{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:25:08Z","timestamp":1786951508759,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10735-026-10911-2","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:55:32Z","timestamp":1784966132000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical hyaluronic acid serum, oral vitamin C, and their combined regimen modulate collagen-related repair indices in a sutured primary-intention rat incisional wound model"],"prefix":"10.1007","volume":"57","author":[{"given":"Sara Mohamed Mokhtar","family":"Abdelrazek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama Yaseen","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4177-5035","authenticated-orcid":false,"given":"Mayada Saad","family":"Farrag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Hemada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"issue":"5","key":"10911_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70221","volume":"24","author":"N Adel","year":"2025","unstructured":"Adel N, Stankovic N, Cervantes G, Gindi A, Shawky LM (2025a) Skin wound healing following injecting hyaluronic acid rejuvenating complex, polycaprolactone, or combination therapy: an experimental study. J Cosmet Dermatol 24(5):e70221. https:\/\/doi.org\/10.1111\/jocd.70221","journal-title":"J Cosmet Dermatol"},{"issue":"12","key":"10911_CR2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70561","volume":"24","author":"N Adel","year":"2025","unstructured":"Adel N, Kolenda J, Thulesen J et al (2025b) Regenerative potential of various plant-derived exosome injections in laser-induced skin wound healing in a rabbit model. J Cosmet Dermatol 24(12):e70561. https:\/\/doi.org\/10.1111\/jocd.70561","journal-title":"J Cosmet Dermatol"},{"issue":"5","key":"10911_CR3","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000006837","volume":"13","author":"N Adel","year":"2025","unstructured":"Adel N, Harhash T, Abdallah N (2025c) Combined effect of low-level laser therapy and hyaluronic acid injection in oral wound healing: an experimental study. Plast Reconstr Surg Glob Open 13(5):e6837. https:\/\/doi.org\/10.1097\/GOX.0000000000006837","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"8","key":"10911_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081605","volume":"11","author":"N Bechara","year":"2022","unstructured":"Bechara N, Flood VM, Gunton JE (2022) A systematic review on the role of vitamin C in tissue healing. Antioxidants 11(8):1605","journal-title":"Antioxidants"},{"issue":"1","key":"10911_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF01225021","volume":"106","author":"P Betz","year":"1993","unstructured":"Betz P, Nerlich A, Wilske J, T\u00fcbel J, Wiest I, Penning R et al (1993) Immunohistochemical localization of collagen types I and VI in human skin wounds. Int J Legal Med 106(1):31\u201334","journal-title":"Int J Legal Med"},{"issue":"3","key":"10911_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1046\/j.1467-2494.1998.171747.x","volume":"20","author":"N Boyera","year":"1998","unstructured":"Boyera N, Galey I, Bernard BA (1998) Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. Int J Cosmet Sci 20(3):151\u2013158","journal-title":"Int J Cosmet Sci"},{"issue":"17","key":"10911_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/polym14173442","volume":"14","author":"C Buckley","year":"2022","unstructured":"Buckley C, Murphy EJ, Montgomery TR, Major I (2022) Hyaluronic acid: a review of the drug delivery capabilities of this naturally occurring polysaccharide. Polymers 14(17):3442","journal-title":"Polymers"},{"issue":"3","key":"10911_CR8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3390\/medicina57030285","volume":"57","author":"E Canciani","year":"2021","unstructured":"Canciani E, Sirello R, Pellegrini G, Cuffari B, Agliardi C, Grisoli P et al (2021) Effects of vitamin and amino acid-enriched hyaluronic acid gel on the healing of oral mucosa: in vivo and in vitro study. Medicina 