{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:18:01Z","timestamp":1792783081279,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82360418"],"award-info":[{"award-number":["82360418"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Yunnan Provincial Science and Technology Talent and Platform Program (Academics and Experts Workstation) Project","award":["2019IC045"],"award-info":[{"award-number":["2019IC045"]}]},{"name":"Kunming Municipal Health Commission and Chunchengjihua","award":["C202112002"],"award-info":[{"award-number":["C202112002"]}]},{"name":"Kunming Health Science & Technology Talent Training and Technology Center Construction Project","award":["2023-SW (Houbei)-57"],"award-info":[{"award-number":["2023-SW (Houbei)-57"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10735-026-10965-2","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:30:00Z","timestamp":1789525800000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SIRT3-mediated DRP1 acetylation changes are associated with the restoration of mitochondrial function and alleviation of anterior cruciate ligament injury-induced osteoarthritis"],"prefix":"10.1007","volume":"57","author":[{"given":"Wenchuan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weirong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"1","key":"10965_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/acel.12538","volume":"16","author":"A Ansari","year":"2017","unstructured":"Ansari A, Rahman MS, Saha SK, Saikot FK, Deep A, Kim KH (2017) Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease. Aging Cell 16(1):4\u201316. https:\/\/doi.org\/10.1111\/acel.12538","journal-title":"Aging Cell"},{"key":"10965_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110452","volume":"129","author":"MY Ansari","year":"2020","unstructured":"Ansari MY, Ahmad N, Haqqi TM (2020) Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols. Biomed Pharmacother 129:110452. https:\/\/doi.org\/10.1016\/j.biopha.2020.110452","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10965_CR3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.joca.2021.11.003","volume":"30","author":"MY Ansari","year":"2022","unstructured":"Ansari MY, Novak K, Haqqi TM (2022) ERK1\/2-mediated activation of DRP1 regulates mitochondrial dynamics and apoptosis in chondrocytes. Osteoarthr Cartil 30(2):315\u2013328. https:\/\/doi.org\/10.1016\/j.joca.2021.11.003","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"10965_CR4","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.joca.2018.07.004","volume":"26","author":"LY Chen","year":"2018","unstructured":"Chen LY, Wang Y, Terkeltaub R, Liu-Bryan R (2018) Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function. Osteoarthr Cartil 26(11):1539\u20131550. https:\/\/doi.org\/10.1016\/j.joca.2018.07.004","journal-title":"Osteoarthr Cartil"},{"key":"10965_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104741","volume":"136","author":"M Cherubini","year":"2020","unstructured":"Cherubini M, Lopez-Molina L, Gines S (2020) Mitochondrial fission in Huntington\u2019s disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca(2+) efflux and reactive oxygen species (ROS) homeostasis. Neurobiol Dis 136:104741. https:\/\/doi.org\/10.1016\/j.nbd.2020.104741","journal-title":"Neurobiol Dis"},{"key":"10965_CR6","doi-asserted-by":"publisher","first-page":"103212","DOI":"10.1016\/j.redox.2024.103212","volume":"73","author":"Y Cho","year":"2024","unstructured":"Cho Y, Kim YK (2024) ROS-mediated cytoplasmic localization of CARM1 induces mitochondrial fission through DRP1 methylation. Redox Biol 73:103212. https:\/\/doi.org\/10.1016\/j.redox.2024.103212","journal-title":"Redox Biol"},{"key":"10965_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.116019","volume":"169","author":"R Dai","year":"2026","unstructured":"Dai R, Zheng M-M, Shi Y-N, Luo M-H, Wang Y, Wang H-W et al (2026) Melatonin alleviates atherosclerosis by inhibiting pro-inflammatory differentiation of