{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:47:07Z","timestamp":1782103627386,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10735-026-10792-5","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T15:40:46Z","timestamp":1776699646000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DNMT3a mediates FSTL3 methylation to regulate trophoblast proliferation, migration and invasion"],"prefix":"10.1007","volume":"57","author":[{"given":"Ning","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"issue":"4","key":"10792_CR1","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/pd.6478","volume":"44","author":"M Aerden","year":"2024","unstructured":"Aerden M, DE Borre M, Thienpont B (2024) Cell-free DNA methylation-based preeclampsia prediction: a\u00a0journey to improve maternal health. Prenat Diagn 44(4):418\u2013421","journal-title":"Prenat Diagn"},{"key":"10792_CR2","doi-asserted-by":"crossref","unstructured":"Chappell L C, Peter B, Green M E, et al. (2019) Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial. Lancet 394(10204):1181\u201390.","DOI":"10.1016\/S0140-6736(19)31963-4"},{"issue":"10","key":"10792_CR3","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1177\/1933719118765967","volume":"26","author":"Q Deng","year":"2019","unstructured":"Deng Q, Liu X, Yang Z et al (2019) Expression of N-Acetylglucosaminyltransferase III promotes trophoblast invasion and migration in early human placenta. Reprod Sci 26(10):1373\u20131381","journal-title":"Reprod Sci"},{"issue":"2","key":"10792_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1093\/humupd\/dml048","volume":"13","author":"C Ferretti","year":"2007","unstructured":"Ferretti C, Bruni L, Dangles-Marie V et al (2007) Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts. Hum Reprod Update 13(2):121\u2013141","journal-title":"Hum Reprod Update"},{"issue":"4","key":"10792_CR5","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1177\/1933719114529372","volume":"22","author":"SA Founds","year":"2015","unstructured":"Founds SA, Ren D, Roberts JM et al (2015) Follistatin-like 3 across gestation in preeclampsia and uncomplicated pregnancies among lean and obese women. Reprod Sci 22(4):402\u2013409","journal-title":"Reprod Sci"},{"key":"10792_CR6","doi-asserted-by":"crossref","unstructured":"Gehrs S, Jakab M, Gutjahr E, et al. (2022) Endothelial Dnmt3a controls placenta vascularization and function to support fetal growth. bioRxiv.","DOI":"10.1101\/2022.07.28.501807"},{"issue":"3","key":"10792_CR7","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s10735-025-10427-1","volume":"56","author":"X Huang","year":"2025","unstructured":"Huang X, Liao E, Chen A et al (2025) Mechanism of mitochondrial dysfunction on placental trophoblastic cells in intrahepatic cholestasis of pregnancy. J Mol Histol 56(3):140","journal-title":"J Mol Histol"},{"issue":"2","key":"10792_CR8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1161\/HYPERTENSIONAHA.116.08483","volume":"69","author":"Y Jia","year":"2017","unstructured":"Jia Y, Li T, Huang X et al (2017) Dysregulated DNA methyltransferase 3A upregulates IGFBP5 to suppress trophoblast cell migration and invasion in preeclampsia. Hypertension 69(2):356","journal-title":"Hypertension"},{"key":"10792_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111506","volume":"125","author":"Y Jia","year":"2025","unstructured":"Jia Y, Xie H, Wu S et al (2025) Induction of FAM46C expression mediated by DNMT3A downregulation is involved in early-onset preeclampsia through gene body methylation. Cell Signal 125:111506","journal-title":"Cell Signal"},{"issue":"18","key":"10792_CR10","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","volume":"76","author":"M KN\u00f6FLER","year":"2019","unstructured":"Kn\u00f6fler M, Haider S, Saleh L et al (2019) Human placenta and trophoblast development: key molecular mechanisms and model systems. Cell Mol Life Sci 76(18):3479\u20133496","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"10792_CR11","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1080\/14767058.2018.1515196","volume":"33","author":"Y Liu","year":"2020","unstructured":"Liu Y, Shan N, Yuan Y et al (2020) Knockdown of activated Cdc42-associated kinase inhibits human extravillous trophoblast migration and invasion and decreases protein expression of pho-Akt and matrix metalloproteinase. J Matern-Fetal Neonatal Med 33(7):1125\u20131133","journal-title":"The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet"},{"issue":"6","key":"10792_CR12","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1161\/HYPERTENSIONAHA.113.01892","volume":"62","author":"F