57(3):285","journal-title":"Medicina"},{"issue":"6","key":"10911_CR9","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1101\/pdb.prot073411","volume":"2014","author":"RD Cardiff","year":"2014","unstructured":"Cardiff RD, Miller CH, Munn RJ (2014) Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harb Protoc 2014(6):655\u2013658","journal-title":"Cold Spring Harb Protoc"},{"issue":"6","key":"10911_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/app12063091","volume":"12","author":"F Della Sala","year":"2022","unstructured":"Della Sala F, Longobardo G, Fabozzi A, Di Gennaro M, Borzacchiello A (2022) Hyaluronic acid-based wound dressing with antimicrobial properties for wound healing application. Appl Sci 12(6):3091","journal-title":"Appl Sci"},{"key":"10911_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122783","volume":"351","author":"M Ghanbari","year":"2024","unstructured":"Ghanbari M, Salkovskiy Y, Carlson MA (2024) The rat as an animal model in chronic wound research: an update. Life Sci 351:122783","journal-title":"Life Sci"},{"key":"10911_CR12","unstructured":"Kangal MK, Regan JP (2024) Wound healing. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing"},{"key":"10911_CR13","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.actbio.2023.08.001","volume":"169","author":"J Karam","year":"2023","unstructured":"Karam J, Singer BJ, Miwa H, Chen LH, Maran K, Hasani M et al (2023) The molecular weight of hyaluronic acid crosslinked into biomaterial scaffolds affects the scaffolds\u2019 angiogenic potential. Acta Biomater 169:228\u2013242","journal-title":"Acta Biomater"},{"issue":"24","key":"10911_CR14","doi-asserted-by":"publisher","first-page":"6850","DOI":"10.1111\/febs.15776","volume":"288","author":"NK Karamanos","year":"2021","unstructured":"Karamanos NK, Theocharis AD, Piperigkou Z, Manou D, Passi A, Skandalis SS et al (2021) A guide to the composition and functions of the extracellular matrix. FEBS J 288(24):6850\u20136912","journal-title":"FEBS J"},{"issue":"4","key":"10911_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3390\/ph14040301","volume":"14","author":"Y Kawano","year":"2021","unstructured":"Kawano Y, Kageyama R, Patrulea V, Matos M, Borchard G, M\u00f6ller M et al (2021) Wound healing promotion by hyaluronic acid: effect of molecular weight on gene expression and in vivo wound closure. Pharmaceuticals 14(4):301","journal-title":"Pharmaceuticals"},{"issue":"6","key":"10911_CR16","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s13770-024-00644-2","volume":"21","author":"DY Kim","year":"2024","unstructured":"Kim DY, Ko E, Ryu YH, Lee SJ, Jun YJ (2024) Hyaluronic acid-based adipose tissue-derived extracellular matrix scaffold in wound healing: histological and immunohistochemical study. Tissue Eng Regen Med 21(6):829\u2013842","journal-title":"Tissue Eng Regen Med"},{"issue":"5","key":"10911_CR17","doi-asserted-by":"publisher","first-page":"224","DOI":"10.7181\/acfs.2024.00381","volume":"25","author":"HM Lee","year":"2024","unstructured":"Lee HM, Jang EJ, Choi KH, Na YC (2024) Comparative evaluation of hyaluronic acid-based dressing versus hydrocolloid dressing in rat dermal wound healing. Arch Craniofac Surg 25(5):224\u2013229","journal-title":"Arch Craniofac Surg"},{"issue":"4","key":"10911_CR18","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1111\/iwj.12484","volume":"13","author":"BM Mohammed","year":"2016","unstructured":"Mohammed BM, Fisher BJ, Kraskauskas D, Farkas D, Brophy DF, Fowler AA 3rd et al (2016) Vitamin C promotes wound healing through novel pleiotropic mechanisms. Int Wound J 13(4):572\u2013584","journal-title":"Int Wound J"},{"issue":"Suppl 12","key":"10911_CR19","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.12968\/bjcn.2013.18.Sup12.S6","volume":"18","author":"J Moores","year":"2013","unstructured":"Moores J (2013) Vitamin C: a wound healing perspective. Br J Commun Nurs 18(Suppl 12):S6\u2013S11","journal-title":"Br J Commun Nurs"},{"issue":"16","key":"10911_CR20","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.3390\/polym13162642","volume":"13","author":"R