{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:25:55Z","timestamp":1786955155336,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10735-026-10933-w","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T01:57:31Z","timestamp":1786067851000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quercetin and hesperidin attenuate cyclophosphamide-induced renal injury in rats"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2825-7401","authenticated-orcid":false,"given":"\u015eemsi G\u00fcl","family":"Y\u0131lmaz Kocaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8641-9475","authenticated-orcid":false,"given":"Serkan","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-9571","authenticated-orcid":false,"given":"Asl\u0131","family":"U\u00e7ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"10933_CR1","first-page":"121","volume-title":"Methods in enzymology","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods in enzymology, vol Vol. 105. Academic Press, pp 121\u2013126"},{"issue":"1","key":"10933_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/09674845.2010.11730285","volume":"67","author":"FQ Alenzi","year":"2010","unstructured":"Alenzi FQ, El-Bolkiny YES, Salem ML (2010) Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide. Br J Biomed Sci 67(1):20\u201328","journal-title":"Br J Biomed Sci"},{"issue":"12","key":"10933_CR3","first-page":"1717","volume":"11","author":"S Alsawaf","year":"2022","unstructured":"Alsawaf S, Alnuaimi F, Afzal S, Thomas RM, Chelakkot AL, Ramadan WS, Vazhappilly CG (2022) Plant flavonoids on oxidative stress-mediated kidney inflammation. Biology (Basel) 11(12):1717","journal-title":"Biology (Basel)"},{"issue":"5","key":"10933_CR4","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1179\/1351000212Y.0000000019","volume":"17","author":"R Anandan","year":"2012","unstructured":"Anandan R, Subramanian P (2012) Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats. Redox Rep 17(5):219\u2013226","journal-title":"Redox Rep"},{"issue":"3","key":"10933_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70777","volume":"40","author":"\u0130 Ayhan","year":"2026","unstructured":"Ayhan \u0130, Kaplan MN, Kasim DD, Ozmen O, Ciftci O (2026) Protective effects of hesperidin on letrozole-induced neurotoxicity: involvement of oxidative stress, apoptotic signaling, and inflammation. J Biochem Mol Toxicol 40(3):e70777","journal-title":"J Biochem Mol Toxicol"},{"key":"10933_CR6","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1155\/2022\/5096825","volume":"2022","author":"MA Ayza","year":"2022","unstructured":"Ayza MA, Zewdie KA, Yigzaw EF, Ayele SG, Tesfaye BA, Tafere GG, Abrha MG (2022) Potential protective effects of antioxidants against cyclophosphamide-induced nephrotoxicity. Int J Nephrol 2022:218\u2013230","journal-title":"Int J Nephrol"},{"issue":"13","key":"10933_CR7","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.3390\/molecules28134982","volume":"28","author":"S Chen","year":"2023","unstructured":"Chen S, Wang X, Cheng Y, Gao H, Chen X (2023) A review of classification, biosynthesis, biological activities and potential applications of flavonoids. Molecules 28(13):4982\u20135009","journal-title":"Molecules"},{"issue":"3","key":"10933_CR8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10735-026-10843-x","volume":"57","author":"O \u00c7ift\u00e7i","year":"2026","unstructured":"\u00c7ift\u00e7i O, Kaplan MN, \u00d6zmen \u00d6, Co\u011fuplugil A, Bek A, Kili\u00e7 R (2026) The ameliorate effect of 18-beta glycyrrhetinic acid against cadmium-induced reproductive damage. J Mol Histol 57(3):185","journal-title":"J Mol Histol"},{"issue":"1","key":"10933_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3390\/nu13010273","volume":"13","author":"C Di Lorenzo","year":"2021","unstructured":"Di Lorenzo C, Colombo F, Biella S, Stockley C, Restani P (2021) Polyphenols and human health: the role of bioavailability. Nutrients 13(1):273\u2013303","journal-title":"Nutrients"},{"key":"10933_CR10","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.fct.2019.111079","volume":"136","author":"NAG Dos Santos","year":"2020","unstructured":"Dos Santos