{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:08:53Z","timestamp":1772003333265,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10735-025-10703-0","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:38:19Z","timestamp":1768639099000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MiR-874-3p suppresses TNF-\u03b1-induced inflammation in adipocytes by targeting nucleolin"],"prefix":"10.1007","volume":"57","author":[{"given":"Xingxiang","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"issue":"6","key":"10703_CR18","doi-asserted-by":"publisher","first-page":"799","DOI":"10.4161\/rna.19718","volume":"9","author":"K Abdelmohsen","year":"2012","unstructured":"Abdelmohsen K, Gorospe M (2012) RNA-binding protein nucleolin in disease. RNA Biol 9(6):799\u2013808","journal-title":"RNA Biol"},{"key":"10703_CR9","doi-asserted-by":"publisher","first-page":"108493","DOI":"10.1016\/j.intimp.2021.108493","volume":"104","author":"A Asadirad","year":"2022","unstructured":"Asadirad A et al (2022) Dendritic cell immunotherapy with miR-155 enriched tumor-derived exosome suppressed cancer growth and induced antitumor immune responses in murine model of colorectal cancer induced by CT26 cell line. Int Immunopharmacol 104:108493","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"10703_CR3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.15171\/ijhpm.2018.100","volume":"8","author":"N Awofeso","year":"2019","unstructured":"Awofeso N, Imam SA, Ahmed A (2019) Content analysis of media coverage of childhood obesity topics in UAE newspapers and popular social media Platforms, 2014\u20132017. Int J Health Policy Manag 8(2):81\u201389","journal-title":"Int J Health Policy Manag"},{"issue":"2","key":"10703_CR33","doi-asserted-by":"publisher","first-page":"11784","DOI":"10.1080\/21655979.2021.1996508","volume":"12","author":"Z Cai","year":"2021","unstructured":"Cai Z, Chen Y (2021) Synergetic protective effect of Berberine and ginsenoside Rb1 against tumor necrosis factor alpha-induced inflammation in adipocytes. Bioengineered 12(2):11784\u201311796","journal-title":"Bioengineered"},{"issue":"12","key":"10703_CR11","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1515\/jpem-2018-0432","volume":"32","author":"R Chen","year":"2019","unstructured":"Chen R, Xin G, Zhang X (2019) Long non-coding RNA HCP5 serves as a CeRNA sponging miR-17-5p and miR-27a\/b to regulate the pathogenesis of childhood obesity via the MAPK signaling pathway. J Pediatr Endocrinol Metab 32(12):1327\u20131339","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"7","key":"10703_CR2","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s11883-023-01111-4","volume":"25","author":"ST Chung","year":"2023","unstructured":"Chung ST, Krenek A, Magge SN (2023) Childhood obesity and cardiovascular disease risk. Curr Atheroscler Rep 25(7):405\u2013415","journal-title":"Curr Atheroscler Rep"},{"issue":"1","key":"10703_CR35","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1186\/s13046-021-02193-1","volume":"40","author":"R Cuciniello","year":"2021","unstructured":"Cuciniello R, Filosa S, Crispi S (2021) Novel approaches in cancer treatment: preclinical and clinical development of small non-coding RNA therapeutics. J Exp Clin Cancer Res 40(1):383","journal-title":"J Exp Clin Cancer Res"},{"key":"10703_CR38","doi-asserted-by":"publisher","first-page":"109567","DOI":"10.1016\/j.biopha.2019.109567","volume":"120","author":"NA El-Shitany","year":"2019","unstructured":"El-Shitany NA, Eid BG (2019) Icariin modulates carrageenan-induced acute inflammation through HO-1\/Nrf2 and NF-kB signaling pathways. Biomed Pharmacother 120:109567","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10703_CR40","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1007\/s11596-020-2229-6","volume":"40","author":"L Fang","year":"2020","unstructured":"Fang L et al (2020) Nucleolin mediates LPS-induced expression of inflammatory mediators and