{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:48:45Z","timestamp":1792273725656,"version":"4.4.0"},"reference-count":136,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10735-026-10946-5","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:07:13Z","timestamp":1788664033000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The neuroprotective potential of thymoquinone and intermittent fasting on aluminum chloride-induced Alzheimer\u2019s disease like model in rat hippocampus: insights into neurogenesis and autophagy"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-3460","authenticated-orcid":false,"given":"Reem Ahmed","family":"Abd El-Salam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza Radwan","family":"El-Hadidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-4030","authenticated-orcid":false,"given":"Nesreen Moustafa","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6332-2398","authenticated-orcid":false,"given":"Nahla Reda","family":"Sarhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"issue":"1","key":"10946_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-024-05920-4","volume":"7","author":"LS Abasi","year":"2024","unstructured":"Abasi LS, Elathram N, Movva M, Deep A, Corbett KD, Debelouchina GT (2024) Phosphorylation regulates tau\u2019s phase separation behavior and interactions with chromatin. Commun Biol 7(1):1\u201317. https:\/\/doi.org\/10.1038\/s42003-024-05920-4","journal-title":"Commun Biol"},{"key":"10946_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2022.113072","volume":"151","author":"F Abbas","year":"2022","unstructured":"Abbas F, Eladl MA, El-Sherbiny M, Abozied N, Nabil A, Mahmoud SM et al (2022) Celastrol and thymoquinone alleviate aluminum chloride-induced neurotoxicity: behavioral psychomotor performance, neurotransmitter level, oxidative-inflammatory markers, and BDNF expression in rat brain. Biomed Pharmacother 151:1\u20138. https:\/\/doi.org\/10.1016\/j.biopha.2022.113072","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10946_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-025-08186-8","volume":"17","author":"AA Abdulkhaliq","year":"2026","unstructured":"Abdulkhaliq AA, Kim B, Almoghrabi YM, Khan J, Ajoolabady A, Ren J et al (2026) Amyloid-\u03b2 and tau in Alzheimer\u2019s disease: pathogenesis, mechanisms, and interplay. Cell Death Dis 17(1):1\u201312. https:\/\/doi.org\/10.1038\/s41419-025-08186-8","journal-title":"Cell Death Dis"},{"key":"10946_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.prmcm.2024.100492","volume":"12","author":"M Agrawal","year":"2024","unstructured":"Agrawal M, Singhal M, Semwal BC, Arora S, Singh B, Sikarwar V et al (2024) Neuroprotective action of hordenine against the Aluminium Chloride (AlCl3) induced Alzheimer\u2019s diseases & associated memory impairment in experimental rats. PRMCM 12:1\u201311. https:\/\/doi.org\/10.1016\/j.prmcm.2024.100492","journal-title":"PRMCM"},{"issue":"4","key":"10946_CR5","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s11064-021-03495-8","volume":"47","author":"A Al Mamun","year":"2022","unstructured":"Al Mamun A, Matsuzaki K, Islam R, Hossain S, Hossain ME, Katakura M et al (2022) Chronic administration of thymoquinone enhances adult hippocampal neurogenesis and improves memory in rats via regulating the BDNF signaling pathway. Neurochem Res 47(4):933\u2013951. https:\/\/doi.org\/10.1007\/s11064-021-03495-8","journal-title":"Neurochem Res"},{"issue":"19","key":"10946_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu15194270","volume":"15","author":"T Albrahim","year":"2023","unstructured":"Albrahim T, Alangry R, Alotaibi R, Almandil L, Alburikan S (2023) Effects of regular exercise and intermittent fasting on neurotransmitters, inflammation, oxidative stress, and brain-derived neurotrophic factor in cortex of ovariectomized rats. Nutrients 15(19):1\u201319. https:\/\/doi.org\/10.3390\/nu15194270","journal-title":"Nutrients"},{"issue":"1","key":"10946_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/medicina60010191","volume":"60","author":"R Alkurd","year":"2024","unstructured":"Alkurd R, Mahrous L, Zeb F, Khan MA, Alhaj H, Khraiwesh HM, Faris ME (2024) Effect of calorie restriction and intermittent fasting regimens on brain-derived neurotrophic factor levels and cognitive function in humans: a systematic review. Medicina (Kaunas) 60(1):1\u201313. https:\/\/doi.org\/10.3390\/medicina60010191","journal-title":"Medicina (Kaunas)"},{"key":"10946_CR8","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.ibneur.2025.10.001","volume":"19","author":"AS Alsegiani","year":"2025","unstructured":"Alsegiani AS, Alshalawi B, Alzahrani S, Al-Zoman NZ, Almomen A (2025) Obesity-induced cofilin1 pathway dysregulation: possible molecular links between neuroinflammation, cognitive decline, and Alzheimer\u2019s disease biomarkers. IBRO Neurosci Rep 19:699\u2013708. https:\/\/doi.org\/10.1016\/j.ibneur.2025.10.001","journal-title":"IBRO Neurosci Rep"},{"key":"10946_CR9","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221094995","author":"MA Alvarez-Mon","year":"2022","unstructured":"Alvarez-Mon MA, Ortega MA, Garc\u00eda-Montero C, Fraile-Martinez O, Lahera G, Monserrat J et al (2022) Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): a potential biomarker. J Int Med Res. https:\/\/doi.org\/10.1177\/03000605221094995","journal-title":"J Int Med Res"},{"issue":"11","key":"10946_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26113218","volume":"26","author":"MA Alzohairy","year":"2021","unstructured":"Alzohairy MA, Khan AA, Alsahli MA, Almatroodi SA, Rahmani AH (2021) Protective effects of thymoquinone, an active compound of Nigella sativa, on rats with benzo(a)pyrene-induced lung injury through regulation of oxidative stress and inflammation. Molecules 26(11):3218. https:\/\/doi.org\/10.3390\/molecules26113218","journal-title":"Molecules"},{"issue":"6","key":"10946_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox10060947","volume":"10","author":"HM Anwar","year":"2021","unstructured":"Anwar HM, Georgy GS, Hamad SR, Badr WK, El Raey MA, Abdelfattah MAO et al (2021) A leaf extract of harrisonia abyssinica ameliorates neurobehavioral, histological and biochemical changes in the hippocampus of rats with aluminum chloride-induced Alzheimer\u2019s disease. Antioxidants (Basel, Switzerland) 10(6):1\u201316. https:\/\/doi.org\/10.3390\/antiox10060947","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"11","key":"10946_CR12","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1007\/s11064-024-04214-9","volume":"49","author":"M Aschner","year":"2024","unstructured":"Aschner M, Skalny AV, Santamaria A, Rocha JBT, Mansouri B, Tizabi Y, Madeddu R, Lu R, Lee E, Tinkov AA (2024) Epigenetic mechanisms of aluminum-induced neurotoxicity and Alzheimer\u2019s disease: a focus on non-coding RNAs. Neurochem Res 49(11):2988\u20133005. https:\/\/doi.org\/10.1007\/s11064-024-04214-9","journal-title":"Neurochem Res"},{"issue":"1","key":"10946_CR13","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.37212\/jcnos.1117261","volume":"14","author":"R Asirvatham","year":"2022","unstructured":"Asirvatham R, Pa D, Salam S (2022) The beneficial effect of Pluchea lanceolata on aluminum chloride-induced Alzheimer\u2019s disease in rats. J Cell Neurosci Oxid Stress 14(1):1045\u20131062","journal-title":"J Cell Neurosci Oxid Stress"},{"issue":"3","key":"10946_CR14","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1007\/s10787-024-01466-3","volume":"32","author":"HB