{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:48:04Z","timestamp":1792273684966,"version":"4.4.0"},"reference-count":117,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Natural Science Foundation of China","award":["22001250"],"award-info":[{"award-number":["22001250"]}]},{"name":"the Natural Science Foundation of Fujian Province","award":["2023J01084"],"award-info":[{"award-number":["2023J01084"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10735-026-10935-8","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:24:33Z","timestamp":1789007073000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subcellular sirtuin signaling networks: pivotal regulators of cardiovascular homeostasis and remodeling"],"prefix":"10.1007","volume":"57","author":[{"given":"Min","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunkun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"10935_CR1","doi-asserted-by":"publisher","first-page":"14447","DOI":"10.1073\/pnas.0803790105","volume":"105","author":"BH Ahn","year":"2008","unstructured":"Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T (2008) A role for the mitochondrial deacetylase sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A 105:14447\u201314452. https:\/\/doi.org\/10.1073\/pnas.0803790105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10935_CR2","doi-asserted-by":"publisher","first-page":"21590","DOI":"10.1074\/jbc.M109.070169","volume":"285","author":"K Aquilano","year":"2010","unstructured":"Aquilano K, Vigilanza P, Baldelli S, Pagliei B, Rotilio G, Ciriolo MR (2010) Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. J Biol Chem 285:21590\u201321599. https:\/\/doi.org\/10.1074\/jbc.M109.070169","journal-title":"J Biol Chem"},{"key":"10935_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2020.01.002","volume":"139","author":"T Arsiwala","year":"2020","unstructured":"Arsiwala T, Pahla J, van Tits LJ, Bisceglie L, Gaul DS, Costantino S, Miranda MX, Nussbaum K, Stivala S, Blyszczuk P et al (2020) Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - central role of macrophage scavenger receptor 1. J Mol Cell Cardiol 139:24\u201332. https:\/\/doi.org\/10.1016\/j.yjmcc.2020.01.002","journal-title":"J Mol Cell Cardiol"},{"key":"10935_CR4","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1161\/CIRCULATIONAHA.112.097295","volume":"126","author":"SS Barbieri","year":"2012","unstructured":"Barbieri SS, Amadio P, Gianellini S, Tarantino E, Zacchi E, Veglia F, Howe LR, Weksler BB, Mussoni L, Tremoli E (2012) Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner. Circ 126:1373\u20131384. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.097295","journal-title":"Circ"},{"key":"10935_CR5","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature05354","volume":"444","author":"JA Baur","year":"2006","unstructured":"Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K et al (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337\u2013342. https:\/\/doi.org\/10.1038\/nature05354","journal-title":"Nature"},{"key":"10935_CR6","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1039\/c3mb00001j","volume":"9","author":"JM Beauharnois","year":"2013","unstructured":"Beauharnois JM, Bolivar BE, Welch JT (2013) Sirtuin 6: a review of biological effects and potential therapeutic properties. Mol Biosyst 9:1789\u20131806. https:\/\/doi.org\/10.1039\/c3mb00001j","journal-title":"Mol Biosyst"},{"key":"10935_CR7","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.tem.2016.04.015","volume":"27","author":"S Bindu","year":"2016","unstructured":"Bindu S, Pillai VB, Gupta MP (2016) Role of sirtuins in regulating pathophysiology of the heart. Trends Endocrinol Metab 27:563\u2013573. https:\/\/doi.org\/10.1016\/j.tem.2016.04.015","journal-title":"Trends Endocrinol Metab"},{"key":"10935_CR8","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.febslet.2012.02.014","volume":"586","author":"Y Cai","year":"2012","unstructured":"Cai Y, Yu SS, Chen SR, Pi RBAO, Gao S, Li H, Ye JT, Liu PQ (2012) Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6. FEBS Lett 586:866\u2013874. https:\/\/doi.org\/10.1016\/j.febslet.2012.02.014","journal-title":"FEBS Lett"},{"key":"10935_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/cells13171469","author":"R Campagna","year":"2024","unstructured":"Campagna R, Mazzanti L, Pompei V, Alia S, Vignini A, Emanuelli M (2024) The multifaceted role of endothelial SIRT1 in vascular aging: an update. Cells. https:\/\/doi.org\/10.3390\/cells13171469","journal-title":"Cells"},{"key":"10935_CR10","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/cvr\/cvs352","volume":"97","author":"A Cardus","year":"2013","unstructured":"Cardus A, Uryga AK, Walters G, Erusalimsky JD (2013) SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc Res 97:571\u2013579. https:\/\/doi.org\/10.1093\/cvr\/cvs352","journal-title":"Cardiovasc Res"},{"key":"10935_CR11","doi-asserted-by":"publisher","first-page":"32771","DOI":"10.1074\/jbc.M403528200","volume":"279","author":"AYM Chan","year":"2004","unstructured":"Chan AYM, Soltys CLM, Young ME, Proud CG, Dyck JRB (2004) Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J Biol Chem 279:32771\u201332779. https:\/\/doi.org\/10.1074\/jbc.M403528200","journal-title":"J Biol Chem"},{"key":"10935_CR12","doi-asserted-by":"publisher","first-page":"24194","DOI":"10.1074\/jbc.M802869200","volume":"283","author":"AYM Chan","year":"2008","unstructured":"Chan AYM, Dolinsky VW, Soltys CLM, Viollet B, Baksh S, Light PE, Dyck JRB (2008) Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and akt. J Biol Chem 283:24194\u201324201. https:\/\/doi.org\/10.1074\/jbc.M802869200","journal-title":"J Biol Chem"},{"key":"10935_CR13","doi-asserted-by":"publisher","first-page":"3187972","DOI":"10.1155\/2019\/3187972","volume":"2019","author":"KL Chen","year":"2019","unstructured":"Chen KL, Li L, Li CM, Wang YR, Yang FX, Kuang MQ, Wang GL (2019) SIRT7 regulates lipopolysaccharide-induced inflammatory injury by suppressing the NF-kappab signaling pathway. Oxid Med Cell Longev 