activation of signaling pathways. Curr Med Sci 40(4):646\u2013653","journal-title":"Curr Med Sci"},{"issue":"6","key":"10703_CR1","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","volume":"49","author":"J Ferlay","year":"2013","unstructured":"Ferlay J et al (2013) Cancer incidence and mortality patterns in europe: estimates for 40 countries in 2012. Eur J Cancer 49(6):1374\u20131403","journal-title":"Eur J Cancer"},{"issue":"4","key":"10703_CR21","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1159\/000145784","volume":"1","author":"P Fischer-Posovszky","year":"2008","unstructured":"Fischer-Posovszky P et al (2008) Human SGBS cells\u2014a unique tool for studies of human fat cell biology. Obes Facts 1(4):184\u2013189","journal-title":"Obes Facts"},{"issue":"4","key":"10703_CR34","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2174\/2211536609666191209152721","volume":"9","author":"CAR Fl\u00f3rez","year":"2020","unstructured":"Fl\u00f3rez CAR, Garc\u00eda-Perdomo HA, Escudero MM (2020) MicroRNAs associated with overweight and obesity in childhood: A systematic review. Microrna 9(4):255\u2013265","journal-title":"Microrna"},{"issue":"12","key":"10703_CR26","doi-asserted-by":"publisher","first-page":"104258","DOI":"10.1016\/j.psj.2024.104258","volume":"103","author":"W Geng","year":"2024","unstructured":"Geng W et al (2024) IGFBP7 promotes the proliferation and differentiation of primary myoblasts and intramuscular preadipocytes in chicken. Poult Sci 103(12):104258","journal-title":"Poult Sci"},{"issue":"6","key":"10703_CR12","doi-asserted-by":"publisher","first-page":"e23540","DOI":"10.1002\/ajhb.23540","volume":"33","author":"LM Gonz\u00e1lez-Arce","year":"2021","unstructured":"Gonz\u00e1lez-Arce LM et al (2021) High expression levels of Circulating microRNA-122 and microRNA-222 are associated with obesity in children with Mayan ethnicity. Am J Hum Biol 33(6):e23540","journal-title":"Am J Hum Biol"},{"key":"10703_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12263-018-0622-6","volume":"14","author":"G Iacomino","year":"2019","unstructured":"Iacomino G et al (2019) Circulating MicroRNAs are associated with early childhood obesity: results of the I. Family study. Genes Nutr 14:2","journal-title":"Genes Nutr"},{"key":"10703_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2017.07.025","volume":"186","author":"W Jia","year":"2017","unstructured":"Jia W et al (2017) New perspectives of physiological and pathological functions of nucleolin (NCL). Life Sci 186:1\u201310","journal-title":"Life Sci"},{"key":"10703_CR27","doi-asserted-by":"publisher","first-page":"118762","DOI":"10.1016\/j.lfs.2020.118762","volume":"265","author":"Y Jiao","year":"2021","unstructured":"Jiao Y et al (2021) Ad36 promotes differentiation of hADSCs into brown adipocytes by up-regulating LncRNA ROR. Life Sci 265:118762","journal-title":"Life Sci"},{"issue":"4","key":"10703_CR6","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1089\/chi.2016.0176","volume":"13","author":"R Kelishadi","year":"2017","unstructured":"Kelishadi R et al (2017) Association of childhood obesity and the immune system: a systematic review of reviews. Child Obes 13(4):332\u2013346","journal-title":"Child Obes"},{"issue":"10","key":"10703_CR37","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1007\/s00284-021-02626-2","volume":"78","author":"S Mahant","year":"2021","unstructured":"Mahant S et al (2021) The synergistic role of tip \u03b1, nucleolin and Ras in Helicobacter pylori infection regulates the cell fate towards inflammation or apoptosis. Curr Microbiol 78(10):3720\u20133732","journal-title":"Curr Microbiol"},{"issue":"22","key":"10703_CR20","doi-asserted-by":"publisher","first-page":"4360","DOI":"10.1111\/bph.14830","volume":"176","author":"LH Mariero","year":"2019","unstructured":"Mariero LH et al (2019) Inhibiting nucleolin reduces inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation. Br J Pharmacol 