Atya","year":"2024","unstructured":"Atya HB, Sharaf NM, Abdelghany RM, El-Helaly SN, Taha H (2024) Autophagy and exosomes; inter-connected maestros in Alzheimer\u2019s disease. Inflammopharmacology 32(3):2061\u20132073. https:\/\/doi.org\/10.1007\/s10787-024-01466-3","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10946_CR15","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/brv.12797","volume":"97","author":"M Augusto-Oliveira","year":"2022","unstructured":"Augusto-Oliveira M, Arrifano GP, Delage CI, Tremblay M, Crespo-Lopez ME, Verkhratsky A (2022) Plasticity of microglia. Biol Rev Camb Philos Soc 97(1):217\u2013250. https:\/\/doi.org\/10.1111\/brv.12797","journal-title":"Biol Rev Camb Philos Soc"},{"issue":"1","key":"10946_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-22427-2","volume":"12","author":"Y Baba","year":"2022","unstructured":"Baba Y, Onishi-Sakamoto S, Ide K, Nishifuji K (2022) Nestin is a marker of unipotent embryonic and adult progenitors differentiating into an epithelial cell lineage of the hair follicles. Sci Rep 12(1):1\u201318. https:\/\/doi.org\/10.1038\/s41598-022-22427-2","journal-title":"Sci Rep"},{"issue":"4","key":"10946_CR17","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.stemcr.2021.01.019","volume":"16","author":"KR Babcock","year":"2021","unstructured":"Babcock KR, Page JS, Fallon JR, Webb AE (2021) Adult hippocampal neurogenesis in aging and Alzheimer\u2019s disease. Stem Cell Rep 16(4):681\u2013693. https:\/\/doi.org\/10.1016\/j.stemcr.2021.01.019","journal-title":"Stem Cell Rep"},{"issue":"1","key":"10946_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/brb3.1444","volume":"10","author":"SH Baik","year":"2020","unstructured":"Baik SH, Rajeev V, Fann DYW, Jo DG, Arumugam TV (2020) Intermittent fasting increases adult hippocampal neurogenesis. Brain Behav 10(1):1\u20136. https:\/\/doi.org\/10.1002\/brb3.1444","journal-title":"Brain Behav"},{"key":"10946_CR19","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/B978-0-7020-6864-5.00010-4","volume-title":"Bancroft's theory and practice of histological techniques","author":"JD Bancroft","year":"2019","unstructured":"Bancroft JD, Layton C (2019) The hematoxylins and eosin, immunohistochemical and immunofluorescent techniques. In: Suvarna SK, Layton C, Bancroft JD (eds) Bancroft\u2019s theory and practice of histological techniques. Elsevier Health Sci, China, pp 126\u2013138"},{"key":"10946_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnagi.2023.1281338","volume":"15","author":"H Barmaki","year":"2023","unstructured":"Barmaki H, Nourazarian A, Khaki-Khatibi F (2023) Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer\u2019s disease. Front Aging Neurosci 15:1\u201311. https:\/\/doi.org\/10.3389\/fnagi.2023.1281338","journal-title":"Front Aging Neurosci"},{"issue":"12","key":"10946_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/adhm.202304180","volume":"13","author":"M Battaglini","year":"2024","unstructured":"Battaglini M, Marino A, Montorsi M, Carmignani A, Ceccarelli MC, Ciofani G (2024) Nanomaterials as microglia modulators in the treatment of central nervous system disorders. Adv Healthc Mater 13(12):1\u201334. https:\/\/doi.org\/10.1002\/adhm.202304180","journal-title":"Adv Healthc Mater"},{"issue":"10","key":"10946_CR22","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1080\/14728222.2025.2584012","volume":"29","author":"E Brand","year":"2025","unstructured":"Brand E, Ntuli M, Loos B (2025) Autophagic failure with age: influence on metabolic disorders and prospects for therapeutic targeting. Expert Opin Ther Targets 29(10):677\u2013686. https:\/\/doi.org\/10.1080\/14728222.2025.2584012","journal-title":"Expert Opin Ther Targets"},{"key":"10946_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nut.2022.111621","volume":"97","author":"S Cao","year":"2022","unstructured":"Cao S, Li M, Sun Y, Wu P, Yang W, Dai H et al (2022) Intermittent fasting enhances hippocampal NPY expression to promote neurogenesis after traumatic brain injury. Nutrition 97:1\u20137. https:\/\/doi.org\/10.1016\/j.nut.2022.111621","journal-title":"Nutrition"},{"key":"10946_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2019.109670","volume":"121","author":"Y Chen","year":"2020","unstructured":"Chen Y, Chen Y, Liang Y, Chen H, Ji X, Huang M (2020) Berberine mitigates cognitive decline in an Alzheimer\u2019s Disease mouse model by targeting both tau hyperphosphorylation and autophagic clearance. Biomed Pharmacother 121:1\u20139. https:\/\/doi.org\/10.1016\/j.biopha.2019.109670","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10946_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1556\/066.2022.00230","volume":"52","author":"W Chen","year":"2023","unstructured":"Chen W, Wang L, Zhou A, Fan C, Zhang Y, Wang Z et al (2023) The benefits of intermittent fasting: a review of possible mechanisms on central neurological disorders. Acta Aliment 52(1):1\u201311. https:\/\/doi.org\/10.1556\/066.2022.00230","journal-title":"Acta Aliment"},{"key":"10946_CR26","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/j.biopha.2018.04.152","volume":"103","author":"SM Chiroma","year":"2018","unstructured":"Chiroma SM, Mohd Moklas MA, Mat Taib CN, Baharuldin MTH, Amon Z (2018) D-galactose and aluminium chloride induced rat model with cognitive impairments. Biomed Pharmacother 103:1602\u20131608. https:\/\/doi.org\/10.1016\/j.biopha.2018.04.152","journal-title":"Biomed Pharmacother"},{"key":"10946_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2019.112346","volume":"379","author":"KM Christian","year":"2020","unstructured":"Christian KM, Ming G-l, Song H (2020) Adult neurogenesis and the dentate gyrus: predicting function from form. Behav Brain Res 379:1\u20139. https:\/\/doi.org\/10.1016\/j.bbr.2019.112346","journal-title":"Behav Brain Res"},{"issue":"13","key":"10946_CR28","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1002\/cne.25494","volume":"531","author":"TM Corey","year":"2023","unstructured":"Corey TM, Illanes O, Lawrence M, Perez SE, Liddie S, Callanan JJ (2023) Naturally occurring histological findings and Alzheimer\u2019s-like pathology in the brain of aging African green monkeys (Chlorocebus sabaeus). J Comp Neurol 531(13):1276\u20131298. https:\/\/doi.org\/10.1002\/cne.25494","journal-title":"J Comp Neurol"},{"key":"10946_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnut.2025.1603165","volume":"12","author":"C Cui","year":"2025","unstructured":"Cui C, Song D, Yang Y, Wang X, Lv R, Nie S et al (2025) The role of intermittent fasting in the treatment of cognitive dysfunction in type 2 diabetes mellitus. Front Nutr 12:1\u20136. https:\/\/doi.org\/10.3389\/fnut.2025.1603165","journal-title":"Front Nutr"},{"issue":"4","key":"10946_CR30","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41583-021-00433-z","volume":"22","author":"A Denoth-Lippuner","year":"2021","unstructured":"Denoth-Lippuner A, Jessberger S (2021) Formation and integration of new neurons in the adult hippocampus. Nat Rev Neurosci 22(4):223\u2013236. https:\/\/doi.org\/10.1038\/s41583-021-00433-z","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"10946_CR31","doi-asserted-by":"publisher","first-page":"373","DOI":"10.30802\/aalas-jaalas-18-000094","volume":"58","author":"JW Dutton 3rd","year":"2019","unstructured":"Dutton JW 3rd, Artwohl JE, Huang X, Fortman JD (2019) Assessment of pain associated with the injection of sodium pentobarbital in laboratory mice (Mus musculus). JAALAS 