{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:25:11Z","timestamp":1786951511058,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100011493","name":"Taizhou Science and Technology Bureau","doi-asserted-by":"crossref","award":["TS202421"],"award-info":[{"award-number":["TS202421"]}],"id":[{"id":"10.13039\/501100011493","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10735-026-10871-7","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:43:19Z","timestamp":1783129399000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lasiokaurin suppresses hepatocellular carcinoma proliferation and induces apoptosis via the JAK2\/STAT3 pathway"],"prefix":"10.1007","volume":"57","author":[{"given":"Hu","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"issue":"1","key":"10871_CR1","doi-asserted-by":"publisher","first-page":"20220656","DOI":"10.1515\/biol-2022-0656","volume":"18","author":"J Qiu","year":"2023","unstructured":"Qiu J, Wang H, Lv X et al (2023) Hepatocellular carcinoma cell differentiation trajectory predicts immunotherapy, potential therapeutic drugs, and prognosis of patients. Open Life Sci 18(1):20220656. https:\/\/doi.org\/10.1515\/biol-2022-0656","journal-title":"Open Life Sci"},{"issue":"4","key":"10871_CR2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1097\/meg.0000000000003130","volume":"38","author":"H Feng","year":"2026","unstructured":"Feng H, Xiao J, Li Z, Wei Q, Li B, Ren L (2026) The prognostic value of protein induced by vitamin K absence or antagonist-II in hepatocellular carcinoma patients undergoing surgical resection. Eur J Gastroenterol Hepatol 38(4):493\u2013502. https:\/\/doi.org\/10.1097\/meg.0000000000003130","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10871_CR3","doi-asserted-by":"publisher","first-page":"117119","DOI":"10.1016\/j.bcp.2025.117119","volume":"241","author":"R Tu","year":"2025","unstructured":"Tu R, Wang Y, Xu R et al (2025) The CCR5\/ROS\/NRF2 axis mediates dihydrotanshinone I-Induced oxidative stress and apoptosis in hepatocellular carcinoma. Biochem Pharmacol 241:117119. https:\/\/doi.org\/10.1016\/j.bcp.2025.117119","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"10871_CR4","doi-asserted-by":"publisher","first-page":"a021535","DOI":"10.1101\/cshperspect.a021535","volume":"5","author":"CY Liu","year":"2015","unstructured":"Liu CY, Chen KF, Chen PJ (2015) Treatment of liver cancer. Cold Spring Harb Perspect Med 5(9):a021535. https:\/\/doi.org\/10.1101\/cshperspect.a021535","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"1","key":"10871_CR5","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41392-021-00572-w","volume":"6","author":"L Zhong","year":"2021","unstructured":"Zhong L, Li Y, Xiong L et al (2021) Small molecules in targeted cancer therapy: advances, challenges, and future perspectives. Signal Transduct Target Therapy 6(1):201. https:\/\/doi.org\/10.1038\/s41392-021-00572-w","journal-title":"Signal Transduct Target Therapy"},{"issue":"23","key":"10871_CR6","doi-asserted-by":"publisher","first-page":"doi103390molecu","DOI":"10.3390\/molecules28237701","volume":"28","author":"J Lin","year":"2023","unstructured":"Lin J, Qu Z, Pu H et al (2023) In vitro and in vivo anti-cancer activity of Lasiokaurin in a triple-negative breast cancer model. Molecules 28(23):doi103390molecules28237701","journal-title":"Molecules"},{"key":"10871_CR7","doi-asserted-by":"publisher","first-page":"104869","DOI":"10.1016\/j.critrevonc.2025.104869","volume":"213","author":"S Wang","year":"2025","unstructured":"Wang S, He Y, He X, Luo E, Wang J (2025) Targeting hepatocellular carcinoma: molecular mechanisms and clinical studies. Crit Rev Oncol\/Hematol 213:104869. https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104869","journal-title":"Crit Rev Oncol\/Hematol"},{"issue":"4","key":"10871_CR8","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3390\/molecules29040825","volume":"29","author":"X Song","year":"2024","unstructured":"Song X (2024) Antibacterial antifungal, and antiviral bioactive compounds from natural products. Molecules 29(4):825. https:\/\/doi.org\/10.3390\/molecules29040825","journal-title":"Molecules"},{"key":"10871_CR9","doi-asserted-by":"publisher","first-page":"117212","DOI":"10.1016\/j.bcp.2025.117212","volume":"242","author":"R Huang","year":"2025","unstructured":"Huang R, Jin P, Cao J, Liu J, Liu Z, Chen J (2025) Lasiokaurin suppresses breast cancer growth by blocking autophagic flux and regulating cellular energy homeostasis. Biochem Pharmacol 242:117212. https:\/\/doi.org\/10.1016\/j.bcp.2025.117212","journal-title":"Biochem