{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:25:51Z","timestamp":1786955151646,"version":"build-2736575974"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10735-026-10874-4","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:15:10Z","timestamp":1782407710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite\u2013chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-\u03baB expression"],"prefix":"10.1007","volume":"57","author":[{"given":"Dhafer Abdulwasea","family":"Alshaibani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Josef","family":"Kamadjaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratri Maya","family":"Sitalaksmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwi Wahyu","family":"Indrawati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darmawan","family":"Setijanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Ainoosah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Yaseen","family":"Alqutaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redhwan Saleh","family":"Al-Gabri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"10874_CR1","doi-asserted-by":"publisher","first-page":"104986","DOI":"10.1016\/j.jdent.2024.104986","volume":"145","author":"MR Fok","year":"2024","unstructured":"Fok MR, Jin L (2024) Learn, unlearn, and relearn post-extraction alveolar socket healing: Evolving knowledge and practices. J Dent 145:104986","journal-title":"J Dent"},{"key":"10874_CR2","doi-asserted-by":"publisher","first-page":"S229","DOI":"10.1016\/j.identj.2024.07.084","volume":"74","author":"Z Khurshid","year":"2024","unstructured":"Khurshid Z, Alibrahim B, Faheemuddin M, Ashi H, Alfaraj A, Ali RMM et al (2024) Dental Implant Bone Grafting with Camel Dentine Derived Hydroxyapatite. Int Dent J 74:S229\u2013S30","journal-title":"Int Dent J"},{"key":"10874_CR3","doi-asserted-by":"publisher","first-page":"4616","DOI":"10.3390\/ijerph16234616","volume":"16","author":"HK Lin","year":"2019","unstructured":"Lin HK, Pan YH, Salamanca E, Lin YT, Chang WJ (2019) Prevention of bone resorption by HA\/\u03b2-TCP+ collagen composite after tooth extraction: a case series. Int J Environ Res Public Health 16:4616","journal-title":"Int J Environ Res Public Health"},{"key":"10874_CR4","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41415-019-0647-2","volume":"227","author":"AS Kalsi","year":"2019","unstructured":"Kalsi AS, Kalsi JS, Bassi S (2019) Alveolar ridge preservation: why, when and how. Br Dent J 227:264\u2013274","journal-title":"Br Dent J"},{"key":"10874_CR5","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40902-024-00425-w","volume":"46","author":"S Kim","year":"2024","unstructured":"Kim S, Kim SG (2024) Advancements in alveolar bone grafting and ridge preservation: a narrative review on materials, techniques, and clinical outcomes. Maxillofac Plast Reconstr Surg 46:14","journal-title":"Maxillofac Plast Reconstr Surg"},{"key":"10874_CR6","doi-asserted-by":"publisher","first-page":"105612","DOI":"10.1016\/j.jdent.2025.105612","volume":"154","author":"MO Elboraey","year":"2025","unstructured":"Elboraey MO, Alqutaibi AY, Aboalrejal AN, Borzangy S, Zafar MS, Al-Gabri R et al (2025) Regenerative approaches in alveolar bone augmentation for dental implant placement: Techniques, biomaterials, and clinical decision-making: A comprehensive review. J Dent 154:105612","journal-title":"J Dent"},{"key":"10874_CR7","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13104-025-07191-6","volume":"18","author":"S Yasser","year":"2025","unstructured":"Yasser S, Mohammed AAar, El-Safty S, Shon A, Al-Gabri RS, Alqutaibi AY et al (2025) Comparing the effect of using calcified autogenous nano dentin particles versus micro dentin particles in the healing