macrophages via regulating Sirt3-Drp1 mediated mitochondrial fission. Int Immunopharmacol 169:116019. https:\/\/doi.org\/10.1016\/j.intimp.2025.116019","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"10965_CR8","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12491","volume":"65","author":"M Ding","year":"2018","unstructured":"Ding M, Feng N, Tang D, Feng J, Li Z, Jia M et al (2018) Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1\u03b1 pathway. J Pineal Res 65(2):e12491. https:\/\/doi.org\/10.1111\/jpi.12491","journal-title":"J Pineal Res"},{"issue":"20","key":"10965_CR9","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.1091\/mbc.E16-03-0193","volume":"27","author":"AL Hatch","year":"2016","unstructured":"Hatch AL, Ji WK, Merrill RA, Strack S, Higgs HN (2016) Actin filaments as dynamic reservoirs for Drp1 recruitment. Mol Biol Cell 27(20):3109\u20133121. https:\/\/doi.org\/10.1091\/mbc.E16-03-0193","journal-title":"Mol Biol Cell"},{"issue":"1","key":"10965_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-023-01798-z","volume":"22","author":"Z Hu","year":"2023","unstructured":"Hu Z, Zhang H, Wang Y, Li B, Liu K, Ran J et al (2023) Exercise activates Sirt1-mediated Drp1 acetylation and inhibits hepatocyte apoptosis to improve nonalcoholic fatty liver disease. Lipids Health Dis 22(1):33. https:\/\/doi.org\/10.1186\/s12944-023-01798-z","journal-title":"Lipids Health Dis"},{"issue":"10264","key":"10965_CR11","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/s0140-6736(20)32230-3","volume":"396","author":"DJ Hunter","year":"2020","unstructured":"Hunter DJ, March L, Chew M (2020) Osteoarthritis in 2020 and beyond: a lancet commission. Lancet 396(10264):1711\u20131712. https:\/\/doi.org\/10.1016\/s0140-6736(20)32230-3","journal-title":"Lancet"},{"issue":"1","key":"10965_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-025-01221-6","volume":"31","author":"H Jiang","year":"2025","unstructured":"Jiang H, Zhang Y, Ji P, Ming J, Li Y, Zhou Y (2025) Surfactant protein D alleviates chondrocytes senescence by upregulating SIRT3\/SOD2 pathway in osteoarthritis. Mol Med 31(1):161. https:\/\/doi.org\/10.1186\/s10020-025-01221-6","journal-title":"Mol Med"},{"issue":"5","key":"10965_CR13","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41401-020-00518-y","volume":"42","author":"JY Jin","year":"2021","unstructured":"Jin JY, Wei XX, Zhi XL, Wang XH, Meng D (2021) Drp1-dependent mitochondrial fission in cardiovascular disease. Acta Pharmacol Sin 42(5):655\u2013664. https:\/\/doi.org\/10.1038\/s41401-020-00518-y","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"10965_CR14","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.molcel.2015.01.002","volume":"57","author":"JA Kashatus","year":"2015","unstructured":"Kashatus JA, Nascimento A, Myers LJ, Sher A, Byrne FL, Hoehn KL et al (2015) Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth. Mol Cell 57(3):537\u2013551. https:\/\/doi.org\/10.1016\/j.molcel.2015.01.002","journal-title":"Mol Cell"},{"issue":"8","key":"10965_CR15","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1002\/eji.201545518","volume":"45","author":"I Khmaladze","year":"2015","unstructured":"Khmaladze I, Saxena A, Nandakumar KS, Holmdahl R (2015) B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production. Eur J Immunol 45(8):2243\u20132251. https:\/\/doi.org\/10.1002\/eji.201545518","journal-title":"Eur J Immunol"},{"key":"10965_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00048","volume":"5","author":"B Kincaid","year":"2013","unstructured":"Kincaid B, Bossy-Wetzel E (2013) Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci 5:48. https:\/\/doi.org\/10.3389\/fnagi.2013.00048","journal-title":"Front Aging Neurosci"},{"issue":"17","key":"10965_CR17","doi-asserted-by":"publisher","first-page":"7115","DOI":"10.1074\/jbc.M116.762567","volume":"292","author":"H Lee","year":"2017","unstructured":"Lee H, Smith SB, Yoon Y (2017) The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure. J