{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:15:13Z","timestamp":1789028113838,"version":"build-2803163510"},"reference-count":146,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL97979, HL133294"],"award-info":[{"award-number":["HL97979, HL133294"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000967","name":"American Health Assistance Foundation","doi-asserted-by":"publisher","award":["16GRNT31100022"],"award-info":[{"award-number":["16GRNT31100022"]}],"id":[{"id":"10.13039\/100000967","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","award":["Research Chair Grant"],"award-info":[{"award-number":["Research Chair Grant"]}],"id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["RTA6080003"],"award-info":[{"award-number":["RTA6080003"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["RGJ"],"award-info":[{"award-number":["RGJ"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["RGJ"],"award-info":[{"award-number":["RGJ"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Fail Rev"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s10741-018-9700-5","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T21:47:42Z","timestamp":1524174462000},"page":"801-816","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: an update"],"prefix":"10.1007","volume":"23","author":[{"given":"Richard","family":"Gordan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwakon","family":"Wongjaikam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith K.","family":"Gwathmey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C.","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai-Hua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"9700_CR1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3324\/haematol.10701","volume":"92","author":"P Aguilar-Martinez","year":"2007","unstructured":"Aguilar-Martinez P, Lok CY, Cunat S, Cadet E, Robson K, Rochette J (2007) Juvenile hemochromatosis caused by a novel combination of hemojuvelin G320V\/R176C mutations in a 5-year old girl. Haematologica 92:421\u2013422","journal-title":"Haematologica"},{"key":"9700_CR2","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1056\/NEJMoa073286","volume":"358","author":"KJ Allen","year":"2008","unstructured":"Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, McLaren CE, Bahlo M, Nisselle AE, Vulpe CD, Anderson GJ, Southey MC, Giles GG, English DR, Hopper JL, Olynyk JK, Powell LW, Gertig DM (2008) Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med 358:221\u2013230. https:\/\/doi.org\/10.1056\/NEJMoa073286","journal-title":"N Engl J Med"},{"key":"9700_CR3","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1053\/euhj.2001.2822","volume":"22","author":"LJ Anderson","year":"2001","unstructured":"Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, Firmin DN, Wonke B, Porter J, Walker JM, Pennell DJ (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22:2171\u20132179","journal-title":"Eur Heart J"},{"key":"9700_CR4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1177\/109980040000200106","volume":"2","author":"WJ Bartfay","year":"2000","unstructured":"Bartfay WJ, Bartfay E (2000) Iron-overload cardiomyopathy: evidence for a free radical\u2014mediated mechanism of injury and dysfunction in a murine model. Biol Res Nurs 2:49\u201359. https:\/\/doi.org\/10.1177\/109980040000200106","journal-title":"Biol Res Nurs"},{"key":"9700_CR5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/S1054-8807(99)00008-3","volume":"8","author":"WJ Bartfay","year":"1999","unstructured":"Bartfay WJ, Butany J, Lehotay DC, Sole MJ, Hou D, Bartfay E, Liu PP (1999) A biochemical, histochemical, and electron microscopic study on the effects of iron-loading on the hearts of mice. Cardiovasc Pathol 8:305\u2013314","journal-title":"Cardiovasc Pathol"},{"key":"9700_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/anec.12085","volume":"19","author":"N Bayar","year":"2014","unstructured":"Bayar N, Arslan S, Erkal Z, Kucukseymen S (2014) Sustained ventricular tachycardia in a patient with thalassemia major. Ann Noninvasive Electrocardiol 19:193\u2013197. https:\/\/doi.org\/10.1111\/anec.12085","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"9700_CR7","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1182\/blood.V96.9.3256","volume":"96","author":"S Bekri","year":"2000","unstructured":"Bekri S, Kispal G, Lange H, Fitzsimons E, Tolmie J, Lill R, Bishop DF (2000) Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood 96:3256\u20133264","journal-title":"Blood"},{"key":"9700_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1532-429x-11-20","volume":"11","author":"V Berdoukas","year":"2009","unstructured":"Berdoukas V, Chouliaras G, Moraitis P, Zannikos K, Berdoussi E, Ladis V (2009) The efficacy of iron chelator regimes in reducing cardiac and hepatic iron in patients with thalassaemia major: a clinical observational study. J Cardiovasc Magn Reson 11:20. https:\/\/doi.org\/10.1186\/1532-429x-11-20","journal-title":"J Cardiovasc Magn Reson"},{"key":"9700_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2015.07.019","volume":"88","author":"V Berdoukas","year":"2015","unstructured":"Berdoukas V, Coates TD, Cabantchik ZI (2015) Iron and oxidative stress in cardiomyopathy in thalassemia. Free Radic Biol Med 88:3\u20139. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.07.019","journal-title":"Free Radic Biol Med"},{"key":"9700_CR10","doi-asserted-by":"publisher","unstructured":"Brewer C, Otto-Duessel M, Wood RI, Wood JC (2014a) Sex differences and steroid modulation of cardiac iron in a mouse model of iron overload. Translational Research: the journal of laboratory and clinical medicine 163:151\u2013159. https:\/\/doi.org\/10.1016\/j.trsl.2013.08.004","DOI":"10.1016\/j.trsl.2013.08.004"},{"key":"9700_CR11","doi-asserted-by":"publisher","unstructured":"Brewer CJ, Wood RI, Wood JC (2014b) mRNA regulation of cardiac iron transporters and ferritin subunits in a mouse model of iron overload. Exp Hematol 42:1059\u20131067. https:\/\/doi.org\/10.1016\/j.exphem.2014.09.002","DOI":"10.1016\/j.exphem.2014.09.002"},{"key":"9700_CR12","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s00277-014-2291-x","volume":"94","author":"E Cassinerio","year":"2015","unstructured":"Cassinerio E, Roghi A, Orofino N, Pedrotti P, Zanaboni L, Poggiali E, Giuditta M, Consonni D, Cappellini MD (2015) A 5-year follow-up in deferasirox treatment: improvement of cardiac and hepatic iron overload and amelioration in cardiac function in thalassemia major patients. Ann Hematol 94:939\u2013945. https:\/\/doi.org\/10.1007\/s00277-014-2291-x","journal-title":"Ann Hematol"},{"key":"9700_CR13","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.1182\/blood-2006-08-041632","volume":"109","author":"P Cavadini","year":"2007","unstructured":"Cavadini P, Biasiotto G, Poli M, Levi S, Verardi R, Zanella I, Derosas M, Ingrassia R, Corrado M, Arosio P (2007) RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload. Blood 109:3552\u20133559. https:\/\/doi.org\/10.1182\/blood-2006-08-041632","journal-title":"Blood"},{"key":"9700_CR14","first-page":"297","volume":"41","author":"L Cavallaro","year":"1993","unstructured":"Cavallaro L, Meo A, Busa G, Coglitore A, Sergi G, Satullo G, Donato A, Calabro MP, Miceli M (1993) Arrhythmia in thalassemia major: evaluation of iron chelating therapy by dynamic ECG. Minerva Cardioangiol 41:297\u2013301","journal-title":"Minerva Cardioangiol"},{"key":"9700_CR15","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1161\/CIRCRESAHA.116.309746","volume":"119","author":"HC Chang","year":"2016","unstructured":"Chang HC, Shapiro JS, Ardehali H (2016) Getting to the \"heart\" of cardiac disease by decreasing mitochondrial Iron. Circ Res 119:1164\u20131166. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.309746","journal-title":"Circ Res"},{"key":"9700_CR16","doi-asserted-by":"publisher","first-page":"247","DOI":"10.15252\/emmm.201505748","volume":"8","author":"HC Chang","year":"2016","unstructured":"Chang HC, Wu R, Shang M, Sato T, Chen C, Shapiro JS, Liu T, Thakur A, Sawicki KT, Prasad SV, Ardehali H (2016) Reduction in mitochondrial iron alleviates cardiac damage during injury. EMBO Mol Med 8:247\u2013267. https:\/\/doi.org\/10.15252\/emmm.201505748","journal-title":"EMBO Mol Med"},{"key":"9700_CR17","doi-asserted-by":"publisher","first-page":"8749","DOI":"10.1073\/pnas.0702854104","volume":"104","author":"Q Chen","year":"2007","unstructured":"Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M (2007) Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A 104:8749\u20138754. https:\/\/doi.org\/10.1073\/pnas.0702854104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9700_CR18","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1161\/01.RES.76.3.325","volume":"76","author":"N Chiamvimonvat","year":"1995","unstructured":"Chiamvimonvat N, O'Rourke B, Kamp TJ, Kallen RG, Hofmann F, Flockerzi V, Marban E (1995) Functional consequences of sulfhydryl modification in the pore-forming subunits of cardiovascular Ca2+ and Na+ channels. Circ Res 76:325\u2013334","journal-title":"Circ Res"},{"key":"9700_CR19","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1042\/CS20160072","volume":"130","author":"S Chiang","year":"2016","unstructured":"Chiang S, Kovacevic Z, Sahni S, Lane DJ, Merlot AM, Kalinowski DS, Huang ML, Richardson DR (2016) Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia. Clin Sci 130:853\u2013870. https:\/\/doi.org\/10.1042\/CS20160072","journal-title":"Clin Sci"},{"key":"9700_CR20","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1177\/109980040200300404","volume":"3","author":"S Crowe","year":"2002","unstructured":"Crowe S, Bartfay WJ (2002) Amlodipine decreases iron uptake and oxygen free radical production in the heart of chronically iron overloaded mice. Biol Res Nurs 3:189\u2013197. https:\/\/doi.org\/10.1177\/109980040200300404","journal-title":"Biol Res Nurs"},{"key":"9700_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/srep18132","volume":"5","author":"SK Das","year":"2015","unstructured":"Das SK, Wang W, Zhabyeyev P, Basu R, McLean B, Fan D, Parajuli N, DesAulniers J, Patel VB, Hajjar RJ, Dyck JR, Kassiri Z, Oudit GY (2015) Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy. Sci Rep 5:18132. https:\/\/doi.org\/10.1038\/srep18132","journal-title":"Sci Rep"},{"key":"9700_CR22","doi-asserted-by":"publisher","first-page":"e003456","DOI":"10.1161\/jaha.116.003456","volume":"6","author":"SK Das","year":"2017","unstructured":"Das SK, Patel VB, Basu R, Wang W, DesAulniers J, Kassiri Z, Oudit GY (2017) Females are protected from Iron-overload cardiomyopathy independent of iron metabolism: key role of oxidative stress. J Am Heart Assoc 6:e003456. https:\/\/doi.org\/10.1161\/jaha.116.003456","journal-title":"J Am Heart Assoc"},{"key":"9700_CR23","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1385\/bter:99:1-3:255","volume":"99","author":"MT Davis","year":"2004","unstructured":"Davis MT, Bartfay WJ (2004) Dose-dependent effects of chronic iron burden on heart aldehyde and acyloin production in mice. Biol Trace Elem Res 99:255\u2013268. https:\/\/doi.org\/10.1385\/bter:99:1-3:255","journal-title":"Biol Trace Elem Res"},{"key":"9700_CR24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/1099800403261350","volume":"6","author":"MT Davis","year":"2004","unstructured":"Davis MT, Bartfay WJ (2004) Ebselen decreases oxygen free radical production and iron concentrations in the hearts of chronically iron-overloaded mice. Biol Res Nurs 6:37\u201345. https:\/\/doi.org\/10.1177\/1099800403261350","journal-title":"Biol Res Nurs"},{"key":"9700_CR25","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1111\/j.1537-2995.2007.01416.x","volume":"47","author":"TE Delea","year":"2007","unstructured":"Delea TE, Edelsberg J, Sofrygin O, Thomas SK, Baladi JF, Phatak PD, Coates TD (2007) Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review. Transfusion 47:1919\u20131929. https:\/\/doi.org\/10.1111\/j.1537-2995.2007.01416.x","journal-title":"Transfusion"},{"key":"9700_CR26","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1124\/jpet.104.072744","volume":"311","author":"C Demougeot","year":"2004","unstructured":"Demougeot C, Van Hoecke M, Bertrand N, Prigent-Tessier A, Mossiat C, Beley A, Marie C (2004) Cytoprotective efficacy and mechanisms of the liposoluble iron chelator 2,2\u2032-dipyridyl in the rat photothrombotic ischemic stroke model. J Pharmacol Exp Ther 311:1080\u20131087. https:\/\/doi.org\/10.1124\/jpet.104.072744","journal-title":"J Pharmacol Exp Ther"},{"key":"9700_CR27","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1177\/0883073816636087","volume":"31","author":"S Elincx-Benizri","year":"2016","unstructured":"Elincx-Benizri S, Glik A, Merkel D, Arad M, Freimark D, Kozlova E, Cabantchik I, Hassin-Baer S (2016) Clinical experience with deferiprone treatment for Friedreich ataxia. J Child Neurol 31:1036\u20131040. https:\/\/doi.org\/10.1177\/0883073816636087","journal-title":"J Child Neurol"},{"key":"9700_CR28","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.amjmed.2013.05.002","volume":"126","author":"JL Fernandes","year":"2013","unstructured":"Fernandes JL, Sampaio EF, Fertrin K, Coelho OR, Loggetto S, Piga A, Verissimo M, Saad ST (2013) Amlodipine reduces cardiac iron overload in patients with thalassemia major: a pilot trial. Am J Med 126:834\u2013837. https:\/\/doi.org\/10.1016\/j.amjmed.2013.05.002","journal-title":"Am J Med"},{"key":"9700_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00025","volume":"5","author":"E Gammella","year":"2014","unstructured":"Gammella E, Maccarinelli F, Buratti P, Recalcati S, Cairo G (2014) The role of iron in anthracycline cardiotoxicity. Front Pharmacol 5:25. https:\/\/doi.org\/10.3389\/fphar.2014.00025","journal-title":"Front Pharmacol"},{"key":"9700_CR30","doi-asserted-by":"publisher","first-page":"4767","DOI":"10.1074\/jbc.M806235200","volume":"284","author":"X Gao","year":"2009","unstructured":"Gao X, Campian JL, Qian M, Sun XF, Eaton JW (2009) Mitochondrial DNA damage in iron overload. J Biol Chem 284:4767\u20134775. https:\/\/doi.org\/10.1074\/jbc.M806235200","journal-title":"J Biol Chem"},{"key":"9700_CR31","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.1182\/blood-2005-02-0460","volume":"106","author":"H Glickstein","year":"2005","unstructured":"Glickstein H, El RB, Shvartsman M, Cabantchik ZI (2005) Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells. Blood 106:3242\u20133250. https:\/\/doi.org\/10.1182\/blood-2005-02-0460","journal-title":"Blood"},{"key":"9700_CR32","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1182\/blood-2006-05-020867","volume":"108","author":"H Glickstein","year":"2006","unstructured":"Glickstein H, El RB, Link G, Breuer W, Konijn AM, Hershko C, Nick H, Cabantchik ZI (2006) Action of chelators in iron-loaded cardiac cells: accessibility to intracellular labile iron and functional consequences. Blood 108:3195\u20133203. https:\/\/doi.org\/10.1182\/blood-2006-05-020867","journal-title":"Blood"},{"key":"9700_CR33","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1111\/j.1476-5381.1996.tb15534.x","volume":"118","author":"L Guerra","year":"1996","unstructured":"Guerra L, Cerbai E, Gessi S, Borea PA, Mugelli A (1996) The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes. Br J Pharmacol 118:1278\u20131284","journal-title":"Br J Pharmacol"},{"key":"9700_CR34","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/mph.0000000000000467","volume":"38","author":"AA Hamed","year":"2016","unstructured":"Hamed AA, Elguindy W, Elhenawy YI, Ibrahim RH (2016) Early cardiac involvement and risk factors for the development of arrhythmia in patients with beta-thalassemia major. J Pediatr Hematol Oncol 38:5\u201311. https:\/\/doi.org\/10.1097\/mph.0000000000000467","journal-title":"J