58(3):373\u2013379. https:\/\/doi.org\/10.30802\/aalas-jaalas-18-000094","journal-title":"JAALAS"},{"issue":"9","key":"10946_CR32","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1093\/nutrit\/nuad021","volume":"81","author":"A Elias","year":"2023","unstructured":"Elias A, Padinjakara N, Lautenschlager NT (2023) Effects of intermittent fasting on cognitive health and Alzheimer\u2019s disease. Nutr Rev 81(9):1225\u20131233. https:\/\/doi.org\/10.1093\/nutrit\/nuad021","journal-title":"Nutr Rev"},{"key":"10946_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70238","author":"D El-Khouly","year":"2025","unstructured":"El-Khouly D, Thabet NA, Sayed-Ahmed M, Omran MM (2025) Promotion of autophagy and apoptosis in colorectal cancer exposed to imatinib and thymoquinone. J Biochem Mol Toxicol. https:\/\/doi.org\/10.1002\/jbt.70238","journal-title":"J Biochem Mol Toxicol"},{"issue":"1","key":"10946_CR34","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1080\/2314808X.2022.2164136","volume":"10","author":"HA Elreedy","year":"2023","unstructured":"Elreedy HA, Elfiky AM, Mahmoud AA, Ibrahim KS, Ghazy MA (2023) Neuroprotective effect of quercetin through targeting key genes involved in aluminum chloride induced Alzheimer\u2019s disease in rats. Egypt J Basic Appl Sci 10(1):174\u2013184. https:\/\/doi.org\/10.1080\/2314808X.2022.2164136","journal-title":"Egypt J Basic Appl Sci"},{"key":"10946_CR35","doi-asserted-by":"publisher","DOI":"10.1590\/1980-5764-dn-2024-vr01","author":"E Engelhardt","year":"2024","unstructured":"Engelhardt E, Resende EPF, Gomes KB (2024) Physiopathological mechanisms underlying Alzheimer\u2019s disease: a narrative review. Dement Neuropsychol. https:\/\/doi.org\/10.1590\/1980-5764-dn-2024-vr01","journal-title":"Dement Neuropsychol"},{"key":"10946_CR36","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jcornel.2022.03.001","volume":"345","author":"Y Esmaeili","year":"2022","unstructured":"Esmaeili Y, Yarjanli Z, Pakniya F, Bidram E, \u0141os MJ, Eshraghi M et al (2022) Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment. J Control Release 345:147\u2013175. https:\/\/doi.org\/10.1016\/j.jcornel.2022.03.001","journal-title":"J Control Release"},{"issue":"1","key":"10946_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-95535-0","volume":"11","author":"DK Franco-Bocanegra","year":"2021","unstructured":"Franco-Bocanegra DK, Gourari Y, McAuley C, Chatelet DS, Johnston DA, Nicoll JAR et al (2021) Microglial morphology in Alzheimer\u2019s disease and after A\u03b2 immunotherapy. Sci Rep 11(1):1\u201312. https:\/\/doi.org\/10.1038\/s41598-021-95535-0","journal-title":"Sci Rep"},{"issue":"5","key":"10946_CR38","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1002\/med.21719","volume":"41","author":"K Gadhave","year":"2021","unstructured":"Gadhave K, Kumar D, Uversky VN, Giri R (2021) A multitude of signaling pathways associated with Alzheimer\u2019s disease and their roles in AD pathogenesis and therapy. Med Res Rev 41(5):2689\u20132745. https:\/\/doi.org\/10.1002\/med.21719","journal-title":"Med Res Rev"},{"issue":"1","key":"10946_CR39","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/ibra.12091","volume":"9","author":"CG Gawas","year":"2023","unstructured":"Gawas CG, Mathur S, Wani M, Tabassum H (2023) Nigella sativa and its nano-mediated approach toward management of neurodegenerative disorders: a review. Ibrain 9(1):111\u2013123. https:\/\/doi.org\/10.1002\/ibra.12091","journal-title":"Ibrain"},{"issue":"2","key":"10946_CR40","doi-asserted-by":"publisher","first-page":"393","DOI":"10.21608\/ejh.2019.6922.1057","volume":"42","author":"MA Gazia","year":"2019","unstructured":"Gazia MA (2019) The possible protective effect of Gardenia Jasminoides extracts on the dentate gyrus changes in an Alzheimer-induced model in adult male albino rats: Histological and Immunohistochemical study. Egypt. J. Histol 42(2):393\u2013407. https:\/\/doi.org\/10.21608\/ejh.2019.6922.1057","journal-title":"Egypt. J. Histol"},{"issue":"2","key":"10946_CR41","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","volume":"7","author":"GBD 2019 Dementia Forecasting Collaborators","year":"2022","unstructured":"GBD 2019 Dementia Forecasting Collaborators (2022) Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health 7(2):e105\u2013e12. https:\/\/doi.org\/10.1016\/S2468-2667(21)00249-8","journal-title":"Lancet Public Health"},{"key":"10946_CR42","first-page":"239","volume-title":"Bancroft's theory and practice of histological techniques E-book","author":"JA Gilbertson","year":"2019","unstructured":"Gilbertson JA (2019) Amyloid. In: Suvarna KS, Layton C, Bancroft JD (eds) Bancroft\u2019s theory and practice of histological techniques E-book. Elsevier Health Sci, China, pp 239\u2013241"},{"issue":"2 Suppl","key":"10946_CR43","doi-asserted-by":"publisher","first-page":"54","DOI":"10.21010\/Ajidv19i2S.7","volume":"19","author":"S Ginting","year":"2025","unstructured":"Ginting S, Ginting CN, Yulizal O, Siahaan JM (2025) Effect of diurnal intermittent fasting (DIF) on antioxidant and pro inflammatory mediators activity in male rat model of type 2 diabetes mellitus. Afr J Infect Dis 19(2 Suppl):54\u201361. https:\/\/doi.org\/10.21010\/Ajidv19i2S.7","journal-title":"Afr J Infect Dis"},{"key":"10946_CR44","doi-asserted-by":"crossref","unstructured":"Giri M, Kendre PN, Bhalke R, Pande V, Autade K, Sumbe R. et al (2024) Combinatorial therapy in Alzheimer's disease. In. Alzheimer's Disease and Advanced Drug Delivery Strategies. Elsevier Health sci. pp 439\u2013461.","DOI":"10.1016\/B978-0-443-13205-6.00026-1"},{"key":"10946_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2019.104542","volume":"132","author":"A Gregosa","year":"2019","unstructured":"Gregosa A, Vinuesa \u00c1, Todero MF, Pomilio C, Rossi SP, Bentivegna M et al (2019) Periodic dietary restriction ameliorates amyloid pathology and cognitive impairment in PDAPP-J20 mice: potential implication of glial autophagy. Neurobiol Dis 132:1\u201312. https:\/\/doi.org\/10.1016\/j.nbd.2019.104542","journal-title":"Neurobiol Dis"},{"issue":"9","key":"10946_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu13093166","volume":"13","author":"J Gudden","year":"2021","unstructured":"Gudden J, Arias Vasquez A (2021) The effects of intermittent fasting on brain and cognitive function. J Nutr 13(9):1\u201325. https:\/\/doi.org\/10.3390\/nu13093166","journal-title":"J Nutr"},{"issue":"23","key":"10946_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu15234915","volume":"15","author":"M Guo","year":"2023","unstructured":"Guo M, Wang X, Li Y, Luo A, Zhao Y, Luo X et al (2023) Intermittent fasting on neurologic diseases: potential role of gut microbiota. Nutrients 15(23):1\u201327. https:\/\/doi.org\/10.3390\/nu15234915","journal-title":"Nutrients"},{"issue":"1","key":"10946_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/plants13010035","volume":"13","author":"SK Haif","year":"2023","unstructured":"Haif SK, Al Kury LT, Talib WH (2023) Combination of thymoquinone and intermittent fasting as a treatment for breast cancer implanted in mice. Plants (Basel) 13(1):1\u201316. https:\/\/doi.org\/10.3390\/plants13010035","journal-title":"Plants (Basel)"},{"issue":"8","key":"10946_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ph15081008","volume":"15","author":"AME Hamdan","year":"2022","unstructured":"Hamdan AME, Alharthi FHJ, Alanazi AH, El-Emam SZ, Zaghlool SS, Metwally K et al (2022) Neuroprotective effects of phytochemicals against aluminum chloride-induced Alzheimer\u2019s disease through