{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:55:25Z","timestamp":1777373725097,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Fund \u201cScience\u201d of Medical University \u2013 Varna","award":["16011"],"award-info":[{"award-number":["16011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10735-026-10758-7","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:47:32Z","timestamp":1772502452000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Kochia scoparia seed infusion on calorie-rich diet-induced metabolic dysfunction and histopathological alterations in liver, adipose tissue and coronaries in rats"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-4873","authenticated-orcid":false,"given":"Mehmed","family":"Reyzov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-7716","authenticated-orcid":false,"given":"Silvia","family":"Gancheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4107-9752","authenticated-orcid":false,"given":"Stefka","family":"Valcheva-Kuzmanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-6075","authenticated-orcid":false,"given":"Maria","family":"Tzaneva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-4824","authenticated-orcid":false,"given":"Nadezhda","family":"Stefanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Eftimov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8493-7607","authenticated-orcid":false,"given":"Milena","family":"Todorova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1132-8813","authenticated-orcid":false,"given":"Maria","family":"Zhelyazkova-Savova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"issue":"D","key":"10758_CR1","first-page":"75","volume":"52","author":"M Abtulov","year":"2020","unstructured":"Abtulov M, Zhelyazkova-Savova M, Gancheva S, Kuzmanov K, Pavlov D, Kuzmanova V, Kuzmanov A, Salbashian M, Eftimov M, Valcheva-Kuzmanova S (2020) Effects of Kochia scoparia on carrageenan-induced paw edema in experimental model of metabolic syndrome. Bulg Chem Commun 52(D):75\u201377","journal-title":"Bulg Chem Commun"},{"key":"10758_CR2","unstructured":"Abtulov M, Gancheva S, Eftimov M, Todorova M, Valcheva-Kuzmanova S, Zhelyazkova-Savova M (2024) Kochia scoparia seed infusion improves triglyceride levels and glucose tolerance in rats on a high-calorie diet. In: VIII National congress of pharmacology, clinical pharmacology and therapeutics, pp 159\u2013166"},{"issue":"04","key":"10758_CR3","first-page":"2213","volume":"05","author":"AE Al-Snafi","year":"2018","unstructured":"Al-Snafi AE (2018) A review on pharmacological activities of Kochia scoparia\u2014a review. Indo Am J Pharm Sci 05(04):2213\u20132221","journal-title":"Indo Am J Pharm Sci"},{"issue":"7","key":"10758_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/nu16070939","volume":"16","author":"AK Azevedo-Martins","year":"2024","unstructured":"Azevedo-Martins AK, Santos MP, Abayomi J, Ferreira NJR, Evangelista FS (2024) The impact of excessive fructose intake on adipose tissue and the development of childhood obesity. Nutrients 16(7):939. https:\/\/doi.org\/10.3390\/nu16070939","journal-title":"Nutrients"},{"issue":"1","key":"10758_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-02936-1","volume":"20","author":"J Buniam","year":"2020","unstructured":"Buniam J, Chukijrungroat N, Rattanavichit Y, Surapongchai J, Weerachayaphorn J, Bupha-Intr T, Saengsirisuwan V (2020) 20-Hydroxyecdysone ameliorates metabolic and cardiovascular dysfunction in high-fat-high-fructose-fed ovariectomized rats. BMC Complement Med Ther 20(1):140. https:\/\/doi.org\/10.1186\/s12906-020-02936-1","journal-title":"BMC