Pediatr Hematol Oncol"},{"key":"9700_CR35","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.freeradbiomed.2003.08.005","volume":"35","author":"BB Hasinoff","year":"2003","unstructured":"Hasinoff BB, Patel D, Wu X (2003) The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin. Free Radic Biol Med 35:1469\u20131479","journal-title":"Free Radic Biol Med"},{"key":"9700_CR36","first-page":"256","volume":"37","author":"G Heper","year":"2009","unstructured":"Heper G, Ozensoy U, Korkmaz ME (2009) Persistent atrial standstill and idioventricular rhythm in a patient with thalassemia intermedia. Turk Kardiyol Dern Ars 37:256\u2013259","journal-title":"Turk Kardiyol Dern Ars"},{"key":"9700_CR37","first-page":"1307","volume":"91","author":"C Hershko","year":"2006","unstructured":"Hershko C (2006) Oral iron chelators: new opportunities and new dilemmas. Haematologica 91:1307\u20131312","journal-title":"Haematologica"},{"key":"9700_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2010.05544.x","volume":"1202","author":"C Hershko","year":"2010","unstructured":"Hershko C (2010) Pathogenesis and management of iron toxicity in thalassemia. Ann N Y Acad Sci 1202:1\u20139. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05544.x","journal-title":"Ann N Y Acad Sci"},{"key":"9700_CR39","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1749-6632.2010.05573.x","volume":"1202","author":"RC Hider","year":"2010","unstructured":"Hider RC, Silva AM, Podinovskaia M, Ma Y (2010) Monitoring the efficiency of iron chelation therapy: the potential of nontransferrin-bound iron. Ann N Y Acad Sci 1202:94\u201399. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05573.x","journal-title":"Ann N Y Acad Sci"},{"key":"9700_CR40","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1182\/blood-2012-05-370098","volume":"120","author":"AV Hoffbrand","year":"2012","unstructured":"Hoffbrand AV, Taher A, Cappellini MD (2012) How I treat transfusional iron overload. Blood 120:3657\u20133669. https:\/\/doi.org\/10.1182\/blood-2012-05-370098","journal-title":"Blood"},{"key":"9700_CR41","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1172\/jci25049","volume":"115","author":"FW Huang","year":"2005","unstructured":"Huang FW, Pinkus JL, Pinkus GS, Fleming MD, Andrews NC (2005) A mouse model of juvenile hemochromatosis. J Clin Invest 115:2187\u20132191. https:\/\/doi.org\/10.1172\/jci25049","journal-title":"J Clin Invest"},{"key":"9700_CR42","doi-asserted-by":"publisher","first-page":"4152","DOI":"10.1073\/pnas.1119338109","volume":"109","author":"Y Ichikawa","year":"2012","unstructured":"Ichikawa Y, Bayeva M, Ghanefar M, Potini V, Sun L, Mutharasan RK, Wu R, Khechaduri A, Jairaj Naik T, Ardehali H (2012) Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export. Proc Natl Acad Sci U S A 109:4152\u20134157. https:\/\/doi.org\/10.1073\/pnas.1119338109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9700_CR43","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1172\/jci72931","volume":"124","author":"Y Ichikawa","year":"2014","unstructured":"Ichikawa Y, Ghanefar M, Bayeva M, Wu R, Khechaduri A, Naga Prasad SV, Mutharasan RK, Naik TJ, Ardehali H (2014) Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J Clin Invest 124:617\u2013630. https:\/\/doi.org\/10.1172\/jci72931","journal-title":"J Clin Invest"},{"key":"9700_CR44","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.ijcard.2007.08.103","volume":"132","author":"H Isma'eel","year":"2009","unstructured":"Isma'eel H, Shamseddeen W, Taher A, Gharzuddine W, Dimassi A, Alam S, Masri L, Khoury M (2009) Ventricular late potentials among thalassemia patients. Int J Cardiol 132:453\u2013455. https:\/\/doi.org\/10.1016\/j.ijcard.2007.08.103","journal-title":"Int J Cardiol"},{"key":"9700_CR45","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.bcmd.2015.06.003","volume":"55","author":"K Italia","year":"2015","unstructured":"Italia K, Colah R, Ghosh K (2015) Experimental animal model to study iron overload and iron chelation and review of other such models. Blood Cells Mol Dis 55:194\u2013199. https:\/\/doi.org\/10.1016\/j.bcmd.2015.06.003","journal-title":"Blood Cells Mol Dis"},{"key":"9700_CR46","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s12185-016-2002-6","volume":"104","author":"S Ito","year":"2016","unstructured":"Ito S, Ikuta K, Kato D, Lynda A, Shibusa K, Niizeki N, Toki Y, Hatayama M, Yamamoto M, Shindo M, Iizuka N, Kohgo Y, Fujiya M (2016) In vivo behavior of NTBI revealed by automated quantification system. Int J Hematol 104:175\u2013181. https:\/\/doi.org\/10.1007\/s12185-016-2002-6","journal-title":"Int J Hematol"},{"key":"9700_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/srep43439","volume":"7","author":"LH Jackson","year":"2017","unstructured":"Jackson LH, Vlachodimitropoulou E, Shangaris P, Roberts TA, Ryan TM, Campbell-Washburn AE, David AL, Porter JB, Lythgoe MF, Stuckey DJ (2017) Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of beta-thalassemia. Sci Rep 7:43439. https:\/\/doi.org\/10.1038\/srep43439","journal-title":"Sci Rep"},{"key":"9700_CR48","first-page":"419","volume-title":"The journal of laboratory and clinical medicine","author":"L Kaiser","year":"2003","unstructured":"Kaiser L, Davis JM, Schwartz KA (2003) Does the gerbil model mimic human iron overload? In: The journal of laboratory and clinical medicine. author reply 420\u2013412, vol 141, pp 419\u2013420"},{"key":"9700_CR49","first-page":"383","volume":"57","author":"L Kaiser","year":"2007","unstructured":"Kaiser L, Davis J, Patterson J, Boyd RF, Olivier NB, Bohart G, Schwartz KA (2007) Iron does not cause arrhythmias in the guinea pig model of transfusional iron overload. Comp Med 57:383\u2013389","journal-title":"Comp Med"},{"key":"9700_CR50","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1079\/BJN2001319","volume":"85","author":"M Kapsokefalou","year":"2001","unstructured":"Kapsokefalou M, Miller DD (2001) Iron loading and large doses of intravenous ascorbic acid promote lipid peroxidation in whole serum in Guinea pigs. Br J Nutr 85:681\u2013687","journal-title":"Br J Nutr"},{"key":"9700_CR51","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1096\/fj.05-4107com","volume":"19","author":"S Kc","year":"2005","unstructured":"Kc S, Carcamo JM, Golde DW (2005) Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury. FASEB J 19:1657\u20131667. https:\/\/doi.org\/10.1096\/fj.05-4107com","journal-title":"FASEB J"},{"key":"9700_CR52","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/jcp.10284","volume":"196","author":"Y Ke","year":"2003","unstructured":"Ke Y, Chen YY, Chang YZ, Duan XL, Ho KP, Jiang DH, Wang K, Qian ZM (2003) Post-transcriptional expression of DMT1 in the heart of rat. J Cell Physiol 196:124\u2013130. https:\/\/doi.org\/10.1002\/jcp.10284","journal-title":"J Cell Physiol"},{"key":"9700_CR53","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0163-7258(90)90088-J","volume":"47","author":"HG Keizer","year":"1990","unstructured":"Keizer HG, Pinedo HM, Schuurhuis GJ, Joenje H (1990) Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol Ther 47:219\u2013231","journal-title":"Pharmacol Ther"},{"key":"9700_CR54","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ejphar.2017.02.015","volume":"799","author":"J Khamseekaew","year":"2017","unstructured":"Khamseekaew J, Kumfu S, Wongjaikam S, Kerdphoo S, Jaiwongkam T, Srichairatanakool S, Fucharoen S, Chattipakorn SC, Chattipakorn N (2017) Effects of iron overload, an iron chelator and a T-type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice. Eur J Pharmacol 799:118\u2013127. https:\/\/doi.org\/10.1016\/j.ejphar.2017.02.015","journal-title":"Eur J Pharmacol"},{"key":"9700_CR55","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1006\/taap.1995.1008","volume":"130","author":"E Kim","year":"1995","unstructured":"Kim E, Giri SN, Pessah IN (1995) Iron(II) is