{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:36:01Z","timestamp":1769106961137,"version":"3.49.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Fail Rev"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s10741-018-9679-y","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T02:27:09Z","timestamp":1517970429000},"page":"147-156","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Pharmacological treatments for heart failure with preserved ejection fraction\u2014a systematic review and indirect comparison"],"prefix":"10.1007","volume":"23","author":[{"given":"Kwadwo Osei","family":"Bonsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poukwan","family":"Arunmanakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4572-8794","authenticated-orcid":false,"given":"Nathorn","family":"Chaiyakunapruk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"issue":"4","key":"9679_CR1","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1161\/CIR.0000000000000350","volume":"133","author":"D Mozaffarian","year":"2016","unstructured":"Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Despres JP, Fullerton HJ et al (2016) Heart disease and stroke Statistics-2016 update: a report from the American Heart Association. Circulation 133(4):e38\u2013e360","journal-title":"Circulation"},{"issue":"27","key":"9679_CR2","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"P Ponikowski","year":"2016","unstructured":"Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, Gonz\u00e1lez-Juanatey JR, Harjola V-P, Jankowska EA et al (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failureThe Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 37(27):2129\u20132200","journal-title":"Eur Heart J"},{"issue":"1","key":"9679_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/eurjhf\/hfq121","volume":"13","author":"CSP Lam","year":"2011","unstructured":"Lam CSP, Donal E, Kraigher-Krainer E, Vasan RS (2011) Epidemiology and clinical course of heart failure with preserved ejection fraction. Eur J Heart Fail 13(1):18\u201328. https:\/\/doi.org\/10.1093\/eurjhf\/hfq121","journal-title":"Eur J Heart Fail"},{"issue":"04","key":"9679_CR4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.recesp.2016.06.027","volume":"70","author":"E Santas","year":"2017","unstructured":"Santas E, Valero E, Mollar A, Garc\u00eda-Blas S, Palau P, Mi\u00f1ana G, N\u00fa\u00f1ez E, Sanchis J, Chorro FJ, N\u00fa\u00f1ez J (2017) Burden of recurrent hospitalizations following an admission for acute heart failure: preserved versus reduced ejection fraction. Rev Esp Cardiol (English Edition) 70(04):239\u2013246","journal-title":"Rev Esp Cardiol (English Edition)"},{"issue":"1","key":"9679_CR5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.111.080770","volume":"126","author":"BA Steinberg","year":"2012","unstructured":"Steinberg BA, Zhao X, Heidenreich PA, Peterson ED, Bhatt DL, Cannon CP, Hernandez AF, Fonarow GC (2012) Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes. Circulation 126(1):65\u201375. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.080770","journal-title":"Circulation"},{"issue":"14","key":"9679_CR6","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.ehj.2004.06.006","volume":"25","author":"MJ Lenzen","year":"2004","unstructured":"Lenzen MJ, Scholte op Reimer WJ, Boersma E, Vantrimpont PJ, Follath F, Swedberg K, Cleland J, Komajda M (2004) Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey. Eur Heart J 25(14):1214\u20131220. https:\/\/doi.org\/10.1016\/j.ehj.2004.06.006","journal-title":"Eur Heart J"},{"issue":"3","key":"9679_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1056\/NEJMoa052256","volume":"355","author":"TE Owan","year":"2006","unstructured":"Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM (2006) Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355(3):251\u2013259. https:\/\/doi.org\/10.1056\/NEJMoa052256","journal-title":"N Engl J Med"},{"issue":"6","key":"9679_CR8","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1093\/eurheartj\/ehq426","volume":"32","author":"BA Borlaug","year":"2011","unstructured":"Borlaug BA, Paulus WJ (2011) Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J 32(6):670\u2013679. https:\/\/doi.org\/10.1093\/eurheartj\/ehq426","journal-title":"Eur Heart J"},{"issue":"25","key":"9679_CR9","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1016\/j.jacc.2016.03.590","volume":"67","author":"AG Japp","year":"2016","unstructured":"Japp AG, Gulati A, Cook SA, Cowie MR, Prasad SK (2016) The diagnosis and evaluation