{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:16:05Z","timestamp":1789910165885,"version":"4.0.1"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Fail Rev"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s10741-019-09824-y","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T12:02:59Z","timestamp":1562068979000},"page":"245-255","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Gender-related differences in heart failure: beyond the \u201cone-size-fits-all\u201d paradigm"],"prefix":"10.1007","volume":"25","author":[{"given":"Annamaria","family":"De Bellis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"De Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Fabris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cannat\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"9824_CR1","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"P Ponikowski","year":"2016","unstructured":"Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, Gonz\u00e1lez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, ESC Scientific Document Group (2016) 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 37:2129\u20132200m","journal-title":"Eur Heart J"},{"key":"9824_CR2","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/cvr\/cvx066","volume":"113","author":"R Ventura-Clapier","year":"2017","unstructured":"Ventura-Clapier R, Dworatzek E, Seeland U, Kararigas G, Arnal JF, Brunelleschi S, Carpenter TC, Erdmann J, Franconi F, Giannetta E, Glezerman M, Hofmann SM, Junien C, Katai M, Kublickiene K, K\u00f6nig IR, Majdic G, Malorni W, Mieth C, Miller VM, Reynolds RM, Shimokawa H, Tannenbaum C, D\u2019Ursi AM, Regitz-Zagrosek V (2017) Sex in basic research: concepts in the cardiovascular field. Cardiovasc Res 113:711\u2013724","journal-title":"Cardiovasc Res"},{"key":"9824_CR3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/366362a0","volume":"366","author":"E Li","year":"1993","unstructured":"Li E, Beard C, Jaenisch R (1993) Role for DNA methylation in genomic imprinting. Nature. 366:362\u2013365. \nhttps:\/\/doi.org\/10.1038\/366362a0","journal-title":"Nature."},{"key":"9824_CR4","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1096\/fj.13-233320","volume":"28","author":"CG Penaloza","year":"2014","unstructured":"Penaloza CG, Estevez B, Han DM, Norouzi M, Lockshin RA, Zakeri Z (2014) Sex-dependent regulation of cytochrome P450 family members Cyp1a1, Cyp2e1, and Cyp7b1 by methylation of DNA. FASEB J 28:966\u2013977. \nhttps:\/\/doi.org\/10.1096\/fj.13-233320","journal-title":"FASEB J"},{"key":"9824_CR5","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.jacc.2011.09.054","volume":"59","author":"G Kararigas","year":"2012","unstructured":"Kararigas G, Bito V, Tinel H, Becher E, Baczko I, Knosalla C, Albrecht-K\u00fcpper B, Sipido KR, Regitz-Zagrosek V (2012) Transcriptome characterization of estrogen-treated human myocardium identifies myosin regulatory light chain interacting protein as a sex-specific element influencing contractile function. J Am Coll Cardiol 59:410\u2013417. \nhttps:\/\/doi.org\/10.1016\/j.jacc.2011.09.054","journal-title":"J Am Coll Cardiol"},{"key":"9824_CR6","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1073\/pnas.0436564100","volume":"100","author":"KR Boheler","year":"2003","unstructured":"Boheler KR (2003) Sex- and age-dependent human transcriptome variability: implications for chronic heart failure. Proc Natl Acad Sci 100:2754\u20132759. \nhttps:\/\/doi.org\/10.1073\/pnas.0436564100","journal-title":"Proc Natl Acad Sci"},{"key":"9824_CR7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1161\/CIRCGENETICS.108.802652","volume":"1","author":"DR