NAG, Ferreira RS, Dos Santos AC (2020) Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents. Food Chem Toxicol 136:1079\u20131093","journal-title":"Food Chem Toxicol"},{"issue":"9","key":"10933_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70465","volume":"39","author":"AA Elhemiely","year":"2025","unstructured":"Elhemiely AA, El\u2010Fayoumi SH, Gadelmawla MH, Mahran NA, Gad AM (2025) Hesperidin reduces hepatic injury induced by doxorubicin in rat model through its antioxidative and anti\u2010inflammatory effects, focusing on SIRT\u20101\/NRF\u20102 pathways. J Biochem Mol Toxicol 39(9):e70465","journal-title":"J Biochem Mol Toxicol"},{"issue":"6","key":"10933_CR12","first-page":"308","volume":"10","author":"R Estakhri","year":"2013","unstructured":"Estakhri R, Hajipour B, Majidi H, Soleimani H (2013) Vitamin E ameliorates cyclophosphamide induced nephrotoxicity. Life Sci J 10(6):308\u2013313","journal-title":"Life Sci J"},{"issue":"3","key":"10933_CR13","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1080\/01480545.2018.1560467","volume":"44","author":"AA Fouad","year":"2021","unstructured":"Fouad AA, Abdel-Gaber SA, Abdelghany MI (2021) Hesperidin opposes the negative impact of cyclophosphamide on mice kidneys. Drug Chem Toxicol 44(3):223\u2013228","journal-title":"Drug Chem Toxicol"},{"issue":"2","key":"10933_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000525029","volume":"147","author":"C Garcia-Carro","year":"2023","unstructured":"Garcia-Carro C, Draibe J, Soler MJ (2023) Onconephrology: update in anticancer drug-related nephrotoxicity. Nephron 147(2):65\u201377","journal-title":"Nephron"},{"issue":"1","key":"10933_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.5798\/dicletip.534825","volume":"46","author":"S Gedikli","year":"2019","unstructured":"Gedikli S, \u015eeng\u00fcl E (2019) Ratlarda siklofosfamid ile ind\u00fcklenen hepatotoksisite \u00fczerine kuersetinin etkileri. Dicle Tip Derg 46(1):41\u201350","journal-title":"Dicle Tip Derg"},{"key":"10933_CR16","first-page":"1","volume":"5","author":"V Gelen","year":"2021","unstructured":"Gelen V, \u015eeng\u00fcl E, Gedikli S, \u00d6zkanlar S, Gur C, Kara A, \u00c7\u0131nar A (2021) The effects of quercetin on cyclophosphamide-induced cardiotoxicity in rats. Res Sq 5:1\u201316","journal-title":"Res Sq"},{"issue":"1","key":"10933_CR17","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s12011-017-1231-8","volume":"185","author":"S Gunes","year":"2018","unstructured":"Gunes S, Sahinturk V, Uslu S, Ayhanci A, Kacar S, Uyar R (2018) Protective effects of selenium on cyclophosphamide-induced oxidative stress and kidney injury. Biol Trace Elem Res 185(1):116\u2013123","journal-title":"Biol Trace Elem Res"},{"issue":"22","key":"10933_CR18","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 249(22):7130\u20137139","journal-title":"J Biol Chem"},{"issue":"4","key":"10933_CR19","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.4067\/S0717-95022019000401422","volume":"37","author":"MA Haidara","year":"2019","unstructured":"Haidara MA, Al-Hashem F, El Karib AO, Zaki MS, Kamar SS, El-Bidawy MH, Al-Ani B (2019) Inhibition of paracetamol-induced acute kidney damage in rats using a combination of resveratrol and quercetin. Int J Morphol 37(4):1422\u20131428","journal-title":"Int J Morphol"},{"issue":"8","key":"10933_CR20","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.etp.2017.05.004","volume":"69","author":"SM Hamdy","year":"2017","unstructured":"Hamdy SM, Shabaan AM, Latif AKMA, Abdel-Aziz AM, Amin AM (2017) Protective effect of hesperidin and tiger nut against acrylamide toxicity in female rats. Exp Toxicol Pathol 69(8):580\u2013588","journal-title":"Exp Toxicol Pathol"},{"key":"10933_CR21","doi-asserted-by":"publisher","DOI":"10.1177\/1721727X221086530","volume":"20","author":"F Izak-Shirian","year":"2022","unstructured":"Izak-Shirian F, Najafi-Asl M, Azami B, Heidarian E, Najafi M, Khaledi M, Nouri A (2022) Quercetin exerts an ameliorative effect in the rat model of diclofenac-induced renal injury through mitigation of inflammatory response and modulation of oxidative stress. Eur J Inflamm 