{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:49:21Z","timestamp":1777373361881,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Gansu province youth science and technology fund","award":["No.24JRRA1084"],"award-info":[{"award-number":["No.24JRRA1084"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10735-026-10780-9","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:39:24Z","timestamp":1774334364000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silencing soluble epoxide hydrolase protects against myocardial ischemia\u2013reperfusion injury through modulation of the YAP signaling pathway and macrophage polarization"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7127-6712","authenticated-orcid":false,"given":"Pengying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shidong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuntao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"10780_CR1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","volume":"33","author":"M Algoet","year":"2023","unstructured":"Algoet M et al (2023) Myocardial ischemia-reperfusion injury and the influence of inflammation. Trends Cardiovasc Med 33:357\u2013366. https:\/\/doi.org\/10.1016\/j.tcm.2022.02.005","journal-title":"Trends Cardiovasc Med"},{"key":"10780_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111036","volume":"115","author":"X Cheng","year":"2024","unstructured":"Cheng X et al (2024) Glycyrrhizic acid alleviated MI\/R-induced injuries by inhibiting Hippo\/YAP signaling pathways. Cell Signal 115:111036. https:\/\/doi.org\/10.1016\/j.cellsig.2024.111036","journal-title":"Cell Signal"},{"key":"10780_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25235488","author":"A Das Mahapatra","year":"2020","unstructured":"Das Mahapatra A, Choubey R, Datta B (2020) Small molecule soluble epoxide hydrolase inhibitors in multitarget and combination therapies for inflammation and cancer. Molecules (Basel, Switzerland). https:\/\/doi.org\/10.3390\/molecules25235488","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10780_CR4","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.yjmcc.2009.10.022","volume":"48","author":"Y Deng","year":"2010","unstructured":"Deng Y, Theken KN, Lee CR (2010) Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation. J Mol Cell Cardiol 48:331\u2013341. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.10.022","journal-title":"J Mol Cell Cardiol"},{"key":"10780_CR5","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/circulationaha.118.036044","volume":"139","author":"Q Fan","year":"2019","unstructured":"Fan Q et al (2019) Dectin-1 contributes to myocardial ischemia\/reperfusion injury by regulating macrophage polarization and neutrophil infiltration. Circulation 139:663\u2013678. https:\/\/doi.org\/10.1161\/circulationaha.118.036044","journal-title":"Circulation"},{"key":"10780_CR6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.prostaglandins.2016.04.006","volume":"123","author":"DJ Funk","year":"2016","unstructured":"Funk DJ, Sorg BL, Kopka K, Schmeiser HH (2016) Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro. Prostagl Other Lipid Med 123:63\u201367. https:\/\/doi.org\/10.1016\/j.prostaglandins.2016.04.006","journal-title":"Prostagl Other Lipid Med"},{"issue":"3","key":"10780_CR7","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.ecl.2022.02.005","volume":"51","author":"E Goldsborough 3rd","year":"2022","unstructured":"Goldsborough E 3rd, Osuji N, Blaha MJ (2022) Assessment of cardiovascular disease risk: a 2022 update. Endocrinol Metab Clin North Am 51(3):483\u2013509. https:\/\/doi.org\/10.1016\/j.ecl.2022.02.005","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10780_CR8","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1136\/heartjnl-2019-315707","volume":"106","author":"SP Hoole","year":"2020","unstructured":"Hoole SP, Bambrough P (2020) Recent advances in percutaneous coronary intervention. Heart (British Cardiac Society) 106:1380\u20131386. https:\/\/doi.org\/10.1136\/heartjnl-2019-315707","journal-title":"Heart (British Cardiac Society)"},{"key":"10780_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.prostaglandins.2016.05.004","volume":"125","author":"H Huang","year":"2016","unstructured":"Huang H, Weng J, Wang MH (2016) EETs\/sEH in diabetes and obesity-induced cardiovascular diseases. Prostagl Other Lipid Mediat 125:80\u201389. https:\/\/doi.org\/10.1016\/j.prostaglandins.2016.05.004","journal-title":"Prostagl Other Lipid Mediat"},{"key":"10780_CR10","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1159\/000493500","volume":"49","author":"X