Fermin","year":"2008","unstructured":"Fermin DR, Barac A, Lee S, Polster SP, Hannenhalli S, Bergemann TL, Grindle S, Dyke DB, Pagani F, Miller LW, Tan S, dos Remedios C, Cappola TP, Margulies KB, Hall JL (2008) Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure. Circ Cardiovasc Genet 1:117\u2013125. \nhttps:\/\/doi.org\/10.1161\/CIRCGENETICS.108.802652","journal-title":"Circ Cardiovasc Genet"},{"key":"9824_CR8","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1093\/eurheartj\/ehp549","volume":"31","author":"B Heidecker","year":"2010","unstructured":"Heidecker B, Lamirault G, Kasper EK, Wittstein IS, Champion HC, Breton E, Russell SD, Hall J, Kittleson MM, Baughman KL, Hare JM (2010) The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. Eur Heart J 31:1188\u20131196. \nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehp549","journal-title":"Eur Heart J"},{"key":"9824_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1365-2443.2008.01252.x","volume":"14","author":"R Kaneda","year":"2009","unstructured":"Kaneda R, Takada S, Yamashita Y, Choi YL, Nonaka-Sarukawa M, Soda M, Misawa Y, Isomura T, Shimada K, Mano H (2009) Genome-wide histone methylation profile for heart failure. Genes Cells 14:69\u201377. \nhttps:\/\/doi.org\/10.1111\/j.1365-2443.2008.01252.x","journal-title":"Genes Cells"},{"key":"9824_CR10","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0092-8674(02)00861-9","volume":"110","author":"CL Zhang","year":"2002","unstructured":"Zhang CL, McKinsey TA, Chang S et al (2002) Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell. 110:479\u2013488. \nhttps:\/\/doi.org\/10.1016\/S0092-8674(02)00861-9","journal-title":"Cell."},{"key":"9824_CR11","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/sj.emboj.7601513","volume":"26","author":"K Delaval","year":"2007","unstructured":"Delaval K, Govin J, Cerqueira F, Rousseaux S, Khochbin S, Feil R (2007) Differential histone modifications mark mouse imprinting control regions during spermatogenesis. EMBO J 26:720\u2013729. \nhttps:\/\/doi.org\/10.1038\/sj.emboj.7601513","journal-title":"EMBO J"},{"key":"9824_CR12","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1161\/CIRCGENETICS.111.960831","volume":"5","author":"SP Page","year":"2012","unstructured":"Page SP, Kounas S, Syrris P, Christiansen M, Frank-Hansen R, Andersen PS, Elliott PM, McKenna WJ (2012) Cardiac myosin binding protein-C mutations in families with hypertrophic cardiomyopathy: disease expression in relation to age, gender, and long term outcome. Circ Cardiovasc Genet 5:156\u2013166. \nhttps:\/\/doi.org\/10.1161\/CIRCGENETICS.111.960831","journal-title":"Circ Cardiovasc Genet"},{"key":"9824_CR13","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1161\/CIRCULATIONAHA.105.568642","volume":"113","author":"D Dalal","year":"2006","unstructured":"Dalal D, Molin LH, Piccini J, Tichnell C, James C, Bomma C, Prakasa K, Towbin JA, Marcus FI, Spevak PJ, Bluemke DA, Abraham T, Russell SD, Calkins H, Judge DP (2006) Clinical features of arrhythmogenic right ventricular dysplasia\/ cardiomyopathy associated with mutations in plakophilin-2. Circulation 113:1641\u20131649. \nhttps:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.568642","journal-title":"Circulation"},{"key":"9824_CR14","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/eurjhf\/hfs191","volume":"15","author":"IAW van Rijsingen","year":"2013","unstructured":"van Rijsingen IAW, Nannenberg EA, Arbustini E, Elliott PM, Mogensen J, Hermans-van Ast JF, van der Kooi AJ, van Tintelen JP, van den Berg MP, Grasso M, Serio A, Jenkins S, Rowland C, Richard P, Wilde AAM, Perrot A, Pankuweit S, Zwinderman AH, Charron P, Christiaans I, Pinto YM (2013) Gender-specific differences in major cardiac events and mortality in lamin A\/C mutation carriers. Eur J Heart Fail 15:376\u2013384. \nhttps:\/\/doi.org\/10.1093\/eurjhf\/hfs191","journal-title":"Eur J Heart Fail"},{"key":"9824_CR15","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.ijcard.2013.09.002","volume":"169","author":"AM Queir\u00f3s","year":"2013","unstructured":"Queir\u00f3s AM, Eschen C, Fliegner D, Kararigas G, Dworatzek E, Westphal C, Sanchez Ruderisch H, Regitz-Zagrosek V (2013) Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart. Int J Cardiol 169:331\u2013338. \nhttps:\/\/doi.org\/10.1016\/j.ijcard.2013.09.002","journal-title":"Int J Cardiol"},{"key":"9824_CR16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1002\/ejhf.15","volume":"16","author":"S Meyer","year":"2014","unstructured":"Meyer S, Van Der Meer P, Van Tintelen JP, Van Den Berg MP (2014) Sex differences in cardiomyopathies. Eur J Heart Fail 16:238\u2013247","journal-title":"Eur J Heart Fail"},{"key":"9824_CR17","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1128\/MCB.01156-14","volume":"35","author":"T Wang","year":"2015","unstructured":"Wang T, McDonald C, Petrenko NB, Leblanc M, Wang T, Giguere V, Evans RM, Patel VV, Pei L (2015) Estrogen-related receptor \u03b1 (ERR\u03b1) and ERR\u03b3 are essential coordinators of cardiac metabolism and function. Mol Cell Biol 35:1281\u20131298. \nhttps:\/\/doi.org\/10.1128\/MCB.01156-14","journal-title":"Mol Cell Biol"},{"key":"9824_CR18","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1093\/aje\/kwr381","volume":"174","author":"WH James","year":"2011","unstructured":"James WH (2011) Re: sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third national health and nutrition examination survey and the multi-ethnic study of atherosclerosis. Am J Epidemiol 174:1423","journal-title":"Am J Epidemiol"},{"key":"9824_CR19","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","volume":"148","author":"J Nunnari","year":"2012","unstructured":"Nunnari J, Suomalainen A (2012) Mitochondria: in sickness and in health. Cell 148:1145\u20131159","journal-title":"Cell"},{"key":"9824_CR20","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1161\/CIRCRESAHA.109.213645","volume":"106","author":"CJ Lagranha","year":"2010","unstructured":"Lagranha CJ, Deschamps A, Aponte A, Steenbergen C, Murphy E (2010) Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females. Circ Res 106:1681\u20131691. \nhttps:\/\/doi.org\/10.1161\/CIRCRESAHA.109.213645","journal-title":"Circ Res"},{"key":"9824_CR21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jacc.2018.09.081","volume":"73","author":"P Dewan","year":"2019","unstructured":"Dewan P, R\u00f8rth R, Jhund PS, Shen L, Raparelli V, Petrie MC, Abraham WT, Desai AS, Dickstein K, K\u00f8ber L, Mogensen UM, Packer M, Rouleau JL, Solomon SD, Swedberg K, Zile MR, McMurray JJV (2019) Differential impact of heart failure with reduced ejection fraction on men and women. J Am Coll Cardiol 73:29\u201340. \nhttps:\/\/doi.org\/10.1016\/j.jacc.2018.09.081","journal-title":"J Am Coll Cardiol"},{"key":"9824_CR22","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/ejhf.1103","volume":"20","author":"M Merlo","year":"2018","unstructured":"Merlo M, Cannat\u00e0 A, Gobbo M, Stolfo D, Elliott PM, Sinagra G (2018) Evolving concepts in dilated cardiomyopathy. Eur J Heart Fail 20:228\u2013239","journal-title":"Eur J Heart