20:1721727X221086530","journal-title":"Eur J Inflamm"},{"issue":"4","key":"10933_CR22","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.3390\/nu12041010","volume":"12","author":"S Izzo","year":"2020","unstructured":"Izzo S, Naponelli V, Bettuzzi S (2020) Flavonoids as epigenetic modulators for prostate cancer prevention. Nutrients 12(4):1010","journal-title":"Nutrients"},{"issue":"5","key":"10933_CR23","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1515\/tjb-2024-0228","volume":"50","author":"MD Karako\u00e7","year":"2025","unstructured":"Karako\u00e7 MD, \u00d6zmen \u00d6, Zengin MN, \u00c7ift\u00e7i O (2025) Evaluation of hesperidin and taurine for mitigating letrozole-induced uterine toxicity in rats: histopathological, molecular, and biochemical insights. Turk J Biochem 50(5):780\u2013789","journal-title":"Turk J Biochem"},{"issue":"12","key":"10933_CR24","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1177\/1535370215576304","volume":"240","author":"NF Khedr","year":"2015","unstructured":"Khedr NF (2015) Protective effect of mirtazapine and hesperidin on cyclophosphamide-induced oxidative damage and infertility in rat ovaries. Exp Biol Med (Maywood) 240(12):1682\u20131689","journal-title":"Exp Biol Med (Maywood)"},{"issue":"2","key":"10933_CR25","first-page":"124","volume":"11","author":"S Kocahan","year":"2017","unstructured":"Kocahan S, Dogan Z, Erdemli E, Taskin E (2017) Protective effect of quercetin against oxidative stress-induced toxicity associated with doxorubicin and cyclophosphamide in rat kidney and liver tissue. Iran J Kidney Dis 11(2):124\u2013130","journal-title":"Iran J Kidney Dis"},{"issue":"3","key":"10933_CR26","doi-asserted-by":"publisher","first-page":"086","DOI":"10.69613\/nkjgsh79","volume":"3","author":"R Ksheerasagar","year":"2025","unstructured":"Ksheerasagar R, Pattanashetti L (2025) Current perspectives on drug-induced nephrotoxicity. J Pharma Insights Res 3(3):086\u2013094","journal-title":"J Pharma Insights Res"},{"key":"10933_CR27","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/j.biopha.2017.03.008","volume":"89","author":"M Kumar","year":"2017","unstructured":"Kumar M, Dahiya V, Kasala ER, Bodduluru LN, Lahkar M (2017) The renoprotective activity of hesperetin in cisplatin-induced nephrotoxicity in rats: molecular and biochemical evidence. Biomed Pharmacother 89:1207\u20131215","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"10933_CR28","doi-asserted-by":"publisher","first-page":"686","DOI":"10.23876\/j.krcp.23.001","volume":"42","author":"CW Kung","year":"2023","unstructured":"Kung CW, Chou YH (2023) Acute kidney disease: an overview of the epidemiology, pathophysiology, and management. Kidney Res Clin Pract 42(6):686","journal-title":"Kidney Res Clin Pract"},{"issue":"11","key":"10933_CR29","doi-asserted-by":"publisher","first-page":"6109","DOI":"10.3390\/ijms22116109","volume":"22","author":"E Kwiatkowska","year":"2021","unstructured":"Kwiatkowska E, Doma\u0144ski L, Dziedziejko V, Kajdy A, Stefa\u0144ska K, Kwiatkowski S (2021) The mechanism of drug nephrotoxicity and the methods for preventing kidney damage. Int J Mol Sci 22(11):6109","journal-title":"Int J Mol Sci"},{"key":"10933_CR30","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1016\/j.biopha.2016.10.097","volume":"84","author":"Q Liu","year":"2016","unstructured":"Liu Q, Lin X, Li H, Yuan J, Peng Y, Dong L, Dai S (2016) Paeoniflorin ameliorates renal function in cyclophosphamide-induced mice via AMPK suppressed inflammation and apoptosis. Biomed Pharmacother 84:1899\u20131905","journal-title":"Biomed Pharmacother"},{"key":"10933_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fneph.2024.1436896","volume":"4","author":"RMDC Lyrio","year":"2024","unstructured":"Lyrio RMDC, Rocha BRA, Corr\u00eaa ALRM, Mascarenhas MGS, Santos FL, Maia RDH, Sassi RH (2024) Chemotherapy-induced acute kidney injury: epidemiology, pathophysiology, and therapeutic approaches. Front Nephrol 4:1436896","journal-title":"Front Nephrol"},{"issue":"8","key":"10933_CR32","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.apjtm.2017.08.005","volume":"10","author":"P Mahipal","year":"2017","unstructured":"Mahipal