Biol Chem 292(17):7115\u20137130. https:\/\/doi.org\/10.1074\/jbc.M116.762567","journal-title":"J Biol Chem"},{"key":"10965_CR18","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.2147\/ijn.S402170","volume":"18","author":"X Lei","year":"2023","unstructured":"Lei X, Tan G, Wang Y, Chen L, Cao Y, Si B et al (2023) Mitochondrial calcium nanoregulators reverse the macrophage proinflammatory phenotype through restoring mitochondrial calcium homeostasis for the treatment of osteoarthritis. Int J Nanomed 18:1469\u20131489. https:\/\/doi.org\/10.2147\/ijn.S402170","journal-title":"Int J Nanomed"},{"issue":"3","key":"10965_CR19","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.3892\/mmr.2017.6927","volume":"16","author":"N Liu","year":"2017","unstructured":"Liu N, Jiang Z, Liu Y, Nie Y, Chen J, Ouyang B et al (2017) Human trypsin inhibitor reduces the apoptosis of lipopolysaccharide\u2011induced human kidney\u20112 cells by promoting mitochondrial fusion. Mol Med Rep 16(3):2899\u20132906. https:\/\/doi.org\/10.3892\/mmr.2017.6927","journal-title":"Mol Med Rep"},{"issue":"7","key":"10965_CR20","doi-asserted-by":"publisher","first-page":"e2203869","DOI":"10.1002\/advs.202203869","volume":"10","author":"C Liu","year":"2023","unstructured":"Liu C, Li HJ, Duan WX, Duan Y, Yu Q, Zhang T et al (2023) MCU upregulation overactivates mitophagy by promoting VDAC1 dimerization and ubiquitination in the hepatotoxicity of cadmium. Adv Sci (Weinh) 10(7):e2203869. https:\/\/doi.org\/10.1002\/advs.202203869","journal-title":"Adv Sci (Weinh)"},{"issue":"7","key":"10965_CR21","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1248\/bpb.b17-00161","volume":"40","author":"G Park","year":"2017","unstructured":"Park G, Horie T, Fukasawa K, Ozaki K, Onishi Y, Kanayama T et al (2017) Amelioration of the development of osteoarthritis by daily intake of \u03b2-cryptoxanthin. Biol Pharm Bull 40(7):1116\u20131120. https:\/\/doi.org\/10.1248\/bpb.b17-00161","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"10965_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-025-10071-1","volume":"41","author":"J Qiao","year":"2025","unstructured":"Qiao J, Feng R, Yang G, Yang Z, Zhang A, Xu F (2025) Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway. Cell Biol Toxicol 41(1):120. https:\/\/doi.org\/10.1007\/s10565-025-10071-1","journal-title":"Cell Biol Toxicol"},{"issue":"1-2","key":"10965_CR23","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s11010-014-2187-z","volume":"397","author":"KN Reed","year":"2014","unstructured":"Reed KN, Wilson G, Pearsall A, Grishko VI (2014) The role of mitochondrial reactive oxygen species in cartilage matrix destruction. Mol Cell Biochem 397(1\u20132):195\u2013201. https:\/\/doi.org\/10.1007\/s11010-014-2187-z","journal-title":"Mol Cell Biochem"},{"key":"10965_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109880","volume":"78","author":"Y Rellmann","year":"2021","unstructured":"Rellmann Y, Eidhof E, Dreier R (2021) Review: ER stress-induced cell death in osteoarthritic cartilage. Cell Signal 78:109880. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109880","journal-title":"Cell Signal"},{"issue":"6386","key":"10965_CR25","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1126\/science.aao1785","volume":"360","author":"AG Rocha","year":"2018","unstructured":"Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC et al (2018) MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science 360(6386):336\u2013341. https:\/\/doi.org\/10.1126\/science.aao1785","journal-title":"Science"},{"key":"10965_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137461","author":"H Ruan","year":"2024","unstructured":"Ruan H, Zhu T, Wang T, Guo Y, Liu Y, Zheng J (2024) Quercetin modulates ferroptosis via the SIRT1\/Nrf-2\/HO-1 pathway and attenuates cartilage destruction in an osteoarthritis rat model. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25137461","journal-title":"Int J Mol Sci"},{"issue":"Pt 15","key":"10965_CR27","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1242\/jcs.070490","volume":"123","author":"AY Seo","year":"2010","unstructured":"Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP, Leeuwenburgh C (2010) New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci 123(Pt 15):2533\u20132542. https:\/\/doi.org\/10.1242\/jcs.070490","journal-title":"J Cell Sci"},{"key":"10965_CR28","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.2147\/jir.S310831","volume":"14","author":"Y Song","year":"2021","unstructured":"Song Y, Hao D, Jiang H, Huang M, Du Q, Lin Y et al (2021) Nrf2 regulates CHI3L1 to suppress inflammation and improve post-traumatic osteoarthritis. J Inflamm Res 14:4079\u20134088. https:\/\/doi.org\/10.2147\/jir.S310831","journal-title":"J Inflamm Res"},{"key":"10965_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116858","volume":"176","author":"J Sun","year":"2024","unstructured":"Sun J, Shao Y, Pei L, Zhu Q, Yu X, Yao W (2024) AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission. Biomed Pharmacother 176:116858. https:\/\/doi.org\/10.1016\/j.biopha.2024.116858","journal-title":"Biomed Pharmacother"},{"key":"10965_CR30","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuint.2016.05.003","volume":"97","author":"W Suwanjang","year":"2016","unstructured":"Suwanjang W, Abramov AY, Charngkaew K, Govitrapong P, Chetsawang B (2016) Melatonin prevents cytosolic calcium overload, mitochondrial damage and cell death due to toxically high doses of dexamethasone-induced oxidative stress in human neuroblastoma SH-SY5Y cells. Neurochem Int 97:34\u201341. https:\/\/doi.org\/10.1016\/j.neuint.2016.05.003","journal-title":"Neurochem Int"},{"issue":"2","key":"10965_CR31","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1177\/03635465231214697","volume":"52","author":"R Takase","year":"2024","unstructured":"Takase R, Ichinose T, Hashimoto S, Amano I, Ohsawa T, Koibuchi N et al (2024) Protective effects of extracorporeal shockwave therapy on the degenerated meniscus in a rat model. Am J Sports Med 52(2):374\u2013382. https:\/\/doi.org\/10.1177\/03635465231214697","journal-title":"Am J Sports Med"},{"issue":"10","key":"10965_CR32","doi-asserted-by":"publisher","first-page":"e3081","DOI":"10.1038\/cddis.2017.453","volume":"8","author":"Q Tang","year":"2017","unstructured":"Tang Q, Zheng G, Feng Z, Chen Y, Lou Y, Wang C et al (2017) Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development. Cell Death Dis 8(10):e3081. https:\/\/doi.org\/10.1038\/cddis.2017.453","journal-title":"Cell Death Dis"},{"key":"10965_CR33","doi-asserted-by":"publisher","first-page":"16169","DOI":"10.2147\/jir.S572167","volume":"18","author":"Z Tang","year":"2025","unstructured":"Tang Z, Cheng L, Li M, Chen J, Huang C (2025) Astragaloside IV alleviates osteoarthritis by inhibiting chondrocyte ferroptosis via the p53\/SLC7A11\/GPX4 Axis. J Inflamm Res 18:16169\u201316186. https:\/\/doi.org\/10.2147\/jir.S572167","journal-title":"J Inflamm Res"},{"issue":"13","key":"10965_CR34","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.7150\/ijbs.27746","volume":"14","author":"J Wang","year":"2018","unstructured":"Wang J, Wang K, Huang C, Lin D, Zhou Y, Wu Y et al (2018) SIRT3 activation by dihydromyricetin suppresses chondrocytes degeneration via maintaining mitochondrial homeostasis. Int J Biol Sci 14(13):1873\u20131882. https:\/\/doi.org\/10.7150\/ijbs.27746","journal-title":"Int J Biol Sci"},{"issue":"9","key":"10965_CR35","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1002\/jor.25245","volume":"40","author":"Y Wang","year":"2022","unstructured":"Wang Y, Wagner ES, Yu D, Chen KJ, Keel TJ, Pownder SL et al (2022) Assessment of osteoarthritis functional outcomes and intra-articular injection volume in the rat anterior cruciate ligament transection model. J Orthop Res 40(9):2004\u20132014. https:\/\/doi.org\/10.1002\/jor.25245","journal-title":"J Orthop