Fail"},{"key":"9824_CR23","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ppedcard.2014.10.003","volume":"37","author":"L Mestroni","year":"2014","unstructured":"Mestroni L, Brun F, Spezzacatene A, Sinagra G, Taylor MRG (2014) Genetic causes of dilated cardiomyopathy. Prog Pediatr Cardiol 37:13\u201318","journal-title":"Prog Pediatr Cardiol"},{"key":"9824_CR24","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/ejhf.1216","volume":"20","author":"BP Halliday","year":"2018","unstructured":"Halliday BP, Gulati A, Ali A, Newsome S, Lota A, Tayal U, Vassiliou VS, Arzanauskaite M, Izgi C, Krishnathasan K, Singhal A, Chiew K, Gregson J, Frenneaux MP, Cook SA, Pennell DJ, Collins P, Cleland JGF, Prasad SK (2018) Sex- and age-based differences in the natural history and outcome of dilated cardiomyopathy. Eur J Heart Fail 20:1392\u20131400. \nhttps:\/\/doi.org\/10.1002\/ejhf.1216","journal-title":"Eur J Heart Fail"},{"key":"9824_CR25","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1093\/eurheartj\/ehx819","volume":"39","author":"P Charron","year":"2018","unstructured":"Charron P, Elliott PM, Gimeno JR, Caforio ALP, Kaski JP, Tavazzi L, Tendera M, Maupain C, Laroche C, Rubis P, Jurcut R, Cal\u00f2 L, Heli\u00f6 TM, Sinagra G, Zdravkovic M, Kavoli\u016bnien\u0117 A, Felix SB, Grzybowski J, Losi MA, Asselbergs FW, Garc\u00eda-Pinilla JM, Salazar-Mendiguchia J, Mizia-Stec K, Maggioni AP, EORP Cardiomyopathy Registry Investigators, Anastasakis A, Biagini E, Bilinska Z, Castro FJ, Celutkiene J, Chakova N, Chmielewski P, Drago F, Frigy A, Frustaci A, Garcia-Pavia P, Hinic S, Kindermann I, Limongelli G, Medrano C, Monserrat L, Olusegun-Joseph A, Ripoll-Vera T, Rocha Lopes L, Saad A, Sala S, Seferovic PM, Sepp R, Urbano-Moral JA, Villacorta E, Wybraniec M, Yotti R, Zachara E, Zorio E (2018) The Cardiomyopathy Registry of the EURObservational Research Programme of the European Society of Cardiology: baseline data and contemporary management of adult patients with cardiomyopathies. Eur Heart J 39:1784\u20131793. \nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehx819","journal-title":"Eur Heart J"},{"key":"9824_CR26","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1007\/s00059-012-3707-9","volume":"37","author":"A Serio","year":"2012","unstructured":"Serio A, Narula N, Kodama T, Favalli V, Arbustini E (2012) Familial dilated cardiomyopathy: clinical and genetic characteristics. Herz. 37:822\u2013829. \nhttps:\/\/doi.org\/10.1007\/s00059-012-3707-9","journal-title":"Herz."},{"key":"9824_CR27","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","volume":"37","author":"JL Zamorano","year":"2016","unstructured":"Zamorano JL, Lancellotti P, Rodriguez Mu\u00f1oz D, Aboyans V, Asteggiano R, Galderisi M, Habib G, Lenihan DJ, Lip GYH, Lyon AR, Lopez Fernandez T, Mohty D, Piepoli MF, Tamargo J, Torbicki A, Suter TM (2016) 2016 ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for practice guidelines. Eur Heart J 37:2768\u20132801. \nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehw211","journal-title":"Eur Heart J"},{"key":"9824_CR28","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1056\/NEJMoa1110186","volume":"366","author":"DS Herman","year":"2012","unstructured":"Herman DS, Lam L, Taylor MRG, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJR, Cook SA, Mestroni L, Seidman JG, Seidman CE (2012) Truncations of titin causing dilated cardiomyopathy. N Engl J Med 366:619\u2013628. \nhttps:\/\/doi.org\/10.1056\/NEJMoa1110186","journal-title":"N Engl J Med"},{"key":"9824_CR29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1056\/NEJMoa1505517","volume":"374","author":"JS