of mandibular bony defects in New Zealand rabbits. BMC Res Notes 18:125","journal-title":"BMC Res Notes"},{"key":"10874_CR8","first-page":"0","volume":"40","author":"C Sobacchi","year":"2025","unstructured":"Sobacchi C, Menale C, Crisafulli L, Ficara F (2025) Role of RANKL Signaling in bone homeostasis. Physiol (Bethesda) 40:0","journal-title":"Physiol (Bethesda)"},{"key":"10874_CR9","doi-asserted-by":"crossref","unstructured":"Wu Z, Li W, Jiang K, Lin Z, Qian C, Wu M et al (2024) Regulation of bone homeostasis: signaling pathways and therapeutic targets. MedComm (2020) 5:e657","DOI":"10.1002\/mco2.657"},{"key":"10874_CR10","doi-asserted-by":"crossref","unstructured":"Munao S, Armeli A, Bonfiglio D, Iaconis A, Calabrese G (2025) Immune-Guided bone healing: The role of osteoimmunity in tissue engineering approaches. Int J Mol Sci 26:11642","DOI":"10.3390\/ijms262311642"},{"key":"10874_CR11","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/jre.13326","volume":"60","author":"A Valverde","year":"2025","unstructured":"Valverde A, George A, Nares S, Naqvi AR (2025) Emerging therapeutic strategies targeting bone signaling pathways in periodontitis. J Periodontal Res 60:101\u2013120","journal-title":"J Periodontal Res"},{"key":"10874_CR12","doi-asserted-by":"crossref","unstructured":"Marian D, Toro G, D\u2019Amico G, Trotta MC, D\u2019Amico M, Petre A et al (2024) Challenges and innovations in alveolar bone regeneration: A narrative review on materials, techniques, clinical outcomes, and future directions. Med (Kaunas) ;61","DOI":"10.3390\/medicina61010020"},{"key":"10874_CR13","doi-asserted-by":"publisher","first-page":"102236","DOI":"10.1016\/j.apmt.2024.102236","volume":"38","author":"Y Dang","year":"2024","unstructured":"Dang Y, Zhang Y, Luo G, Li D, Ma Y, Xiao Y et al (2024) The decisive early phase of biomaterial-induced bone regeneration. Appl Mater Today 38:102236","journal-title":"Appl Mater Today"},{"key":"10874_CR14","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1186\/s12903-025-06368-6","volume":"25","author":"DA Alshaibani","year":"2025","unstructured":"Alshaibani DA, Kamadjaja MJ, Sitalaksmi RM, Ridwan RD, Al-Gabri RS, Zafar MS et al (2025) Regenerative potential of human dental pulp stem cells in scaffold-based alveolar and jaw bone reconstruction: a systematic review. BMC Oral Health 25:986","journal-title":"BMC Oral Health"},{"key":"10874_CR15","first-page":"415","volume":"44","author":"C Prahasanti","year":"2019","unstructured":"Prahasanti C, Subrata LH, Saskianti T, Suardita K, Ernawati DS (2019) Combined hydroxyapatite scaffold and stem cell from human exfoliated deciduous teeth modulating alveolar bone regeneration via regulating receptor activator of nuclear factor-\u039ab and osteoprotegerin system. Iran J Med Sci 44:415","journal-title":"Iran J Med Sci"},{"key":"10874_CR16","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1177\/1055665620962360","volume":"58","author":"K Bangun","year":"2021","unstructured":"Bangun K, Sukasah CL, Dilogo IH, Indrani DJ, Siregar NC, Pandelaki J et al (2021) Bone growth capacity of human umbilical cord mesenchymal stem cells and BMP-2 seeded into hydroxyapatite\/chitosan\/gelatin scaffold in alveolar cleft defects: an experimental study in goat. Cleft Palate-Craniofacial J 58:707\u2013717","journal-title":"Cleft Palate-Craniofacial J"},{"key":"10874_CR17","doi-asserted-by":"publisher","first-page":"5768285","DOI":"10.1155\/2019\/5768285","volume":"2019","author":"P Zhou","year":"2019","unstructured":"Zhou P, Li X, Zhang B, Shi Q, Li D, Ju X (2019) A human umbilical cord mesenchymal stem cell-conditioned medium\/chitosan\/collagen\/\u03b2\u2010glycerophosphate thermosensitive hydrogel promotes burn injury healing in