2019:3187972. https:\/\/doi.org\/10.1155\/2019\/3187972","journal-title":"Oxid Med Cell Longev"},{"key":"10935_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107984","volume":"221","author":"RR Chen","year":"2025","unstructured":"Chen RR, Li YY, Wu JW, Wang Y, Song W, Shao D, Gao W, Yu H (2025) SIRT6 in health and diseases: from molecular mechanisms to therapeutic prospects. Pharmacol Res 221:107984. https:\/\/doi.org\/10.1016\/j.phrs.2025.107984","journal-title":"Pharmacol Res"},{"key":"10935_CR15","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1161\/CIRCRESAHA.124.325440","volume":"136","author":"YN Ding","year":"2025","unstructured":"Ding YN, Wang HY, Chen XF, Tang X, Chen HZ (2025) Roles of sirtuins in cardiovascular diseases: mechanisms and therapeutics. Circ Res 136:524\u2013550. https:\/\/doi.org\/10.1161\/CIRCRESAHA.124.325440","journal-title":"Circ Res"},{"key":"10935_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1668718","volume":"16","author":"K Dinislam","year":"2025","unstructured":"Dinislam K, Khoso MA, Kataev VA, Meshcheryakova S, Liu H, Liu L, Guo M, Wang S, Lou H, Zhang Y et al (2025) SIRT1: the first key to unlocking the mystery of cardiovascular diseases. Front Pharmacol 16:1668718. https:\/\/doi.org\/10.3389\/fphar.2025.1668718","journal-title":"Front Pharmacol"},{"key":"10935_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/nu17213316","author":"E Domi","year":"2025","unstructured":"Domi E, Hoxha M (2025) Natural compounds targeting SIRT1 and beyond: promising nutraceutical strategies against atherosclerosis. Nutrients. https:\/\/doi.org\/10.3390\/nu17213316","journal-title":"Nutrients"},{"key":"10935_CR18","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.bbadis.2015.03.001","volume":"1852","author":"N D'Onofrio","year":"2015","unstructured":"D\u2019Onofrio N, Vitiello M, Casale R, Servillo L, Giovane A, Balestrieri ML (2015) Sirtuins in vascular diseases: emerging roles and therapeutic potential. Biochim Biophys Acta 1852:1311\u20131322. https:\/\/doi.org\/10.1016\/j.bbadis.2015.03.001","journal-title":"Biochim Biophys Acta"},{"key":"10935_CR19","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature03314","volume":"434","author":"SF El-Khamisy","year":"2005","unstructured":"El-Khamisy SF, Saifi GM, Weinfeld M, Johansson F, Helleday T, Lupski JR, Caldecott KW (2005) Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature 434:108\u2013113. https:\/\/doi.org\/10.1038\/nature03314","journal-title":"Nature"},{"key":"10935_CR20","doi-asserted-by":"publisher","first-page":"42419","DOI":"10.1074\/jbc.R112.378877","volume":"287","author":"JL Feldman","year":"2012","unstructured":"Feldman JL, Dittenhafer-Reed KE, Denu JM (2012) Sirtuin catalysis and regulation. J Biol Chem 287:42419\u201342427. https:\/\/doi.org\/10.1074\/jbc.R112.378877","journal-title":"J Biol Chem"},{"key":"10935_CR21","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.2174\/1381612825666190925163827","volume":"25","author":"GD Flora","year":"2019","unstructured":"Flora GD, Nayak MK (2019) A brief review of cardiovascular diseases, associated risk factors and current treatment regimes. Curr Pharm des 25:4063\u20134084. https:\/\/doi.org\/10.2174\/1381612825666190925163827","journal-title":"Curr Pharm des"},{"key":"10935_CR22","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1161\/CIRCHEARTFAILURE.108.812099","volume":"2","author":"A Garnier","year":"2009","unstructured":"Garnier A, Zoll J, Fortin D, N\u2019Guessan B, Lefebvre F, Geny B, Mettauer B, Veksler V, Ventura-Clapier R (2009) Control by circulating factors of mitochondrial function and transcription cascade in heart failure: a role for endothelin-1 and angiotensin II. Circ Heart Fail 2:342\u2013350. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.108.812099","journal-title":"Circ Heart Fail"},{"key":"10935_CR23","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.42616","volume":"15","author":"GK Ghodeshwar","year":"2023","unstructured":"Ghodeshwar GK, Dube A, Khobragade D (2023) Impact of lifestyle modifications on cardiovascular health: a narrative review. Cureus 15:e42616. https:\/\/doi.org\/10.7759\/cureus.42616","journal-title":"Cureus"},{"key":"10935_CR24","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.ecl.2022.02.005","volume":"51","author":"ER Goldsborough","year":"2022","unstructured":"Goldsborough ER, Osuji N, Blaha MJ (2022) Assessment of cardiovascular disease risk: a 2022 update. Endocrinol Metab Clin North Am 51:483\u2013509. https:\/\/doi.org\/10.1016\/j.ecl.2022.02.005","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10935_CR25","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1161\/CIRCRESAHA.120.318353","volume":"128","author":"MOJ Grootaert","year":"2021","unstructured":"Grootaert MOJ, Finigan A, Figg NL, Uryga AK, Bennett MR (2021) SIRT6 protects smooth muscle cells from senescence and reduces atherosclerosis. Circ Res 128:474\u2013491. https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.318353","journal-title":"Circ Res"},{"key":"10935_CR26","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s12012-021-09639-0","volume":"21","author":"W Gu","year":"2021","unstructured":"Gu W, Cheng Y, Wang S, Sun T, Li Z (2021) PHD finger protein 19 promotes cardiac hypertrophy via epigenetically regulating SIRT2. Cardiovasc Toxicol 21:451\u2013461. https:\/\/doi.org\/10.1007\/s12012-021-09639-0","journal-title":"Cardiovasc Toxicol"},{"key":"10935_CR27","first-page":"3258","volume":"9","author":"X Guo","year":"2017","unstructured":"Guo X, Yan F, Li J, Zhang C, Bu P (2017) SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway. Am J Transl Res 9:3258\u20133269","journal-title":"Am J Transl Res"},{"key":"10935_CR28","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.14336\/AD.2022.0413","volume":"13","author":"Z Guo","year":"2022","unstructured":"Guo Z, Li P, Ge J, Li H (2022) SIRT6 in aging, metabolism, inflammation and cardiovascular diseases. Aging Dis 13:1787\u20131822. https:\/\/doi.org\/10.14336\/AD.2022.0413","journal-title":"Aging Dis"},{"key":"10935_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-27611-6","volume":"13","author":"Z