of dilated cardiomyopathy. J Am Coll Cardiol 67(25):2996\u20133010. https:\/\/doi.org\/10.1016\/j.jacc.2016.03.590","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"9679_CR10","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1001\/jamacardio.2016.1325","volume":"1","author":"AP Kalogeropoulos","year":"2016","unstructured":"Kalogeropoulos AP, Fonarow GC, Georgiopoulou V, Burkman G, Siwamogsatham S, Patel A, Li S, Papadimitriou L, Butler J (2016) Characteristics and outcomes of adult outpatients with heart failure and improved or recovered ejection fraction. JAMA Cardiol 1(5):510\u2013518. https:\/\/doi.org\/10.1001\/jamacardio.2016.1325","journal-title":"JAMA Cardiol"},{"issue":"5","key":"9679_CR11","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1161\/CIRCHEARTFAILURE.114.001583","volume":"7","author":"AM Shah","year":"2014","unstructured":"Shah AM, Claggett B, Sweitzer NK, Shah SJ, Anand IS, O'Meara E, Desai AS, Heitner JF, Li G, Fang J, Rouleau J, Zile MR, Markov V, Ryabov V, Reis G, Assmann SF, McKinlay SM, Pitt B, Pfeffer MA, Solomon SD (2014) Cardiac structure and function and prognosis in heart failure with preserved ejection fraction: findings from the echocardiographic study of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) Trial. Circ Heart Fail 7(5):740\u2013751. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.114.001583","journal-title":"Circ Heart Fail"},{"issue":"5","key":"9679_CR12","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1161\/CIRCULATIONAHA.115.015884","volume":"132","author":"AM Shah","year":"2015","unstructured":"Shah AM, Claggett B, Sweitzer NK, Shah SJ, Anand IS, Liu L, Pitt B, Pfeffer MA, Solomon SD (2015) Prognostic importance of impaired systolic function in heart failure with preserved ejection fraction and the impact of spironolactone. Circulation 132(5):402\u2013414. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.115.015884","journal-title":"Circulation"},{"issue":"2","key":"9679_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10741-012-9361-8","volume":"19","author":"M Gheorghiade","year":"2014","unstructured":"Gheorghiade M, Vaduganathan M, Greene SJ, Mentz RJ, Adams KF, Anker SD, Arnold M, Baschiera F, Cleland JGF, Cotter G, Fonarow GC, Giordano C, Metra M, Misselwitz F, M\u00fchlhofer E, Nodari S, Frank Peacock W, Pieske BM, Sabbah HN, Sato N, Shah MR, Stockbridge NL, Teerlink JR, van Veldhuisen DJ, Zalewski A, Zannad F, Butler J (2014) Site selection in global clinical trials in patients hospitalized for heart failure: perceived problems and potential solutions. Heart Fail Rev 19(2):135\u2013152. https:\/\/doi.org\/10.1007\/s10741-012-9361-8","journal-title":"Heart Fail Rev"},{"issue":"1","key":"9679_CR14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2174\/1573403X09666131117131217","volume":"11","author":"AA Oktay","year":"2015","unstructured":"Oktay AA, Sanjiv JS (2015) Diagnosis and management of heart failure with preserved ejection fraction: 10 key lessons. Curr Cardiol Rev 11(1):42\u201352","journal-title":"Curr Cardiol Rev"},{"key":"9679_CR15","doi-asserted-by":"publisher","first-page":"f2194","DOI":"10.1136\/bmj.f2914","volume":"346","author":"EJ Mills","year":"2013","unstructured":"Mills EJ, Thorlund K, Ioannidis JPA (2013) Demystifying trial networks and network meta-analysis. BMJ 346:f2194","journal-title":"BMJ"},{"issue":"1","key":"9679_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1741-7015-9-1","volume":"9","author":"T Li","year":"2011","unstructured":"Li T, Puhan MA, Vedula SS, Singh S, Dickersin K (2011) Network meta-analysis-highly attractive but more methodological research is needed. BMC Med 9(1):1\u20135","journal-title":"BMC Med"},{"key":"9679_CR17","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jclinepi.2015.06.005","volume":"69","author":"P Whiting","year":"2016","unstructured":"Whiting P, Savovi\u0107 J, Higgins JPT, Caldwell DM, Reeves BC, Shea B, Davies P, Kleijnen J, Churchill R (2016) ROBIS: a new tool to assess risk of bias in systematic reviews was developed. J Clin Epidemiol 69:225\u2013234","journal-title":"J Clin Epidemiol"},{"issue":"10","key":"9679_CR18","doi-asserted-by":"publisher","first-page":"e76654","DOI":"10.1371\/journal.pone.0076654","volume":"8","author":"A Chaimani","year":"2013","unstructured":"Chaimani A, Higgins JP, Mavridis D, Spyridonos P, Salanti G (2013) Graphical tools for network meta-analysis in STATA. PLoS One 8(10):e76654. https:\/\/doi.org\/10.1371\/journal.pone.0076654","journal-title":"PLoS