mice. Biomed Res Int 2019:5768285","journal-title":"Biomed Res Int"},{"key":"10874_CR18","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1080\/09205063.2019.1692641","volume":"31","author":"MI Wahba","year":"2020","unstructured":"Wahba MI (2020) Enhancement of the mechanical properties of chitosan. J Biomater Sci Polym Ed 31:350\u2013375","journal-title":"J Biomater Sci Polym Ed"},{"key":"10874_CR19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.20473\/j.djmkg.v54.i2.p68-73","volume":"54","author":"MJK Kamadjaja","year":"2021","unstructured":"Kamadjaja MJK (2021) Bone remodeling using a three-dimensional chitosan-hydroxyapatite scaffold seeded with hypoxic conditioned human amnion mesenchymal stem cells. Dent J 54:68\u201373","journal-title":"Dent J"},{"key":"10874_CR20","doi-asserted-by":"publisher","first-page":"101416","DOI":"10.1016\/j.jobcr.2026.101416","volume":"16","author":"D Rianti","year":"2026","unstructured":"Rianti D, Fauzia B, Bramantoro T, Ridwan RD, Meizarini A, Wati SM et al (2026) Chitosan-gelatin scaffold reinforced with carbonate hydroxyapatite enhances bone healing in rat extraction sockets: An immunohistochemical study. J Oral Biol Craniofac Res 16:101416","journal-title":"J Oral Biol Craniofac Res"},{"key":"10874_CR21","doi-asserted-by":"publisher","first-page":"140516","DOI":"10.1016\/j.ijbiomac.2025.140516","volume":"302","author":"NA Salem","year":"2025","unstructured":"Salem NA, ElShebiney SA, Mabrouk M, Kishta MS, Galal AF, Osama L et al (2025) Enhanced bone regeneration using mesenchymal stem cell-loaded 3D-printed alginate-calcium Titanate scaffolds: A Calvarial defect model study. Int J Biol Macromol 302:140516","journal-title":"Int J Biol Macromol"},{"key":"10874_CR22","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1007\/s12015-021-10157-3","volume":"17","author":"E Semenova","year":"2021","unstructured":"Semenova E, Grudniak MP, Machaj EK, Bocian K, Chroscinska-Krawczyk M, Trochonowicz M et al (2021) Mesenchymal stromal cells from different parts of umbilical cord: Approach to comparison & characteristics. Stem Cell Rev Rep 17:1780\u20131795","journal-title":"Stem Cell Rev Rep"},{"key":"10874_CR23","doi-asserted-by":"publisher","first-page":"118570","DOI":"10.1016\/j.biopha.2025.118570","volume":"192","author":"T Gornicki","year":"2025","unstructured":"Gornicki T, Jozkowiak M, Data K, Domagala D, Niebora J, Okowinska E et al (2025) Wharton\u2019s jelly mesenchymal stem cells (WJ-MSCs), a Holy Grail in tissue bioengineering and reconstructive medicine. Biomed Pharmacother 192:118570","journal-title":"Biomed Pharmacother"},{"key":"10874_CR24","doi-asserted-by":"publisher","first-page":"410","DOI":"10.4252\/wjsc.v16.i4.410","volume":"16","author":"SN Rajput","year":"2024","unstructured":"Rajput SN, Naeem BK, Ali A, Salim A, Khan I (2024) Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine. World J Stem Cells 16:410\u2013433","journal-title":"World J Stem Cells"},{"key":"10874_CR25","doi-asserted-by":"publisher","first-page":"1421674","DOI":"10.3389\/fbioe.2024.1421674","volume":"12","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Fan M, Zhang Y (2024) Revolutionizing bone defect healing: the power of mesenchymal stem cells as seeds. Front Bioeng Biotechnol 12:1421674","journal-title":"Front Bioeng Biotechnol"},{"key":"10874_CR26","doi-asserted-by":"publisher","first-page":"1063815","DOI":"10.3389\/fendo.2022.1063815","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Liang J, Liu P, Wang Q, Liu L, Zhao H (2022) The RANK\/RANKL\/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies. Front Endocrinol 13:1063815","journal-title":"Front Endocrinol"},{"key":"10874_CR27","doi-asserted-by":"publisher","first-page":"1518398","DOI":"10.3389\/fbioe.2025.1518398","volume":"13","author":"L