Naomi","year":"2021","unstructured":"Naomi R, Fauzi MB, Bahari H (2021) Current insights into collagen type I. Polymers 13(16):2642","journal-title":"Polymers"},{"issue":"12","key":"10911_CR21","volume":"12","author":"LFDG Oliva","year":"2020","unstructured":"Oliva LFDG, Dourado DM (2020) Healing process of rat skin wounds treated with vitamin C and low-intensity laser therapy. Cureus 12(12):e11933","journal-title":"Cureus"},{"issue":"4","key":"10911_CR22","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/lsm.22498","volume":"48","author":"H Petersen","year":"2016","unstructured":"Petersen H, Tavakoli I, Schmidt M, Yuan F, Pulikkottil B, Fischer C et al (2016) Comparative study of wound healing in rat skin following incision with a novel picosecond infrared laser (PIRL) and different surgical modalities. Lasers Surg Med 48(4):385\u2013391","journal-title":"Lasers Surg Med"},{"issue":"12","key":"10911_CR23","doi-asserted-by":"publisher","first-page":"7461","DOI":"10.1021\/acsbiomaterials.5c01601","volume":"11","author":"A Salem","year":"2025","unstructured":"Salem A, El-Ghlban S, Montaser AS, Abdelhameed MF, Attia MF (2025) Enhanced wound healing, anti-inflammatory, and anti-oxidative effects of vitamin C-loaded hyaluronic acid-coll scaffolds in preclinical rat models. ACS Biomater Sci Eng 11(12):7461\u20137473","journal-title":"ACS Biomater Sci Eng"},{"key":"10911_CR24","first-page":"23","volume-title":"Mechanisms of vascular disease","author":"GS Schultz","year":"2011","unstructured":"Schultz GS, Chin GA, Moldawer L, Diegelmann RF (2011) Principles of wound healing. In: Fitridge R, Thompson M (eds) Mechanisms of vascular disease. University of Adelaide Press, Adelaide (AU), pp 23\u201341"},{"issue":"1-2","key":"10911_CR25","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000454919","volume":"58","author":"H Sorg","year":"2017","unstructured":"Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U (2017) Skin wound healing: an update on the current knowledge and concepts. Eur Surg Res 58(1\u20132):81\u201394","journal-title":"Eur Surg Res"},{"issue":"1","key":"10911_CR26","first-page":"39","volume":"3","author":"A Suvik","year":"2012","unstructured":"Suvik A, Effendy AWM (2012) The use of modified Masson\u2019s trichrome staining in collagen evaluation in a wound healing study. Malays J Vet Res 3(1):39\u201347","journal-title":"Malays J Vet Res"},{"issue":"1","key":"10911_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s12262-023-03750-y","volume":"86","author":"T Thiyu","year":"2024","unstructured":"Thiyu T, Thanigasalam A, Abas AL, Rajan M (2024) The effects of vitamin C on wound healing: systematic review. Indian J Surg 86(1):23\u201329","journal-title":"Indian J Surg"},{"issue":"3","key":"10911_CR28","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/wound.2013.0485","volume":"4","author":"M Xue","year":"2015","unstructured":"Xue M, Jackson CJ (2015) Extracellular matrix reorganization during wound healing and its impact on abnormal scarring. Adv Wound Care 4(3):119\u2013136","journal-title":"Adv Wound Care"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10911-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10911-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10911-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:49:01Z","timestamp":1786949341000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-026-10911-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,25]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10911"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10911-2","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,25]]},"assertion":[{"value":"22 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures involving animals were conducted in accordance with institutional guidelines for the care and use of laboratory animals. The study protocol was approved by the Research Ethics Committee, Faculty of Medicine, Port Said University, Egypt (ERN: MED 4\/5\/2025; S. No. 286; HIS801a_003).","order":3,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"245"}}