One"},{"issue":"2","key":"9679_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jclinepi.2010.03.016","volume":"64","author":"G Salanti","year":"2011","unstructured":"Salanti G, Ades AE, Ioannidis JP (2011) Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol 64(2):163\u2013171. https:\/\/doi.org\/10.1016\/j.jclinepi.2010.03.016","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"9679_CR20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/jrsm.1044","volume":"3","author":"JP Higgins","year":"2012","unstructured":"Higgins JP, Jackson D, Barrett JK, Lu G, Ades AE, White IR (2012) Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies. Res Synth Methods 3(2):98\u2013110. https:\/\/doi.org\/10.1002\/jrsm.1044","journal-title":"Res Synth Methods"},{"issue":"4","key":"9679_CR21","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/jrsm.1085","volume":"4","author":"S Donegan","year":"2013","unstructured":"Donegan S, Williamson P, D'Alessandro U, Tudur Smith C (2013) Assessing key assumptions of network meta-analysis: a review of methods. Res Synth Methods 4(4):291\u2013323. https:\/\/doi.org\/10.1002\/jrsm.1085","journal-title":"Res Synth Methods"},{"issue":"7109","key":"9679_CR22","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ (Clin Res ed) 315(7109):629\u2013634","journal-title":"BMJ (Clin Res ed)"},{"issue":"9386","key":"9679_CR23","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0140-6736(03)14285-7","volume":"362","author":"S Yusuf","year":"2003","unstructured":"Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J (2003) Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet (London, England) 362(9386):777\u2013781. https:\/\/doi.org\/10.1016\/S0140-6736(03)14285-7","journal-title":"Lancet (London, England)"},{"issue":"5","key":"9679_CR24","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1161\/01.CIR.0000138680.89536.A9","volume":"110","author":"PM Mottram","year":"2004","unstructured":"Mottram PM, Haluska B, Leano R, Cowley D, Stowasser M, Marwick TH (2004) Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure. Circulation 110(5):558\u2013565. https:\/\/doi.org\/10.1161\/01.CIR.0000138680.89536.A9","journal-title":"Circulation"},{"issue":"8","key":"9679_CR25","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.cardfail.2011.04.007","volume":"17","author":"A Deswal","year":"2011","unstructured":"Deswal A, Richardson P, Bozkurt B, Mann DL (2011) Results of the Randomized Aldosterone Antagonism in Heart Failure with Preserved Ejection Fraction trial (RAAM-PEF). J Card Fail 17(8):634\u2013642. https:\/\/doi.org\/10.1016\/j.cardfail.2011.04.007","journal-title":"J Card Fail"},{"issue":"8","key":"9679_CR26","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cardfail.2014.05.010","volume":"20","author":"KM Kurrelmeyer","year":"2014","unstructured":"Kurrelmeyer KM, Ashton Y, Xu J, Nagueh SF, Torre-Amione G, Deswal A (2014) Effects of spironolactone treatment in elderly women with heart failure and preserved left ventricular ejection fraction. J Card Fail 20(8):560\u2013568. https:\/\/doi.org\/10.1016\/j.cardfail.2014.05.010","journal-title":"J Card Fail"},{"issue":"15","key":"9679_CR27","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1056\/NEJMoa1313731","volume":"370","author":"B Pitt","year":"2014","unstructured":"Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, Clausell N, Desai AS, Diaz R, Fleg JL et al (2014) Spironolactone for heart failure with preserved ejection fraction. N Engl J Med 370(15):1383\u20131392. https:\/\/doi.org\/10.1056\/NEJMoa1313731","journal-title":"N Engl J Med"},{"issue":"8","key":"9679_CR28","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1001\/jama.2013.905","volume":"309","author":"F Edelmann","year":"2013","unstructured":"Edelmann F, Wachter R, Schmidt AG, Kraigher-Krainer E, Colantonio C, Kamke W, Duvinage A, Stahrenberg R, Durstewitz K, Loffler M et al (2013) Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial. JAMA 309(8):781\u2013791. https:\/\/doi.org\/10.1001\/jama.2013.905","journal-title":"JAMA"},{"issue":"19","key":"9679_CR29","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1093\/eurheartj\/ehl250","volume":"27","author":"JG Cleland","year":"2006","unstructured":"Cleland JG, Tendera M, Adamus J, Freemantle N, Polonski L, Taylor J (2006) The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J 27(19):2338\u20132345. https:\/\/doi.org\/10.1093\/eurheartj\/ehl250","journal-title":"Eur Heart J"},{"issue":"4","key":"9679_CR30","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1161\/CIRCHEARTFAILURE.109.898916","volume":"3","author":"DW Kitzman","year":"2010","unstructured":"Kitzman DW, Hundley WG, Brubaker PH, Morgan TM, Moore JB, Stewart KP, Little WC (2010) A randomized double-blind trial of enalapril in older patients with heart failure and preserved ejection fraction: effects on exercise tolerance and arterial distensibility. Circ Heart Fail 3(4):477\u2013485. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.109.898916","journal-title":"Circ Heart Fail"},{"issue":"7","key":"9679_CR31","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/0002-9149(93)90520-M","volume":"71","author":"WS Aronow","year":"1993","unstructured":"Aronow WS, Kronzon I (1993) Effect of enalapril on congestive heart failure treated with diuretics in elderly patients with prior myocardial infarction and normal left ventricular ejection fraction. Am J Cardiol 71(7):602\u2013604. https:\/\/doi.org\/10.1016\/0002-9149(93)90520-M","journal-title":"Am J Cardiol"},{"issue":"8","key":"9679_CR32","first-page":"567","volume":"25","author":"JZ Liu Gang","year":"2006","unstructured":"Liu Gang JZ, Shen LK (2006) Spironolactone in the treatment of elderly patients with hypertension and diastolic heart failure. Chin J New Drugs Clin Remedies 25(8):567\u2013570","journal-title":"Chin J New Drugs Clin Remedies"},{"issue":"1","key":"9679_CR33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1742-1241.2002.tb11193.x","volume":"56","author":"MJ Hung","year":"2002","unstructured":"Hung MJ, Cherng WJ, Kuo LT, Wang CH (2002) Effect of verapamil in elderly patients with left ventricular diastolic dysfunction as a cause of congestive heart failure. Int J Clin Pract 56(1):57\u201362","journal-title":"Int J Clin Pract"},{"issue":"8","key":"9679_CR34","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.amjcard.2012.05.049","volume":"110","author":"N Kampourides","year":"2012","unstructured":"Kampourides N, Tziakas D, Chalikias G, Papazoglou D, Maltezos E, Symeonides D, Konstantinides S (2012) Usefulness of matrix metalloproteinase-9 plasma levels to identify patients with preserved left ventricular systolic function after acute myocardial infarction who could benefit from eplerenone. Am J Cardiol 110(8):1085\u20131091","journal-title":"Am J Cardiol"},{"issue":"12","key":"9679_CR35","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1001\/jama.2013.2024","volume":"309","author":"MM Redfield","year":"2013","unstructured":"Redfield MM, Chen HH, Borlaug BA, Semigran MJ, Lee KL, Lewis G, MM LW, Rouleau JL, Bull DA, Mann DL et al (2013) Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA 309(12):1268\u20131277. https:\/\/doi.org\/10.1001\/jama.2013.2024","journal-title":"JAMA"},{"issue":"2","key":"9679_CR36","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jchf.2013.12.002","volume":"2","author":"MR Zile","year":"2014","unstructured":"Zile MR, Bourge RC, Redfield MM, Zhou D, Baicu CF, Little WC (2014) Randomized, double-blind, placebo-controlled study of sitaxsentan to improve impaired exercise tolerance in patients with heart failure and a preserved ejection fraction. JACC Heart Fail 2(2):123\u2013130. https:\/\/doi.org\/10.1016\/j.jchf.2013.12.002","journal-title":"JACC Heart Fail"},{"issue":"17","key":"9679_CR37","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1016\/j.jacc.2016.07.763","volume":"68","author":"W Kosmala","year":"2016","unstructured":"Kosmala W, Rojek A, Przewlocka-Kosmala M, Wright L, Mysiak A, Marwick TH (2016) Effect of aldosterone antagonism on exercise tolerance in heart failure with preserved ejection fraction. J Am Coll Cardiol 68(17):1823\u20131834. https:\/\/doi.org\/10.1016\/j.jacc.2016.07.763","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"9679_CR38","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.amjcard.2004.05.004","volume":"94","author":"Y Takeda","year":"2004","unstructured":"Takeda Y, Fukutomi T, Suzuki S, Yamamoto K, Ogata M, Kondo H, Sugiura M, Shigeyama J, Itoh M (2004) Effects of carvedilol on plasma B-type natriuretic peptide concentration and symptoms in patients with heart failure and preserved ejection fraction. Am J Cardiol 94(4):448\u2013453","journal-title":"Am J Cardiol"},{"issue":"4","key":"9679_CR39","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1001\/jama.2012.216476","volume":"309","author":"K Dharmarajan","year":"2013","unstructured":"Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, Barreto-Filho JA, Kim N, Bernheim SM, Suter LG, Drye EE, Krumholz HM (2013) Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia. JAMA 