Ware","year":"2016","unstructured":"Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J III, McNamara DM, Seidman CE, Seidman JG, Arany Z (2016) Shared genetic predisposition in peripartum and dilated cardiomyopathies. N Engl J Med 374:233\u2013241. \nhttps:\/\/doi.org\/10.1056\/NEJMoa1505517","journal-title":"N Engl J Med"},{"key":"9824_CR30","doi-asserted-by":"publisher","first-page":"R778","DOI":"10.1152\/ajpregu.00203.2006","volume":"292","author":"TC Vary","year":"2007","unstructured":"Vary TC, Kimball SR, Sumner A (2007) Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption. Am J Physiol Integr Comp Physiol 292:R778\u2013R787. \nhttps:\/\/doi.org\/10.1152\/ajpregu.00203.2006","journal-title":"Am J Physiol Integr Comp Physiol"},{"key":"9824_CR31","doi-asserted-by":"publisher","unstructured":"Laura VS, Cristina L, Elena C et al (2017) Conflicting gender-related differences in the natural history of patients with idiopathic dilated cardiomyopathy. Epidemiol Biostat Public Health. \nhttps:\/\/doi.org\/10.2427\/12527","DOI":"10.2427\/12527"},{"key":"9824_CR32","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1253\/circj","volume":"78","author":"SW Sharkey","year":"2014","unstructured":"Sharkey SW, Maron BJ (2014) Epidemiology and clinical profile of Takotsubo cardiomyopathy. Circ J 78:2119\u20132128. \nhttps:\/\/doi.org\/10.1253\/circj\n\n. CJ-14-0770","journal-title":"Circ J"},{"key":"9824_CR33","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/eurheartj\/ehv598","volume":"37","author":"V Regitz-Zagrosek","year":"2016","unstructured":"Regitz-Zagrosek V, Oertelt-Prigione S, Prescott E et al (2016) Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. Eur Heart J 37:24\u201334. \nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehv598","journal-title":"Eur Heart J"},{"key":"9824_CR34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"B Ibanez","year":"2018","unstructured":"Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimsk\u00fd P, ESC Scientific Document Group, Collet JP, Kristensen SD, Aboyans V, Baumbach A, Bugiardini R, Coman IM, Delgado V, Fitzsimons D, Gaemperli O, Gershlick AH, Gielen S, Harjola VP, Katus HA, Knuuti J, Kolh P, Leclercq C, Lip GYH, Morais J, Neskovic AN, Neumann FJ, Niessner A, Piepoli MF, Richter DJ, Shlyakhto E, Simpson IA, Steg PG, Terkelsen CJ, Thygesen K, Windecker S, Zamorano JL, Zeymer U, Windecker S, Aboyans V, Agewall S, Barbato E, Bueno H, Coca A, Collet JP, Coman IM, Dean V, Delgado V, Fitzsimons D, Gaemperli O, Hindricks G, Iung B, J\u00fcni P, Katus HA, Knuuti J, Lancellotti P, Leclercq C, McDonagh T, Piepoli MF, Ponikowski P, Richter DJ, Roffi M, Shlyakhto E, Simpson IA, Zamorano JL, Chettibi M, Hayrapetyan HG, Metzler B, Ibrahimov F, Sujayeva V, Beauloye C, Dizdarevic-Hudic L, Karamfiloff K, Skoric B, Antoniades L, Tousek P, Terkelsen PCJ, Shaheen SM, Marandi T, Niemel\u00e4 M, Kedev S, Gilard M, Aladashvili A, Elsaesser A, Kanakakis IG, Merkely B, Gudnason T, Iakobishvili Z, Bolognese L, Berkinbayev S, Bajraktari G, Beishenkulov M, Zake I, Lamin HB, Gustiene O, Pereira B, Xuereb RG, Ztot S, Julieb\u00f8 V, Legutko J, Tim\u00f3teo AT, Tatu-Chi\u0163oiu G, Yakovlev A, Bertelli L, Nedeljkovic M, Studen\u010dan M, Bunc M, Garc\u00eda de Castro AM, Petursson P, Jeger R, Mourali MS, Yildirir A, Parkhomenko A, Gale CP (2018) 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 39:119\u2013177","journal-title":"Eur Heart J"},{"issue":"17","key":"9824_CR35","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1016\/j.jacc.2015.08.876","volume":"66","author":"CJ Pepine","year":"2015","unstructured":"Pepine CJ, Ferdinand KC, Shaw