Res"},{"issue":"12","key":"10965_CR36","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nrm3013","volume":"11","author":"B Westermann","year":"2010","unstructured":"Westermann B (2010) Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 11(12):872\u2013884. https:\/\/doi.org\/10.1038\/nrm3013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10965_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113643","volume":"144","author":"G Yang","year":"2025","unstructured":"Yang G, Ji B, Li H, Liu X, Liu G, Sun J et al (2025) Inhibition of CRLF1 expression by miR-8485 alleviates IL-1\u03b2-induced chondrocyte inflammation, apoptosis, and extracellular matrix degradation. Int Immunopharmacol 144:113643. https:\/\/doi.org\/10.1016\/j.intimp.2024.113643","journal-title":"Int Immunopharmacol"},{"key":"10965_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00753","volume":"8","author":"T Zhang","year":"2017","unstructured":"Zhang T, Ikejima T, Li L, Wu R, Yuan X, Zhao J et al (2017) Impairment of mitochondrial biogenesis and dynamics involved in isoniazid-induced apoptosis of HepG2 cells was alleviated by p38 MAPK pathway. Front Pharmacol 8:753. https:\/\/doi.org\/10.3389\/fphar.2017.00753","journal-title":"Front Pharmacol"},{"issue":"10","key":"10965_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206144","volume":"10","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Liu Y, Hou M, Xia X, Liu J, Xu Y et al (2023) Reprogramming of mitochondrial respiratory chain complex by targeting SIRT3-COX4I2 axis attenuates osteoarthritis progression. Adv Sci 10(10):e2206144. https:\/\/doi.org\/10.1002\/advs.202206144","journal-title":"Adv Sci"},{"key":"10965_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120005","volume":"286","author":"W Zhao","year":"2021","unstructured":"Zhao W, Sui M, Chen R, Lu H, Zhu Y, Zhang L et al (2021) SIRT3 protects kidneys from ischemia-reperfusion injury by modulating the DRP1 pathway to induce mitochondrial autophagy. Life Sci 286:120005. https:\/\/doi.org\/10.1016\/j.lfs.2021.120005","journal-title":"Life Sci"},{"issue":"1","key":"10965_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-025-02611-9","volume":"24","author":"J Zhao","year":"2025","unstructured":"Zhao J, Shu Z, Li X, Zhang W, Sun M, Song W et al (2025) Dehydrodiisoeugenol alleviates palmitate-induced mitochondrial dysfunction in human vascular smooth muscle cells through the activation of SIRT1-mediated Drp1 deacetylation. Lipids Health Dis 24(1):187. https:\/\/doi.org\/10.1186\/s12944-025-02611-9","journal-title":"Lipids Health Dis"},{"issue":"12","key":"10965_CR42","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1002\/jbmr.4721","volume":"37","author":"S Zhu","year":"2022","unstructured":"Zhu S, Donovan EL, Makosa D, Mehta-D\u2019souza P, Jopkiewicz A, Batushansky A et al (2022) Sirt3 promotes chondrogenesis, chondrocyte mitochondrial respiration and the development of high-fat diet-induced osteoarthritis in mice. J Bone Miner Res 37(12):2531\u20132547. https:\/\/doi.org\/10.1002\/jbmr.4721","journal-title":"J Bone Miner Res"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10965-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10965-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-026-10965-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:19:13Z","timestamp":1792271953000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-026-10965-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10965"],"URL":"https:\/\/doi.org\/10.1007\/s10735-026-10965-2","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"assertion":[{"value":"15 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no relevant financial or nonfinancial interests to disclose.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experimental protocols were approved by the Animal Experiment Ethics Review Committee of Kunming Medical University (kmmu20230134), and the animal procedures adhered to the ARRIVE 2.0 guidelines.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"309"}}