176(22):4360\u20134372","journal-title":"Br J Pharmacol"},{"issue":"12","key":"10703_CR5","doi-asserted-by":"publisher","first-page":"e0168610","DOI":"10.1371\/journal.pone.0168610","volume":"11","author":"RT Mattos","year":"2016","unstructured":"Mattos RT et al (2016) Chronic Low-Grade inflammation in childhood obesity is associated with decreased IL-10 expression by monocyte subsets. PLoS ONE 11(12):e0168610","journal-title":"PLoS ONE"},{"issue":"2","key":"10703_CR29","first-page":"124","volume":"31","author":"BW McCrindle","year":"2015","unstructured":"McCrindle BW (2015) Cardiovascular consequences of childhood obesity. Can J Cardiol 31(2):124\u2013130","journal-title":"Can J Cardiol"},{"issue":"7","key":"10703_CR7","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1007\/s00394-017-1515-y","volume":"57","author":"NI Medeiros","year":"2018","unstructured":"Medeiros NI et al (2018) IL-10 and TGF-\u03b2 unbalanced levels in neutrophils contribute to increase inflammatory cytokine expression in childhood obesity. Eur J Nutr 57(7):2421\u20132430","journal-title":"Eur J Nutr"},{"issue":"2","key":"10703_CR13","doi-asserted-by":"publisher","first-page":"11756","DOI":"10.1080\/21655979.2021.2009618","volume":"12","author":"L Mei","year":"2021","unstructured":"Mei L, Li M, Zhang T (2021) MicroRNA miR-874-3p inhibits osteoporosis by targeting leptin (LEP). Bioengineered 12(2):11756\u201311767","journal-title":"Bioengineered"},{"issue":"7","key":"10703_CR32","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1016\/j.clnu.2019.09.004","volume":"39","author":"P Navarro","year":"2020","unstructured":"Navarro P et al (2020) Predictors of the dietary inflammatory index in children and associations with childhood weight status: A longitudinal analysis in the lifeways Cross-Generation cohort study. Clin Nutr 39(7):2169\u20132179","journal-title":"Clin Nutr"},{"issue":"13","key":"10703_CR8","doi-asserted-by":"publisher","first-page":"4528","DOI":"10.1093\/jxb\/erac098","volume":"73","author":"H Pietrykowska","year":"2022","unstructured":"Pietrykowska H et al (2022) Biogenesis, conservation, and function of MiRNA in liverworts. J Exp Bot 73(13):4528\u20134545","journal-title":"J Exp Bot"},{"issue":"10","key":"10703_CR22","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.3390\/biom11101545","volume":"11","author":"S Quarta","year":"2021","unstructured":"Quarta S et al (2021) Coffee bioactive N-Methylpyridinium attenuates tumor necrosis factor (TNF)-\u03b1-Mediated insulin resistance and inflammation in human adipocytes. Biomolecules 11(10):1545","journal-title":"Biomolecules"},{"issue":"1","key":"10703_CR4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/nu12010043","volume":"12","author":"LD Ruiz","year":"2019","unstructured":"Ruiz LD et al (2019) Adolescent obesity: diet quality, psychosocial Health, and cardiometabolic risk factors. Nutrients 12(1):43","journal-title":"Nutrients"},{"key":"10703_CR39","doi-asserted-by":"publisher","first-page":"112471","DOI":"10.1016\/j.biopha.2021.112471","volume":"145","author":"S Shahbazi","year":"2022","unstructured":"Shahbazi S, Zakerali T (2022) The inhibitory role of benzo-dioxole-piperamide on the phosphorylation process as an NF-Kappa B silencer. Biomed Pharmacother 145:112471","journal-title":"Biomed Pharmacother"},{"key":"10703_CR10","doi-asserted-by":"publisher","first-page":"108707","DOI":"10.1016\/j.meatsci.2021.108707","volume":"185","author":"L Shen","year":"2021","unstructured":"Shen L et al (2021) miR-152 targets pyruvate kinase to regulate the glycolytic activity of pig skeletal muscles and affects pork quality. Meat Sci 185:108707","journal-title":"Meat Sci"},{"issue":"3","key":"10703_CR31","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s11121-014-0505-z","volume":"16","author":"JD Smith","year":"2015","unstructured":"Smith JD et al (2015) Preventing weight gain and obesity: indirect effects of the family check-up in early childhood. Prev