LJ et al (2015) Emergence of nonobstructive coronary artery disease: a woman\u2019s problem and need for change in definition on angiography. J Am Coll Cardiol 66(17):1918\u20131933","journal-title":"J Am Coll Cardiol"},{"key":"9824_CR36","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1177\/1932202X18760280","volume":"29","author":"L Jespersen","year":"2014","unstructured":"Jespersen L, Abildstrom SZ, Hvelplund A et al (2014) Burden of hospital admission and repeat angiography in angina pectoris patients with and without coronary artery disease: a registry-based cohort study. PLoS One 29:171\u2013194. \nhttps:\/\/doi.org\/10.1177\/1932202X18760280","journal-title":"PLoS One"},{"key":"9824_CR37","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jjcc.2013.03.001","volume":"62","author":"NA Papakonstantinou","year":"2013","unstructured":"Papakonstantinou NA, Stamou MI, Baikoussis NG, Goudevenos J, Apostolakis E (2013) Sex differentiation with regard to coronary artery disease. J Cardiol 62:4\u201311","journal-title":"J Cardiol"},{"issue":"3","key":"9824_CR38","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1001\/archinte.164.3.289","volume":"164","author":"S Wassertheil-Smoller","year":"2004","unstructured":"Wassertheil-Smoller S, Shumaker S, Ockene J et al (2004) Depression and cardiovascular sequelae in postmenopausal women: the women\u2019s health initiative (WHI). Arch Intern Med 164(3):289\u2013298","journal-title":"Arch Intern Med"},{"key":"9824_CR39","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.ahj.2012.01.022","volume":"163","author":"L Pilote","year":"2012","unstructured":"Pilote L, Karp I (2012) GENESIS-PRAXY (GENdEr and sex determInantS of cardiovascular disease: from bench to beyond-premature acute coronary SYndrome). Am Heart J 163:741\u2013746.e2","journal-title":"Am Heart J"},{"key":"9824_CR40","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1089\/jwh.2012.4031","volume":"22","author":"J-A Eastwood","year":"2013","unstructured":"Eastwood J-A, Johnson BD, Rutledge T, Bittner V, Whittaker KS, Krantz DS, Cornell CE, Eteiba W, Handberg E, Vido D, Bairey Merz CN (2013) Anginal symptoms, coronary artery disease, and adverse outcomes in black and white women: the NHLBI-sponsored Women\u2019s ischemia syndrome evaluation (WISE) study. J Women's Health 22:724\u2013732. \nhttps:\/\/doi.org\/10.1089\/jwh.2012.4031","journal-title":"J Women's Health"},{"key":"9824_CR41","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.hlc.2013.03.078","volume":"22","author":"RP Dreyer","year":"2013","unstructured":"Dreyer RP, Beltrame JF, Tavella R, Air T, Hoffmann B, Pati PK, di Fiore D, Arstall M, Zeitz C (2013) Evaluation of gender differences in door-to-balloon time in st-elevation myocardial infarction. Hear Lung Circ 22:861\u2013869. \nhttps:\/\/doi.org\/10.1016\/j.hlc.2013.03.078","journal-title":"Hear Lung Circ"},{"key":"9824_CR42","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1002\/ejhf.1280","volume":"20","author":"G Sinagra","year":"2018","unstructured":"Sinagra G, Merlo M, Cannat\u00e0 A (2018) Gender medicine in dilated cardiomyopathy: pride and prejudice. Eur J Heart Fail 20:1401\u20131403","journal-title":"Eur J Heart Fail"},{"key":"9824_CR43","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1161\/CIRCOUTCOMES.109.884361","volume":"3","author":"HL Nguyen","year":"2010","unstructured":"Nguyen HL, Saczynski JS, Gore JM, Goldberg RJ (2010) Age and sex differences in duration of prehospital delay in patients with acute myocardial infarction a systematic review. Circ Cardiovasc Qual Outcomes 