Guo","year":"2023","unstructured":"Guo Z, Wang M, Ying X, Yuan J, Wang C, Zhang W, Tian S, Yan X (2023) Caloric restriction increases the resistance of aged heart to myocardial ischemia\/reperfusion injury via modulating AMPK-SIRT(1)-PGC(1a) energy metabolism pathway. Sci Rep 13:2045. https:\/\/doi.org\/10.1038\/s41598-023-27611-6","journal-title":"Sci Rep"},{"key":"10935_CR30","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.cmet.2020.01.009","volume":"31","author":"M He","year":"2020","unstructured":"He M, Chiang HH, Luo H, Zheng Z, Qiao Q, Wang L, Tan M, Ohkubo R, Mu WC, Zhao S et al (2020) An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance. Cell Metab 31:580\u2013591. https:\/\/doi.org\/10.1016\/j.cmet.2020.01.009","journal-title":"Cell Metab"},{"key":"10935_CR31","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nature08778","volume":"464","author":"MD Hirschey","year":"2010","unstructured":"Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR et al (2010) SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464:121\u2013125. https:\/\/doi.org\/10.1038\/nature08778","journal-title":"Nature"},{"key":"10935_CR32","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nrm3293","volume":"13","author":"RH Houtkooper","year":"2012","unstructured":"Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 13:225\u2013238. https:\/\/doi.org\/10.1038\/nrm3293","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10935_CR33","doi-asserted-by":"publisher","first-page":"20768","DOI":"10.1074\/jbc.M113.476903","volume":"288","author":"ME Hubbi","year":"2013","unstructured":"Hubbi ME, Hu H, Kshitiz, Gilkes DM, Semenza GL (2013) Sirtuin-7 inhibits the activity of hypoxia-inducible factors. J Biol Chem 288:20768\u201320775. https:\/\/doi.org\/10.1074\/jbc.M113.476903","journal-title":"J Biol Chem"},{"key":"10935_CR34","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/s41388-024-02976-8","volume":"43","author":"A Ianni","year":"2024","unstructured":"Ianni A, Kumari P, Tarighi S, Braun T, Vaquero A (2024) SIRT7: a novel molecular target for personalized cancer treatment? Oncogene 43:993\u20131006. https:\/\/doi.org\/10.1038\/s41388-024-02976-8","journal-title":"Oncogene"},{"key":"10935_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-023-00423-2","volume":"28","author":"A Janaszak-Jasiecka","year":"2023","unstructured":"Janaszak-Jasiecka A, P\u0142oska A, Wiero\u0144ska JM, Dobrucki LW, Kalinowski L (2023) Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets. Cell Mol Biol Lett 28:21. https:\/\/doi.org\/10.1186\/s11658-023-00423-2","journal-title":"Cell Mol Biol Lett"},{"key":"10935_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114253","volume":"442","author":"D Jia","year":"2024","unstructured":"Jia D, Ping W, Wang M, Wang D, Zhang L, Cao Y (2024) SIRT1 mediates the inflammatory response of macrophages and regulates the TIMP3\/ADAM17 pathway in atherosclerosis. Exp Cell Res 442:114253. https:\/\/doi.org\/10.1016\/j.yexcr.2024.114253","journal-title":"Exp Cell Res"},{"key":"10935_CR37","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1161\/CIRCRESAHA.118.312498","volume":"123","author":"AE Kane","year":"2018","unstructured":"Kane AE, Sinclair DA (2018) Sirtuins and NAD(+) in the development and treatment of metabolic and cardiovascular diseases. Circ Res 123:868\u2013885. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.312498","journal-title":"Circ Res"},{"key":"10935_CR38","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/j.1474-9726.2009.00544.x","volume":"9","author":"Y Kanfi","year":"2010","unstructured":"Kanfi Y, Peshti V, Gil R, Naiman S, Nahum L, Levin E, Kronfeld-Schor N, Cohen HY (2010) SIRT6 protects against pathological damage caused by diet-induced obesity. Aging Cell 9:162\u2013173. https:\/\/doi.org\/10.1111\/j.1474-9726.2009.00544.x","journal-title":"Aging Cell"},{"key":"10935_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002153","volume":"7","author":"TLA Kawahara","year":"2011","unstructured":"Kawahara TLA, Rapicavoli NA, Wu AR, Qu K, Quake SR, Chang HY (2011) Dynamic chromatin localization of sirt6 shapes stress- and aging-related transcriptional networks. PLoS Genet 7:e1002153. https:\/\/doi.org\/10.1371\/journal.pgen.1002153","journal-title":"PLoS Genet"},{"key":"10935_CR40","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.cellsig.2014.11.026","volume":"27","author":"S Kiran","year":"2015","unstructured":"Kiran S, Anwar T, Kiran M, Ramakrishna G (2015) Sirtuin 7 in cell proliferation, stress and disease: rise of the seventh sirtuin! Cell Signal 27:673\u2013682. https:\/\/doi.org\/10.1016\/j.cellsig.2014.11.026","journal-title":"Cell Signal"},{"key":"10935_CR41","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1089\/ars.2014.6213","volume":"22","author":"S Kumar","year":"2015","unstructured":"Kumar S, Lombard DB (2015) Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal 22:1060\u20131077. https:\/\/doi.org\/10.1089\/ars.2014.6213","journal-title":"Antioxid Redox Signal"},{"key":"10935_CR42","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/597514","author":"M Lappas","year":"2012","unstructured":"Lappas M (2012) Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells. Mediators Inflamm. https:\/\/doi.org\/10.1155\/2012\/597514","journal-title":"Mediators Inflamm"},{"key":"10935_CR43","doi-asserted-by":"publisher","first-page":"4552","DOI":"10.1128\/MCB.00087-13","volume":"33","author":"G Laurent","year":"2013","unstructured":"Laurent G, de Boer VCJ, Finley LWS, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA et al (2013) SIRT4 represses peroxisome proliferator-activated receptor \u03b1 activity to suppress hepatic fat oxidation. Mol Cell Biol 33:4552\u20134561. https:\/\/doi.org\/10.1128\/MCB.00087-13","journal-title":"Mol Cell Biol"},{"key":"10935_CR44","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1073\/pnas.0712145105","volume":"105","author":"IH Lee","year":"2008","unstructured":"Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T (2008) A role