309(4):355\u2013363. https:\/\/doi.org\/10.1001\/jama.2012.216476","journal-title":"JAMA"},{"issue":"1","key":"9679_CR40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ijcard.2011.01.081","volume":"155","author":"M Fu","year":"2012","unstructured":"Fu M, Zhou J, Sun A, Zhang S, Zhang C, Zou Y, Fu M, Ge J (2012) Efficacy of ACE inhibitors in chronic heart failure with preserved ejection fraction--a meta analysis of 7 prospective clinical studies. Int J Cardiol 155(1):33\u201338. https:\/\/doi.org\/10.1016\/j.ijcard.2011.01.081","journal-title":"Int J Cardiol"},{"issue":"23","key":"9679_CR41","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1056\/NEJMoa0805450","volume":"359","author":"BM Massie","year":"2008","unstructured":"Massie BM, Carson PE, McMurray JJ, Komajda M, McKelvie R, Zile MR, Anderson S, Donovan M, Iverson E, Staiger C et al (2008) Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med 359(23):2456\u20132467. https:\/\/doi.org\/10.1056\/NEJMoa0805450","journal-title":"N Engl J Med"},{"issue":"3","key":"9679_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090555","volume":"9","author":"F Liu","year":"2014","unstructured":"Liu F, Chen Y, Feng X, Teng Z, Yuan Y, Bin J (2014) Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis. PLoS One 9(3):e90555. https:\/\/doi.org\/10.1371\/journal.pone.0090555","journal-title":"PLoS One"},{"issue":"1","key":"9679_CR43","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1161\/CIRCULATIONAHA.114.013255","volume":"131","author":"MA Pfeffer","year":"2015","unstructured":"Pfeffer MA, Claggett B, Assmann SF, Boineau R, Anand IS, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Heitner JF, Lewis EF, O'Meara E, Rouleau JL, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, McKinlay SM, Pitt B (2015) Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial. Circulation 131(1):34\u201342. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.013255","journal-title":"Circulation"},{"issue":"1","key":"9679_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12916-014-0261-8","volume":"13","author":"Y Chen","year":"2015","unstructured":"Chen Y, Wang H, Lu Y, Huang X, Liao Y, Bin J (2015) Effects of mineralocorticoid receptor antagonists in patients with preserved ejection fraction: a meta-analysis of randomized clinical trials. BMC Med 13(1):10. https:\/\/doi.org\/10.1186\/s12916-014-0261-8","journal-title":"BMC Med"},{"issue":"4","key":"9679_CR45","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s12471-016-0810-1","volume":"24","author":"L Heerebeek van","year":"2016","unstructured":"van Heerebeek L, Paulus WJ (2016) Understanding heart failure with preserved ejection fraction: where are we today? Neth Hear J 24(4):227\u2013236. https:\/\/doi.org\/10.1007\/s12471-016-0810-1","journal-title":"Neth Hear J"},{"key":"9679_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/heartjnl-2017-311652","volume":"0","author":"SL Zheng","year":"2017","unstructured":"Zheng SL, Chan FT, Nabeebaccus AA, Shah AM, McDonagh T, Okonko DO, Ayis S (2017) Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis. Heart 0:1\u20139. https:\/\/doi.org\/10.1136\/heartjnl-2017-311652","journal-title":"Heart"},{"issue":"16","key":"9679_CR47","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1161\/CIR.0b013e31829e8807","volume":"128","author":"CW Yancy","year":"2013","unstructured":"Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJV, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WHW, Tsai EJ, Wilkoff BL (2013) 2013 ACCF\/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines. Circulation 128(16):1810\u20131852. https:\/\/doi.org\/10.1161\/CIR.0b013e31829e8807","journal-title":"Circulation"}],"container-title":["Heart Failure Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10741-018-9679-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10741-018-9679-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10741-018-9679-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T21:53:43Z","timestamp":1693518823000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10741-018-9679-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,7]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["9679"],"URL":"https:\/\/doi.org\/10.1007\/s10741-018-9679-y","relation":{},"ISSN":["1382-4147","1573-7322"],"issn-type":[{"value":"1382-4147","type":"print"},{"value":"1573-7322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,7]]},"assertion":[{"value":"7 February 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}