{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:47:12Z","timestamp":1782103632592,"version":"3.54.5"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10735-026-10826-y","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:15:44Z","timestamp":1778652944000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dendrobine promotes osteogenesis-angiogenesis in postmenopausal osteoporosis by inhibiting Hippo signaling pathway"],"prefix":"10.1007","volume":"57","author":[{"given":"Xiangping","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingtao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"issue":"13","key":"10826_CR7","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1001\/jama.290.13.1729","volume":"290","author":"JA Cauley","year":"2003","unstructured":"Cauley JA et al (2003) Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women\u2019s Health Initiative randomized trial. JAMA 290(13):1729\u20131738","journal-title":"JAMA"},{"issue":"4","key":"10826_CR2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.eprac.2021.01.019","volume":"27","author":"M Chandran","year":"2021","unstructured":"Chandran M (2021) AACE\/ACE clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update: risk stratification and intervention thresholds. Endocr Pract 27(4):378","journal-title":"Endocr Pract"},{"issue":"3","key":"10826_CR18","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.3390\/ijms24032365","volume":"24","author":"H Chen","year":"2023","unstructured":"Chen H et al (2023) Dendrobine alleviates cellular senescence and osteoarthritis via the ROS\/NF-\u03baB axis. Int J Mol Sci 24(3):2365","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10826_CR38","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1093\/jbmr\/zjae079","volume":"39","author":"JR Curtis","year":"2024","unstructured":"Curtis JR et al (2024) Comparative effectiveness of denosumab vs alendronate among postmenopausal women with osteoporosis. J Bone Min Res 39(7):826\u2013834","journal-title":"J Bone Min Res"},{"key":"10826_CR23","doi-asserted-by":"publisher","first-page":"153838","DOI":"10.1016\/j.phymed.2021.153838","volume":"96","author":"W Deng","year":"2022","unstructured":"Deng W et al (2022) Dendrobine attenuates osteoclast differentiation through modulating ROS\/NFATc1\/ MMP9 pathway and prevents inflammatory bone destruction. Phytomedicine 96:153838","journal-title":"Phytomedicine"},{"issue":"1","key":"10826_CR37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00774-024-01536-0","volume":"43","author":"K Ebina","year":"2025","unstructured":"Ebina K et al (2025) Clinical effects of teriparatide, abaloparatide, and romosozumab in postmenopausal osteoporosis. J Bone Min Metab 43(1):3\u20139","journal-title":"J Bone Min Metab"},{"issue":"3","key":"10826_CR15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/bcpt.13524","volume":"128","author":"Y Feng","year":"2021","unstructured":"Feng Y et al (2021) Dendrobine attenuates gestational diabetes mellitus in mice by inhibiting Th17 cells. Basic Clin Pharmacol Toxicol 128(3):379\u2013385","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"10826_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1242\/dev.045500","volume":"138","author":"G Halder","year":"2011","unstructured":"Halder G, Johnson RL (2011) Hippo signaling: growth control and beyond. Development 138(1):9\u201322","journal-title":"Development"},{"issue":"4","key":"10826_CR32","doi-asserted-by":"publisher","first-page":"8950","DOI":"10.1080\/21655979.2022.2056825","volume":"13","author":"Y Han","year":"2022","unstructured":"Han Y et al (2022) Epigallocatechin gallate attenuates tumor necrosis factor (TNF)-\u03b1-induced inhibition of osteoblastic differentiation by up-regulating lncRNA TUG1 in osteoporosis. Bioengineered 13(4):8950\u20138961","journal-title":"Bioengineered"},{"key":"10826_CR20","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fendo.2016.00108","volume":"7","author":"FA Jacobs","year":"2016","unstructured":"Jacobs FA et al (2016) Vanadate impedes adipogenesis in mesenchymal stem cells derived from different depots within bone. Front Endocrinol (Lausanne) 7:108","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"10826_CR30","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0169-6009(91)90124-I","volume":"15","author":"DN Kalu","year":"1991","unstructured":"Kalu DN (1991) The ovariectomized rat model of postmenopausal bone loss. Bone Min 15(3):175\u2013191","journal-title":"Bone Min"},{"issue":"1","key":"10826_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/jbmr.2405","volume":"30","author":"AA Khan","year":"2015","unstructured":"Khan AA et al (2015) Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Min Res 30(1):3\u201323","journal-title":"J Bone Min Res"},{"issue":"1","key":"10826_CR21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/BF01880411","volume":"1","author":"MA Kotowicz","year":"1990","unstructured":"Kotowicz MA et al (1990) Relationship between serum intact parathyroid hormone concentrations and bone remodeling in type I osteoporosis: evidence that skeletal sensitivity