for the NAD-dependent deacetylase sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A 105:3374\u20133379. https:\/\/doi.org\/10.1073\/pnas.0712145105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10935_CR45","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.2337\/db16-1446","volume":"66","author":"Y Lee","year":"2017","unstructured":"Lee Y, Ka SO, Cha HN, Chae YN, Kim MK, Park SY, Bae EJ, Park BH (2017) Myeloid sirtuin 6 deficiency causes insulin resistance in high-fat diet-fed mice by eliciting macrophage polarization toward an M1 phenotype. Diabetes 66:2659\u20132668. https:\/\/doi.org\/10.2337\/db16-1446","journal-title":"Diabetes"},{"key":"10935_CR46","doi-asserted-by":"publisher","first-page":"20946","DOI":"10.18632\/aging.202176","volume":"12","author":"OHE Lee","year":"2020","unstructured":"Lee OHE, Woo YM, Moon S, Lee J, Park H, Jang H, Park YY, Bae SK, Park KH, Heo JH et al (2020) Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression. Aging 12:20946\u201320967. https:\/\/doi.org\/10.18632\/aging.202176","journal-title":"Aging"},{"key":"10935_CR47","doi-asserted-by":"publisher","first-page":"40429","DOI":"10.1074\/jbc.M606596200","volume":"281","author":"M Li","year":"2006","unstructured":"Li M, Chiu JF, Mossman BT, Fukagawa NK (2006) Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by akt in explanted vascular smooth muscle cells from old rats. J Biol Chem 281:40429\u201340439. https:\/\/doi.org\/10.1074\/jbc.M606596200","journal-title":"J Biol Chem"},{"key":"10935_CR48","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s00395-011-0213-9","volume":"106","author":"L Li","year":"2011","unstructured":"Li L, Muhlfeld C, Niemann B, Pan R, Li R, Hilfiker-Kleiner D, Chen Y, Rohrbach S (2011) Mitochondrial biogenesis and PGC-1alpha deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle. Basic Res Cardiol 106:1221\u20131234. https:\/\/doi.org\/10.1007\/s00395-011-0213-9","journal-title":"Basic Res Cardiol"},{"key":"10935_CR49","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13026","volume":"18","author":"J Li","year":"2019","unstructured":"Li J, Li SH, Dong J, Alibhai FJ, Zhang C, Shao ZB, Song HF, He S, Yin WJ, Wu J et al (2019) Long-term repopulation of aged bone marrow stem cells using young sca-1 cells promotes aged heart rejuvenation. Aging Cell 18:e13026. https:\/\/doi.org\/10.1111\/acel.13026","journal-title":"Aging Cell"},{"key":"10935_CR50","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/j.immuni.2025.09.012","volume":"58","author":"P Libby","year":"2025","unstructured":"Libby P, Soehnlein O (2025) Inflammation in atherosclerosis: lessons and therapeutic implications. Immunity 58:2383\u20132401. https:\/\/doi.org\/10.1016\/j.immuni.2025.09.012","journal-title":"Immunity"},{"key":"10935_CR51","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1159\/000354469","volume":"32","author":"B Liu","year":"2013","unstructured":"Liu B, Che W, Xue J, Zheng C, Tang K, Zhang J, Wen J, Xu Y (2013) SIRT4 prevents hypoxia-induced apoptosis in h9c2 cardiomyoblast cells. Cell Physiol Biochem 32:655\u2013662. https:\/\/doi.org\/10.1159\/000354469","journal-title":"Cell Physiol Biochem"},{"key":"10935_CR52","first-page":"978","volume":"21","author":"Y Liu","year":"2017","unstructured":"Liu Y, Liu YL, Cheng W, Yin XM, Jiang B (2017) The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects. Eur Rev Med Pharmacol Sci 21:978\u2013998","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10935_CR53","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20211775","author":"Y Liu","year":"2022","unstructured":"Liu Y, Yang J, Yang X, Lai P, Mou Y, Deng J, Li X, Wang H, Liu X, Zhou L et al (2022) H2O2 down-regulates SIRT7\u2019s protective role of endothelial premature dysfunction via microRNA-335-5p. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20211775"},{"key":"10935_CR54","doi-asserted-by":"publisher","first-page":"8807","DOI":"10.1128\/MCB.01636-07","volume":"27","author":"DB Lombard","year":"2007","unstructured":"Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A et al (2007) Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol 27:8807\u20138814. https:\/\/doi.org\/10.1128\/MCB.01636-07","journal-title":"Mol Cell Biol"},{"key":"10935_CR55","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","volume":"128","author":"GD Lopaschuk","year":"2021","unstructured":"Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED (2021) Cardiac energy metabolism in heart failure. Circ Res 128:1487\u20131513. https:\/\/doi.org\/10.1161\/CIRCRESAHA.121.318241","journal-title":"Circ Res"},{"key":"10935_CR56","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400469","volume":"9","author":"Y Lu","year":"2025","unstructured":"Lu Y, Yang J, Wu Q, Wang X (2025) The role and molecular pathways of SIRT6 in senescence and age-related diseases. Adv Biol 9:e2400469. https:\/\/doi.org\/10.1002\/adbi.202400469","journal-title":"Adv Biol"},{"key":"10935_CR57","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1093\/eurheartj\/ehw138","volume":"38","author":"YX Luo","year":"2017","unstructured":"Luo YX, Tang X, An XZ, Xie XM, Chen XF, Zhao X, Hao DL, Chen HZ, Liu DP (2017) SIRT4 accelerates ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. Eur Heart J 38:1389\u20131398. https:\/\/doi.org\/10.1093\/eurheartj\/ehw138","journal-title":"Eur Heart J"},{"key":"10935_CR58","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.yexcr.2014.07.013","volume":"330","author":"A Maksin-Matveev","year":"2015","unstructured":"Maksin-Matveev A, Kanfi Y, Hochhauser E, Isak A, Cohen HY, Shainberg A (2015) Sirtuin 6 protects the heart from hypoxic damage. Exp Cell Res 330:81\u201390. https:\/\/doi.org\/10.1016\/j.yexcr.2014.07.013","journal-title":"Exp Cell Res"},{"key":"10935_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112245","volume":"396","author":"ZL Mei","year":"2020","unstructured":"Mei ZL, Wang HB, Hu YH, Xiong L (2020) CSN6 aggravates ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2. Exp Cell Res 396:112245. https:\/\/doi.org\/10.1016\/j.yexcr.2020.112245","journal-title":"Exp