Pharmacol"},{"key":"10871_CR10","doi-asserted-by":"publisher","first-page":"100303","DOI":"10.1016\/j.prmcm.2023.100303","volume":"9","author":"H Pu","year":"2023","unstructured":"Pu H, Lin J, Shen L-S et al (2023) Exploring the in vitro and in vivo anticancer activity of Lasiokaurin on nasopharyngeal carcinoma. Pharmacol Res Mod Chin Med 9:100303. https:\/\/doi.org\/10.1016\/j.prmcm.2023.100303","journal-title":"Pharmacol Res Mod Chin Med"},{"issue":"1","key":"10871_CR11","doi-asserted-by":"publisher","first-page":"6010","DOI":"10.1080\/21655979.2021.1972199","volume":"12","author":"H Zhang","year":"2021","unstructured":"Zhang H, Fang Z, Guo Y, Wang D (2021) Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690. Bioengineered 12(1):6010\u20136020. https:\/\/doi.org\/10.1080\/21655979.2021.1972199","journal-title":"Bioengineered"},{"key":"10871_CR12","doi-asserted-by":"publisher","first-page":"101968","DOI":"10.1016\/j.tice.2022.101968","volume":"79","author":"H Ghufran","year":"2022","unstructured":"Ghufran H, Azam M, Mehmood A et al (2022) Tumoricidal effects of unprimed and curcumin-primed adipose-derived stem cells on human hepatoma HepG2 cells under oxidative conditions. Tissue Cell 79:101968. https:\/\/doi.org\/10.1016\/j.tice.2022.101968","journal-title":"Tissue Cell"},{"issue":"6","key":"10871_CR13","doi-asserted-by":"publisher","first-page":"469","DOI":"10.14218\/jcth.2024.00369","volume":"13","author":"T Li","year":"2025","unstructured":"Li T, Shen X, Zhang T et al (2025) Oleanolic acid restores drug sensitivity in sorafenib-resistant hepatocellular carcinoma: evidence from in vitro and in vivo studies. J Clin Transl Hepatol 13(6):469\u2013483. https:\/\/doi.org\/10.14218\/jcth.2024.00369","journal-title":"J Clin Transl Hepatol"},{"issue":"8","key":"10871_CR14","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1002\/glia.24007","volume":"69","author":"W Quan","year":"2005","unstructured":"Quan W, Luo Q, Hao W et al (2005) Haploinsufficiency of microglial MyD88 ameliorates Alzheimer\u2019s pathology and vascular disorders in APP\/PS1-transgenic mice. Glia 2021 69(8):1987. https:\/\/doi.org\/10.1002\/glia.24007","journal-title":"Glia 2021"},{"issue":"1","key":"10871_CR15","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1186\/s12885-024-12848-9","volume":"24","author":"H Tao","year":"2024","unstructured":"Tao H, Chen Z, Yao B et al (2024) Galaxamide alleviates cisplatin-induced premature ovarian insufficiency via the PI3K signaling pathway in HeLa tumor-bearing mice. BMC Cancer 24(1):1060. https:\/\/doi.org\/10.1186\/s12885-024-12848-9","journal-title":"BMC Cancer"},{"issue":"2","key":"10871_CR16","doi-asserted-by":"publisher","first-page":"e24461","DOI":"10.1016\/j.heliyon.2024.e24461","volume":"10","author":"J Li","year":"2024","unstructured":"Li J, Zhu C, Zhang Z, Zheng X, Wang C, Zhang H (2024) Paeoniflorin increases the anti-tumor efficacy of sorafenib in tumor-bearing mice with liver cancer via suppressing the NF-\u03bab\/PD-l1 axis. Heliyon 10(2):e24461. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e24461","journal-title":"Heliyon"},{"issue":"9","key":"10871_CR17","doi-asserted-by":"publisher","first-page":"4743","DOI":"10.3390\/ijms22094743","volume":"22","author":"IJ Cho","year":"2021","unstructured":"Cho IJ, Kim JK, Kim EO et al (2021) Hemistepsin a Induces apoptosis of hepatocellular carcinoma cells by downregulating STAT3. Int J Mol Sci 22(9):4743. https:\/\/doi.org\/10.3390\/ijms22094743","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10871_CR18","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.4161\/auto.29639","volume":"10","author":"LM Lindqvist","year":"2014","unstructured":"Lindqvist LM, Vaux DL (2014) BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy.10(8),1474-5. https:\/\/doi.org\/10.4161\/auto.29639","journal-title":"Autophagy"},{"key":"10871_CR19","doi-asserted-by":"publisher","first-page":"654986","DOI":"10.3389\/fphar.2021.654986","volume":"12","author":"X Hu","year":"2021","unstructured":"Hu X, Jiao F, Zhang L, Jiang Y (2021) Dihydrotanshinone inhibits hepatocellular carcinoma by suppressing the JAK2\/STAT3 pathway. Front Pharmacol 12:654986. https:\/\/doi.org\/10.3389\/fphar.2021.654986","journal-title":"Front Pharmacol"},{"issue":"5","key":"10871_CR20","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.3390\/cancers12051107","volume":"12","author":"J Mohrherr","year":"2020","unstructured":"Mohrherr J, Uras IZ, Moll HP, Casanova E (2020) STAT3: versatile functions in non-small cell lung cancer. Cancers (Basel) 