ApoE4\/LRP1, Wnt3\/\u03b2-catenin\/GSK3\u03b2, and TLR4\/NLRP3 pathways with physical and mental activities in a rat model. Pharmaceuticals (Basel, Switzerland) 15(8):1\u201323. https:\/\/doi.org\/10.3390\/ph15081008","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"issue":"6","key":"10946_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/toxics11060509","volume":"11","author":"ZAS Hawash","year":"2023","unstructured":"Hawash ZAS, Yassien EM, Alotaibi BS, El-Moslemany AM, Shukry M (2023) Assessment of anti-alzheimer pursuit of jambolan fruit extract and\/or choline against AlCl3 toxicity in rats. Toxics 11(6):1\u201323. https:\/\/doi.org\/10.3390\/toxics11060509","journal-title":"Toxics"},{"issue":"3","key":"10946_CR51","doi-asserted-by":"publisher","first-page":"251","DOI":"10.4103\/0019-5154.182416","volume":"61","author":"A Hazra","year":"2016","unstructured":"Hazra A, Gogtay N (2016) Biostatistics series module 3: comparing groups: numerical variables. Indian J Dermatol 61(3):251\u2013260. https:\/\/doi.org\/10.4103\/0019-5154.182416","journal-title":"Indian J Dermatol"},{"issue":"12","key":"10946_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells14120911","volume":"14","author":"ZM Hein","year":"2025","unstructured":"Hein ZM, Vishnumukkala T, Karikalan B, Alkatiri A, Hussan F, Jagadeesan S et al (2025) Autophagy and Alzheimer\u2019s disease: mechanisms and impact beyond the brain. Cells 14(12):1\u201326. https:\/\/doi.org\/10.3390\/cells14120911","journal-title":"Cells"},{"issue":"9","key":"10946_CR53","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1002\/ptr.6686","volume":"34","author":"MO Hindam","year":"2020","unstructured":"Hindam MO, Sayed RH, Skalicka-Wo\u017aniak K, Budzy\u0144ska B, El Sayed NS (2020) Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer\u2019s disease: the role of JAK2\/STAT3 and Nrf2\/HO-1 signalling pathway modulation. Phytother Res 34(9):2351\u20132365. https:\/\/doi.org\/10.1002\/ptr.6686","journal-title":"Phytother Res"},{"issue":"4","key":"10946_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbadis.2024.167086","volume":"1870","author":"H Huang","year":"2024","unstructured":"Huang H, Sharoar MG, Pathoulas J, Fan L, He W, Xiang R et al (2024) Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer\u2019s disease. Biochim Biophys Acta Mol Basis Dis 1870(4):1\u201314. https:\/\/doi.org\/10.1016\/j.bbadis.2024.167086","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"4","key":"10946_CR55","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1177\/0960327120960775","volume":"40","author":"MA Ibrahim","year":"2021","unstructured":"Ibrahim MA, Haleem M, AbdelWahab SA, Abdel-Aziz AM (2021) Sildenafil ameliorates Alzheimer disease via the modulation of vascular endothelial growth factor and vascular cell adhesion molecule-1 in rats. Hum Exp Toxicol 40(4):596\u2013607. https:\/\/doi.org\/10.1177\/0960327120960775","journal-title":"Hum Exp Toxicol"},{"issue":"2","key":"10946_CR56","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1134\/S0006297920020042","volume":"85","author":"NK Isaev","year":"2020","unstructured":"Isaev NK, Chetverikov NS, Stelmashook EV, Genrikhs EE, Khaspekov LG, Illarioshkin SN (2020) Thymoquinone as a potential neuroprotector in acute and chronic forms of cerebral pathology. Biochem (Mosc) 85(2):167\u2013176. https:\/\/doi.org\/10.1134\/S0006297920020042","journal-title":"Biochem (Mosc)"},{"issue":"2","key":"10946_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox12020433","volume":"12","author":"NK Isaev","year":"2023","unstructured":"Isaev NK, Genrikhs EE, Stelmashook EV (2023) Antioxidant thymoquinone and its potential in the treatment of neurological diseases. Antioxidants (Basel, Switzerland) 12(2):1\u201314. https:\/\/doi.org\/10.3390\/antiox12020433","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"7","key":"10946_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heliyon.2022.e09874","volume":"8","author":"FZ Khan","year":"2022","unstructured":"Khan FZ, Mostaid MS, Apu MNH (2022) Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer\u2019s disease. Heliyon 8(7):1\u201310. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e09874","journal-title":"Heliyon"},{"key":"10946_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2024.1399121","volume":"15","author":"AY Kim","year":"2024","unstructured":"Kim AY, Al Jerdi S, MacDonald R, Triggle CR (2024) Alzheimer\u2019s disease and its treatment-yesterday, today, and tomorrow. Front Pharmacol 15:1\u201330. https:\/\/doi.org\/10.3389\/fphar.2024.1399121","journal-title":"Front Pharmacol"},{"key":"10946_CR60","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108863","author":"DJ Klionsky","year":"2021","unstructured":"Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P et al (2021) Autophagy in major human diseases. EMBO J. https:\/\/doi.org\/10.15252\/embj.2021108863","journal-title":"EMBO J"},{"key":"10946_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2021.111492","volume":"138","author":"Z Kohandel","year":"2021","unstructured":"Kohandel Z, Farkhondeh T, Aschner M, Samarghandian S (2021) Anti-inflammatory effects of thymoquinone and its protective effects against several diseases. Biomed Pharmacother 138:1\u20136. https:\/\/doi.org\/10.1016\/j.biopha.2021.111492","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10946_CR62","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1177\/09731296241239153","volume":"20","author":"D Li","year":"2024","unstructured":"Li D, Wang M (2024) Shikonin attenuate behavioral defects, oxidative stress, and neuroinflammation during aluminum chloride-induced Alzheimer\u2019s disease condition in an in vivo experimental model. Pharmacogn Mag 20(3):983\u2013995. https:\/\/doi.org\/10.1177\/09731296241239153","journal-title":"Pharmacogn Mag"},{"issue":"1","key":"10946_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-025-05336-z","volume":"63","author":"S Li","year":"2026","unstructured":"Li S, Wang D, Li A, Wang T, Chen X, Li H et al (2026) ZuoGui pill ameliorates Alzheimer\u2019s disease-like pathology in 3xTg-AD mice by targeting A\u03b2 production, tau phosphorylation, synaptic loss, and neuroinflammation. Mol Neurobiol 63(1):1\u201318. https:\/\/doi.org\/10.1007\/s12035-025-05336-z","journal-title":"Mol Neurobiol"},{"key":"10946_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tice.2022.101998","volume":"80","author":"R-n Liang","year":"2023","unstructured":"Liang R-n, Yan D-q, Zhang X-p, Chen X, Zhang W-h, Jia H-l (2023) Kidney mesenchymal stem cells alleviate cisplatin-induced kidney injury and apoptosis in rats. Tissue Cell 80:1\u201312. https:\/\/doi.org\/10.1016\/j.tice.2022.101998","journal-title":"Tissue Cell"},{"issue":"9","key":"10946_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells10092236","volume":"10","author":"J Lier","year":"2021","unstructured":"Lier J, Streit WJ, Bechmann I (2021) Beyond activation: characterizing microglial functional phenotypes. Cells 10(9):1\u201313. https:\/\/doi.org\/10.3390\/cells10092236","journal-title":"Cells"},{"issue":"5","key":"10946_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/etm.2022.11630","volume":"24","author":"D Liu","year":"2022","unstructured":"Liu D, Zhao L (2022) Thymoquinone-induced autophagy mitigates doxorubicin-induced H9c2 cell apoptosis. Exp Ther Med 24(5):1\u20138. https:\/\/doi.org\/10.3892\/etm.2022.11630","journal-title":"Exp Ther Med"},{"issue":"3","key":"10946_CR67","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.3892\/mmr.2016.4823","volume":"13","author":"H