Complement Med Ther"},{"issue":"7","key":"10758_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11072071","volume":"11","author":"J Buniam","year":"2023","unstructured":"Buniam J, Chansela P, Weerachayaphorn J, Saengsirisuwan V (2023) Dietary supplementation with 20-hydroxyecdysone ameliorates hepatic steatosis and reduces white adipose tissue mass in ovariectomized rats fed a high-fat, high-fructose diet. Biomedicines 11(7):2071. https:\/\/doi.org\/10.3390\/biomedicines11072071","journal-title":"Biomedicines"},{"issue":"2","key":"10758_CR7","first-page":"1691","volume":"8","author":"J Chai","year":"2015","unstructured":"Chai J, Du X, Chen S, Feng X, Cheng Y, Zhang L, Gao Y, Li S, He X, Wang R, Zhou X, Yang Y, Luo W, Chen W (2015) Oral administration of oleanolic acid, isolated from Swertia mussotii Franch, attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats. Int J Clin Exp Med 8(2):1691\u20131702","journal-title":"Int J Clin Exp Med"},{"issue":"4","key":"10758_CR8","doi-asserted-by":"publisher","first-page":"830","DOI":"10.3390\/ijms20040830","volume":"20","author":"CT Che","year":"2019","unstructured":"Che CT, Zhang H (2019) Plant natural products for human health. Int J Mol Sci 20(4):830. https:\/\/doi.org\/10.3390\/ijms20040830","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10758_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0572-9","volume":"16","author":"Z Chen","year":"2017","unstructured":"Chen Z, Yu R, Xiong Y, Du F, Zhu S (2017) A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease. Lipids Health Dis 16(1):203. https:\/\/doi.org\/10.1186\/s12944-017-0572-9","journal-title":"Lipids Health Dis"},{"issue":"3","key":"10758_CR10","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/bf02976636","volume":"25","author":"J Choi","year":"2002","unstructured":"Choi J, Lee KT, Jung H, Park HS, Park HJ (2002) Anti-rheumatoid arthritis effect of the Kochia scoparia fruits and activity comparison of momordin Ic, its prosapogenin and sapogenin. Arch Pharm Res 25(3):336\u2013342. https:\/\/doi.org\/10.1007\/bf02976636","journal-title":"Arch Pharm Res"},{"issue":"2","key":"10758_CR11","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.jep.2014.04.009","volume":"154","author":"YY Choi","year":"2014","unstructured":"Choi YY, Kim MH, Lee JY, Hong J, Kim SH, Yang WM (2014) Topical application of Kochia scoparia inhibits the development of contact dermatitis in mice. J Ethnopharmacol 154(2):380\u2013385. https:\/\/doi.org\/10.1016\/j.jep.2014.04.009","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"10758_CR12","doi-asserted-by":"publisher","first-page":"E713","DOI":"10.1152\/ajpendo.00194.2007","volume":"293","author":"BM De Taeye","year":"2007","unstructured":"De Taeye BM, Novitskaya T, McGuinness OP, Gleaves L, Medda M, Covington JW, Vaughan DE (2007) Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity. Am J Physiol Endocrinol Metab 293(3):E713\u2013E725. https:\/\/doi.org\/10.1152\/ajpendo.00194.2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10758_CR13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jnutbio.2017.07.009","volume":"49","author":"J Dobner","year":"2017","unstructured":"Dobner J, Ress C, Rufinatscha K, Salzmann K, Salvenmoser W, Folie S, Wieser V, Moser P, Weiss G, Goebel G, Tilg H, Kaser S (2017) Fat-enriched rather than high-fructose diets promote whitening of adipose tissue in a sex-dependent manner. J Nutr Biochem 49:22\u201329. https:\/\/doi.org\/10.1016\/j.jnutbio.2017.07.009","journal-title":"J Nutr Biochem"},{"issue":"35","key":"10758_CR14","doi-asserted-by":"publisher","first-page":"9377","DOI":"10.1021\/acs.jafc.0c03310","volume":"68","author":"YZ Dong","year":"2020","unstructured":"Dong YZ, Li L, Espe M, Lu KL, Rahimnejad S (2020) Hydroxytyrosol attenuates hepatic fat accumulation via activating mitochondrial biogenesis and autophagy through the AMPK pathway. J Agric Food Chem 68(35):9377\u20139386. https:\/\/doi.org\/10.1021\/acs.jafc.0c03310","journal-title":"J Agric Food Chem"},{"issue":"4","key":"10758_CR15","first-page":"497","volume":"35","author":"K Drost-Karbowska","year":"1978","unstructured":"Drost-Karbowska K (1978) Alkaloidy Kochia scoparia L. Acta Pol Pharm 35(4):497\u2013501","journal-title":"Acta Pol Pharm"},{"issue":"3","key":"10758_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ani11030886","volume":"11","author":"SS Elblehi","year":"2021","unstructured":"Elblehi SS, El-Sayed YS, Soliman MM, Shukry M (2021) Date palm pollen extract averts doxorubicin-induced cardiomyopathy fibrosis and associated oxidative\/nitrosative stress, inflammatory cascade, and apoptosis-targeting Bax\/Bcl-2 and caspase-3 signaling pathways. Animals 11(3):886. https:\/\/doi.org\/10.3390\/ani11030886","journal-title":"Animals"},{"issue":"1","key":"10758_CR17","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","volume":"73","author":"M Eslam","year":"2020","unstructured":"Eslam M, Newsome PN, Sarin SK, Anstee QM, Targher G, Romero-Gomez M, Zelber-Sagi S, Wong VW-S, Dufour JF, Schattenberg JM, Kawaguchi T, Arrese M, Valenti L, Shiha G, Tiribelli C, Yki-J\u00e4rvinen H, Fan J-G, Gr\u00f8nb\u00e6k H, Yilmaz Y, Cortez-Pinto H, Oliveira CP, Bedossa P, Adams LA, Zheng M-H, Fouad Y, Chan W-K, Mendez-Sanchez N, Ahn S-H, Castera L, Bugianesi E, Ratziu V, George J (2020) A new definition for metabolic dysfunction\u2013associated fatty liver disease: an international expert consensus statement. J Hepatol 73(1):202\u2013209. https:\/\/doi.org\/10.1016\/j.jhep.2020.03.039","journal-title":"J Hepatol"},{"issue":"Suppl 2","key":"10758_CR18","doi-asserted-by":"publisher","first-page":"S362","DOI":"10.2337\/dc09-S340","volume":"32","author":"E Esteve","year":"2009","unstructured":"Esteve E, Ricart W, Fern\u00e1ndez-Real JM (2009) Adipocytokines and insulin resistance: the possible role of lipocalin-2, retinol binding protein-4, and adiponectin. Diabetes Care 32(Suppl 2):S362\u2013S367. https:\/\/doi.org\/10.2337\/dc09-S340","journal-title":"Diabetes Care"},{"issue":"9","key":"10758_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092056","volume":"11","author":"R Fabiani","year":"2019","unstructured":"Fabiani R, Naldini G, Chiavarini M (2019) Dietary patterns and metabolic syndrome in adult subjects: a systematic review and meta-analysis. Nutrients 11(9):2056. https:\/\/doi.org\/10.3390\/nu11092056","journal-title":"Nutrients"},{"issue":"11","key":"10758_CR20","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1161\/CIRCRESAHA.115.306885","volume":"118","author":"JJ Fuster","year":"2016","unstructured":"Fuster JJ, Ouchi N, Gokce N, Walsh K (2016) Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease. Circ Res 118(11):1786\u20131807. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.306885","journal-title":"Circ Res"},{"key":"10758_CR21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.14748\/ssm.v47i2.1145","volume":"47","author":"S Gancheva","year":"2015","unstructured":"Gancheva S, Zhelyazkova-Savova M, Galunska B, Chervenkov T (2015) Experimental models of metabolic syndrome in rats. Scr Sci Med 47:14\u201321. https:\/\/doi.org\/10.14748\/ssm.v47i2.1145","journal-title":"Scr Sci Med"},{"issue":"D","key":"10758_CR22","first-page":"60","volume":"52","author":"S Gancheva","year":"2020","unstructured":"Gancheva S, Tzaneva M, Valcheva-Kuzmanova S, Zhelyazkova-Savova M (2020) Antiobesity, antioxidant and hepatoprotective properties of aqueous infusion of Kochia scoparia seeds in rats with diet-induced metabolic syndrome. Bulg Chem Commun 52(D):60\u201367","journal-title":"Bulg Chem Commun"},{"issue":"4","key":"10758_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167110","volume":"1870","author":"T Ghatage","year":"2024","unstructured":"Ghatage T, Singh S, Mandal K, Dhar A (2024) Co-activation of Mas and pGC-A receptors suppresses endothelin-1-induced endothelial dysfunction via nitric oxide\/cGMP system. Biochimica Et Biophysica Acta Mol Basis Dis 1870(4):167110. https:\/\/doi.org\/10.1016\/j.bbadis.2024.167110","journal-title":"Biochimica Et Biophysica Acta Mol Basis Dis"},{"issue":"2","key":"10758_CR24","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00281-017-0666-5","volume":"40","author":"G Grandl","year":"2018","unstructured":"Grandl G, Wolfrum C (2018) Hemostasis, endothelial stress, inflammation, and the metabolic syndrome. Semin Immunopathol 40(2):215\u2013224. https:\/\/doi.org\/10.1007\/s00281-017-0666-5","journal-title":"Semin Immunopathol"},{"issue":"7","key":"10758_CR25","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1210\/jc.2010-0288","volume":"95","author":"F Guerrero-Romero","year":"2010","unstructured":"Guerrero-Romero F, Simental-Mend\u00eda LE, Gonz\u00e1lez-Ortiz M, Mart\u00ednez-Abundis E, Ramos-Zavala MG, Hern\u00e1ndez-Gonz\u00e1lez SO, Jacques-Camarena O, Rodr\u00edguez-Mor\u00e1n M (2010) The product of triglycerides and glucose, a simple measure of insulin sensitivity: comparison with the euglycemic\u2013hyperinsulinemic clamp. J Clin Endocrinol Metab 95(7):3347\u20133351. https:\/\/doi.org\/10.1210\/jc.2010-0288","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10758_CR26","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/ptr.1981","volume":"20","author":"LK Han","year":"2006","unstructured":"Han LK, Nose R, Li W, Gong XJ, Zheng YN, Yoshikawa M, Koike K, Nikaido T, Okuda H, Kimura Y (2006) Reduction of fat storage in mice fed a high-fat diet long term by treatment with saponins prepared from Kochia scoparia fruit. Phytother Res 20(10):877\u2013882. https:\/\/doi.org\/10.1002\/ptr.1981","journal-title":"Phytother Res"},{"key":"10758_CR27","unstructured":"Indiana State Board of Animal Health (n.d.) Rat Care Guidelines. Indiana State Board of Animal Health. https:\/\/www.in.gov\/boah\/files\/Rat-Care.pdf. Accessed 29 Jan 2026"},{"key":"10758_CR28","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5029414","volume":"2016","author":"K Jarukamjorn","year":"2016","unstructured":"Jarukamjorn K, Jearapong N, Pimson C, Chatuphonprasert W (2016) A high-fat, high-fructose diet induces antioxidant imbalance and increases the risk and progression of nonalcoholic fatty liver disease in mice. Scientifica (Cairo) 2016:5029414. https:\/\/doi.org\/10.1155\/2016\/5029414","journal-title":"Scientifica (Cairo)"},{"issue":"4","key":"10758_CR29","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3892\/ijo.2014.2535","volume":"45","author":"H Jin","year":"2014","unstructured":"Jin H, Lee WS, Eun SY, Jung JH, Park HS, Kim G, Choi YH, Ryu CH, Jung JM, Hong SC, Shin SC, Kim HJ (2014) Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB-231 partly through suppression of the Akt pathway. Int J Oncol 45(4):1629\u20131637. https:\/\/doi.org\/10.3892\/ijo.2014.2535","journal-title":"Int J Oncol"},{"issue":"2","key":"10758_CR30","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.3892\/mmr.2015.4698","volume":"13","author":"S