12(5):1107. https:\/\/doi.org\/10.3390\/cancers12051107","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10871_CR21","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3892\/ijo.2025.5766","volume":"67","author":"Y Li","year":"2025","unstructured":"Li Y, Du X, Mao J (2025) Advancements in the therapeutic potential of sesquiterpenoids for the treatment of hepatocellular carcinoma (Review). Int J Oncol 67(1):60. https:\/\/doi.org\/10.3892\/ijo.2025.5766","journal-title":"Int J Oncol"},{"issue":"1","key":"10871_CR22","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/s12964-024-01630-w","volume":"22","author":"Y Groza","year":"2024","unstructured":"Groza Y, Lacina L, Kucha\u0159 M et al (2024) Small protein blockers of human IL-6 receptor alpha inhibit proliferation and migration of cancer cells. Cell Commun Signal 22(1):261. https:\/\/doi.org\/10.1186\/s12964-024-01630-w","journal-title":"Cell Commun Signal"},{"issue":"44","key":"10871_CR23","doi-asserted-by":"publisher","first-page":"77915","DOI":"10.18632\/oncotarget.20946","volume":"8","author":"PY Zhuang","year":"2017","unstructured":"Zhuang PY, Zhang KW, Wang JD et al (2017) Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells. Oncotarget 8(44):77915\u201377927. https:\/\/doi.org\/10.18632\/oncotarget.20946","journal-title":"Oncotarget"},{"key":"10871_CR24","doi-asserted-by":"publisher","first-page":"101828","DOI":"10.1016\/j.tranon.2023.101828","volume":"39","author":"Q Peng","year":"2024","unstructured":"Peng Q, Tao J, Xu Y et al (2024) Lipid metabolism-associated genes serve as potential predictive biomarkers in neoadjuvant chemoradiotherapy combined with immunotherapy in rectal cancer. Transl Oncol 39:101828. https:\/\/doi.org\/10.1016\/j.tranon.2023.101828","journal-title":"Transl Oncol"},{"issue":"8Supplement","key":"10871_CR25","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1158\/1538-7445.Am2011-1018","volume":"71","author":"C Han","year":"2011","unstructured":"Han C, Huang S, Wu T (2011) Abstract 1018: Regulation of STAT3 by PPARdelta in human hepatocellular carcinoma. Cancer Res 71(8Supplement):1018\u20131018. https:\/\/doi.org\/10.1158\/1538-7445.Am2011-1018","journal-title":"Cancer Res"},{"key":"10871_CR26","doi-asserted-by":"publisher","first-page":"726909","DOI":"10.3389\/fimmu.2021.726909","volume":"12","author":"L Wang","year":"2021","unstructured":"Wang L, Li Y, Xu M et al (2021) Regulation of inflammatory cytokine storms by mesenchymal stem cells. Front Immunol 12:726909. https:\/\/doi.org\/10.3389\/fimmu.2021.726909","journal-title":"Front Immunol"},{"issue":"1\u20132","key":"10871_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11010-013-1896-z","volume":"388","author":"GS Chew","year":"2014","unstructured":"Chew GS, Myers S, Shu-Chien AC, Muhammad TS (2014) Interleukin-6 inhibition of peroxisome proliferator-activated receptor alpha expression is mediated by JAK2- and PI3K-induced STAT1\/3 in HepG2 hepatocyte cells. Mol Cell Biochem 388(1\u20132):25\u201337. https:\/\/doi.org\/10.1007\/s11010-013-1896-z","journal-title":"Mol Cell Biochem"},{"key":"10871_CR28","doi-asserted-by":"publisher","unstructured":"Wang X, Liu M, Cai GH et al (2020) A potential nutraceutical candidate Lactucin inhibits adipogenesis through downregulation of JAK2\/STAT3 signaling pathway-mediated mitotic clonal expansion. Cells 9(2). https:\/\/doi.org\/10.3390\/cells9020331","DOI":"10.3390\/cells9020331"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10871-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10871-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10871-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:49:19Z","timestamp":1786949359000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-026-10871-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10871"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10871-7","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"20 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animals were cared for in strict accordance with the Guide for the Care and Use of Laboratory Animals (Chinese 8th Guide, revised 2012), and the experimental design was approved by the Ethics Committee of Jiangsu Hanjiang Biotechnology Co., Ltd. (Ethical approval number: HJSW-24111401) on November 14, 2024.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In the process of writing this article, the author did not use AI or AI-assisted Technologies.","order":3,"name":"Ethics","label":"Declaration of AI and AI-assisted technologies in the writing process","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"221"}}