He","year":"2025","unstructured":"He L, Li Q (2025) Application of biomaterials in mesenchymal stem cell based endometrial reconstruction: current status and challenges. Front Bioeng Biotechnol 13:1518398","journal-title":"Front Bioeng Biotechnol"},{"key":"10874_CR28","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/17435889.2024.2439242","volume":"20","author":"D Han","year":"2025","unstructured":"Han D, Wang W, Gong J, Ma Y, Li Y (2025) Controlled delivery of mesenchymal stem cells via biodegradable scaffolds for fracture healing. Nanomed (Lond) 20:207\u2013224","journal-title":"Nanomed (Lond)"},{"key":"10874_CR29","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG (2010) The ARRIVE guidelines animal research: reporting in vivo experiments. PLoS Biol 8:e1000412","journal-title":"PLoS Biol"},{"key":"10874_CR30","doi-asserted-by":"publisher","first-page":"1400640","DOI":"10.3389\/fendo.2024.1400640","volume":"15","author":"PE Cornejo Ulloa","year":"2024","unstructured":"Cornejo Ulloa PE, Krom BP, Schoonmade LJ, van der Veen MH (2024) Sex steroid hormones: an overlooked yet fundamental factor in oral homeostasis in humans. Front Endocrinol (Lausanne) 15:1400640","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10874_CR31","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1902\/jop.2017.160771","volume":"88","author":"ES Willett","year":"2017","unstructured":"Willett ES, Liu J, Berke M, Giannini PJ, Schmid M, Jia Z et al (2017) Standardized rat model testing effects of inflammation and grafting on extraction healing. J Periodontol 88:799\u2013807","journal-title":"J Periodontol"},{"key":"10874_CR32","doi-asserted-by":"publisher","first-page":"e20170326","DOI":"10.1590\/1678-7757-2017-0326","volume":"26","author":"JS Hassumi","year":"2018","unstructured":"Hassumi JS, Mulinari-Santos G, Fabris A, Jacob RGM, Goncalves A, Rossi AC et al (2018) Alveolar bone healing in rats: micro-CT, immunohistochemical and molecular analysis. J Appl Oral Sci 26:e20170326","journal-title":"J Appl Oral Sci"},{"key":"10874_CR33","doi-asserted-by":"publisher","first-page":"420","DOI":"10.4236\/jbise.2015.87039","volume":"8","author":"N Hendrijantini","year":"2015","unstructured":"Hendrijantini N, Utari Kresnoadi N, Salim S, Agustono B, Retnowati E, Syahrial I et al (2015) Study biocompatibility and osteogenic differentiation potential of human umbilical cord mesenchymal stem cells (hUCMSCs) with gelatin solvent. J Biomedical Sci Eng 8:420\u2013428","journal-title":"J Biomedical Sci Eng"},{"key":"10874_CR34","doi-asserted-by":"crossref","unstructured":"Kent L (2009) Freezing and thawing human embryonic stem cells. J Vis Exp 1555","DOI":"10.3791\/1555-v"},{"key":"10874_CR35","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315\u2013317","journal-title":"Cytotherapy"},{"key":"10874_CR36","doi-asserted-by":"publisher","first-page":"6682223","DOI":"10.1155\/2023\/6682223","volume":"2023","author":"T -Al-Arafat","year":"2023","unstructured":"-Al-Arafat T, Ahmed S, Karmakar PC, Zohora US, Akhtar N, Asaduzzaman S (2023) Effects of gamma irradiation on the properties of Hydroxyapatite-Collagen\u2010Chitosan\u2010Mg\u2010ZnO scaffolds for bone tissue engineering. Int J Polym Sci 2023:6682223","journal-title":"Int J Polym Sci"},{"key":"10874_CR37","doi-asserted-by":"publisher","first-page":"110890","DOI":"10.18632\/oncotarget.22917","volume":"8","author":"S Zang","year":"2017","unstructured":"Zang S, Zhu L, Luo K, Mu R, Chen F, Wei X et al (2017) Chitosan composite scaffold combined with bone marrow-derived mesenchymal stem cells for bone regeneration: in vitro and in vivo evaluation. Oncotarget 