Cell Res"},{"key":"10935_CR60","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1038\/s12276-024-01362-4","volume":"56","author":"HY Nam","year":"2024","unstructured":"Nam HY, Park SH, Lee GHE, Kim EY, Lee S, Chang HW, Chang EJ, Choi KC, Kim SW (2024) TIGAR coordinates senescence-associated secretory phenotype via lysosome repositioning and \u03b1-tubulin deacetylation. Exp Mol Med 56:2726\u20132738. https:\/\/doi.org\/10.1038\/s12276-024-01362-4","journal-title":"Exp Mol Med"},{"key":"10935_CR61","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1126\/science.1117728","volume":"310","author":"E Nisoli","year":"2005","unstructured":"Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E et al (2005) Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310:314\u2013317. https:\/\/doi.org\/10.1126\/science.1117728","journal-title":"Science"},{"key":"10935_CR62","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3390\/metabo16050338","volume":"16","author":"M Nobile","year":"2026","unstructured":"Nobile M, Fontanini V, Serrao S, Burtscher J, Re F, Paglia G (2026) Targeting NAD homeostasis: compartmentalization, quantification, and modulation. Metabolites 16:338. https:\/\/doi.org\/10.3390\/metabo16050338","journal-title":"Metabolites"},{"key":"10935_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082604","volume":"9","author":"SJ Pecher","year":"2020","unstructured":"Pecher SJ, Potthast AB, von Versen-H\u00f6ynck F, Das AM (2020) Impact of short-term hypoxia on sirtuins as regulatory elements in HUVECs. J Clin Med 9:2604. https:\/\/doi.org\/10.3390\/jcm9082604","journal-title":"J Clin Med"},{"key":"10935_CR64","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.mito.2011.07.003","volume":"12","author":"CV Pereira","year":"2012","unstructured":"Pereira CV, Lebiedzinska M, Wieckowski MR, Oliveira PJ (2012) Regulation and protection of mitochondrial physiology by sirtuins. Mitochondrion 12:66\u201376. https:\/\/doi.org\/10.1016\/j.mito.2011.07.003","journal-title":"Mitochondrion"},{"key":"10935_CR65","doi-asserted-by":"publisher","first-page":"34082","DOI":"10.18632\/oncotarget.16133","volume":"8","author":"VB Pillai","year":"2017","unstructured":"Pillai VB, Kanwal A, Fang YH, Sharp WW, Samant S, Arbiser J, Gupta MP (2017) Honokiol, an activator of sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice. Oncotarget 8:34082\u201334098. https:\/\/doi.org\/10.18632\/oncotarget.16133","journal-title":"Oncotarget"},{"key":"10935_CR66","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41392-024-01756-w","volume":"9","author":"L Qian","year":"2024","unstructured":"Qian L, Zhu Y, Deng C, Liang Z, Chen J, Chen Y, Wang X, Liu Y, Tian Y, Yang Y (2024) Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases. Signal Transduct Target Ther 9:50. https:\/\/doi.org\/10.1038\/s41392-024-01756-w","journal-title":"Signal Transduct Target Ther"},{"key":"10935_CR67","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.cmet.2011.10.007","volume":"14","author":"L Qiang","year":"2011","unstructured":"Qiang L, Lin HV, Kim-Muller JY, Welch CL, Gu W, Accili D (2011) Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through creb deacetylation. Cell Metab 14:758\u2013767. https:\/\/doi.org\/10.1016\/j.cmet.2011.10.007","journal-title":"Cell Metab"},{"key":"10935_CR68","doi-asserted-by":"publisher","first-page":"70600","DOI":"10.1002\/mco2.70600","volume":"7","author":"Y Qin","year":"2020","unstructured":"Qin Y et al (2020) Oxidative stress: molecular mechanisms, diseases, and therapeutic targets. MedComm 7:70600. https:\/\/doi.org\/10.1002\/mco2.70600","journal-title":"MedComm"},{"key":"10935_CR69","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41392-023-01577-3","volume":"8","author":"Y Qiu","year":"2023","unstructured":"Qiu Y, Xu S, Chen X, Wu X, Zhou Z, Zhang J, Tu Q, Dong B, Liu Z, He J et al (2023) NAD(+) exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension. Signal Transduct Target Ther 8:353. https:\/\/doi.org\/10.1038\/s41392-023-01577-3","journal-title":"Signal Transduct Target Ther"},{"key":"10935_CR70","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/j.jmb.2013.10.027","volume":"426","author":"JGM Rack","year":"2014","unstructured":"Rack JGM, Van Linden MR, Lutter T, Aasland R, Ziegler M (2014) Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. J Mol Biol 426:1677\u20131691. https:\/\/doi.org\/10.1016\/j.jmb.2013.10.027","journal-title":"J Mol Biol"},{"key":"10935_CR71","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2013.11.013","volume":"18","author":"MJ Rardin","year":"2013","unstructured":"Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B et al (2013) SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab 18:920\u2013933. https:\/\/doi.org\/10.1016\/j.cmet.2013.11.013","journal-title":"Cell Metab"},{"key":"10935_CR72","doi-asserted-by":"publisher","first-page":"1393181","DOI":"10.3389\/fgene.2024.1393181","volume":"15","author":"B Rogina","year":"2024","unstructured":"Rogina B, Tissenbaum HA (2024) SIRT1, resveratrol and aging. Front Genet 15:1393181. https:\/\/doi.org\/10.3389\/fgene.2024.1393181","journal-title":"Front Genet"},{"key":"10935_CR73","doi-asserted-by":"publisher","first-page":"H1428","DOI":"10.1152\/ajpheart.00735.2012","volume":"305","author":"CM Roos","year":"2013","unstructured":"Roos CM, Hagler M, Zhang B, Oehler EA, Arghami A, Miller JD (2013) Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice. Am J Physiol Heart Circ Physiol 305:H1428\u2013H1439. https:\/\/doi.org\/10.1152\/ajpheart.00735.2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10935_CR74","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1016\/j.jacc.2020.11.021","volume":"76","author":"GA Roth","year":"2020","unstructured":"Roth GA, Mensah GA, Fuster V (2020) The global burden of cardiovascular diseases and risks: a compass for global action. J Am Coll Cardiol 76:2980\u20132981. https:\/\/doi.org\/10.1016\/j.jacc.2020.11.021","journal-title":"J Am Coll Cardiol"},{"key":"10935_CR75","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1073\/pnas.1519858113","volume":"113","author":"S