Liu","year":"2016","unstructured":"Liu H, Liu HY, Jiang YN, Li N (2016) Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K\/Akt pathway in diabetic rats. Mol Med Rep 13(3):2836\u20132842. https:\/\/doi.org\/10.3892\/mmr.2016.4823","journal-title":"Mol Med Rep"},{"issue":"1","key":"10946_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/4038546","volume":"2023","author":"S Liu","year":"2023","unstructured":"Liu S, Zeng M, Wan W, Huang M, Li X, Xie Z et al (2023) The health-promoting effects and the mechanism of intermittent fasting. J Diabetes Res 2023(1):1\u201315. https:\/\/doi.org\/10.1155\/2023\/4038546","journal-title":"J Diabetes Res"},{"issue":"1","key":"10946_CR69","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41392-025-02141-x","volume":"10","author":"H Liu","year":"2025","unstructured":"Liu H, Wang S, Wang J, Guo X, Song Y, Fu K, Gao Z, Liu D, He W, Yang LL (2025) Energy metabolism in health and diseases. Signal Transduct Target Ther 10(1):69. https:\/\/doi.org\/10.1038\/s41392-025-02141-x","journal-title":"Signal Transduct Target Ther"},{"issue":"19","key":"10946_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells11193002","volume":"11","author":"V Llorente","year":"2022","unstructured":"Llorente V, Velarde P, Desco M, G\u00f3mez-Gaviro MV (2022) Current understanding of the neural stem cell niches. Cells 11(19):1\u201327. https:\/\/doi.org\/10.3390\/cells11193002","journal-title":"Cells"},{"issue":"11","key":"10946_CR71","doi-asserted-by":"publisher","first-page":"10912","DOI":"10.18632\/aging.103305","volume":"12","author":"Z Long","year":"2020","unstructured":"Long Z, Chen J, Zhao Y, Zhou W, Yao Q, Wang Y et al (2020) Dynamic changes of autophagic flux induced by Abeta in the brain of postmortem Alzheimer\u2019s disease patients, animal models and cell models. Aging (Albany NY) 12(11):10912\u201310930. https:\/\/doi.org\/10.18632\/aging.103305","journal-title":"Aging (Albany NY)"},{"key":"10946_CR72","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28741-7","author":"A Lopez","year":"2022","unstructured":"Lopez A, Reyna DE, Gitego N, Kopp F, Zhou H, Miranda-Roman MA et al (2022) Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-022-28741-7","journal-title":"Nat Commun"},{"key":"10946_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2023.106150","volume":"182","author":"R Mabrouk","year":"2023","unstructured":"Mabrouk R, Miettinen PO, Tanila H (2023) Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals. Neurobiol Dis 182:1\u201310. https:\/\/doi.org\/10.1016\/j.nbd.2023.106150","journal-title":"Neurobiol Dis"},{"issue":"4","key":"10946_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmjgh-2021-007409","volume":"7","author":"SM Mattap","year":"2022","unstructured":"Mattap SM, Mohan D, McGrattan AM, Allotey P, Stephan BC, Reidpath DD et al (2022) The economic burden of dementia in low-and middle-income countries (LMICs): a systematic review. BMJ Glob Health 7(4):1\u201314. https:\/\/doi.org\/10.1136\/bmjgh-2021-007409","journal-title":"BMJ Glob Health"},{"issue":"4","key":"10946_CR75","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s42255-025-01254-5","volume":"7","author":"MP Mattson","year":"2025","unstructured":"Mattson MP (2025) The cyclic metabolic switching theory of intermittent fasting. Nat Metab 7(4):665\u2013678. https:\/\/doi.org\/10.1038\/s42255-025-01254-5","journal-title":"Nat Metab"},{"issue":"5","key":"10946_CR76","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s00432-020-03174-1","volume":"146","author":"YC Meng","year":"2020","unstructured":"Meng YC, Lou XL, Yang LY, Li D, Hou YQ (2020) Role of the autophagy-related marker LC3 expression in hepatocellular carcinoma: a meta-analysis. J Cancer Res Clin Oncol 146(5):1103\u20131113. https:\/\/doi.org\/10.1007\/s00432-020-03174-1","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"10946_CR77","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.3390\/ijms15034671","volume":"15","author":"A Mietelska-Porowska","year":"2014","unstructured":"Mietelska-Porowska A, Wasik U, Goras M, Filipek A, Niewiadomska G (2014) Tau protein modifications and interactions: their role in function and dysfunction. Int J Mol Sci 15(3):4671\u20134713. https:\/\/doi.org\/10.3390\/ijms15034671","journal-title":"Int J Mol Sci"},{"key":"10946_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jprot.2020.103645","volume":"217","author":"AL Mindikoglu","year":"2020","unstructured":"Mindikoglu AL, Abdulsada MM, Jain A, Choi JM, Jalal PK, Devaraj S et al (2020) Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects. J Proteomics 217:1\u201312. https:\/\/doi.org\/10.1016\/j.jprot.2020.103645","journal-title":"J Proteomics"},{"issue":"3","key":"10946_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drudis.2023.103487","volume":"28","author":"KBE Moore","year":"2023","unstructured":"Moore KBE, Hung TJ, Fortin JS (2023) Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer\u2019s disease and related tauopathies. Drug Discov Today 28(3):1\u201317. https:\/\/doi.org\/10.1016\/j.drudis.2023.103487","journal-title":"Drug Discov Today"},{"issue":"2","key":"10946_CR80","doi-asserted-by":"publisher","DOI":"10.3390\/nu17020292","volume":"17","author":"S Msane","year":"2025","unstructured":"Msane S, Khathi A, Sosibo AM (2025) The effect of the 14:10-hour time-restricted feeding (TRF) regimen on selected markers of glucose homeostasis in diet-induced prediabetic male Sprague Dawley rats. Nutrients 17(2):292. https:\/\/doi.org\/10.3390\/nu17020292","journal-title":"Nutrients"},{"key":"10946_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcell.2021.629503","volume":"9","author":"PC Nahirney","year":"2021","unstructured":"Nahirney PC, Tremblay M-E (2021) Brain ultrastructure: putting the pieces together. Front Cell Dev Biol 9:1\u201322. https:\/\/doi.org\/10.3389\/fcell.2021.629503","journal-title":"Front Cell Dev Biol"},{"key":"10946_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-13-1370-7_1","volume":"1091","author":"Q Niu","year":"2023","unstructured":"Niu Q (2023) Overview of the relationship between aluminum exposure and human health. Neurotox Alum 1091:1\u201332. https:\/\/doi.org\/10.1007\/978-981-13-1370-7_1","journal-title":"Neurotox Alum"},{"issue":"2","key":"10946_CR83","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1080\/01480545.2020.1754849","volume":"45","author":"B Ogunlade","year":"2022","unstructured":"Ogunlade B, Adelakun SA, Agie JA (2022) Nutritional supplementation of gallic acid ameliorates Alzheimer-type hippocampal neurodegeneration and cognitive impairment induced by aluminum chloride exposure in adult Wistar rats. Drug Chem Toxicol 45(2):651\u2013662. https:\/\/doi.org\/10.1080\/01480545.2020.1754849","journal-title":"Drug Chem Toxicol"},{"issue":"2","key":"10946_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox12020517","volume":"12","author":"EO Olufunmilayo","year":"2023","unstructured":"Olufunmilayo EO, Gerke-Duncan MB, Holsinger RD (2023) Oxidative stress and antioxidants in neurodegenerative disorders. Antioxidants (Basel) 12(2):1\u201330. https:\/\/doi.org\/10.3390\/antiox12020517","journal-title":"Antioxidants (Basel)"},{"issue":"11","key":"10946_CR85","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/s43587-022-00311-y","volume":"2","author":"R-Y Pan","year":"2022","unstructured":"Pan R-Y, Zhang J, Wang J, Wang Y, Li Z, Liao Y et al (2022) Intermittent fasting protects against Alzheimer\u2019s disease in mice by altering metabolism through