a modulator of ryanodine-sensitive calcium channels of cardiac muscle sarcoplasmic reticulum. Toxicol Appl Pharmacol 130:57\u201366. https:\/\/doi.org\/10.1006\/taap.1995.1008","journal-title":"Toxicol Appl Pharmacol"},{"key":"9700_CR56","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1179\/135100001101536373","volume":"6","author":"WH Koppenol","year":"2001","unstructured":"Koppenol WH (2001) The Haber-Weiss cycle--70 years later. Redox Rep 6:229\u2013234. https:\/\/doi.org\/10.1179\/135100001101536373","journal-title":"Redox Rep"},{"key":"9700_CR57","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1161\/circulationaha.111.050773","volume":"124","author":"DT Kremastinos","year":"2011","unstructured":"Kremastinos DT, Farmakis D (2011) Iron overload cardiomyopathy in clinical practice. Circulation 124:2253\u20132263. https:\/\/doi.org\/10.1161\/circulationaha.111.050773","journal-title":"Circulation"},{"key":"9700_CR58","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.mrfmmm.2003.08.004","volume":"531","author":"M Kruszewski","year":"2003","unstructured":"Kruszewski M (2003) Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res 531:81\u201392","journal-title":"Mutat Res"},{"key":"9700_CR59","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1600-0609.2010.01549.x","volume":"86","author":"S Kumfu","year":"2011","unstructured":"Kumfu S, Chattipakorn S, Srichairatanakool S, Settakorn J, Fucharoen S, Chattipakorn N (2011) T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice. Eur J Haematol 86:156\u2013166. https:\/\/doi.org\/10.1111\/j.1600-0609.2010.01549.x","journal-title":"Eur J Haematol"},{"key":"9700_CR60","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/j.1600-0609.2012.01779.x","volume":"88","author":"S Kumfu","year":"2012","unstructured":"Kumfu S, Chattipakorn S, Chinda K, Fucharoen S, Chattipakorn N (2012) T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice. Eur J Haematol 88:535\u2013548. https:\/\/doi.org\/10.1111\/j.1600-0609.2012.01779.x","journal-title":"Eur J Haematol"},{"key":"9700_CR61","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s10534-012-9579-x","volume":"25","author":"S Kumfu","year":"2012","unstructured":"Kumfu S, Chattipakorn S, Fucharoen S, Chattipakorn N (2012) Mitochondrial calcium uniporter blocker prevents cardiac mitochondrial dysfunction induced by iron overload in thalassemic mice. Biometals 25:1167\u20131175. https:\/\/doi.org\/10.1007\/s10534-012-9579-x","journal-title":"Biometals"},{"key":"9700_CR62","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3109\/01480545.2012.726625","volume":"36","author":"S Kumfu","year":"2013","unstructured":"Kumfu S, Chattipakorn S, Fucharoen S, Chattipakorn N (2013) Ferric iron uptake into cardiomyocytes of beta-thalassemic mice is not through calcium channels. Drug Chem Toxicol 36:329\u2013334. https:\/\/doi.org\/10.3109\/01480545.2012.726625","journal-title":"Drug Chem Toxicol"},{"key":"9700_CR63","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1113\/ep085517","volume":"101","author":"S Kumfu","year":"2016","unstructured":"Kumfu S, Chattipakorn SC, Fucharoen S, Chattipakorn N (2016) Dual T-type and L-type calcium channel blocker exerts beneficial effects in attenuating cardiovascular dysfunction in iron-overloaded thalassaemic mice. Exp Physiol 101:521\u2013539. https:\/\/doi.org\/10.1113\/ep085517","journal-title":"Exp Physiol"},{"key":"9700_CR64","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1177\/1535370217708977","volume":"242","author":"S Kumfu","year":"2017","unstructured":"Kumfu S, Fucharoen S, Chattipakorn SC, Chattipakorn N (2017) Cardiac complications in beta-thalassemia: from mice to men. Exp Biol Med (Maywood, NJ) 242:1126\u20131135. https:\/\/doi.org\/10.1177\/1535370217708977","journal-title":"Exp Biol Med (Maywood, NJ)"},{"key":"9700_CR65","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1080\/10715762.2017.1414208","volume":"52","author":"S Kumfu","year":"2018","unstructured":"Kumfu S, Khamseekaew J, Palee S, Srichairatanakool S, Fucharoen S, Chattipakorn SC, Chattipakorn N (2018) A combination of an iron chelator with an antioxidant exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice. Free Radic Res 52:70\u201379. https:\/\/doi.org\/10.1080\/10715762.2017.1414208","journal-title":"Free Radic Res"},{"key":"9700_CR66","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1196\/annals.1345.067","volume":"1054","author":"V Ladis","year":"2005","unstructured":"Ladis V, Chouliaras G, Berdousi H, Kanavakis E, Kattamis C (2005) Longitudinal study of survival and causes of death in patients with thalassemia major in Greece. Ann N Y Acad Sci 1054:445\u2013450. https:\/\/doi.org\/10.1196\/annals.1345.067","journal-title":"Ann N Y Acad Sci"},{"key":"9700_CR67","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1073\/pnas.1422373112","volume":"112","author":"S Lakhal-Littleton","year":"2015","unstructured":"Lakhal-Littleton S, Wolna M, Carr CA, Miller JJ, Christian HC, Ball V, Santos A, Diaz R, Biggs D, Stillion R, Holdship P, Larner F, Tyler DJ, Clarke K, Davies B, Robbins PA (2015) Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function. Proc Natl Acad Sci U S A 112:3164\u20133169. https:\/\/doi.org\/10.1073\/pnas.1422373112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9700_CR68","doi-asserted-by":"publisher","unstructured":"Lakhal-Littleton S, Wolna M, Chung YJ, Christian HC, Heather LC, Brescia M, Ball V, Diaz R, Santos A, Biggs D, Clarke K, Davies B, Robbins PA (2016) An essential cell-autonomous role for hepcidin in cardiac iron homeostasis. eLife 5. https:\/\/doi.org\/10.7554\/eLife.19804","DOI":"10.7554\/eLife.19804"},{"key":"9700_CR69","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/s0022-2143(03)00060-x","volume":"142","author":"KR Laurita","year":"2003","unstructured":"Laurita KR, Chuck ET, Yang T, Dong WQ, Kuryshev YA, Brittenham GM, Rosenbaum DS, Brown AM (2003) Optical mapping reveals conduction slowing and impulse block in iron-overload cardiomyopathy. J Lab Clin Med 142:83\u201389. https:\/\/doi.org\/10.1016\/s0022-2143(03)00060-x","journal-title":"J Lab Clin Med"},{"key":"9700_CR70","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1440-1827.1995.tb03443.x","volume":"45","author":"JP Lu","year":"1995","unstructured":"Lu JP, Hayashi K (1995) Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats. Pathol Int 45:202\u2013206","journal-title":"Pathol Int"},{"key":"9700_CR71","doi-asserted-by":"publisher","first-page":"C645","DOI":"10.1152\/ajpcell.00186.2012","volume":"303","author":"AR Ludke","year":"2012","unstructured":"Ludke AR, Sharma AK, Akolkar G, Bajpai G, Singal PK (2012) Downregulation of vitamin C transporter SVCT-2 in doxorubicin-induced cardiomyocyte injury. Am J Physiol Cell Physiol 303:C645\u2013C653. https:\/\/doi.org\/10.1152\/ajpcell.00186.2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"9700_CR72","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/187152909787581345","volume":"9","author":"L Mancuso","year":"2009","unstructured":"Mancuso L, Mancuso A, Bevacqua E, Rigano P (2009) Electrocardiographic abnormalities in thalassemia patients with heart failure. Cardiovasc Hematol Disord Drug Targets 9:29\u201335","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"9700_CR73","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.lfs.2015.10.034","volume":"143","author":"VB Marques","year":"2015","unstructured":"Marques VB, Nascimento TB, Ribeiro RF Jr, Broseghini-Filho GB, Rossi EM, Graceli JB, dos Santos L (2015) Chronic iron overload in rats increases vascular reactivity by increasing oxidative stress and reducing nitric oxide bioavailability. Life Sci 143:89\u201397. https:\/\/doi.org\/10.1016\/j.lfs.2015.10.034","journal-title":"Life Sci"},{"key":"9700_CR74","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-1-4615-0059-9_5","volume":"531","author":"JJ Marx","year":"2003","unstructured":"Marx JJ (2003) Pathophysiology and treatment of iron overload in thalassemia patients in tropical countries. Adv Exp Med Biol 531:57\u201368","journal-title":"Adv Exp Med Biol"},{"key":"9700_CR75","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1111\/j.1440-1746.2005.03930.x","volume":"20","author":"L McNamara","year":"2005","unstructured":"McNamara L, Gordeuk VR, MacPhail AP (2005) Ferroportin (Q248H) mutations in African families with dietary iron overload. J Gastroenterol Hepatol 20:1855\u20131858. https:\/\/doi.org\/10.1111\/j.1440-1746.2005.03930.x","journal-title":"J Gastroenterol Hepatol"},{"key":"9700_CR76","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1124\/pr.56.2.6","volume":"56","author":"G Minotti","year":"2004","unstructured":"Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56:185\u2013229. https:\/\/doi.org\/10.1124\/pr.56.2.6","journal-title":"Pharmacol Rev"},{"key":"9700_CR77","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s00246-011-0019-4","volume":"32","author":"SN Moon","year":"2011","unstructured":"Moon SN, Han JW, Hwang HS, Kim MJ, Lee SJ, Lee JY, Oh CK, Jeong DC (2011) Establishment of secondary iron overloaded mouse model: evaluation of cardiac function and analysis according to iron concentration. Pediatr Cardiol 32:947\u2013952. https:\/\/doi.org\/10.1007\/s00246-011-0019-4","journal-title":"Pediatr Cardiol"},{"key":"9700_CR78","doi-asserted-by":"publisher","first-page":"581a","DOI":"10.1016\/j.bpj.2013.11.3224","volume":"106","author":"AL Nieminen","year":"2014","unstructured":"Nieminen AL, Schwartz J, Hung HI, Blocker ER, Gooz M, Lemasters JJ (2014) Mitoferrin-2 (MFRN2) Regulates the Electrogenic Mitochondrial Calcium Uniporter and Interacts Physically with MCU. Biophys J 106:581a","journal-title":"Biophys J"},{"key":"9700_CR79","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2223\/JPED.1982","volume":"86","author":"K Nisli","year":"2010","unstructured":"Nisli K, Taner Y, Naci O, Zafer S, Zeynep K, Aygun D, Umrah A, Rukiye E, Turkan E (2010) Electrocardiographic markers for the early detection of cardiac disease in patients with beta-thalassemia major. J Pediatr 86:159\u2013162. https:\/\/doi.org\/10.2223\/JPED.1982","journal-title":"J Pediatr"},{"key":"9700_CR80","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1067\/mlc.2003.18","volume":"141","author":"CA Obejero-Paz","year":"2003","unstructured":"Obejero-Paz CA, Yang T, Dong WQ, Levy MN, Brittenham GM, Kuryshev YA, Brown AM (2003) Deferoxamine promotes survival and prevents electrocardiographic abnormalities in the gerbil model of iron-overload cardiomyopathy. J Lab Clin Med 141:121\u2013130. https:\/\/doi.org\/10.1067\/mlc.2003.18","journal-title":"J Lab Clin Med"},{"key":"9700_CR81","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/trf.13961","volume":"57","author":"H Oduor","year":"2017","unstructured":"Oduor H, Minniti CP, Brofferio A, Gharib AM, Abd-Elmoniem KZ, Hsieh MM, Tisdale JF, Fitzhugh CD (2017) Severe cardiac iron toxicity in two adults with sickle cell disease. Transfusion 57:700\u2013704. https:\/\/doi.org\/10.1111\/trf.13961","journal-title":"Transfusion"},{"key":"9700_CR82","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1097\/01.fjc.0000138163.11612.7b","volume":"44","author":"N Ohashi","year":"2004","unstructured":"Ohashi N, Mitamura H, Tanimoto K, Fukuda Y, Kinebuchi O, Kurita Y, Shiroshita-Takeshita A, Miyoshi S, Hara M, Takatsuki S, Ogawa S (2004) A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling. J Cardiovasc Pharmacol 44:386\u2013392","journal-title":"J Cardiovasc Pharmacol"},{"key":"9700_CR83","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1159\/000109879","volume":"118","author":"M Otto-Duessel","year":"2007","unstructured":"Otto-Duessel M, Aguilar M, Moats R, Wood JC (2007) Antioxidant-mediated effects in a gerbil model of iron overload. Acta Haematol 118:193\u2013199. https:\/\/doi.org\/10.1159\/000109879","journal-title":"Acta Haematol"},{"key":"9700_CR84","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.exphem.2007.04.001","volume":"35","author":"M Otto-Duessel","year":"2007","unstructured":"Otto-Duessel M, Aguilar M, Nick H, Moats R, Wood JC (2007) Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy. Exp Hematol 35:1069\u20131073. https:\/\/doi.org\/10.1016\/j.exphem.2007.04.001","journal-title":"Exp Hematol"},{"key":"9700_CR85","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.trsl.2010.11.002","volume":"157","author":"M Otto-Duessel","year":"2011","unstructured":"Otto-Duessel M, Brewer C, Wood JC (2011) Interdependence of cardiac iron and calcium in a murine model of iron overload. Transl Res 157:92\u201399. https:\/\/doi.org\/10.1016\/j.trsl.2010.11.002","journal-title":"Transl Res"},{"key":"9700_CR86","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/nm920","volume":"9","author":"GY Oudit","year":"2003","unstructured":"Oudit GY, Sun H, Trivieri MG, Koch SE, Dawood F, Ackerley C, Yazdanpanah M, Wilson GJ, Schwartz A, Liu PP, Backx PH (2003) L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat Med 9:1187\u20131194. https:\/\/doi.org\/10.1038\/nm920","journal-title":"Nat Med"},{"key":"9700_CR87","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1161\/01.cir.0000124229.40424.80","volume":"109","author":"GY Oudit","year":"2004","unstructured":"Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, Liu P, Sole MJ, Backx PH (2004) Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation 109:1877\u20131885. https:\/\/doi.org\/10.1161\/01.cir.0000124229.40424.80","journal-title":"Circulation"},{"key":"9700_CR88","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00109-005-0029-x","volume":"84","author":"GY Oudit","year":"2006","unstructured":"Oudit GY, Trivieri MG, Khaper N, Liu PP, Backx PH (2006) Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy. J Mol Med (Berlin, Germany) 84:349\u2013364. https:\/\/doi.org\/10.1007\/s00109-005-0029-x","journal-title":"J Mol Med (Berlin, Germany)"},{"key":"9700_CR89","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1002\/hep.23581","volume":"51","author":"X Pan","year":"2010","unstructured":"Pan X, Kelly S, Melin-Aldana H, Malladi P, Whitington PF (2010) Novel mechanism of fetal hepatocyte injury in congenital alloimmune hepatitis involves the terminal complement cascade. Hepatology (Baltimore, Md) 51:2061\u20132068. https:\/\/doi.org\/10.1002\/hep.23581","journal-title":"Hepatology (Baltimore, Md)"},{"key":"9700_CR90","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1128\/mcb.01685-08","volume":"29","author":"PN Paradkar","year":"2009","unstructured":"Paradkar PN, Zumbrennen KB, Paw BH, Ward DM, Kaplan J (2009) Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol 29:1007\u20131016. https:\/\/doi.org\/10.1128\/mcb.01685-08","journal-title":"Mol Cell Biol"},{"key":"9700_CR91","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ppedcard.2011.02.007","volume":"31","author":"RM Payne","year":"2011","unstructured":"Payne RM (2011) The heart in Friedreich's ataxia: basic findings and clinical implications. Prog Pediatr Cardiol 31:103\u2013109. https:\/\/doi.org\/10.1016\/j.ppedcard.2011.02.007","journal-title":"Prog Pediatr Cardiol"},{"key":"9700_CR92","doi-asserted-by":"publisher","first-page":"3738","DOI":"10.1182\/blood-2005-07-2948","volume":"107","author":"DJ Pennell","year":"2006","unstructured":"Pennell DJ, Berdoukas V, Karagiorga M, Ladis V, Piga A, Aessopos A, Gotsis ED, Tanner MA, Smith GC, Westwood MA, Wonke B, Galanello R (2006) Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. Blood 107:3738\u20133744. https:\/\/doi.org\/10.1182\/blood-2005-07-2948","journal-title":"Blood"},{"key":"9700_CR93","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1182\/blood-2009-04-217455","volume":"115","author":"DJ Pennell","year":"2010","unstructured":"Pennell DJ, Porter JB, Cappellini MD, El-Beshlawy A, Chan LL, Aydinok Y, Elalfy