Jo","year":"2016","unstructured":"Jo S, Ryu J, Han HY, Lee G, Ryu MH, Kim H (2016) Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice. Mol Med Rep 13(2):1695\u20131700. https:\/\/doi.org\/10.3892\/mmr.2015.4698","journal-title":"Mol Med Rep"},{"issue":"7121","key":"10758_CR31","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/nature05482","volume":"444","author":"SE Kahn","year":"2006","unstructured":"Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444(7121):840\u2013846. https:\/\/doi.org\/10.1038\/nature05482","journal-title":"Nature"},{"issue":"7","key":"10758_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071745","volume":"10","author":"M Kajikawa","year":"2022","unstructured":"Kajikawa M, Higashi Y (2022) Obesity and endothelial function. Biomedicines 10(7):1745. https:\/\/doi.org\/10.3390\/biomedicines10071745","journal-title":"Biomedicines"},{"issue":"2","key":"10758_CR33","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1021\/jf60186a041","volume":"21","author":"JA Kernan","year":"1973","unstructured":"Kernan JA, Coxworth E, Fleming S (1973) Microdetermination of triterpene sapogenin content of Kochia scoparia seed using gas-liquid chromatography. J Agric Food Chem 21(2):232\u2013234. https:\/\/doi.org\/10.1021\/jf60186a041","journal-title":"J Agric Food Chem"},{"issue":"2","key":"10758_CR34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1089\/jmf.2005.8.177","volume":"8","author":"NY Kim","year":"2005","unstructured":"Kim NY, Lee MK, Park MJ, Kim SJ, Park HJ, Choi JW, Kim SH, Cho SY, Lee JS (2005) Momordin Ic and oleanolic acid from Kochiae fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food 8(2):177\u2013183. https:\/\/doi.org\/10.1089\/jmf.2005.8.177","journal-title":"J Med Food"},{"issue":"23","key":"10758_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314982","volume":"23","author":"TV Kirichenko","year":"2022","unstructured":"Kirichenko TV, Markina YV, Bogatyreva AI, Tolstik TV, Varaeva YR, Starodubova AV (2022) The role of adipokines in inflammatory mechanisms of obesity. Int J Mol Sci 23(23):14982. https:\/\/doi.org\/10.3390\/ijms232314982","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10758_CR36","doi-asserted-by":"publisher","first-page":"E433","DOI":"10.1152\/ajpendo.90772.2008","volume":"296","author":"P Kizelsztein","year":"2009","unstructured":"Kizelsztein P, Govorko D, Komarnytsky S, Evans A, Wang Z, Cefalu WT, Raskin I (2009) 20-hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. Am J Physiol Endocrinol Metab 296(3):E433\u2013E439. https:\/\/doi.org\/10.1152\/ajpendo.90772.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"10758_CR37","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1530\/jme-21-0033","volume":"68","author":"R Lafont","year":"2021","unstructured":"Lafont R, Serova M, Didry-Barca B, Raynal S, Guibout L, Dinan L, Veillet S, Latil M, Dioh W, Dilda PJ (2021) 20-hydroxyecdysone activates the protective arm of the RAAS via the Mas receptor. J Mol Endocrinol 68(2):77\u201387. https:\/\/doi.org\/10.1530\/jme-21-0033","journal-title":"J Mol Endocrinol"},{"issue":"13","key":"10758_CR38","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.jacc.2018.08.1037","volume":"72","author":"CJ Lavie","year":"2018","unstructured":"Lavie CJ, Laddu D, Arena R, Ortega FB, Alpert MA, Kushner RF (2018) Healthy weight and obesity prevention: JACC health promotion series. J Am Coll Cardiol 72(13):1506\u20131531. https:\/\/doi.org\/10.1016\/j.jacc.2018.08.1037","journal-title":"J Am Coll Cardiol"},{"key":"10758_CR39","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/170532","volume":"2013","author":"Y