remodeling of the gut microbiota. Nat Aging 2(11):1024\u20131039. https:\/\/doi.org\/10.1038\/s43587-022-00311-y","journal-title":"Nat Aging"},{"issue":"4","key":"10946_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ph15040408","volume":"15","author":"FH Pottoo","year":"2022","unstructured":"Pottoo FH, Ibrahim AM, Alammar A, Alsinan R, Aleid M, Alshehhi A et al (2022) Thymoquinone: review of its potential in the treatment of neurological diseases. Pharmaceuticals (Basel, Switzerland) 15(4):1\u201311. https:\/\/doi.org\/10.3390\/ph15040408","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"issue":"1","key":"10946_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biomedicines9010005","volume":"9","author":"MA Rahman","year":"2020","unstructured":"Rahman MA, Rahman MS, Rahman MDH, Rasheduzzaman M, Mamun-Or-Rashid A, Uddin MJ et al (2020) Modulatory effects of autophagy on APP processing as a potential treatment target for Alzheimer\u2019s disease. Biomedicines 9(1):1\u201320. https:\/\/doi.org\/10.3390\/biomedicines9010005","journal-title":"Biomedicines"},{"issue":"3","key":"10946_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox10030408","volume":"10","author":"MA Rahman","year":"2021","unstructured":"Rahman MA, Cho Y, Nam G, Rhim H (2021) Antioxidant compound, oxyresveratrol, inhibits APP production through the AMPK\/ULK1\/mTOR-mediated autophagy pathway in mouse cortical astrocytes. Antioxidants (Basel, Switzerland) 10(3):1\u201317. https:\/\/doi.org\/10.3390\/antiox10030408","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10946_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2023.1103940","volume":"14","author":"P Rajendran","year":"2023","unstructured":"Rajendran P, Althumairy D, Bani-Ismail M, Bekhet GM, Ahmed EA (2023) Isoimperatorin therapeutic effect against aluminum induced neurotoxicity in albino mice. Front Pharmacol 14:1\u201313. https:\/\/doi.org\/10.3389\/fphar.2023.1103940","journal-title":"Front Pharmacol"},{"key":"10946_CR90","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2023.1211188","author":"J Reddaway","year":"2023","unstructured":"Reddaway J, Richardson PE, Bevan RJ, Stoneman J, Palombo M (2023) Microglial morphometric analysis: so many options, so little consistency. Front Neuroinform. https:\/\/doi.org\/10.3389\/fninf.2023.1211188","journal-title":"Front Neuroinform"},{"issue":"8","key":"10946_CR91","doi-asserted-by":"publisher","first-page":"7370","DOI":"10.1021\/acsomega.2c00028","volume":"7","author":"S Sabir","year":"2022","unstructured":"Sabir S, Saleem U, Akash MSH, Qasim M, Chauhdary Z (2022) Thymoquinone induces Nrf2 mediated adaptive homeostasis: implication for mercuric chloride-induced nephrotoxicity. ACS Omega 7(8):7370\u20137379. https:\/\/doi.org\/10.1021\/acsomega.2c00028","journal-title":"ACS Omega"},{"issue":"6","key":"10946_CR92","doi-asserted-by":"publisher","first-page":"5439","DOI":"10.1007\/s11033-023-08363-y","volume":"50","author":"E Sadeghi","year":"2023","unstructured":"Sadeghi E, Imenshahidi M, Hosseinzadeh H (2023) Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review. Mol Biol Rep 50(6):5439\u20135454. https:\/\/doi.org\/10.1007\/s11033-023-08363-y","journal-title":"Mol Biol Rep"},{"issue":"3","key":"10946_CR93","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1002\/2211-5463.70150","volume":"16","author":"K Saito","year":"2026","unstructured":"Saito K, Arakawa M, Maeda K, Morita E (2026) Autophagosome marker, LC3, is released extracellularly via several distinct pathways. FEBS Open Bio 16(3):542\u2013560. https:\/\/doi.org\/10.1002\/2211-5463.70150","journal-title":"FEBS Open Bio"},{"key":"10946_CR94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rechem.2025.102487","volume":"16","author":"M Sajad","year":"2025","unstructured":"Sajad M, Ali R, Kumar R, Khan NJ, Wahab S, Alshehri SA et al (2025) Therapeutic potential of cedrol in alleviating cognitive impairments in aluminum chloride-induced Alzheimer\u2019s disease: a biomarker-based approach. Results Chem 16:1\u201316. https:\/\/doi.org\/10.1016\/j.rechem.2025.102487","journal-title":"Results Chem"},{"key":"10946_CR95","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/B978-0-7020-6864-5.00019-0","volume-title":"Bancroft's theory and practice of histological techniques E-Book","author":"T Sanderson","year":"2019","unstructured":"Sanderson T, Wild G, Cull AM, Marston J, Zardin G (2019) Immunohistochemical and immunofluorescent techniques. In: Suvarna KS, Layton C, Bancroft JD (eds) Bancroft\u2019s theory and practice of histological techniques E-Book. Elsevier Health Sci, China, pp 337\u2013394"},{"issue":"12","key":"10946_CR96","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1002\/ar.23687","volume":"300","author":"M Sandikci","year":"2017","unstructured":"Sandikci M, Karagenc L, Yildiz M (2017) Changes on the pancreas in experimental diabetes and the effect of lycopene on these changes: Pdx\u20101, Ngn\u20103, and nestin expressions. Anat Rec 300(12):2200\u20132207. https:\/\/doi.org\/10.1002\/ar.23687","journal-title":"Anat Rec"},{"key":"10946_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2023.102192","volume":"84","author":"NR Sarhan","year":"2023","unstructured":"Sarhan NR, El Nashar EM, Hamza E, El-Beah SM, Alghamdi MA, Al-Khater KM et al (2023) Nuclear factor erythrogen-2 associated factor 2 (Nrf2) signaling is an essential molecular pathway for the anti-aging effect of whey protein in the prefrontal cortex of aging rat model (histological and biochemical study). Tissue Cell 84:102192. https:\/\/doi.org\/10.1016\/j.tice.2023.102192","journal-title":"Tissue Cell"},{"issue":"1","key":"10946_CR98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10529-021-03200-3","volume":"44","author":"P Saxena","year":"2022","unstructured":"Saxena P, Selvaraj K, Khare SK, Chaudhary N (2022) Superoxide dismutase as multipotent therapeutic antioxidant enzyme: role in human diseases. Biotechnol Lett 44(1):1\u201322. https:\/\/doi.org\/10.1007\/s10529-021-03200-3","journal-title":"Biotechnol Lett"},{"issue":"8","key":"10946_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cns.14897","volume":"30","author":"F Sayehmiri","year":"2024","unstructured":"Sayehmiri F, Motamedi F, Batool Z, Naderi N, Shaerzadeh F, Zoghi A et al (2024) Mitochondrial plasticity and synaptic plasticity crosstalk; in health and Alzheimer\u2019s disease. CNS Neurosci Ther 30(8):1\u201315. https:\/\/doi.org\/10.1111\/cns.14897","journal-title":"CNS Neurosci Ther"},{"issue":"21","key":"10946_CR100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms232112924","volume":"23","author":"U Sehar","year":"2022","unstructured":"Sehar U, Rawat P, Reddy AP, Kopel J, Reddy PH (2022) Amyloid beta in aging and Alzheimer\u2019s disease. Int J Mol Sci 23(21):1\u201325. https:\/\/doi.org\/10.3390\/ijms232112924","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10946_CR101","doi-asserted-by":"publisher","first-page":"208","DOI":"10.62347\/YXVS6225","volume":"17","author":"S Selvaraj","year":"2024","unstructured":"Selvaraj S, Srinivas BH, Verma SK, Ms G (2024) Significance of Nestin and CD133 as cancer stem cell markers in diffuse glioma and association with p53 expression and IDH status. Int J Clin Exp Pathol 17(7):208\u2013218. https:\/\/doi.org\/10.62347\/YXVS6225","journal-title":"Int J Clin Exp Pathol"},{"issue":"6","key":"10946_CR102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cbdv.202301858","volume":"21","author":"T Shamim","year":"2024","unstructured":"Shamim T, Asif HM, Abida Ejaz S, Hussain