is increased. Osteoporos Int 1(1):14\u201322","journal-title":"Osteoporos Int"},{"issue":"7492","key":"10826_CR8","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature13145","volume":"507","author":"AP Kusumbe","year":"2014","unstructured":"Kusumbe AP, Ramasamy SK, Adams RH (2014) Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 507(7492):323\u2013328","journal-title":"Nature"},{"issue":"1","key":"10826_CR40","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s10020-024-00893-w","volume":"30","author":"J Li","year":"2024","unstructured":"Li J et al (2024) Epimedin A inhibits the PI3K\/AKT\/NF-\u03baB signalling axis and osteoclast differentiation by negatively regulating TRAF6 expression. Mol Med 30(1):125","journal-title":"Mol Med"},{"issue":"18","key":"10826_CR14","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1021\/acs.jafc.7b00276","volume":"65","author":"R Li","year":"2017","unstructured":"Li R et al (2017) Anti-influenza a virus activity of dendrobine and its mechanism of action. J Agric Food Chem 65(18):3665\u20133674","journal-title":"J Agric Food Chem"},{"key":"10826_CR13","doi-asserted-by":"publisher","first-page":"109073","DOI":"10.1016\/j.biopha.2019.109073","volume":"117","author":"S Li","year":"2019","unstructured":"Li S et al (2019) Induction of Nrf2 pathway by Dendrobium nobile Lindl. alkaloids protects against carbon tetrachloride induced acute liver injury. Biomed Pharmacother 117:109073","journal-title":"Biomed Pharmacother"},{"key":"10826_CR11","doi-asserted-by":"publisher","first-page":"104497","DOI":"10.1016\/j.fitote.2020.104497","volume":"142","author":"GY Liu","year":"2020","unstructured":"Liu GY et al (2020) Dendrobine-type alkaloids and bibenzyl derivatives from Dendrobium findlayanum. Fitoterapia 142:104497","journal-title":"Fitoterapia"},{"issue":"10","key":"10826_CR5","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.metabol.2015.07.011","volume":"64","author":"P Makras","year":"2015","unstructured":"Makras P, Delaroudis S, Anastasilakis AD (2015) Novel therapies for osteoporosis. Metabolism 64(10):1199\u20131214","journal-title":"Metabolism"},{"key":"10826_CR4","doi-asserted-by":"publisher","first-page":"h3783","DOI":"10.1136\/bmj.h3783","volume":"351","author":"S Maraka","year":"2015","unstructured":"Maraka S, Kennel KA (2015) Bisphosphonates for the prevention and treatment of osteoporosis. BMJ 351:h3783","journal-title":"BMJ"},{"issue":"7","key":"10826_CR25","doi-asserted-by":"publisher","first-page":"11842","DOI":"10.1002\/jcp.27821","volume":"234","author":"HY Min","year":"2019","unstructured":"Min HY et al (2019) OVO homologue-like 1 promotes osteoblast differentiation through BMP2 expression. J Cell Physiol 234(7):11842\u201311849","journal-title":"J Cell Physiol"},{"issue":"5","key":"10826_CR10","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1021\/jf970930a","volume":"47","author":"M Miyazawa","year":"1999","unstructured":"Miyazawa M et al (1999) Moscatilin from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. J Agric Food Chem 47(5):2163\u20132167","journal-title":"J Agric Food Chem"},{"key":"10826_CR12","doi-asserted-by":"publisher","first-page":"e2739","DOI":"10.7717\/peerj.2739","volume":"4","author":"J Nie","year":"2016","unstructured":"Nie J et al (2016) Dendrobium alkaloids prevent A\u03b2(25\u201335)-induced neuronal and synaptic loss via promoting neurotrophic factors expression in mice. PeerJ 4:e2739","journal-title":"PeerJ"},{"issue":"10","key":"10826_CR33","doi-asserted-by":"publisher","first-page":"5255","DOI":"10.1021\/acsbiomaterials.9b00618","volume":"5","author":"P Nie","year":"2019","unstructured":"Nie P et al (2019) Dasatinib promotes chondrogenic differentiation of human mesenchymal stem cells via the Src\/Hippo-YAP signaling pathway. ACS Biomater Sci Eng 5(10):5255\u20135265","journal-title":"ACS Biomater Sci Eng"},{"issue":"3\u20134","key":"10826_CR28","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1242\/dmm.004226","volume":"3","author":"N Ortega","year":"2010","unstructured":"Ortega N et al (2010) Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Dis Model Mech 3(3\u20134):224\u2013235","journal-title":"Dis Model Mech"},{"issue":"4","key":"10826_CR19","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/s41401-021-00690-9","volume":"43","author":"H Pan","year":"2022","unstructured":"Pan H et al (2022) Metabolic characterization of a potent natural neuroprotective agent dendrobine in vitro and in rats. Acta Pharmacol Sin 43(4):1059\u20131071","journal-title":"Acta Pharmacol Sin"},{"key":"10826_CR24","doi-asserted-by":"publisher","first-page":"1730978","DOI":"10.1155\/2019\/1730978","volume":"2019","author":"V Paspaliaris","year":"2019","unstructured":"Paspaliaris V, Kolios G (2019) Stem cells in osteoporosis: from biology to new therapeutic approaches. Stem Cells Int 2019:1730978","journal-title":"Stem Cells Int"},{"issue":"9773","key":"10826_CR3","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","volume":"377","author":"TD Rachner","year":"2011","unstructured":"Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet 377(9773):1276\u20131287","journal-title":"Lancet"},{"issue":"10329","key":"10826_CR36","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/S0140-6736(21)02646-5","volume":"399","author":"IR Reid","year":"2022","unstructured":"Reid IR, Billington EO (2022) Drug therapy for osteoporosis in older adults. Lancet 399(10329):1080\u20131092","journal-title":"Lancet"},{"key":"10826_CR16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.phymed.2018.06.018","volume":"53","author":"TH Song","year":"2019","unstructured":"Song TH et al (2019) Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo. Phytomedicine 53:18\u201327","journal-title":"Phytomedicine"},{"issue":"1","key":"10826_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","volume":"4","author":"T S\u00f6zen","year":"2017","unstructured":"S\u00f6zen T, \u00d6z\u0131\u015f\u0131k L, Ba\u015faran N (2017) An overview and management of osteoporosis. Eur J Rheumatol 4(1):46\u201356","journal-title":"Eur J Rheumatol"},{"issue":"Suppl 5","key":"10826_CR22","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00198-003-1473-5","volume":"14","author":"DA Towler","year":"2003","unstructured":"Towler DA (2003) Angiogenesis and marrow stromal cell fates: roles in bone strength. Osteoporos Int 14(Suppl 5):46\u20135","journal-title":"Osteoporos Int"},{"key":"10826_CR29","doi-asserted-by":"publisher","first-page":"66","DOI":"10.22203\/eCM.v001a08","volume":"1","author":"AS Turner","year":"2001","unstructured":"Turner AS (2001) Animal models of osteoporosis\u2013necessity and limitations. Eur Cell Mater 1:66\u201381","journal-title":"Eur Cell Mater"},{"issue":"4","key":"10826_CR27","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1002\/jbmr.2087","volume":"29","author":"T Weng","year":"2014","unstructured":"Weng T et al (2014) Inactivation of Vhl in osteochondral progenitor cells causes high bone mass phenotype and protects against age-related bone loss in adult mice. J Bone Min Res 29(4):820\u2013829","journal-title":"J Bone Min Res"},{"key":"10826_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/1471-2164-11-229","volume":"11","author":"A Wilson","year":"2010","unstructured":"Wilson A et al (2010) Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells. BMC Genomics 11:229","journal-title":"BMC Genomics"},{"issue":"4","key":"10826_CR31","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s00223-019-00647-5","volume":"106","author":"W Xie","year":"2020","unstructured":"Xie W et al (2020) Neuropeptide Y1 receptor antagonist alters gut microbiota and alleviates the ovariectomy-induced osteoporosis in rats. Calcif Tissue Int 106(4):444\u2013454","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"10826_CR26","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1159\/000494531","volume":"50","author":"H Yin","year":"2018","unstructured":"Yin H et al (2018) Inhibition of Src homology 2 domain-containing protein tyrosine phosphatase-2 facilitates CD31hiEndomucinhi blood vessel and bone formation in ovariectomized mice. Cell Physiol Biochem 50(3):1068\u20131083","journal-title":"Cell Physiol Biochem"},{"key":"10826_CR39","doi-asserted-by":"publisher","first-page":"156705","DOI":"10.1016\/j.phymed.2025.156705","volume":"141","author":"L Zeng","year":"2025","unstructured":"Zeng L et al (2025) Gusongan capsule enhances osteogenic differentiation to mitigate bone loss in ovariectomized rats via the TLR2\/NF-\u03baB pathway. Phytomedicine 141:156705","journal-title":"Phytomedicine"},{"issue":"8","key":"10826_CR34","doi-asserted-by":"publisher","first-page":"13969","DOI":"10.1002\/jcp.28082","volume":"234","author":"Q Zhang","year":"2019","unstructured":"Zhang Q et al (2019) Receptor activity-modifying protein 1 regulates the phenotypic expression of BMSCs via the Hippo\/Yap pathway. J Cell Physiol 234(8):13969\u201313976","journal-title":"J Cell Physiol"},{"issue":"1","key":"10826_CR41","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41392-023-01354-2","volume":"8","author":"Q Zhu","year":"2023","unstructured":"Zhu Q et al (2023) OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2. Signal Transduct Target Ther 8(1):142","journal-title":"Signal Transduct Target Ther"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10826-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10826-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10826-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:48:38Z","timestamp":1782100118000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-026-10826-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10826"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10826-y","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"4 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Xiangping Meng, Xingtao Chen and Jin Huang declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal experiments were authorized under the Ethics Committee approval of Wuhan Myhalic Biotechnology Co., Ltd. (Approval number: HLK-202405078; Approval date: May 8, 2024).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}}],"article-number":"164"}}