Lyall","year":"2013","unstructured":"Lyall F, Robson SC, Bulmer JN (2013) Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction: relationship to clinical outcome. Hypertension (Dallas, Tex\u202f: 1979) 6(6):10461054","journal-title":"Hypertension (Dallas, Tex : 1979)"},{"key":"10792_CR13","doi-asserted-by":"crossref","unstructured":"Macdonald T M, Walker S P, Hannan N J, et al. (2022) Clinical tools and biomarkers to predict preeclampsia. EBioMedicine 75:103780.","DOI":"10.1016\/j.ebiom.2021.103780"},{"issue":"8","key":"10792_CR14","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1161\/CIRCULATIONAHA.113.003664","volume":"130","author":"K Melchiorre","year":"2014","unstructured":"Melchiorre K, Sharma R, Thilaganathan B (2014) Cardiovascular implications in preeclampsia: an overview. Circulation 130(8):703\u2013714","journal-title":"Circulation"},{"key":"10792_CR15","doi-asserted-by":"crossref","unstructured":"Practice C O O, Gynecol S F M-F M J O (2018) ACOG Committee Opinion No. 743: low-dose aspirin use during pregnancy. Obstet Gynecol 132(1): e44\u201352.","DOI":"10.1097\/AOG.0000000000002708"},{"issue":"1","key":"10792_CR16","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1080\/14767058.2019.1588877","volume":"34","author":"A Rafii Tabrizi","year":"2021","unstructured":"Rafii Tabrizi A, Ayoubi JM, Ahmed B (2021) Practical approach to the prevention of preeclampsia: from screening to pharmaceutical intervention. J Matern Fetal Neonatal Med 34(1):152\u2013158","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"5","key":"10792_CR17","doi-asserted-by":"publisher","first-page":"679","DOI":"10.2174\/1570159X18666200807130637","volume":"19","author":"AK Ramachandran","year":"2021","unstructured":"Ramachandran AK, Das S, Joseph A et al (2021) Neurodegenerative pathways in Alzheimer\u2019s disease: a review. Curr Neuropharmacol 19(5):679\u2013692","journal-title":"Curr Neuropharmacol"},{"key":"10792_CR18","doi-asserted-by":"crossref","unstructured":"Rana, Sarosh, Lemoine, et al. (2019) Preeclampsia pathophysiology, challenges, and perspectives. Circulat Res 124(7):1094\u20131112","DOI":"10.1161\/CIRCRESAHA.118.313276"},{"issue":"3","key":"10792_CR19","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.bbrc.2018.10.139","volume":"506","author":"J Xie","year":"2018","unstructured":"Xie J, Xu Y, Wan L et al (2018) Involvement of Follistatin-like 3 in preeclampsia. Biochem Biophys Res Commun 506(3):692\u2013697","journal-title":"Biochem Biophys Res Commun"},{"key":"10792_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.573781","volume":"8","author":"J Xie","year":"2020","unstructured":"Xie J, Zhu H, Chang HM et al (2020) GDF8 promotes the cell invasiveness in human trophoblasts by upregulating the expression of Follistatin-Like 3 through the ALK5-SMAD2\/3 signaling pathway. Front Cell Dev Biol 8:573781","journal-title":"Front Cell Dev Biol"},{"issue":"13","key":"10792_CR21","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202302705R","volume":"38","author":"YF Yang","year":"2024","unstructured":"Yang YF, Li ZH, Liu TH et al (2024) Evaluating the role of DNA methyltransferases in trophoblast fusion and preeclampsia development: insights from methylation-regulated genes. FASEB J 38(13):e23706","journal-title":"FASEB J"},{"issue":"1","key":"10792_CR22","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12933-024-02258-3","volume":"23","author":"J Zhang","year":"2024","unstructured":"Zhang J, Wang G, Shi Y et al (2024) Growth differentiation factor 11 regulates high glucose-induced cardiomyocyte pyroptosis and diabetic cardiomyopathy by inhibiting inflammasome activation. Cardiovasc Diabetol 23(1):160","journal-title":"Cardiovasc Diabetol"},{"key":"10792_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121623","volume":"321","author":"X Zheng","year":"2023","unstructured":"Zheng X, Lian Y, Zhou J et al (2023) Placental ischemia disrupts DNA methylation patterns in distal regulatory regions in rats. Life Sci 321:121623","journal-title":"Life Sci"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10792-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10792-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10792-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:48:23Z","timestamp":1782100103000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-026-10792-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10792"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10792-5","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"21 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"144"}}