3:82\u201392. \nhttps:\/\/doi.org\/10.1161\/CIRCOUTCOMES.109.884361","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"9824_CR44","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1161\/CIR.0000000000000061","volume":"130","author":"JH Mieres","year":"2005","unstructured":"Mieres JH, Shaw LJ, Arai A et al (2005) Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Coun. Circulation 130:350\u2013379","journal-title":"Circulation"},{"key":"9824_CR45","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1056\/NEJMoa032292","volume":"349","author":"MA Pfeffer","year":"2003","unstructured":"Pfeffer MA, McMurray JJV, Velazquez EJ, Rouleau JL, K\u00f8ber L, Maggioni AP, Solomon SD, Swedberg K, van de Werf F, White H, Leimberger JD, Henis M, Edwards S, Zelenkofske S, Sellers MA, Califf RM, Valsartan in Acute Myocardial Infarction Trial Investigators (2003) Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 349:1893\u20131906. \nhttps:\/\/doi.org\/10.1056\/NEJMoa032292","journal-title":"N Engl J Med"},{"key":"9824_CR46","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/cvr\/cvq394","volume":"90","author":"V Vaccarino","year":"2011","unstructured":"Vaccarino V, Badimon L, Corti R, de Wit C, Dorobantu M, Hall A, Koller A, Marzilli M, Pries A, Bugiardini R, on behalf of the Working Group on Coronary Pathophysiology and Microcirculation (2011) Ischaemic heart disease in women: are there sex differences in pathophysiology and risk factors. Cardiovasc Res 90:9\u201317","journal-title":"Cardiovasc Res"},{"key":"9824_CR47","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00059-005-2716-3","volume":"30","author":"H Tillmanns","year":"2005","unstructured":"Tillmanns H, Waas W, Voss R, Grempels E, H\u00f6lschermann H, Haberbosch W, Waldecker B (2005) Gender differences in the outcome of cardiac interventions. Herz. 30:375\u2013389. \nhttps:\/\/doi.org\/10.1007\/s00059-005-2716-3","journal-title":"Herz."},{"key":"9824_CR48","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s11897-012-0107-7","volume":"9","author":"SM Dunlay","year":"2012","unstructured":"Dunlay SM, Roger VL (2012) Gender differences in the pathophysiology, clinical presentation, and outcomes of ischemic heart failure. Curr Heart Fail Rep 9:267\u2013276. \nhttps:\/\/doi.org\/10.1007\/s11897-012-0107-7","journal-title":"Curr Heart Fail Rep"},{"key":"9824_CR49","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.jacc.2013.11.053","volume":"63","author":"AP Ambrosy","year":"2014","unstructured":"Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, Nodari S, Lam CSP, Sato N, Shah AN, Gheorghiade M (2014) The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol 63:1123\u20131133. \nhttps:\/\/doi.org\/10.1016\/j.jacc.2013.11.053","journal-title":"J Am Coll Cardiol"},{"key":"9824_CR50","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1056\/NEJMoa020265","volume":"347","author":"D Levy","year":"2002","unstructured":"Levy D, Kenchaiah S, Larson MG, Benjamin EJ, Kupka MJ, Ho KKL, Murabito JM, Vasan RS (2002) Long-term trends in the incidence of and survival with heart failure. N Engl J Med 347:1397\u20131402. \nhttps:\/\/doi.org\/10.1056\/NEJMoa020265","journal-title":"N Engl J Med"},{"key":"9824_CR51","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/S0195-668X(02)00700-5","volume":"24","author":"M Komajda","year":"2003","unstructured":"Komajda M, Follath F, Swedberg K et al (2003) The EuroHeart failure survey programme - a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment. Eur Heart J 24:464\u2013474. \nhttps:\/\/doi.org\/10.1016\/S0195-668X(02)00700-5","journal-title":"Eur Heart