8:110890\u2013110903","journal-title":"Oncotarget"},{"key":"10874_CR38","unstructured":"Plumb DC (2018) Plumb\u2019s veterinary drug handbook: desk. Wiley"},{"key":"10874_CR39","doi-asserted-by":"crossref","unstructured":"Papanicolaou P, Chrysomali E, Stylogianni E, Donta C, Vlachodimitropoulos D (2012) Increased TNF-\u03b1, IL-6 and decreased IL-1\u03b2 immunohistochemical expression by the stromal spindle-shaped cells in the central giant cell granuloma of the jaws. Med Oral Patol Oral Cir Bucal 17:e56-62","DOI":"10.4317\/medoral.17205"},{"key":"10874_CR40","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.lfs.2016.04.033","volume":"155","author":"LAC Brizeno","year":"2016","unstructured":"Brizeno LAC, Assreuy AMS, Alves APN, Sousa FB, de Silva PGdB SCOM et al (2016) Delayed healing of oral mucosa in a diabetic rat model: Implication of TNF-\u03b1, IL-1\u03b2 and FGF-2. Life Sci 155:36\u201347","journal-title":"Life Sci"},{"key":"10874_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","volume":"39","author":"N Udagawa","year":"2021","unstructured":"Udagawa N, Koide M, Nakamura M, Nakamichi Y, Yamashita T, Uehara S et al (2021) Osteoclast differentiation by RANKL and OPG signaling pathways. J Bone Min Metab 39:19\u201326","journal-title":"J Bone Min Metab"},{"key":"10874_CR42","doi-asserted-by":"crossref","unstructured":"De Leon-Oliva D, Barrena-Blazquez S, Jimenez-Alvarez L, Fraile-Martinez O, Garcia-Montero C, Lopez-Gonzalez L et al (2023) The RANK-RANKL-OPG System: A Multifaceted Regulator of Homeostasis, Immunity, and Cancer. Med (Kaunas) 59:1752","DOI":"10.3390\/medicina59101752"},{"key":"10874_CR43","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.dental.2018.11.025","volume":"35","author":"A Bakopoulou","year":"2019","unstructured":"Bakopoulou A, Georgopoulou \u0391, Grivas I, Bekiari C, Prymak O, Loza \u039a et al (2019) Dental pulp stem cells in chitosan\/gelatin scaffolds for enhanced orofacial bone regeneration. Dent Mater 35:310\u2013327","journal-title":"Dent Mater"},{"key":"10874_CR44","doi-asserted-by":"publisher","first-page":"e19474","DOI":"10.1016\/j.heliyon.2023.e19474","volume":"9","author":"Y Wan","year":"2023","unstructured":"Wan Y, Hu C, Hou Y, Si C, Zhao Q, Wang Z et al (2023) OPG gene-modified adipose-derived stem cells improve bone formation around implants in osteoporotic rat maxillae. Heliyon 9:e19474","journal-title":"Heliyon"},{"key":"10874_CR45","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","volume":"473","author":"BF Boyce","year":"2008","unstructured":"Boyce BF, Xing L (2008) Functions of RANKL\/RANK\/OPG in bone modeling and remodeling. Arch Biochem Biophys 473:139\u2013146","journal-title":"Arch Biochem Biophys"},{"key":"10874_CR46","first-page":"e2","volume":"10","author":"P de Sousa Gomes","year":"2019","unstructured":"de Sousa Gomes P, Daugela P, Poskevicius L, Mariano L, Fernandes MH (2019) Molecular and cellular aspects of socket healing in the absence and presence of graft materials and autologous platelet concentrates: A focused review. J Oral Maxillofac Res 10:e2","journal-title":"J Oral Maxillofac Res"},{"key":"10874_CR47","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.3390\/cells13121065","volume":"13","author":"E Saberian","year":"2024","unstructured":"Saberian E, Jen\u010da A, Zafari Y, Jen\u010da A, Petr\u00e1\u0161ov\u00e1 A, Zare-Zardini H et al (2024) Scaffold application for bone regeneration with stem cells in dentistry: literature review. Cells 13:1065","journal-title":"Cells"},{"key":"10874_CR48","doi-asserted-by":"publisher","first-page":"358","DOI":"10.4103\/ejd.ejd_342_17","volume":"12","author":"N Hendrijantini","year":"2018","unstructured":"Hendrijantini N, Kusumaningsih T, Rostiny R, Mulawardhana P, Danudiningrat CP, Rantam FA (2018) A