Sadhukhan","year":"2016","unstructured":"Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW et al (2016) Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proc Natl Acad Sci U S A 113:4320\u20134325. https:\/\/doi.org\/10.1073\/pnas.1519858113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10935_CR76","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/nature05602","volume":"446","author":"M Sano","year":"2007","unstructured":"Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M et al (2007) P53-induced inhibition of HIF-1 causes cardiac dysfunction during pressure overload. Nature 446:444\u2013448. https:\/\/doi.org\/10.1038\/nature05602","journal-title":"Nature"},{"key":"10935_CR77","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41467-017-02586-x","volume":"9","author":"I Santos-Barriopedro","year":"2018","unstructured":"Santos-Barriopedro I, Bosch-Presegue L, Marazuela-Duque A, de la Torre C, Colomer C, Vazquez BN, Fuhrmann T, Martinez-Pastor B, Lu W, Braun T et al (2018) SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of suv39h1 regulates the NF-kappab pathway. Nat Commun 9:101. https:\/\/doi.org\/10.1038\/s41467-017-02586-x","journal-title":"Nat Commun"},{"key":"10935_CR78","doi-asserted-by":"publisher","first-page":"5281","DOI":"10.1074\/jbc.RA117.000915","volume":"293","author":"M Sarikhani","year":"2018","unstructured":"Sarikhani M, Maity S, Mishra S, Jain A, Tamta AK, Ravi V, Kondapalli MS, Desingu PA, Khan D, Kumar S et al (2018) SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis. J Biol Chem 293:5281\u20135294. https:\/\/doi.org\/10.1074\/jbc.RA117.000915","journal-title":"J Biol Chem"},{"key":"10935_CR79","doi-asserted-by":"publisher","first-page":"6726","DOI":"10.7150\/thno.100667","volume":"14","author":"H Shen","year":"2024","unstructured":"Shen H, Qi X, Hu Y, Wang Y, Zhang J, Liu Z, Qin Z (2024) Targeting sirtuins for cancer therapy: epigenetics modifications and beyond. Theranostics 14:6726\u20136767. https:\/\/doi.org\/10.7150\/thno.100667","journal-title":"Theranostics"},{"key":"10935_CR80","doi-asserted-by":"publisher","DOI":"10.1038\/srep03085","volume":"3","author":"F Simeoni","year":"2013","unstructured":"Simeoni F, Tasselli L, Tanaka S, Villanova L, Hayashi M, Kubota K, Isono F, Garcia BA, Michishita-Kioi E, Chua KF (2013) Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling. Sci Rep 3:3085. https:\/\/doi.org\/10.1038\/srep03085","journal-title":"Sci Rep"},{"key":"10935_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.110882","volume":"133","author":"MP Singulani","year":"2020","unstructured":"Singulani MP, Pereira CPM, Ferreira AFF, Garcia PC, Ferrari GD, Alberici LC, Britto LR (2020) Impairment of PGC-1alpha-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and alzheimer\u2019s pathology in the 3xtg mouse model of alzheimer\u2019s disease. Exp Gerontol 133:110882. https:\/\/doi.org\/10.1016\/j.exger.2020.110882","journal-title":"Exp Gerontol"},{"key":"10935_CR82","doi-asserted-by":"publisher","first-page":"682","DOI":"10.4103\/NRR.NRR-D-23-02063","volume":"20","author":"N Sola-Sevilla","year":"2025","unstructured":"Sola-Sevilla N, Garmendia-Berges M, Mera-Delgado M, Puerta E (2025) Context-dependent role of sirtuin 2 in inflammation. Neural Regen Res 20:682\u2013694. https:\/\/doi.org\/10.4103\/NRR.NRR-D-23-02063","journal-title":"Neural Regen Res"},{"key":"10935_CR83","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.bbadis.2018.09.024","volume":"1865","author":"MDL Sousa Fialho","year":"2019","unstructured":"Sousa Fialho MDL, Abd Jamil AH, Stannard GA, Heather LC (2019) Hypoxia-inducible factor 1 signalling, metabolism and its therapeutic potential in cardiovascular disease. Biochimica Et Biophysica Acta (BBA) 1865:831\u2013843. https:\/\/doi.org\/10.1016\/j.bbadis.2018.09.024","journal-title":"Biochimica Et Biophysica Acta (BBA)"},{"key":"10935_CR84","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061085","author":"M Su","year":"2022","unstructured":"Su M, Zhao W, Xu S, Weng J (2022) Resveratrol in treating diabetes and its cardiovascular complications: a review of its mechanisms of action. Antioxidants. https:\/\/doi.org\/10.3390\/antiox11061085","journal-title":"Antioxidants"},{"key":"10935_CR85","doi-asserted-by":"publisher","first-page":"eaay5556","DOI":"10.1126\/sciadv.aay5556","volume":"6","author":"S Sun","year":"2020","unstructured":"Sun S, Qin W, Tang X, Meng Y, Hu W, Zhang S, Qian M, Liu Z, Cao X, Pang Q et al (2020) Vascular endothelium-targeted sirt7 gene therapy rejuvenates blood vessels and extends life span in a hutchinson-gilford progeria model. Sci Adv 6:eaay5556. https:\/\/doi.org\/10.1126\/sciadv.aay5556","journal-title":"Sci Adv"},{"key":"10935_CR86","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1465849","volume":"15","author":"H Sun","year":"2024","unstructured":"Sun H, Li D, Wei C, Liu L, Xin Z, Gao H, Gao R (2024) The relationship between SIRT1 and inflammation: a systematic review and meta-analysis. Front Immunol 15:1465849. https:\/\/doi.org\/10.3389\/fimmu.2024.1465849","journal-title":"Front Immunol"},{"key":"10935_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27010095","author":"J Sun","year":"2025","unstructured":"Sun J, Zhou D, Cheng M (2025) Potential biomarker and therapeutic tools for pathological cardiac hypertrophy and heart failure: extracellular vesicles. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms27010095","journal-title":"Int J Mol Sci"},{"key":"10935_CR88","doi-asserted-by":"publisher","first-page":"6384","DOI":"10.1128\/MCB.00426-08","volume":"28","author":"NR Sundaresan","year":"2008","unstructured":"Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP (2008) SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of ku70. Mol Cell Biol 28:6384\u20136401. https:\/\/doi.org\/10.1128\/MCB.00426-08","journal-title":"Mol Cell Biol"},{"key":"10935_CR89","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1172\/JCI39162","volume":"119","author":"NR Sundaresan","year":"2009","unstructured":"Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP (2009) Sirt3 blocks the cardiac hypertrophic response by augmenting foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Investig 119:2758\u20132771. https:\/\/doi.org\/10.1172\/JCI39162","journal-title":"J Clin Investig"},{"key":"10935_CR90","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1128\/MCB.00586-15","volume":"36","author":"NR Sundaresan","year":"2015","unstructured":"Sundaresan NR, Bindu S, Pillai VB, Samant S, Pan Y, Huang JY, Gupta M, Nagalingam RS, Wolfgeher D, Verdin E et al (2015) SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3\u03b2. Mol Cell Biol 36:678\u2013692. https:\/\/doi.org\/10.1128\/MCB.00586-15","journal-title":"Mol Cell Biol"},{"key":"10935_CR91","doi-asserted-by":"publisher","first-page":"29730","DOI":"10.1074\/jbc.M805514200","volume":"283","author":"WQ Tan","year":"2008","unstructured":"Tan WQ, Wang K, Lv DY, Li PF (2008) Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. J Biol Chem 283:29730\u201329739. https:\/\/doi.org\/10.1074\/jbc.M805514200","journal-title":"J Biol Chem"},{"key":"10935_CR92","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1161\/CIRCULATIONAHA.117.028728","volume":"136","author":"X Tang","year":"2017","unstructured":"Tang X, Chen XF, Wang NY, Wang XM, Liang ST, Zheng W, Lu YBAO, Zhao X, Hao DL, Zhang ZQ et al (2017) SIRT2 acts as a cardioprotective deacetylase in pathological cardiac hypertrophy. Circulation 136:2051\u20132067. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.028728","journal-title":"Circulation"},{"key":"10935_CR93","doi-asserted-by":"publisher","first-page":"6823","DOI":"10.1074\/jbc.M609554200","volume":"282","author":"M Tanno","year":"2007","unstructured":"Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y (2007) Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem 282:6823\u20136832. https:\/\/doi.org\/10.1074\/jbc.M609554200","journal-title":"J Biol Chem"},{"key":"10935_CR94","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.molcel.2010.12.013","volume":"40","author":"R Tao","year":"2010","unstructured":"Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W et al (2010) Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell 40:893\u2013904. https:\/\/doi.org\/10.1016\/j.molcel.2010.12.013","journal-title":"Mol Cell"},{"key":"10935_CR95","doi-asserted-by":"publisher","first-page":"29252","DOI":"10.1074\/jbc.M113.481473","volume":"288","author":"R Tao","year":"2013","unstructured":"Tao R, Xiong X, DePinho RA, Deng CX, Dong XC (2013) FoxO3 transcription factor and sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin\/kexin type 9 (pcsk9) gene expression. J Biol Chem 288:29252\u201329259. https:\/\/doi.org\/10.1074\/jbc.M113.481473","journal-title":"J Biol Chem"},{"key":"10935_CR96","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12012-014-9287-6","volume":"15","author":"Y Tao","year":"2015","unstructured":"Tao Y, Huang C, Huang Y, Hong L, Wang H, Zhou Z, Qiu Y (2015) SIRT4 suppresses inflammatory responses in human umbilical vein endothelial cells. Cardiovasc Toxicol 15:217\u2013223. https:\/\/doi.org\/10.1007\/s12012-014-9287-6","journal-title":"Cardiovasc Toxicol"},{"key":"10935_CR97","doi-asserted-by":"publisher","first-page":"4973","DOI":"10.3892\/mmr.2019.10161","volume":"19","author":"Y Tao","year":"2019","unstructured":"Tao Y, Yu S, Chao M, Wang Y, Xiong J, Lai H (2019) SIRT4 suppresses the PI3k\/akt\/NF-\u03bab signaling pathway and attenuates HUVEC injury induced by oxLDL. Mol Med Rep 19:4973\u20134979. https:\/\/doi.org\/10.3892\/mmr.2019.10161","journal-title":"Mol Med Rep"},{"key":"10935_CR98","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.cmet.2011.10.002","volume":"14","author":"S Timmers","year":"2011","unstructured":"Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S et al (2011) Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 14:612\u2013622. https:\/\/doi.org\/10.1016\/j.cmet.2011.10.002","journal-title":"Cell Metab"},{"key":"10935_CR99","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1111\/j.1474-9726.2010.00586.x","volume":"9","author":"S Turdi","year":"2010","unstructured":"Turdi S, Fan X, Li J, Zhao J, Huff AF, Du M, Ren J (2010) AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction. Aging Cell 9:592\u2013606. https:\/\/doi.org\/10.1111\/j.1474-9726.2010.00586.x","journal-title":"Aging Cell"},{"key":"10935_CR100","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1161\/CIRCRESAHA.107.164558","volume":"102","author":"O Vakhrusheva","year":"2008","unstructured":"Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E (2008) Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res 102:703\u2013710. https:\/\/doi.org\/10.1161\/CIRCRESAHA.107.164558","journal-title":"Circ Res"},{"key":"10935_CR101","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.molmed.2017.02.005","volume":"23","author":"RAH van de Ven","year":"2017","unstructured":"van de Ven RAH, Santos D, Haigis MC (2017) Mitochondrial sirtuins and molecular mechanisms of aging. Trends Mol Med 23:320\u2013331. https:\/\/doi.org\/10.1016\/j.molmed.2017.02.005","journal-title":"Trends Mol Med"},{"key":"10935_CR102","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/cvr\/cvn098","volume":"79","author":"R Ventura-Clapier","year":"2008","unstructured":"Ventura-Clapier R, Garnier A, Veksler V (2008) Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. Cardiovasc Res 79:208\u2013217. https:\/\/doi.org\/10.1093\/cvr\/cvn098","journal-title":"Cardiovasc Res"},{"key":"10935_CR103","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1474-9726.2007.00304.x","volume":"6","author":"F Wang","year":"2007","unstructured":"Wang F, Nguyen M, Qin FXF, Tong Q (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6:505\u2013514. https:\/\/doi.org\/10.1111\/j.1474-9726.2007.00304.x","journal-title":"Aging Cell"},{"key":"10935_CR104","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100961","volume":"55","author":"Y Wang","year":"2019","unstructured":"Wang Y, Yang J, Hong T, Chen X, Cui L (2019) SIRT2: controversy and multiple roles in disease and