MS, Sutcharitchan P, Li CK, Ibrahim H, Viprakasit V, Kattamis A, Smith G, Habr D, Domokos G, Roubert B, Taher A (2010) Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia. Blood 115:2364\u20132371. https:\/\/doi.org\/10.1182\/blood-2009-04-217455","journal-title":"Blood"},{"key":"9700_CR94","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1182\/blood-2013-04-497842","volume":"123","author":"DJ Pennell","year":"2014","unstructured":"Pennell DJ, Porter JB, Piga A, Lai Y, El-Beshlawy A, Belhoul KM, Elalfy M, Yesilipek A, Kilinc Y, Lawniczek T, Habr D, Weisskopf M, Zhang Y, Aydinok Y (2014) A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in beta-thalassemia major (CORDELIA). Blood 123:1447\u20131454. https:\/\/doi.org\/10.1182\/blood-2013-04-497842","journal-title":"Blood"},{"key":"9700_CR95","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3324\/haematol.2009.019042","volume":"96","author":"A Pepe","year":"2011","unstructured":"Pepe A, Meloni A, Capra M, Cianciulli P, Prossomariti L, Malaventura C, Putti MC, Lippi A, Romeo MA, Bisconte MG, Filosa A, Caruso V, Quarta A, Pitrolo L, Missere M, Midiri M, Rossi G, Positano V, Lombardi M, Maggio A (2011) Deferasirox, deferiprone and desferrioxamine treatment in thalassemia major patients: cardiac iron and function comparison determined by quantitative magnetic resonance imaging. Haematologica 96:41\u201347. https:\/\/doi.org\/10.3324\/haematol.2009.019042","journal-title":"Haematologica"},{"key":"9700_CR96","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1002\/hep.510290435","volume":"29","author":"F Petrat","year":"1999","unstructured":"Petrat F, Rauen U, de Groot H (1999) Determination of the chelatable iron pool of isolated rat hepatocytes by digital fluorescence microscopy using the fluorescent probe, phen green SK. Hepatology (Baltimore, Md) 29:1171\u20131179. https:\/\/doi.org\/10.1002\/hep.510290435","journal-title":"Hepatology (Baltimore, Md)"},{"key":"9700_CR97","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1042\/bj3620137","volume":"362","author":"F Petrat","year":"2002","unstructured":"Petrat F, Weisheit D, Lensen M, de Groot H, Sustmann R, Rauen U (2002) Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor. Biochem J 362:137\u2013147","journal-title":"Biochem J"},{"key":"9700_CR98","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/ajh.21317","volume":"84","author":"A Piga","year":"2009","unstructured":"Piga A, Longo F, Duca L, Roggero S, Vinciguerra T, Calabrese R, Hershko C, Cappellini MD (2009) High nontransferrin bound iron levels and heart disease in thalassemia major. Am J Hematol 84:29\u201333. https:\/\/doi.org\/10.1002\/ajh.21317","journal-title":"Am J Hematol"},{"key":"9700_CR99","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1749-6632.2010.05586.x","volume":"1202","author":"A Piga","year":"2010","unstructured":"Piga A, Roggero S, Salussolia I, Massano D, Serra M, Longo F (2010) Deferiprone. Ann N Y Acad Sci 1202:75\u201378. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05586.x","journal-title":"Ann N Y Acad Sci"},{"key":"9700_CR100","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00277-016-2633-y","volume":"95","author":"M Poggi","year":"2016","unstructured":"Poggi M, Sorrentino F, Pugliese P, Smacchia MP, Daniele C, Equitani F, Terlizzi F, Guitarrini MR, Monti S, Maffei L, Losardo A, Pasin M, Toscano V (2016) Longitudinal changes of endocrine and bone disease in adults with beta-thalassemia major receiving different iron chelators over 5 years. Ann Hematol 95:757\u2013763. https:\/\/doi.org\/10.1007\/s00277-016-2633-y","journal-title":"Ann Hematol"},{"key":"9700_CR101","doi-asserted-by":"publisher","first-page":"411","DOI":"10.2450\/2012.0008-12","volume":"10","author":"E Poggiali","year":"2012","unstructured":"Poggiali E, Cassinerio E, Zanaboni L, Cappellini MD (2012) An update on iron chelation therapy. Blood Transfus 10:411\u2013422. https:\/\/doi.org\/10.2450\/2012.0008-12","journal-title":"Blood Transfus"},{"key":"9700_CR102","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1182\/blood-2004-02-0630","volume":"104","author":"P Pootrakul","year":"2004","unstructured":"Pootrakul P, Breuer W, Sametband M, Sirankapracha P, Hershko C, Cabantchik ZI (2004) Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia\/HbE patients treated with an oral chelator. Blood 104:1504\u20131510. https:\/\/doi.org\/10.1182\/blood-2004-02-0630","journal-title":"Blood"},{"key":"9700_CR103","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1124\/jpet.108.137604","volume":"326","author":"O Popelova","year":"2008","unstructured":"Popelova O, Sterba M, Simunek T, Mazurova Y, Guncova I, Hroch M, Adamcova M, Gersl V (2008) Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo. J Pharmacol Exp Ther 326:259\u2013269. https:\/\/doi.org\/10.1124\/jpet.108.137604","journal-title":"J Pharmacol Exp Ther"},{"key":"9700_CR104","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1749-6632.2010.05582.x","volume":"1202","author":"JB Porter","year":"2010","unstructured":"Porter JB (2010) Deferasirox--current knowledge and future challenges. Ann N Y Acad Sci 1202:87\u201393. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05582.x","journal-title":"Ann N Y Acad Sci"},{"issue":"683\u2013701","key":"9700_CR105","doi-asserted-by":"publisher","first-page":"vi","DOI":"10.1016\/j.hoc.2014.04.003","volume":"28","author":"JB Porter","year":"2014","unstructured":"Porter JB, Garbowski M (2014) The pathophysiology of transfusional iron overload. Hematol Oncol Clin North Am 28(683\u2013701):vi\u2013701. https:\/\/doi.org\/10.1016\/j.hoc.2014.04.003","journal-title":"Hematol Oncol Clin North Am"},{"key":"9700_CR106","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1196\/annals.1345.018","volume":"1054","author":"JB Porter","year":"2005","unstructured":"Porter JB, Rafique R, Srichairatanakool S, Davis BA, Shah FT, Hair T, Evans P (2005) Recent insights into interactions of deferoxamine with cellular and plasma iron pools: implications for clinical use. Ann N Y Acad Sci 1054:155\u2013168. https:\/\/doi.org\/10.1196\/annals.1345.018","journal-title":"Ann N Y Acad Sci"},{"key":"9700_CR107","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.2147\/dddt.s49763","volume":"7","author":"V Prachayasittikul","year":"2013","unstructured":"Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V (2013) 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications. Drug Des Devel Ther 7:1157\u20131178. https:\/\/doi.org\/10.2147\/dddt.s49763","journal-title":"Drug Des Devel Ther"},{"key":"9700_CR108","doi-asserted-by":"crossref","first-page":"16046","DOI":"10.1016\/S0021-9258(17)33971-6","volume":"269","author":"EW Randell","year":"1994","unstructured":"Randell EW, Parkes JG, Olivieri NF, Templeton DM (1994) Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron. J Biol Chem 269:16046\u201316053","journal-title":"J Biol Chem"},{"key":"9700_CR109","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jhep.2003.12.021","volume":"40","author":"U Rauen","year":"2004","unstructured":"Rauen U, Petrat F, Sustmann R, de Groot H (2004) Iron-induced mitochondrial permeability transition in cultured hepatocytes. J Hepatol 40:607\u2013615. https:\/\/doi.org\/10.1016\/j.jhep.2003.12.021","journal-title":"J Hepatol"},{"key":"9700_CR110","doi-asserted-by":"publisher","first-page":"10775","DOI":"10.1073\/pnas.0912925107","volume":"107","author":"DR Richardson","year":"2010","unstructured":"Richardson DR, Lane DJ, Becker EM, Huang ML, Whitnall M, Suryo Rahmanto Y, Sheftel AD, Ponka P (2010) Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proc Natl Acad Sci U S A 107:10775\u201310782. https:\/\/doi.org\/10.1073\/pnas.0912925107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9700_CR111","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3324\/haematol.10545","volume":"92","author":"A Rideau","year":"2007","unstructured":"Rideau