Huang","year":"2018","unstructured":"Huang X et al (2018) Ophiopogonin D reduces myocardial ischemia-reperfusion injury via upregulating CYP2J3\/EETs in rats. Cell Physiol Biochem 49:1646\u20131658. https:\/\/doi.org\/10.1159\/000493500","journal-title":"Cell Physiol Biochem"},{"key":"10780_CR11","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/fjc.0000000000000980","volume":"77","author":"H Kakavand","year":"2021","unstructured":"Kakavand H, Aghakouchakzadeh M, Coons JC, Talasaz AH (2021) Pharmacologic prevention of myocardial ischemia-reperfusion injury in patients with acute coronary syndrome undergoing percutaneous coronary intervention. J Cardiovas Pharmacol 77:430\u2013449. https:\/\/doi.org\/10.1097\/fjc.0000000000000980","journal-title":"J Cardiovas Pharmacol"},{"key":"10780_CR12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.14797\/mdcj-16-1-16","volume":"16","author":"NK Kapur","year":"2020","unstructured":"Kapur NK, Thayer KL, Zweck E (2020) Cardiogenic shock in the setting of acute myocardial infarction. Methodist DeBakey Cardiovas J 16:16\u201321. https:\/\/doi.org\/10.14797\/mdcj-16-1-16","journal-title":"Methodist DeBakey Cardiovas J"},{"key":"10780_CR13","doi-asserted-by":"publisher","DOI":"10.14503\/thij-23-8178","author":"SJ Kim","year":"2023","unstructured":"Kim SJ, Mesquita FCP, Hochman-Mendez C (2023) neW biomarkers for cardiovascular disease. Texas Heart Instit J. https:\/\/doi.org\/10.14503\/thij-23-8178","journal-title":"Texas Heart Instit J"},{"key":"10780_CR14","doi-asserted-by":"publisher","first-page":"9125","DOI":"10.1007\/s12274-022-4553-6","volume":"15","author":"M Lan","year":"2022","unstructured":"Lan M et al (2022) Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury. Nano Res 15:9125\u20139134. https:\/\/doi.org\/10.1007\/s12274-022-4553-6","journal-title":"Nano Res"},{"key":"10780_CR15","doi-asserted-by":"publisher","first-page":"520","DOI":"10.7150\/ijbs.8879","volume":"10","author":"YC Liu","year":"2014","unstructured":"Liu YC, Zou XB, Chai YF, Yao YM (2014) Macrophage polarization in inflammatory diseases. Int J Biol Sci 10:520\u2013529. https:\/\/doi.org\/10.7150\/ijbs.8879","journal-title":"Int J Biol Sci"},{"key":"10780_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2025.130821","volume":"1869","author":"T Liu","year":"2025","unstructured":"Liu T, Guo X, Fu Y, Zhang W (2025) SLAMF9 aggravates myocardial ischemia reperfusion injury through activating the Hippo-YAP pathway. Biochim Biophys Acta Gen Subj 1869:130821. https:\/\/doi.org\/10.1016\/j.bbagen.2025.130821","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"10780_CR17","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1161\/circresaha.116.308586","volume":"119","author":"T Matsuda","year":"2016","unstructured":"Matsuda T et al (2016) NF2 Activates Hippo signaling and promotes ischemia\/reperfusion injury in the heart. Circ Res 119:596\u2013606. https:\/\/doi.org\/10.1161\/circresaha.116.308586","journal-title":"Circ Res"},{"key":"10780_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.593225","volume":"11","author":"J Niu","year":"2020","unstructured":"Niu J et al (2020) Cardioprotective effect of Echinatin against ischemia\/reperfusion injury: Involvement of Hippo\/Yes-Associated Protein signaling. Front Pharmacol 11:593225. https:\/\/doi.org\/10.3389\/fphar.2020.593225","journal-title":"Front Pharmacol"},{"key":"10780_CR19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jjcc.2022.07.003","volume":"81","author":"Y Saito","year":"2023","unstructured":"Saito Y, Oyama K, Tsujita K, Yasuda S, Kobayashi Y (2023) Treatment strategies of acute myocardial infarction: updates on revascularization, pharmacological therapy, and beyond. J Cardiol 81:168\u2013178. https:\/\/doi.org\/10.1016\/j.jjcc.2022.07.003","journal-title":"J Cardiol"},{"key":"10780_CR20","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","volume":"233","author":"A Shapouri-Moghaddam","year":"2018","unstructured":"Shapouri-Moghaddam A et al (2018) Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol 233:6425\u20136440. https:\/\/doi.org\/10.1002\/jcp.26429","journal-title":"J Cell Physiol"},{"key":"10780_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/s0163-7827(03)00049-3","volume":"43","author":"AA Spector","year":"2004","unstructured":"Spector AA, Fang X, Snyder GD, Weintraub NL (2004) Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. Prog Lipid Res 43:55\u201390. https:\/\/doi.org\/10.1016\/s0163-7827(03)00049-3","journal-title":"Prog Lipid Res"},{"key":"10780_CR22","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.abb.2004.10.009","volume":"433","author":"M