Li","year":"2013","unstructured":"Li Y, Ding L, Hassan W, Abdelkader D, Shang J (2013) Adipokines and hepatic insulin resistance. J Diabetes Res 2013:170532. https:\/\/doi.org\/10.1155\/2013\/170532","journal-title":"J Diabetes Res"},{"issue":"1","key":"10758_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-023-00363-z","volume":"18","author":"IF Liu","year":"2023","unstructured":"Liu IF, Lin TC, Wang SC, Yen CH, Li CY, Kuo HF, Hsieh CC, Chang CY, Chang CR, Chen YH, Liu YR, Lee TY, Huang CY, Hsu CH, Lin SJ, Liu PL (2023) Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression. Biol Direct 18(1):9. https:\/\/doi.org\/10.1186\/s13062-023-00363-z","journal-title":"Biol Direct"},{"key":"10758_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev-arplant-050312-120142","volume":"64","author":"C Martin","year":"2013","unstructured":"Martin C, Zhang Y, Tonelli C, Petroni K (2013) Plants, diet, and health. Annu Rev Plant Biol 64:19\u201346. https:\/\/doi.org\/10.1146\/annurev-arplant-050312-120142","journal-title":"Annu Rev Plant Biol"},{"issue":"10","key":"10758_CR42","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1248\/bpb.20.1086","volume":"20","author":"H Matsuda","year":"1997","unstructured":"Matsuda H, Dai Y, Ido Y, Ko S, Yoshikawa M, Kubo M (1997) Studies on Kochiae Fructus. III. Antinociceptive and anti-inflammatory effects of 70% ethanol extract and its component, momordin Ic, from dried fruits of Kochia scoparia L. Biol Pharm Bull 20(10):1086\u20131091. https:\/\/doi.org\/10.1248\/bpb.20.1086","journal-title":"Biol Pharm Bull"},{"key":"10758_CR43","unstructured":"Moneva-Marinova K (2024) Pharmacological investigation of the effects of Chaenomeles maulei fruit juice in an experimental model of metabolic syndrome. Dissertation, Medical University of Varna"},{"issue":"10","key":"10758_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101502","volume":"10","author":"S Moreno-Fern\u00e1ndez","year":"2018","unstructured":"Moreno-Fern\u00e1ndez S, Garc\u00e9s-Rim\u00f3n M, Vera G, Astier J, Landrier JF, Miguel M (2018) High fat\/high glucose diet induces metabolic syndrome in an experimental rat model. Nutrients 10(10):1502. https:\/\/doi.org\/10.3390\/nu10101502","journal-title":"Nutrients"},{"issue":"1","key":"10758_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e12963","volume":"9","author":"C Noguera-Navarro","year":"2023","unstructured":"Noguera-Navarro C, Montoro-Garc\u00eda S, Orenes-Pi\u00f1ero E (2023) Hydroxytyrosol: its role in the prevention of cardiovascular diseases. Heliyon 9(1):e12963. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e12963","journal-title":"Heliyon"},{"issue":"suppl 2","key":"10758_CR46","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765202320220784","volume":"95","author":"B Oliveira-Cordeiro","year":"2023","unstructured":"Oliveira-Cordeiro B, Fernandes-da-Silva A, Silva-Veiga FM, Miranda CS, Martins FF, Souza-Mello V (2023) Long-term hepatic damage in high-fructose-fed C57BL\/6 mice: hepatic fibrogenesis, endoplasmic reticulum stress markers, and fibrosis. An Acad Bras Cienc 95(suppl 2):e20220784. https:\/\/doi.org\/10.1590\/0001-3765202320220784","journal-title":"An Acad Bras Cienc"},{"issue":"3","key":"10758_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2021.100078","volume":"1","author":"NN Orie","year":"2021","unstructured":"Orie NN, Raees A, Aljaber MY, Mohamed-Ali N, Bensmail H, Hamza MM, Al-Ansari N, Beotra A, Mohamed-Ali V, Almaadheed M (2021) 20-hydroxyecdysone dilates muscle arterioles in a nitric oxide-dependent, estrogen ER-\u03b2 