potential therapy of human umbilical cord mesenchymal stem cells for bone regeneration on osteoporotic mandibular bone. Eur J Dent 12:358\u2013362","journal-title":"Eur J Dent"},{"key":"10874_CR49","doi-asserted-by":"publisher","first-page":"654","DOI":"10.3892\/ijmm.2017.2872","volume":"39","author":"K Marupanthorn","year":"2017","unstructured":"Marupanthorn K, Tantrawatpan C, Kheolamai P, Tantikanlayaporn D, Manochantr S (2017) Bone morphogenetic protein-2 enhances the osteogenic differentiation capacity of mesenchymal stromal cells derived from human bone marrow and umbilical cord. Int J Mol Med 39:654\u2013662","journal-title":"Int J Mol Med"},{"key":"10874_CR50","doi-asserted-by":"crossref","unstructured":"Kuntjoro M, Hendrijantini N, Kamadjaja MJK, Tumali BAS, Widjaja J, Prasetyo EP et al (2026) Immunohistochemical evaluation of bone regeneration induced by human umbilical cord mesenchymal stem cells around implants in an osteoporotic rat model. J Dent Sci 21:294-304","DOI":"10.1016\/j.jds.2025.08.042"},{"key":"10874_CR51","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1055\/s-0044-1791530","volume":"19","author":"M Kuntjoro","year":"2025","unstructured":"Kuntjoro M, Hendrijantini N, Prasetyo EP, Agustono B, Hong G (2025) Hypoxia-preconditioned human umbilical cord mesenchymal stem cells transplantation ameliorates inflammation and bone regeneration in peri-implantitis rat model. Eur J Dentistry 19:420\u2013427","journal-title":"Eur J Dentistry"},{"key":"10874_CR52","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.56499\/jppres24.2310_13.6.1728","volume":"13","author":"YA Pratama","year":"2025","unstructured":"Pratama YA, Ananta IP, Haris MS, Maghfiroh N, Nabila H, Ardianto C et al (2025) Accelerated bone defect closure after administration of nano bovine hydroxyapatite-calcium sulfate-gelatin scaffold in bone defect models. J Pharm Pharmacognosy Res 13:1728\u20131741","journal-title":"J Pharm Pharmacognosy Res"},{"key":"10874_CR53","doi-asserted-by":"publisher","first-page":"1355950","DOI":"10.3389\/fbioe.2024.1355950","volume":"12","author":"M Souto-Lopes","year":"2024","unstructured":"Souto-Lopes M, Grenho L, Manrique Y, Dias MM, Lopes JCB, Fernandes MH et al (2024) Bone regeneration driven by a nano-hydroxyapatite\/chitosan composite bioaerogel for periodontal regeneration. Front Bioeng Biotechnol 12:1355950","journal-title":"Front Bioeng Biotechnol"},{"key":"10874_CR54","doi-asserted-by":"crossref","unstructured":"Zaczek-Moczydlowska MA, Joszko K, Kavoosi M, Markowska A, Likus W, Ghavami S et al (2024) Biomimetic natural biomaterial nanocomposite scaffolds: A Rising prospect for bone replacement. Int J Mol Sci ;25:13467","DOI":"10.3390\/ijms252413467"},{"key":"10874_CR55","doi-asserted-by":"publisher","first-page":"112158","DOI":"10.1016\/j.injury.2025.112158","volume":"56","author":"JV Helaehil","year":"2025","unstructured":"Helaehil JV, Huang B, Bartolo P, Santamaria-Jr M, Caetano GF (2025) Bone regeneration: The influence of composite HA\/TCP scaffolds and electrical stimulation on TGF\/BMP and RANK\/RANKL\/OPG pathways. Injury 56:112158","journal-title":"Injury"},{"key":"10874_CR56","doi-asserted-by":"publisher","first-page":"58","DOI":"10.22203\/eCM.v052a05","volume":"52","author":"Z Yao","year":"2025","unstructured":"Yao Z, Xie W, Yang Y, Chen J, Zhan Y, Wu X et al (2025) Chitosan scaffolds for bone applications: A detailed review of main types, features and multifaceted uses. Eur Cells Mater 52:58\u201379","journal-title":"Eur Cells Mater"},{"key":"10874_CR57","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s12276-024-01157-7","volume":"56","author":"N Takegahara","year":"2024","unstructured":"Takegahara N, Kim H, Choi Y (2024) Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases. Exp Mol Med 56:264\u2013272","journal-title":"Exp Mol Med"},{"key":"10874_CR58","doi-asserted-by":"crossref","unstructured":"Zhang Y, Wei X, Sheng R, Yang G, Han X, Wang J et al (2025) A Novel RANKL\/RANK Inhibitor IMB-R38 Inhibits Osteoporosis Through Regulating Bone Metabolism. Int J Mol Sci 26:12151","DOI":"10.3390\/ijms262412151"},{"key":"10874_CR59","doi-asserted-by":"publisher","first-page":"110190","DOI":"10.4252\/wjsc.v17.i10.110190","volume":"17","author":"H Lv","year":"2025","unstructured":"Lv H, Zheng CF, Chen XY, Wei JH, Tao YZ, Feng L et al (2025) Sclerostin-silenced human umbilical cord mesenchymal stem cells ameliorate bone metabolism in steroid-induced femoral head necrosis. World J Stem Cells 17:110190","journal-title":"World J Stem Cells"},{"key":"10874_CR60","doi-asserted-by":"publisher","first-page":"1639430","DOI":"10.3389\/fcell.2025.1639430","volume":"13","author":"L Yin","year":"2025","unstructured":"Yin L, Sun C, Zhang J, Li Y, Wang Y, Bai L et al (2025) Critical signaling pathways in osteoclast differentiation and bone resorption: Mechanisms and therapeutic implications for periprosthetic osteolysis. Front Cell Dev Biology 13:1639430","journal-title":"Front Cell Dev Biology"},{"key":"10874_CR61","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/s41392-025-02313-9","volume":"10","author":"X Han","year":"2025","unstructured":"Han X, Liao R, Li X, Zhang C, Huo S, Qin L et al (2025) Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies. Signal Transduct Target Therapy 10:262","journal-title":"Signal Transduct Target Therapy"},{"key":"10874_CR62","doi-asserted-by":"publisher","first-page":"1568914","DOI":"10.3389\/fbioe.2025.1568914","volume":"13","author":"D Han","year":"2025","unstructured":"Han D, Liu W, Gong J, Ma Y, Sun Z (2025) Challenges and future perspectives in using mesenchymal stem cells for efficient bone fracture healing. Front Bioeng Biotechnol 13:1568914","journal-title":"Front Bioeng Biotechnol"},{"key":"10874_CR63","doi-asserted-by":"crossref","unstructured":"Xue HY, Shen XL, Wang ZH, Bi HC, Xu HG, Wu J et al (2025) Research progress on mesenchymal stem cell\u2013derived exosomes in the treatment of osteoporosis induced by knee osteoarthritis (Review). Int J Mol Med 56:160","DOI":"10.3892\/ijmm.2025.5601"},{"key":"10874_CR64","doi-asserted-by":"crossref","unstructured":"Udeabor SE, Heselich A, Al-Maawi S, Alqahtani AF, Sader R, Ghanaati S (2023) Current knowledge on the healing of the extraction socket: A narrative review. Bioeng (Basel) 10:1145","DOI":"10.3390\/bioengineering10101145"},{"key":"10874_CR65","doi-asserted-by":"crossref","unstructured":"Ghanaati S, Smieszek-Wilczewska J, Al-Maawi S, Heselich A, Sader R (2025) After extraction, upper premolars undergo programmed socket collapse with development of cavitations rather than complete socket healing: A Radiological Study. Bioeng (Basel) 12:128","DOI":"10.3390\/bioengineering12020128"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10874-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10874-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10874-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:01:55Z","timestamp":1786953715000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-026-10874-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10874"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10874-4","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"31 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experiment received ethical approval from the Research Ethics Committee, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia (No.1060\/HRECC.FODM\/X\/2025).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"204"}}