P, Pawar RS (2017) Nephroprotective effect of Murraya koenigii on cyclophosphamide-induced nephrotoxicity in rats. Asian Pac J Trop Med 10(8):808\u2013812","journal-title":"Asian Pac J Trop Med"},{"issue":"9","key":"10933_CR33","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1139\/cjpp-2014-0204","volume":"92","author":"AM Mahmoud","year":"2014","unstructured":"Mahmoud AM (2014) Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPAR\u03b3 and abrogation of oxidative stress and inflammation. Can J Physiol Pharmacol 92(9):717\u2013724","journal-title":"Can J Physiol Pharmacol"},{"issue":"3","key":"10933_CR34","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47(3):469\u2013474","journal-title":"Eur J Biochem"},{"issue":"6","key":"10933_CR35","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1053\/j.ajkd.2017.06.031","volume":"70","author":"DG Moledina","year":"2017","unstructured":"Moledina DG, Hall IE, Thiessen-Philbrook H, Reese PP, Weng FL, Schroffel B, Parikh CR (2017) Performance of serum creatinine and kidney injury biomarkers for diagnosing histologic acute tubular injury. Am J Kidney Dis 70(6):807\u2013816","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10933_CR36","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358","journal-title":"Anal Biochem"},{"issue":"3","key":"10933_CR37","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/ilar\/ilw029","volume":"57","author":"IAS Olsson","year":"2017","unstructured":"Olsson IAS, Silva SPD, Townend D, Sand\u00f8e P (2017) Protecting animals and enabling research in the European Union: an overview of development and implementation of directive 2010\/63\/EU. ILAR J 57(3):347\u2013357","journal-title":"ILAR J"},{"key":"10933_CR38","unstructured":"Organization for Economic Cooperation and Development (2015) OECD guideline for the testing of chemicals: TG 413. https:\/\/www.oecd.org\/env\/ehs\/testing\/TG%20413%20Revised%2016-OCT-2015.pdf"},{"issue":"1","key":"10933_CR39","first-page":"158","volume":"70","author":"DE Paglia","year":"1967","unstructured":"Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70(1):158\u2013169","journal-title":"J Lab Clin Med"},{"key":"10933_CR40","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.toxrep.2014.11.003","volume":"2","author":"L Pari","year":"2015","unstructured":"Pari L, Karthikeyan A, Karthika P, Rathinam A (2015) Protective effects of hesperidin on oxidative stress, dyslipidaemia and histological changes in iron-induced hepatic and renal toxicity in rats. Toxicol Rep 2:46\u201355","journal-title":"Toxicol Rep"},{"issue":"1","key":"10933_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13010130","volume":"13","author":"AH Rahmani","year":"2023","unstructured":"Rahmani AH, Alsahli MA, Khan AA, Almatroodi SA (2023) Quercetin, a plant flavonol attenuates diabetic complications, renal tissue damage, renal oxidative stress and inflammation in streptozotocin-induced diabetic rats. Metabolites 13(1):130","journal-title":"Metabolites"},{"issue":"17","key":"10933_CR42","doi-asserted-by":"publisher","first-page":"49197","DOI":"10.1007\/s11356-023-25694-2","volume":"30","author":"SA Ramadan","year":"2023","unstructured":"Ramadan SA, Kamel EM, Ewais MA, Khowailed AA, Hassanein EH, Mahmoud AM (2023) Flavonoids of Haloxylon salicornicum (Rimth) prevent cisplatin-induced acute kidney injury by modulating oxidative stress, inflammation, Nrf2, and SIRT1. Environ Sci Pollut Res 30(17):49197\u201349214","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"10933_CR43","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1196\/annals.1288.019","volume":"1005","author":"S Reddy","year":"2003","unstructured":"Reddy S, Ross JM (2003) Fas and Fas ligand immunoexpression in pancreatic islets of NOD mice during spontaneous and cyclophosphamide-accelerated diabetes. Ann N Y Acad Sci 1005(1):166\u2013169","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"10933_CR44","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3892\/ijo.2018.4661","volume":"54","author":"V Schirrmacher","year":"2019","unstructured":"Schirrmacher V (2019) From chemotherapy to biological therapy: a review of novel concepts