Z, Wani TA, Sumreen L et al (2024) Investigations of Limeum indicum plant for diabetes mellitus and Alzheimer\u2019s disease dual therapy: phytochemical, GC-MS chemical profiling, enzyme inhibition, molecular docking and in-vivo studies. Chem Biodivers 21(6):1\u201325. https:\/\/doi.org\/10.1002\/cbdv.202301858","journal-title":"Chem Biodivers"},{"issue":"1","key":"10946_CR103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-021-00464-1","volume":"16","author":"MG Sharoar","year":"2021","unstructured":"Sharoar MG, Palko S, Ge Y, Saido TC, Yan R (2021) Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer\u2019s disease brains. Mol Neurodegener 16(1):1\u201317. https:\/\/doi.org\/10.1186\/s13024-021-00464-1","journal-title":"Mol Neurodegener"},{"issue":"1","key":"10946_CR104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-020-01948-5","volume":"17","author":"DC Shippy","year":"2020","unstructured":"Shippy DC, Wilhelm C, Viharkumar PA, Raife TJ, Ulland TK (2020) \u0392-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer\u2019s disease pathology. J Neuroinflammation 17(1):1\u201312. https:\/\/doi.org\/10.1186\/s12974-020-01948-5","journal-title":"J Neuroinflammation"},{"key":"10946_CR105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ant.2020.12.00","volume":"5","author":"AV Skalny","year":"2021","unstructured":"Skalny AV, Aschner M, Jiang Y, Gluhcheva YG, Tizabi Y, Lobinski R, Tinkov AA (2021) Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies. Adv Neurotoxicol 5:1\u201334. https:\/\/doi.org\/10.1016\/bs.ant.2020.12.00","journal-title":"Adv Neurotoxicol"},{"issue":"2","key":"10946_CR106","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/jnc.15112","volume":"156","author":"T Soares Martins","year":"2021","unstructured":"Soares Martins T, Trindade D, Vaz M, Campelo I, Almeida M, Trigo G et al (2021) Diagnostic and therapeutic potential of exosomes in Alzheimer\u2019s disease. J Neurochem 156(2):162\u2013181. https:\/\/doi.org\/10.1111\/jnc.15112","journal-title":"J Neurochem"},{"issue":"10","key":"10946_CR107","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1007\/s00018-021-03802-0","volume":"78","author":"J Spaas","year":"2021","unstructured":"Spaas J, van Veggel L, Schepers M, Tiane A, van Horssen J, Wilson DM 3rd et al (2021) Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders. Cell Mol Life Sci 78(10):4615\u20134637. https:\/\/doi.org\/10.1007\/s00018-021-03802-0","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10946_CR108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-21224-1","volume":"12","author":"AZ Spitz","year":"2021","unstructured":"Spitz AZ, Zacharioudakis E, Reyna DE, Garner TP, Gavathiotis E (2021) Eltrombopag directly inhibits BAX and prevents cell death. Nat Commun 12(1):1\u201315. https:\/\/doi.org\/10.1038\/s41467-021-21224-1","journal-title":"Nat Commun"},{"key":"10946_CR109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2022.1094351","volume":"13","author":"A Subramanian","year":"2022","unstructured":"Subramanian A, Tamilanban T, Alsayari A, Ramachawolran G, Wong LS, Sekar M et al (2022) Trilateral association of autophagy, mTOR and Alzheimer\u2019s disease: potential pathway in the development for Alzheimer\u2019s disease therapy. Front Pharmacol 13:1\u201315. https:\/\/doi.org\/10.3389\/fphar.2022.1094351","journal-title":"Front Pharmacol"},{"issue":"3","key":"10946_CR110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21030701","volume":"21","author":"PS Sung","year":"2020","unstructured":"Sung PS, Lin PY, Liu CH, Su HC, Tsai KJ (2020) Neuroinflammation and neurogenesis in Alzheimer\u2019s disease and potential therapeutic approaches. Int J Mol Sci 21(3):1\u201323. https:\/\/doi.org\/10.3390\/ijms21030701","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10946_CR111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40478-023-01561-6","volume":"11","author":"ME Swanson","year":"2023","unstructured":"Swanson ME, Mrkela M, Murray HC, Cao MC, Turner C, Curtis MA et al (2023) Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain. Acta Neuropathol Commun 11(1):1\u201322. https:\/\/doi.org\/10.1186\/s40478-023-01561-6","journal-title":"Acta Neuropathol Commun"},{"key":"10946_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/11795549211038256","volume":"15","author":"A Szyma\u0144ska-Chabowska","year":"2021","unstructured":"Szyma\u0144ska-Chabowska A, \u015awi\u0105tkowski F, Jankowska-Pola\u0144ska B, Mazur G, Chabowski M (2021) Nestin expression as a diagnostic and prognostic marker in colorectal cancer and other tumors. Clin Med Insights Oncol 15:1\u201310. https:\/\/doi.org\/10.1177\/11795549211038256","journal-title":"Clin Med Insights Oncol"},{"issue":"11","key":"10946_CR113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms23115938","volume":"23","author":"DM Teleanu","year":"2022","unstructured":"Teleanu DM, Niculescu A-G, Lungu II, Radu CI, Vlad\u00e2cenco O, Roza E et al (2022) An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. Int J Mol Sci 23(11):1\u201322. https:\/\/doi.org\/10.3390\/ijms23115938","journal-title":"Int J Mol Sci"},{"issue":"23","key":"10946_CR114","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms262311656","volume":"26","author":"R Teschke","year":"2025","unstructured":"Teschke R, Xuan TD (2025) Heavy metals like aluminum, arsenic, cadmium, chromium, copper, iron, lead, manganese, mercury, nickel, and zinc polluting the drinking water: their individual health hazards. Int J Mol Sci 26(23):1\u201317. https:\/\/doi.org\/10.3390\/ijms262311656","journal-title":"Int J Mol Sci"},{"key":"10946_CR115","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jare.2023.08.013","volume":"61","author":"Z Tong","year":"2024","unstructured":"Tong Z, Yin Z (2024) Distribution, contribution and regulation of nestin(+) cells. J Adv Res 61:47\u201363. https:\/\/doi.org\/10.1016\/j.jare.2023.08.013","journal-title":"J Adv Res"},{"issue":"2","key":"10946_CR116","doi-asserted-by":"publisher","first-page":"44","DOI":"10.33640\/2405-609X.3219","volume":"8","author":"Y Toy","year":"2022","unstructured":"Toy Y, Kivrik M, Alkhafaji MH, Faraj AM, Gecibesler IH, A\u011fca CA (2022) Nigella sativa methanol extract inhibits PC-3 cell line colonization, induced apoptosis, and modulated LC3-based autophagy. KIJOMS 8(2):44\u201351. https:\/\/doi.org\/10.33640\/2405-609X.3219","journal-title":"KIJOMS"},{"issue":"5-6","key":"10946_CR117","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/10520290400015423","volume":"79","author":"JR Walton","year":"2004","unstructured":"Walton JR (2004) A bright field\/fluorescent stain for aluminum: its specificity, validation, and staining characteristics. Biotech Histochem 79(5\u20136):169\u2013176. https:\/\/doi.org\/10.1080\/10520290400015423","journal-title":"Biotech Histochem"},{"key":"10946_CR118","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/914947","author":"JR Walton","year":"2012","unstructured":"Walton JR (2012) Cognitive deterioration and associated pathology induced by chronic low-level aluminum ingestion in a translational rat model provides an explanation of Alzheimer\u2019s disease, tests for susceptibility and avenues for treatment. Int J Alzheimers Dis. https:\/\/doi.org\/10.1155\/2012\/914947","journal-title":"Int J Alzheimers Dis"},{"issue":"4","key":"10946_CR119","doi-asserted-by":"publisher","first-page":"765","DOI":"10.3233\/jad-132204","volume":"40","author":"JR Walton","year":"2014","unstructured":"Walton JR (2014) Chronic aluminum intake causes Alzheimer\u2019s disease: applying Sir Austin Bradford Hill\u2019s causality criteria. JAD 40(4):765\u2013838. https:\/\/doi.org\/10.3233\/jad-132204","journal-title":"JAD"},{"issue":"4","key":"10946_CR120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heliyon.2023.e14713","volume":"9","author":"J Wang","year":"2023","unstructured":"Wang J, He W, Zhang J (2023) A richer and more diverse future for microglia phenotypes. Heliyon 9(4):1\u201310. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e14713","journal-title":"Heliyon"},{"issue":"1","key":"10946_CR121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12979-022-00300-0","volume":"19","author":"Y Wei","year":"2022","unstructured":"Wei Y, Li X (2022) Different phenotypes of microglia in animal models of Alzheimer disease. Immun Ageing 19(1):1\u201316. https:\/\/doi.org\/10.1186\/s12979-022-00300-0","journal-title":"Immun Ageing"},{"issue":"13","key":"10946_CR122","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells11132091","volume":"11","author":"MY Wendimu","year":"2022","unstructured":"Wendimu MY, Hooks SB (2022) Microglia phenotypes in aging and neurodegenerative diseases. Cells 11(13):1\u201352. https:\/\/doi.org\/10.3390\/cells11132091","journal-title":"Cells"},{"key":"10946_CR123","unstructured":"WHO (2020) Alzheimers & Dementia in Egypt. Health Profile Egypt. https:\/\/www.worldlifeexpectancy.com\/"},{"issue":"10","key":"10946_CR124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms26104742","volume":"26","author":"W Wolska","year":"2025","unstructured":"Wolska W, Gutowska I, Wszo\u0142ek A, \u017bwiere\u0142\u0142o W (2025) The role of intermittent fasting in the activation of autophagy processes in the context of cancer diseases. Int J Mol Sci 26(10):1\u201318. https:\/\/doi.org\/10.3390\/ijms26104742","journal-title":"Int J Mol Sci"},{"key":"10946_CR125","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/B978-0-7020-6864-5.00021-9","volume-title":"Bancroft's theory and practice of histological techniques E-Book","author":"AE Woods","year":"2019","unstructured":"Woods AE, Stirling JW (2019) Transmission electron microscopy. In: Suvarna KS, Layton C, Bancroft JD (eds) Bancroft\u2019s theory and practice of histological techniques E-Book. Elsevier Health Sci, China, pp 434\u2013475"},{"issue":"13","key":"10946_CR126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells14131016","volume":"14","author":"S Xiao","year":"2025","unstructured":"Xiao S, Yu Y, Liao M, Song D, Xu X, Tian L et al (2025) Post-translational modification of p62: roles and regulations in autophagy. Cells 14(13):1\u201325. https:\/\/doi.org\/10.3390\/cells14131016","journal-title":"Cells"},{"issue":"7","key":"10946_CR127","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbadis.2023.166725","volume":"1869","author":"F Xiong","year":"2023","unstructured":"Xiong F, Jiang K, Wu Y, Lou C, Ding C, Zhang W et al (2023) Intermittent fasting alleviates type 1 diabetes-induced cognitive dysfunction by improving the frontal cortical metabolic disorder. Biochim Biophys Acta Mol Basis Dis 1869(7):1\u201311. https:\/\/doi.org\/10.1016\/j.bbadis.2023.166725","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"10946_CR128","first-page":"106","volume":"15","author":"J Yisa","year":"2024","unstructured":"Yisa J, Abraham A, Nwankwo M, Omolara AS, Opoola FO (2024) Neuroprotective effects of Buccholzia coriacea seed on AlCl3-induced memory impairment in adult albino rats. J Anat Sci 15(1):106\u2013116","journal-title":"J Anat Sci"},{"issue":"3","key":"10946_CR129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/1541-4337.70175","volume":"24","author":"RA Yokel","year":"2025","unstructured":"Yokel RA (2025) Aluminum in beverages and foods: a comprehensive compilation of regulations; concentrations in raw, prepared, and stored beverages and foods; and intake. Compr Rev Food Sci Food Saf 24(3):1\u201324. https:\/\/doi.org\/10.1111\/1541-4337.70175","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"2","key":"10946_CR130","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/nan.12978","volume":"50","author":"K Yoshida","year":"2024","unstructured":"Yoshida K, Forrest SL, Ichimata S, Tanaka H, Kon T, Tartaglia MC et al (2024) Revisiting the relevance of Hirano bodies in neurodegenerative diseases. Neuropathol Appl Neurobiol 50(2):1\u201315. https:\/\/doi.org\/10.1111\/nan.12978","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"6","key":"10946_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/JPRI\/2019\/v31i630358","volume":"31","author":"MF Zaher","year":"2019","unstructured":"Zaher MF, Bendary MA, Abd El-Aziz GS, Ali AS (2019) Potential protective role of thymoquinone on experimentally-induced Alzheimer rats. J Pharma Res Int 31(6):1\u201318. https:\/\/doi.org\/10.9734\/JPRI\/2019\/v31i630358","journal-title":"J Pharma Res Int"},{"key":"10946_CR132","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2303050","author":"Z Zeng","year":"2024","unstructured":"Zeng Z, Zhang H, Wang X, Shen J, Chen D (2024) Fasting, a potential intervention in Alzheimer\u2019s disease. J Integr Neurosci. https:\/\/doi.org\/10.31083\/j.jin2303050","journal-title":"J Integr Neurosci"},{"issue":"1","key":"10946_CR133","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/cr.2017.133","volume":"28","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Chen X, Gueydan C, Han J (2018) Plasma membrane changes during programmed cell deaths. Cell Res 28(1):9\u201321. https:\/\/doi.org\/10.1038\/cr.2017.133","journal-title":"Cell Res"},{"issue":"1","key":"10946_CR134","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-11503-2","volume":"12","author":"J Zhang","year":"2022","unstructured":"Zhang J, Li S, Liu F, Yang K (2022) Role of CD68 in tumor immunity and prognosis prediction in pan-cancer. Sci Rep 12(1):1\u201322. https:\/\/doi.org\/10.1038\/s41598-022-11503-2","journal-title":"Sci Rep"},{"issue":"8","key":"10946_CR135","doi-asserted-by":"publisher","first-page":"720","DOI":"10.2174\/1570159x18666200114163636","volume":"18","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, Zhang Y, Zhang J, Zhang X, Yang G (2020) Molecular mechanism of autophagy: its role in the therapy of Alzheimer\u2019s disease. Curr Neuropharmacol 18(8):720\u2013739. https:\/\/doi.org\/10.2174\/1570159x18666200114163636","journal-title":"Curr Neuropharmacol"},{"issue":"19","key":"10946_CR136","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2047-9158-1-19","volume":"1","author":"L Zheng","year":"2012","unstructured":"Zheng L, Cedazo-Minguez A, Hallbeck M, Jerhammar F, Marcusson J, Terman A (2012) Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system. Transl Neurodegener 1(19):1\u20137. https:\/\/doi.org\/10.1186\/2047-9158-1-19","journal-title":"Transl Neurodegener"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10946-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10946-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10946-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:19:18Z","timestamp":1792271958000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10946-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":136,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10946"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10946-5","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,6]]},"assertion":[{"value":"19 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"No potential conflict of interest was reported by the authors.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"299"}}