physiology. Ageing Res Rev 55:100961. https:\/\/doi.org\/10.1016\/j.arr.2019.100961","journal-title":"Ageing Res Rev"},{"key":"10935_CR105","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1097\/CM9.0000000000003056","volume":"137","author":"Z Wei","year":"2024","unstructured":"Wei Z, Yang B, Wang H, Lv S, Chen H, Liu D (2024) Caloric restriction, sirtuins, and cardiovascular diseases. Chin Med J 137:921\u2013935. https:\/\/doi.org\/10.1097\/CM9.0000000000003056","journal-title":"Chin Med J"},{"key":"10935_CR106","doi-asserted-by":"publisher","first-page":"6470","DOI":"10.1111\/jcmm.16618","volume":"25","author":"B Wu","year":"2021","unstructured":"Wu B, You S, Qian H, Wu S, Lu S, Zhang Y, Sun Y, Zhang N (2021) The role of SIRT2 in vascular-related and heart-related diseases: a review. J Cell Mol Med 25:6470\u20136478. https:\/\/doi.org\/10.1111\/jcmm.16618","journal-title":"J Cell Mol Med"},{"key":"10935_CR107","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01257-8","volume":"7","author":"QJ Wu","year":"2022","unstructured":"Wu QJ, Zhang TN, Chen HH, Yu XF, Lv JL, Liu YY, Liu YS, Zheng G, Zhao JQ, Wei YF et al (2022) The sirtuin family in health and disease. Signal Transduct Target Ther 7:402. https:\/\/doi.org\/10.1038\/s41392-022-01257-8","journal-title":"Signal Transduct Target Ther"},{"key":"10935_CR108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168078","volume":"11","author":"Y Xiao","year":"2016","unstructured":"Xiao Y, Zhang X, Fan S, Cui G, Shen Z (2016) MicroRNA-497 inhibits cardiac hypertrophy by targeting sirt4. PLoS ONE 11:e0168078. https:\/\/doi.org\/10.1371\/journal.pone.0168078","journal-title":"PLoS ONE"},{"key":"10935_CR109","doi-asserted-by":"publisher","first-page":"H1003","DOI":"10.1152\/ajpheart.00676.2015","volume":"310","author":"T Yamamoto","year":"2016","unstructured":"Yamamoto T, Tamaki K, Shirakawa K, Ito K, Yan X, Katsumata Y, Anzai A, Matsuhashi T, Endo J, Inaba T et al (2016) Cardiac sirt1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion. Am J Physiol Heart Circ Physiol 310:H1003\u2013H1014. https:\/\/doi.org\/10.1152\/ajpheart.00676.2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10935_CR110","doi-asserted-by":"publisher","DOI":"10.3390\/biom15101445","author":"S Yang","year":"2025","unstructured":"Yang S, Chen W, Li S, Zhao S, Cheng F (2025) Sirtuin family in acute kidney injury: insights into cellular mechanisms and potential targets for treatment. Biomolecules. https:\/\/doi.org\/10.3390\/biom15101445","journal-title":"Biomolecules"},{"key":"10935_CR111","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/jcb.22169","volume":"107","author":"W Yu","year":"2009","unstructured":"Yu W, Fu YC, Zhou XH, Chen CJ, Wang X, Lin RB, Wang W (2009) Effects of resveratrol on H2O2-induced apoptosis and expression of SIRTs in h9c2 cells. J Cell Biochem 107:741\u2013747. https:\/\/doi.org\/10.1002\/jcb.22169","journal-title":"J Cell Biochem"},{"key":"10935_CR112","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nchembio.495","volume":"7","author":"Z Zhang","year":"2011","unstructured":"Zhang Z, Tan M, Xie Z, Dai L, Chen Y, Zhao Y (2011) Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol 7:58\u201363. https:\/\/doi.org\/10.1038\/nchembio.495","journal-title":"Nat Chem Biol"},{"key":"10935_CR113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122297","volume":"10","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Bharathi SS, Rardin MJ, Uppala R, Verdin E, Gibson BW, Goetzman ES (2015) SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase. PLoS ONE 10:e0122297. https:\/\/doi.org\/10.1371\/journal.pone.0122297","journal-title":"PLoS ONE"},{"key":"10935_CR114","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1080\/15384101.2016.1152427","volume":"15","author":"N Zhang","year":"2016","unstructured":"Zhang N, Li Z, Mu W, Li L, Liang Y, Lu M, Wang Z, Qiu Y, Wang Z (2016) Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-\u03baB signaling. Cell Cycle 15:1009\u20131018. https:\/\/doi.org\/10.1080\/15384101.2016.1152427","journal-title":"Cell Cycle"},{"key":"10935_CR115","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10529-017-2487-y","volume":"40","author":"W Zhang","year":"2018","unstructured":"Zhang W, Liu D, Ren J, Zhou P, Han X (2018a) Overexpression of sirtuin2 prevents high glucose-induced vascular endothelial cell injury by regulating the p53 and NF-\u03bab signaling pathways. Biotechnol Lett 40:271\u2013278. https:\/\/doi.org\/10.1007\/s10529-017-2487-y","journal-title":"Biotechnol Lett"},{"key":"10935_CR116","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.biopha.2017.11.061","volume":"97","author":"B Zhang","year":"2018","unstructured":"Zhang B, Ma Y, Xiang C (2018b) SIRT2 decreases atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice by modulating macrophage polarization. Biomed Pharmacother 97:1238\u20131242. https:\/\/doi.org\/10.1016\/j.biopha.2017.11.061","journal-title":"Biomed Pharmacother"},{"key":"10935_CR117","doi-asserted-by":"publisher","DOI":"10.3390\/nu18060890","volume":"18","author":"M Zhang","year":"2026","unstructured":"Zhang M, Chen Y, Jiang N, Zeng J, Zhang J, Wu C, Liu Y, Nie Z, Yang J, Han S (2026) Effects of nicotinamide mononucleotide supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Nutrients 18:890. https:\/\/doi.org\/10.3390\/nu18060890","journal-title":"Nutrients"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10935-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10935-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10935-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:19:15Z","timestamp":1792271955000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10935-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":117,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10935"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10935-8","relation":{"references":[{"id-type":"doi","id":"10.1042\/BSR20211775","asserted-by":"subject"}]},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"8 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"300"}}