receptor-independent manner. Phytomed plus 1(3):100078. https:\/\/doi.org\/10.1016\/j.phyplu.2021.100078","journal-title":"Phytomed plus"},{"issue":"8","key":"10758_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14082750","volume":"14","author":"M Pecani","year":"2025","unstructured":"Pecani M, Andreozzi P, Cangemi R, Corica B, Miglionico M, Romiti GF, Stefanini L, Raparelli V, Basili S (2025) Metabolic syndrome and liver disease: re-appraisal of screening, diagnosis, and treatment through the paradigm shift from NAFLD to MASLD. J Clin Med 14(8):2750. https:\/\/doi.org\/10.3390\/jcm14082750","journal-title":"J Clin Med"},{"key":"10758_CR49","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2020","author":"J Ren","year":"2021","unstructured":"Ren J, Wu NN, Wang S, Sowers JR, Zhang Y (2021) Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications. Physiol Rev. https:\/\/doi.org\/10.1152\/physrev.00030.2020","journal-title":"Physiol Rev"},{"issue":"3","key":"10758_CR50","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12913","volume":"18","author":"A Romero","year":"2019","unstructured":"Romero A, San Hip\u00f3lito-Luengo \u00c1, Villalobos LA, Vallejo S, Valencia I, Michalska P, Pajuelo-Lozano N, S\u00e1nchez-P\u00e9rez I, Le\u00f3n R, Bartha JL, Sanz MJ, Erusalimsky JD, S\u00e1nchez-Ferrer CF, Peir\u00f3 C (2019) The angiotensin-(1-7)\/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation. Aging Cell 18(3):e12913. https:\/\/doi.org\/10.1111\/acel.12913","journal-title":"Aging Cell"},{"issue":"2","key":"10758_CR51","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/eci.12583","volume":"46","author":"L S\u00e1nchez-\u00cd\u00f1igo","year":"2016","unstructured":"S\u00e1nchez-\u00cd\u00f1igo L, Navarro-Gonz\u00e1lez D, Fern\u00e1ndez-Montero A, Pastrana-Delgado J, Mart\u00ednez JA (2016) The tyg index may predict the development of cardiovascular events. Eur J Clin Invest 46(2):189\u2013197. https:\/\/doi.org\/10.1111\/eci.12583","journal-title":"Eur J Clin Invest"},{"issue":"11","key":"10758_CR52","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2811312","volume":"28","author":"MP Santos","year":"2023","unstructured":"Santos MP, Cauduro LFR, Ferreira MM, Martucci LF, Vecchiatto B, Vilas-Boas EA, Am\u00e9rico ALV, Pereira RO, Rogero MM, Fiorino P, Evangelista FS, Azevedo-Martins AK (2023) Effect of low-dose progesterone on glycemic metabolism, morphology and function of adipose tissue and pancreatic islets in diet-induced obese female mice. Front Biosci (Landmark Ed) 28(11):312. https:\/\/doi.org\/10.31083\/j.fbl2811312","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"4","key":"10758_CR53","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1248\/bpb.27.538","volume":"27","author":"KM Shin","year":"2004","unstructured":"Shin KM, Kim YH, Park WS, Kang I, Ha J, Choi JW, Park HJ, Lee KT (2004) Inhibition of methanol extract from the fruits of Kochia scoparia on lipopolysaccharide-induced nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha production from murine macrophage RAW 264.7 cells. Biol Pharm Bull 27(4):538\u2013543. https:\/\/doi.org\/10.1248\/bpb.27.538","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"10758_CR54","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1089\/met.2008.0034","volume":"6","author":"LE Simental-Mend\u00eda","year":"2008","unstructured":"Simental-Mend\u00eda LE, Rodr\u00edguez-Mor\u00e1n M, Guerrero-Romero F (2008) The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord 6(4):299\u2013304. https:\/\/doi.org\/10.1089\/met.2008.0034","journal-title":"Metab Syndr Relat