to reduce the side effects of systemic cancer treatment. Int J Oncol 54(2):407\u2013419","journal-title":"Int J Oncol"},{"key":"10933_CR45","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.biopha.2017.05.047","volume":"92","author":"E \u015eeng\u00fcl","year":"2017","unstructured":"\u015eeng\u00fcl E, Gelen V, Gedikli S, \u00d6zkanlar S, G\u00fcr C, \u00c7elebi F, \u00c7\u0131nar A (2017) The protective effect of quercetin on cyclophosphamide-induced lung toxicity in rats. Biomed Pharmacother 92:303\u2013307","journal-title":"Biomed Pharmacother"},{"key":"10933_CR46","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00210-019-01741-z","volume":"393","author":"Y Temel","year":"2020","unstructured":"Temel Y, Kucukler S, Yildirim S, Caglayan C, Kandemir FM (2020) Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis. Naunyn Schmiedebergs Arch Pharmacol 393:325\u2013337","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10933_CR47","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/bcpt.13944","volume":"133","author":"P Tveden-Nyborg","year":"2023","unstructured":"Tveden-Nyborg P, Bergmann TK, Jessen N, Simonsen U, Lykkesfeldt J (2023) BCPT 2023 policy for experimental and clinical studies. Basic Clin Pharmacol Toxicol 133:391\u2013396","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"9","key":"10933_CR48","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1210\/en.2002-220412","volume":"143","author":"JL Wang","year":"2002","unstructured":"Wang JL, Qian X, Chinookoswong N, Lu J, Chow G, Theill LE, Shi ZQ (2002) Polyethylene glycolated recombinant TNF receptor I improves insulitis and reduces incidence of spontaneous and cyclophosphamide-accelerated diabetes in nonobese diabetic mice. Endocrinology 143(9):3490\u20133497","journal-title":"Endocrinology"},{"issue":"4","key":"10933_CR49","doi-asserted-by":"publisher","first-page":"22","DOI":"10.53388\/TMR20240704001","volume":"10","author":"Y Wang","year":"2025","unstructured":"Wang Y, Chen WJ, Mo Z, He Y, Nie K (2025) Therapeutic potential of the citrus flavonoid hesperidin and its aglycone hesperetin against chemotherapy-induced toxicity. Tradit Med Res 10(4):22","journal-title":"Tradit Med Res"},{"key":"10933_CR50","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.ijbiomac.2013.12.029","volume":"64","author":"Q Yu","year":"2014","unstructured":"Yu Q, Nie SP, Wang JQ, Liu XZ, Yin PF, Huang DF, Xie MY (2014) Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice. Int J Biol Macromol 64:395\u2013401","journal-title":"Int J Biol Macromol"},{"key":"10933_CR51","doi-asserted-by":"publisher","first-page":"6573","DOI":"10.1007\/s00210-025-04805-5","volume":"399","author":"MN Zengin","year":"2025","unstructured":"Zengin MN, \u00c7ift\u00e7i O, Yildirim S (2025) Investigation of the protective effects of hesperidin against nivolumab toxicity in rat testis tissue. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 399:6573\u20136583","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"issue":"17","key":"10933_CR52","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.3390\/molecules25173894","volume":"25","author":"M Zielinska","year":"2020","unstructured":"Zielinska M, Zielinska D, Oracz J (2020) Citrus flavonoids in fruit juices and non-alcoholic beverages. Molecules 25(17):3894\u20133903","journal-title":"Molecules"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10933-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10933-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10933-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:02:10Z","timestamp":1786953730000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-026-10933-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10933"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10933-w","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"27 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ankara University Ethics Committee (Reference number: 2021-14-121). The study was conducted in accordance with the Basic & Clinical Pharmacology and Toxicology policy for experimental and clinical studies.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"260"}}