u00edn M\u00c1 (2021) Impact of diet on gut microbiota. Curr Opin Food Sci 37:83\u201390","journal-title":"Curr Opin Food Sci"},{"issue":"5","key":"10693_CR63","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/ajcn\/20.5.457","volume":"20","author":"R Rath","year":"1967","unstructured":"Rath R et al (1967) Excretion of vanilmandelic acid by obese women: preliminary report. Am J Clin Nutr 20(5):457\u2013461","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10693_CR64","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/obr.12524","volume":"18","author":"GA Ribaroff","year":"2017","unstructured":"Ribaroff GA et al (2017) Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis. Obes Rev 18(6):673\u2013686","journal-title":"Obes Rev"},{"issue":"1","key":"10693_CR65","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrcardio.2017.115","volume":"15","author":"RS Rosenson","year":"2018","unstructured":"Rosenson RS et al (2018) HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology. Nat Rev Cardiol 15(1):9\u201319","journal-title":"Nat Rev Cardiol"},{"key":"10693_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2024.100614","volume":"29","author":"J Scarborough","year":"2024","unstructured":"Scarborough J et al (2024) Prenatal and postnatal influences on behavioral development in a mouse model of preconceptional stress. Neurobiol Stress 29:100614","journal-title":"Neurobiol Stress"},{"key":"10693_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121151","volume":"311","author":"VG Sheth","year":"2022","unstructured":"Sheth VG et al (2022) Lactobacillus rhamnosus supplementation ameliorates high fat diet-induced epigenetic alterations and prevents its intergenerational inheritance. Life Sci 311:121151","journal-title":"Life Sci"},{"issue":"3","key":"10693_CR68","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3109\/10409231003667500","volume":"45","author":"MS Strable","year":"2010","unstructured":"Strable MS, Ntambi JM (2010) Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit Rev Biochem Mol Biol 45(3):199\u2013214","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"21","key":"10693_CR69","doi-asserted-by":"publisher","first-page":"5267","DOI":"10.1113\/jphysiol.2012.242453","volume":"590","author":"EL Sullivan","year":"2012","unstructured":"Sullivan EL (2012) Maternal high fat diet programming of the endocrine system. J Physiol 590(21):5267\u20135268","journal-title":"J Physiol"},{"issue":"6","key":"10693_CR70","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0890-6238(98)00041-0","volume":"12","author":"WJ Swartz","year":"1998","unstructured":"Swartz WJ, Eroschenko VP (1998) Neonatal exposure to technical methoxychlor alters pregnancy outcome in female mice. Reprod Toxicol 12(6):565\u2013573","journal-title":"Reprod Toxicol"},{"key":"10693_CR71","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.cca.2015.03.041","volume":"446","author":"N Tohmola","year":"2015","unstructured":"Tohmola N et al (2015) Preanalytical validation and reference values for a mass spectrometric assay of serum vanillylmandelic acid for screening of catecholamine secreting neuroendocrine tumors. Clin Chim Acta 446:206\u2013212","journal-title":"Clin Chim Acta"},{"issue":"Pt. 2","key":"10693_CR72","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1113\/jphysiol.2006.126151","volume":"580","author":"IH Trevenzoli","year":"2007","unstructured":"Trevenzoli IH et al (2007) Neonatal hyperleptinaemia programmes adrenal medullary function in adult rats: effects on cardiovascular parameters. J Physiol 580(Pt. 2):629\u2013637","journal-title":"J Physiol"},{"key":"10693_CR73","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.yjmcc.2012.12.007","volume":"55","author":"S Turdi","year":"2013","unstructured":"Turdi S et al (2013) Interaction between maternal and postnatal high fat diet leads to a greater risk of myocardial dysfunction in offspring via enhanced lipotoxicity, IRS-1 serine phosphorylation and mitochondrial defects. J Mol Cell Cardiol 55:117\u2013129","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"10693_CR74","doi-asserted-by":"publisher","first-page":"307","DOI":"10.33549\/physiolres.934687","volume":"70","author":"A Vavrinova","year":"2021","unstructured":"Vavrinova A et al (2021) The abnormalities of adrenomedullary hormonal system in genetic hypertension: their contribution to altered regulation of blood pressure. Physiol Res 70(3):307\u2013326","journal-title":"Physiol Res"},{"key":"10693_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2407-7-42","volume":"7","author":"G Ventrucci","year":"2007","unstructured":"Ventrucci G, Mello MAR, Gomes-Marcondes MCC (2007) Leucine-rich diet alters the eukaryotic translation initiation factors expression in skeletal muscle of tumour-bearing rats. BMC Cancer 7:1\u201311","journal-title":"BMC Cancer"},{"key":"10693_CR76","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00394-015-1108-6","volume":"56","author":"AD von Frankenberg","year":"2017","unstructured":"von Frankenberg AD et al (2017) A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat in weight-stable overweight and obese adults. Eur J Nutr 56:431\u2013443","journal-title":"Eur J Nutr"},{"issue":"5","key":"10693_CR77","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.3390\/nu12051505","volume":"12","author":"JA Wali","year":"2020","unstructured":"Wali JA et al (2020) Cardio-metabolic effects of high-fat diets and their underlying mechanisms\u2014a narrative review. Nutrients 12(5):1505","journal-title":"Nutrients"},{"issue":"1","key":"10693_CR78","doi-asserted-by":"publisher","first-page":"16502","DOI":"10.1038\/s41598-018-34453-0","volume":"8","author":"UD Wankhade","year":"2018","unstructured":"Wankhade UD et al (2018) Maternal high-fat diet programs offspring liver steatosis in a sexually dimorphic manner in association with changes in gut microbial ecology in mice. Sci Rep 8(1):16502","journal-title":"Sci Rep"},{"key":"10693_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.909151","volume":"9","author":"B-H Zhang","year":"2022","unstructured":"Zhang B-H et al (2022) Triglyceride and triglyceride-rich lipoproteins in atherosclerosis. Front Mol Biosci 9:909151","journal-title":"Front Mol Biosci"},{"issue":"11","key":"10693_CR80","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s41569-021-00559-8","volume":"18","author":"B Zhou","year":"2021","unstructured":"Zhou B et al (2021) Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension. Nat Rev Cardiol 18(11):785\u2013802","journal-title":"Nat Rev Cardiol"}],"updated-by":[{"DOI":"10.1007\/s10735-026-11021-9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T00:00:00Z","timestamp":1794182400000}}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10693-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10693-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10693-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:02:37Z","timestamp":1794258157000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10693-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10693"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10693-z","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10735-026-11021-9","URL":"https:\/\/doi.org\/10.1007\/s10735-026-11021-9","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"68"}}