Spiecker","year":"2005","unstructured":"Spiecker M, Liao JK (2005) Vascular protective effects of Cytochrome P450 epoxygenase-derived eicosanoids. Arch Biochem Biophys 433:413\u2013420. https:\/\/doi.org\/10.1016\/j.abb.2004.10.009","journal-title":"Arch Biochem Biophys"},{"key":"10780_CR23","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1016\/s0140-6736(21)00684-x","volume":"397","author":"B Vogel","year":"2021","unstructured":"Vogel B et al (2021) The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030. Lancet (London, England) 397:2385\u20132438. https:\/\/doi.org\/10.1016\/s0140-6736(21)00684-x","journal-title":"Lancet (London, England)"},{"key":"10780_CR24","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2022.00055","author":"Y Wang","year":"2022","unstructured":"Wang Y, Ding J, Song H (2022) VSIG4 regulates macrophages polarization and alleviates inflammation through activating PI3K\/AKT and inhibiting TLR4\/NF-\u03baB pathway in myocardial ischemia-reperfusion injury rats. Physiol Int. https:\/\/doi.org\/10.1556\/2060.2022.00055","journal-title":"Physiol Int"},{"key":"10780_CR25","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1007\/s12012-024-09926-6","volume":"24","author":"H Wu","year":"2024","unstructured":"Wu H et al (2024) The multifaceted roles of Hippo-YAP in cardiovascular diseases. Cardiovasc Toxicol 24:1410\u20131427. https:\/\/doi.org\/10.1007\/s12012-024-09926-6","journal-title":"Cardiovasc Toxicol"},{"key":"10780_CR26","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.tem.2023.10.010","volume":"35","author":"Q Xiang","year":"2024","unstructured":"Xiang Q, Yi X, Zhu XH, Wei X, Jiang DS (2024) Regulated cell death in myocardial ischemia-reperfusion injury. Trends Endocrinol Metabol TEM 35:219\u2013234. https:\/\/doi.org\/10.1016\/j.tem.2023.10.010","journal-title":"Trends Endocrinol Metabol TEM"},{"key":"10780_CR27","doi-asserted-by":"publisher","first-page":"8707061","DOI":"10.1155\/2022\/8707061","volume":"2022","author":"S Xu","year":"2022","unstructured":"Xu S, Tao D (2022) Leptin alleviates inflammatory response in myocardial ischemia reperfusion injury. Dis Mark 2022:8707061. https:\/\/doi.org\/10.1155\/2022\/8707061","journal-title":"Dis Mark"},{"key":"10780_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00690","volume":"11","author":"C Yang","year":"2020","unstructured":"Yang C et al (2020) Neuroprotective effect of Catalpol via anti-oxidative, anti-inflammatory, and anti-apoptotic mechanisms. Front Pharmacol 11:690. https:\/\/doi.org\/10.3389\/fphar.2020.00690","journal-title":"Front Pharmacol"},{"key":"10780_CR29","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5089872","volume":"2021","author":"H Yu","year":"2021","unstructured":"Yu H et al (2021) RRM2 Improves cardiomyocyte proliferation after myocardial ischemia reperfusion injury through the Hippo-YAP pathway. Dis Markers 2021:5089872. https:\/\/doi.org\/10.1155\/2021\/5089872","journal-title":"Dis Markers"},{"key":"10780_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090","volume":"877","author":"C Yunna","year":"2020","unstructured":"Yunna C, Mengru H, Lei W, Weidong C (2020) Macrophage M1\/M2 polarization. Eur J Pharmacol 877:173090. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173090","journal-title":"Eur J Pharmacol"},{"key":"10780_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121122","volume":"310","author":"Y Zhang","year":"2022","unstructured":"Zhang Y et al (2022) Role of epoxyeicosatrienoic acids in cardiovascular diseases and cardiotoxicity of drugs. Life Sci 310:121122. https:\/\/doi.org\/10.1016\/j.lfs.2022.121122","journal-title":"Life Sci"},{"key":"10780_CR32","doi-asserted-by":"publisher","first-page":"e13762","DOI":"10.1111\/cpr.13762","volume":"58","author":"L Zhang","year":"2025","unstructured":"Zhang L et al (2025) Modelling myocardial ischemia\/reperfusion injury with inflammatory response in human ventricular cardiac organoids. Cell Prolifer 58:e13762. https:\/\/doi.org\/10.1111\/cpr.13762","journal-title":"Cell Prolifer"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10780-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10780-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10780-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:55:24Z","timestamp":1777366524000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-026-10780-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10780"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10780-9","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"10 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"125"}}