A, Mangeat B, Matthes T, Trono D, Beris P (2007) Molecular mechanism of hepcidin deficiency in a patient with juvenile hemochromatosis. Haematologica 92:127\u2013128","journal-title":"Haematologica"},{"key":"9700_CR112","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1006\/bcmd.2002.0585","volume":"29","author":"A Roetto","year":"2002","unstructured":"Roetto A, Daraio F, Alberti F, Porporato P, Cali A, De Gobbi M, Camaschella C (2002) Hemochromatosis due to mutations in transferrin receptor 2. Blood Cells Mol Dis 29:465\u2013470","journal-title":"Blood Cells Mol Dis"},{"key":"9700_CR113","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1161\/circep.110.960401","volume":"4","author":"RA Rose","year":"2011","unstructured":"Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH (2011) Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation. Circ Arrhythm Electrophysiol 4:733\u2013742. https:\/\/doi.org\/10.1161\/circep.110.960401","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"9700_CR114","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/21548331.1998.11443654","volume":"33","author":"HR Schumacher Jr","year":"1998","unstructured":"Schumacher HR Jr (1998) Arthropathy in hemochromatosis. Hosp Pract (1995) 33:81\u201386 89\u201390, 93; discussion 93\u201384","journal-title":"Hosp Pract (1995)"},{"key":"9700_CR115","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1001\/jama.2008.600","volume":"300","author":"HD Sesso","year":"2008","unstructured":"Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM (2008) Vitamins E and C in the prevention of cardiovascular disease in men: the physicians' health study II randomized controlled trial. JAMA 300:2123\u20132133. https:\/\/doi.org\/10.1001\/jama.2008.600","journal-title":"JAMA"},{"key":"9700_CR116","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00210-013-0863-2","volume":"386","author":"HL Shan","year":"2013","unstructured":"Shan HL, Wang Y, Wu JW, Hang PZ, Li X, Sun LH, Qi JC, Mao YY, Sun ZD, Du ZM (2013) Verapamil reverses cardiac iron overload in streptozocin-induced diabetic rats. Naunyn Schmiedeberg's Arch Pharmacol 386:645\u2013650. https:\/\/doi.org\/10.1007\/s00210-013-0863-2","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"9700_CR117","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nature04512","volume":"440","author":"GC Shaw","year":"2006","unstructured":"Shaw GC, Cope JJ, Li L, Corson K, Hersey C, Ackermann GE, Gwynn B, Lambert AJ, Wingert RA, Traver D, Trede NS, Barut BA, Zhou Y, Minet E, Donovan A, Brownlie A, Balzan R, Weiss MJ, Peters LL, Kaplan J, Zon LI, Paw BH (2006) Mitoferrin is essential for erythroid iron assimilation. Nature 440:96\u2013100. https:\/\/doi.org\/10.1038\/nature04512","journal-title":"Nature"},{"key":"9700_CR118","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164300","volume":"11","author":"S Silvilairat","year":"2016","unstructured":"Silvilairat S, Charoenkwan P, Saekho S, Tantiworawit A, Phrommintikul A, Srichairatanakool S, Chattipakorn N (2016) Heart rate variability for early detection of cardiac Iron deposition in patients with transfusion-dependent thalassemia. PLoS One 11:e0164300. https:\/\/doi.org\/10.1371\/journal.pone.0164300","journal-title":"PLoS One"},{"key":"9700_CR119","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S1734-1140(09)70018-0","volume":"61","author":"T Simunek","year":"2009","unstructured":"Simunek T, Sterba M, Popelova O, Adamcova M, Hrdina R, Gersl V (2009) Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacol Rep 61:154\u2013171","journal-title":"Pharmacol Rep"},{"key":"9700_CR120","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.lfs.2013.01.004","volume":"92","author":"J Sripetchwandee","year":"2013","unstructured":"Sripetchwandee J, Sanit J, Chattipakorn N, Chattipakorn SC (2013) Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload. Life Sci 92:298\u2013304. https:\/\/doi.org\/10.1016\/j.lfs.2013.01.004","journal-title":"Life Sci"},{"key":"9700_CR121","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/apha.12162","volume":"210","author":"J Sripetchwandee","year":"2014","unstructured":"Sripetchwandee J, KenKnight SB, Sanit J, Chattipakorn S, Chattipakorn N (2014) Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload. Acta Physiol (Oxford, England) 210:330\u2013341. https:\/\/doi.org\/10.1111\/apha.12162","journal-title":"Acta Physiol (Oxford, England)"},{"key":"9700_CR122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085115","volume":"9","author":"J Sripetchwandee","year":"2014","unstructured":"Sripetchwandee J, Pipatpiboon N, Chattipakorn N, Chattipakorn S (2014) Combined therapy of iron chelator and antioxidant completely restores brain dysfunction induced by iron toxicity. PLoS One 9:e85115. https:\/\/doi.org\/10.1371\/journal.pone.0085115","journal-title":"PLoS One"},{"key":"9700_CR123","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuroscience.2016.07.003","volume":"332","author":"J Sripetchwandee","year":"2016","unstructured":"Sripetchwandee J, Wongjaikam S, Krintratun W, Chattipakorn N, Chattipakorn SC (2016) A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-beta accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload. Neuroscience 332:191\u2013202. https:\/\/doi.org\/10.1016\/j.neuroscience.2016.07.003","journal-title":"Neuroscience"},{"key":"9700_CR124","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1536\/ihj.50.829","volume":"50","author":"K Sugishita","year":"2009","unstructured":"Sugishita K, Asakawa M, Usui S, Takahashi T (2009) A case of iron overload cardiomyopathy: beneficial effects of iron chelating agent and calcium channel blocker on left ventricular dysfunction. Int Heart J 50:829\u2013838","journal-title":"Int Heart J"},{"key":"9700_CR125","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s12185-016-1991-5","volume":"103","author":"A Tantiworawit","year":"2016","unstructured":"Tantiworawit A, Charoenkwan P, Hantrakool S, Choeyprasert W, Sivasomboon C, Sanguansermsri T (2016) Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors. Int J Hematol 103:643\u2013648. https:\/\/doi.org\/10.1007\/s12185-016-1991-5","journal-title":"Int J Hematol"},{"key":"9700_CR126","doi-asserted-by":"publisher","first-page":"62","DOI":"10.2174\/157340611794072724","volume":"7","author":"C Thephinlap","year":"2011","unstructured":"Thephinlap C, Phisalaphong C, Lailerd N, Chattipakorn N, Winichagoon P, Vadolas J, Fucharoen S, Porter JB, Srichairatanakool S (2011) Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids. Med Chem (Shariqah (United Arab Emirates)) 7:62\u201369","journal-title":"Med Chem (Shariqah (United Arab Emirates))"},{"key":"9700_CR127","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/19986","volume":"399","author":"H Tsukaguchi","year":"1999","unstructured":"Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (1999) A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature 399:70\u201375. https:\/\/doi.org\/10.1038\/19986","journal-title":"Nature"},{"key":"9700_CR128","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1161\/01.RES.84.11.1302","volume":"84","author":"RG Tsushima","year":"1999","unstructured":"Tsushima RG, Wickenden AD, Bouchard RA, Oudit GY, Liu PP, Backx PH (1999) Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload. Circ Res 84:1302\u20131309","journal-title":"Circ Res"},{"key":"9700_CR129","doi-asserted-by":"publisher","first-page":"Cd005008","DOI":"10.1002\/14651858.CD005008.pub4","volume":"3","author":"EC van Dalen","year":"2016","unstructured":"van Dalen EC, van der Pal HJ, Kremer LC (2016) Different dosage schedules for reducing cardiotoxicity in people with cancer receiving anthracycline chemotherapy. Cochrane Database Syst Rev 3:Cd005008. https:\/\/doi.org\/10.1002\/14651858.CD005008.