Disord"},{"key":"10758_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-137","volume":"10","author":"TH Tsai","year":"2012","unstructured":"Tsai TH, Chai HT, Sun CK, Yen CH, Leu S, Chen YL, Chung SY, Ko SF, Chang HW, Wu CJ, Yip HK (2012) Obesity suppresses circulating level and function of endothelial progenitor cells and heart function. J Transl Med 10:137. https:\/\/doi.org\/10.1186\/1479-5876-10-137","journal-title":"J Transl Med"},{"issue":"4","key":"10758_CR56","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3920\/QAS2012.0218","volume":"6","author":"J Wang","year":"2014","unstructured":"Wang J, Yuan L, Cheng B, Li W, Xiao C, Wang Y, Liu X (2014) Antioxidant capacity and antitumor activity of Fructus kochiae extracts. Qual Assur Saf Crops Foods 6(4):383\u2013393. https:\/\/doi.org\/10.3920\/QAS2012.0218","journal-title":"Qual Assur Saf Crops Foods"},{"issue":"51","key":"10758_CR57","doi-asserted-by":"publisher","first-page":"339","DOI":"10.4103\/0973-1296.211023","volume":"13","author":"SR Yoo","year":"2017","unstructured":"Yoo SR, Jeong SJ, Lee NR, Shin HK, Seo CS (2017) Quantification analysis and in vitro anti-inflammatory effects of 20-hydroxyecdysone, momordin Ic, and oleanolic acid from the fructus of Kochia scoparia. Pharmacogn Mag 13(51):339\u2013344. https:\/\/doi.org\/10.4103\/0973-1296.211023","journal-title":"Pharmacogn Mag"},{"issue":"10","key":"10758_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e10896","volume":"8","author":"I Yustisia","year":"2022","unstructured":"Yustisia I, Tandiari D, Cangara MH, Hamid F, Daud NA (2022) A high-fat, high-fructose diet induced hepatic steatosis, renal lesions, dyslipidemia, and hyperuricemia in non-obese rats. Heliyon 8(10):e10896. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e10896","journal-title":"Heliyon"},{"issue":"2","key":"10758_CR59","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1076\/ceyr.17.2.149.5600","volume":"17","author":"LH Zeng","year":"1998","unstructured":"Zeng LH, Rootman DS, Burnstein A, Wu J, Wu TW (1998) Morin hydrate: a better protector than purpurogallin of corneal endothelial cell damage induced by xanthine oxidase and SIN-1. Curr Eye Res 17(2):149\u2013152. https:\/\/doi.org\/10.1076\/ceyr.17.2.149.5600","journal-title":"Curr Eye Res"},{"issue":"4","key":"10758_CR60","doi-asserted-by":"publisher","DOI":"10.3390\/nu8040198","volume":"8","author":"MG Zubir\u00eda","year":"2016","unstructured":"Zubir\u00eda MG, Alzamendi A, Moreno G, Rey MA, Spinedi E, Giovambattista A (2016) Long-term fructose intake increases adipogenic potential: evidence of direct effects of fructose on adipocyte precursor cells. Nutrients 8(4):198. https:\/\/doi.org\/10.3390\/nu8040198","journal-title":"Nutrients"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10758-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10758-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10758-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:56:37Z","timestamp":1777366597000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-026-10758-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10758"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10758-7","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"9 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal treatment and experimentation procedures were conducted in compliance with the national and international rules and regulations (EU directive 2010\/63\/EU for animal research). The animal study protocol was approved by the Bulgarian Food Safety Agency (document number 177\/07\/2017).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"99"}}