Sci 16(3):408\u2013419","journal-title":"Prev Sci"},{"issue":"6","key":"10703_CR25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3892\/ijmm.2024.5432","volume":"54","author":"JH Song","year":"2024","unstructured":"Song JH et al (2024) Nervonic acid improves fat transplantation by promoting adipogenesis and angiogenesis. Int J Mol Med 54(6):108","journal-title":"Int J Mol Med"},{"issue":"4","key":"10703_CR19","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1177\/1074248421989570","volume":"26","author":"Y Tang","year":"2021","unstructured":"Tang Y et al (2021) Nucleolin improves heart function during recovery from myocardial infarction by modulating macrophage polarization. J Cardiovasc Pharmacol Ther 26(4):386\u2013395","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"1","key":"10703_CR14","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s11010-021-04271-6","volume":"477","author":"Y Wang","year":"2022","unstructured":"Wang Y et al (2022) miR-874-3p mitigates cisplatin resistance through modulating NF-\u03baB\/inhibitor of apoptosis protein signaling pathway in epithelial ovarian cancer cells. Mol Cell Biochem 477(1):307\u2013317","journal-title":"Mol Cell Biochem"},{"issue":"13","key":"10703_CR30","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1056\/NEJM199709253371301","volume":"337","author":"RC Whitaker","year":"1997","unstructured":"Whitaker RC et al (1997) Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 337(13):869\u2013873","journal-title":"N Engl J Med"},{"issue":"6","key":"10703_CR24","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.3892\/ijmm.2020.4753","volume":"46","author":"J Wu","year":"2020","unstructured":"Wu J et al (2020) Modulation of MiRNAs by vitamin C in H2O2\u2013exposed human umbilical vein endothelial cells. Int J Mol Med 46(6):2150\u20132160","journal-title":"Int J Mol Med"},{"issue":"3","key":"10703_CR16","doi-asserted-by":"publisher","first-page":"C579","DOI":"10.1152\/ajpcell.00001.2020","volume":"319","author":"K Xie","year":"2020","unstructured":"Xie K et al (2020) Upregulating microRNA-874-3p inhibits CXCL12 expression to promote angiogenesis and suppress inflammatory response in ischemic stroke. Am J Physiol Cell Physiol 319(3):C579\u2013c588","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"10703_CR28","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s10735-025-10607-z","volume":"56","author":"Y Xu","year":"2025","unstructured":"Xu Y, Wang Y (2025) LncRNA TMEM147-AS1 promotes acute myeloid leukemia development by regulating miR-873-3p\/ZFX axis. J Mol Histol 56(5):334","journal-title":"J Mol Histol"},{"issue":"2","key":"10703_CR15","first-page":"231","volume":"68","author":"H Yang","year":"2021","unstructured":"Yang H et al (2021a) Overexpression of miR-874-3p alleviates LPS-induced apoptosis and inflammation in alveolar epithelial cell by targeting EGR3\/NF-\u03baB. Acta Biochim Pol 68(2):231\u2013238","journal-title":"Acta Biochim Pol"},{"issue":"4","key":"10703_CR23","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.cmet.2020.12.019","volume":"33","author":"W Ying","year":"2021","unstructured":"Ying W et al (2021b) MiR-690, an exosomal-derived MiRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. Cell Metab 33(4):781\u2013790e5","journal-title":"Cell Metab"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10703-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-025-10703-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-025-10703-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:24:06Z","timestamp":1772000646000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-025-10703-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,17]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10703"],"URL":"https:\/\/doi.org\/10.1007\/s10735-025-10703-0","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,17]]},"assertion":[{"value":"21 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"49"}}