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"9700_CR130","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ceca.2006.04.025","volume":"40","author":"G Vassort","year":"2006","unstructured":"Vassort G, Talavera K, Alvarez JL (2006) Role of T-type Ca2+ channels in the heart. Cell Calcium 40:205\u2013220. https:\/\/doi.org\/10.1016\/j.ceca.2006.04.025","journal-title":"Cell Calcium"},{"key":"9700_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12311-010-0212-7","volume":"10","author":"D Velasco-Sanchez","year":"2011","unstructured":"Velasco-Sanchez D, Aracil A, Montero R, Mas A, Jimenez L, O'Callaghan M, Tondo M, Capdevila A, Blanch J, Artuch R, Pineda M (2011) Combined therapy with idebenone and deferiprone in patients with Friedreich's ataxia. Cerebellum 10:1\u20138. https:\/\/doi.org\/10.1007\/s12311-010-0212-7","journal-title":"Cerebellum"},{"key":"9700_CR132","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1002\/hep.26401","volume":"58","author":"CY Wang","year":"2013","unstructured":"Wang CY, Knutson MD (2013) Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice. Hepatology (Baltimore, Md) 58:788\u2013798. https:\/\/doi.org\/10.1002\/hep.26401","journal-title":"Hepatology (Baltimore, Md)"},{"key":"9700_CR133","first-page":"385","volume":"7","author":"M Wang","year":"2015","unstructured":"Wang M, Liu RR, Wang CJ, Kang W, Yang GH, Zhong WN, Lai YR (2015) Combined histological and hematological assessment of iron-induced organ damage in a gerbil model of iron overload. Am J Transl Res 7:385\u2013392","journal-title":"Am J Transl Res"},{"key":"9700_CR134","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1055\/s-2007-985069","volume":"27","author":"PF Whitington","year":"2007","unstructured":"Whitington PF (2007) Neonatal hemochromatosis: a congenital alloimmune hepatitis. Semin Liver Dis 27:243\u2013250. https:\/\/doi.org\/10.1055\/s-2007-985069","journal-title":"Semin Liver Dis"},{"key":"9700_CR135","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130837","volume":"10","author":"K Wijarnpreecha","year":"2015","unstructured":"Wijarnpreecha K, Siri-Angkul N, Shinlapawittayatorn K, Charoenkwan P, Silvilairat S, Siwasomboon C, Visarutratna P, Srichairatanakool S, Tantiworawit A, Phrommintikul A, Chattipakorn SC, Chattipakorn N (2015) Heart rate variability as an alternative Indicator for identifying cardiac iron status in non-transfusion dependent thalassemia patients. PLoS One 10:e0130837. https:\/\/doi.org\/10.1371\/journal.pone.0130837","journal-title":"PLoS One"},{"key":"9700_CR136","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ejphar.2015.08.017","volume":"765","author":"S Wongjaikam","year":"2015","unstructured":"Wongjaikam S, Kumfu S, Chattipakorn SC, Fucharoen S, Chattipakorn N (2015) Current and future treatment strategies for iron overload cardiomyopathy. Eur J Pharmacol 765:86\u201393. https:\/\/doi.org\/10.1016\/j.ejphar.2015.08.017","journal-title":"Eur J Pharmacol"},{"key":"9700_CR137","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159414","volume":"11","author":"S Wongjaikam","year":"2016","unstructured":"Wongjaikam S, Kumfu S, Khamseekaew J, Sripetchwandee J, Srichairatanakool S, Fucharoen S, Chattipakorn SC, Chattipakorn N (2016) Combined iron chelator and antioxidant exerted greater efficacy on cardioprotection than Monotherapy in Iron-overloaded rats. PLoS One 11:e0159414. https:\/\/doi.org\/10.1371\/journal.pone.0159414","journal-title":"PLoS One"},{"key":"9700_CR138","doi-asserted-by":"publisher","DOI":"10.1038\/srep44460","volume":"7","author":"S Wongjaikam","year":"2017","unstructured":"Wongjaikam S, Kumfu S, Khamseekaew J, Chattipakorn SC, Chattipakorn N (2017) Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine. Sci Rep 7:44460. https:\/\/doi.org\/10.1038\/srep44460","journal-title":"Sci Rep"},{"key":"9700_CR139","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1196\/annals.1345.047","volume":"1054","author":"JC Wood","year":"2005","unstructured":"Wood JC, Enriquez C, Ghugre N, Otto-Duessel M, Aguilar M, Nelson MD, Moats R, Coates TD (2005) Physiology and pathophysiology of iron cardiomyopathy in thalassemia. Ann N Y Acad Sci 1054:386\u2013395. https:\/\/doi.org\/10.1196\/annals.1345.047","journal-title":"Ann N Y Acad Sci"},{"key":"9700_CR140","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1161\/circulationaha.104.504415","volume":"112","author":"JC Wood","year":"2005","unstructured":"Wood JC, Otto-Duessel M, Aguilar M, Nick H, Nelson MD, Coates TD, Pollack H, Moats R (2005) Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation 112:535\u2013543. https:\/\/doi.org\/10.1161\/circulationaha.104.504415","journal-title":"Circulation"},{"key":"9700_CR141","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1353\/hpu.2014.0008","volume":"24","author":"LH Xie","year":"2013","unstructured":"Xie LH, Doye AA, Conley E, Gwathmey JK (2013) Sickle cell anemia: the impact of discovery, politics, and business. J Health Care Poor Underserved 24:147\u2013158. https:\/\/doi.org\/10.1353\/hpu.2014.0008","journal-title":"J Health Care Poor Underserved"},{"key":"9700_CR142","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1124\/mol.105.013383","volume":"68","author":"X Xu","year":"2005","unstructured":"Xu X, Persson HL, Richardson DR (2005) Molecular pharmacology of the interaction of anthracyclines with iron. Mol Pharmacol 68:261\u2013271. https:\/\/doi.org\/10.1124\/mol.105.013383","journal-title":"Mol Pharmacol"},{"key":"9700_CR143","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.celrep.2015.09.023","volume":"13","author":"W Xu","year":"2015","unstructured":"Xu W, Barrientos T, Mao L, Rockman HA, Sauve AA, Andrews NC (2015) Lethal cardiomyopathy in mice lacking transferrin receptor in the heart. Cell Rep 13:533\u2013545. https:\/\/doi.org\/10.1016\/j.celrep.2015.09.023","journal-title":"Cell Rep"},{"key":"9700_CR144","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1067\/mlc.2002.127725","volume":"140","author":"T Yang","year":"2002","unstructured":"Yang T, Dong WQ, Kuryshev YA, Obejero-Paz C, Levy MN, Brittenham GM, Kiatchoosakun S, Kirkpatrick D, Hoit BD, Brown AM (2002) Bimodal cardiac dysfunction in an animal model of iron overload. J Lab Clin Med 140:263\u2013271","journal-title":"J Lab Clin Med"},{"key":"9700_CR145","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/s0022-2143(03)00135-5","volume":"142","author":"T Yang","year":"2003","unstructured":"Yang T, Brittenham GM, Dong WQ, Levy MN, Obejero-Paz CA, Kuryshev YA, Brown AM (2003) Deferoxamine prevents cardiac hypertrophy and failure in the gerbil model of iron-induced cardiomyopathy. J Lab Clin Med 142:332\u2013340. https:\/\/doi.org\/10.1016\/s0022-2143(03)00135-5","journal-title":"J Lab Clin Med"},{"key":"9700_CR146","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124061","volume":"10","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Wang H, Cui L, Zhang Y, Liu Y, Chu X, Liu Z, Zhang J, Chu L (2015) Continuing treatment with Salvia miltiorrhiza injection attenuates myocardial fibrosis in chronic iron-overloaded mice. PLoS One 10:e0124061. https:\/\/doi.org\/10.1371\/journal.pone.0124061","journal-title":"PLoS One"}],"container-title":["Heart Failure Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10741-018-9700-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10741-018-9700-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10741-018-9700-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T10:06:10Z","timestamp":1660989970000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10741-018-9700-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,19]]},"references-count":146,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["9700"],"URL":"https:\/\/doi.org\/10.1007\/s10741-018-9700-5","relation":{},"ISSN":["1382-4147","1573-7322"],"issn-type":[{"value":"1382-4147","type":"print"},{"value":"1573-7322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,19]]},"assertion":[{"value":"19 April 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}