J"},{"key":"9824_CR52","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","volume":"62","author":"WJ Paulus","year":"2013","unstructured":"Paulus WJ, Tsch\u00f6pe C (2013) A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol 62:263\u2013271. \nhttps:\/\/doi.org\/10.1016\/j.jacc.2013.02.092","journal-title":"J Am Coll Cardiol"},{"key":"9824_CR53","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0002-9378(99)70239-5","volume":"180","author":"CWG Redman","year":"1999","unstructured":"Redman CWG, Sacks GP, Sargent IL (1999) Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 180:499\u2013506","journal-title":"Am J Obstet Gynecol"},{"key":"9824_CR54","doi-asserted-by":"crossref","unstructured":"Wu P, Haththotuwa R, Kwok CS, et al (2017) Preeclampsia and future cardiovascular health. Circ Cardiovasc Qual Outcomes","DOI":"10.1161\/CIRCOUTCOMES.116.003497"},{"key":"9824_CR55","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/eurjhf\/hfs056","volume":"14","author":"IC Macdougall","year":"2012","unstructured":"Macdougall IC, Canaud B, De Francisco ALM et al (2012) Beyond the cardiorenal anaemia syndrome: recognizing the role of iron deficiency. Eur J Heart Fail 14:882\u2013886","journal-title":"Eur J Heart Fail"},{"key":"9824_CR56","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1186\/2193-1801-3-445","volume":"3","author":"CM Wheatley","year":"2014","unstructured":"Wheatley CM, Snyder EM, Johnson BD, Olson TP (2014) Sex differences in cardiovascular function during submaximal exercise in humans. Springerplus. 3:445. \nhttps:\/\/doi.org\/10.1186\/2193-1801-3-445","journal-title":"Springerplus."},{"key":"9824_CR57","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1161\/01.CIR.70.3.357","volume":"70","author":"MB Higginbotham","year":"1984","unstructured":"Higginbotham MB, Morris KG, Colemen RE, Cobb FR (1984) Sex-related differences in the normal cardiac response to upright exercise. Circulation. 70:357\u2013366. \nhttps:\/\/doi.org\/10.1161\/01.CIR.70.3.357","journal-title":"Circulation."},{"key":"9824_CR58","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1161\/HYPERTENSIONAHA.112.191148","volume":"60","author":"C Russo","year":"2012","unstructured":"Russo C, Jin Z, Palmieri V, Homma S, Rundek T, Elkind MSV, Sacco RL, di Tullio MR (2012) Arterial stiffness and wave reflection: sex differences and relationship with left ventricular diastolic function. Hypertension. 60:362\u2013368. \nhttps:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.112.191148","journal-title":"Hypertension."},{"key":"9824_CR59","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1089\/met.2016.0078","volume":"14","author":"H-L Kim","year":"2016","unstructured":"Kim H-L, Kim M-A, Oh S, Kim M, Park SM, Yoon HJ, Shin MS, Hong KS, Shin GJ, Shim WJ (2016) Sex difference in the association between metabolic syndrome and left ventricular diastolic dysfunction. Metab Syndr Relat Disord 14:507\u2013512. \nhttps:\/\/doi.org\/10.1089\/met.2016.0078","journal-title":"Metab Syndr Relat Disord"},{"key":"9824_CR60","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1161\/CIRCULATIONAHA.105.541078","volume":"112","author":"MM Redfield","year":"2005","unstructured":"Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA (2005) Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation. 112:2254\u20132262. \nhttps:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.541078","journal-title":"Circulation."},{"key":"9824_CR61","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/S0008-6363(00)00280-7","volume":"49","author":"CS Hayward","year":"2001","unstructured":"Hayward CS, Kalnins WV, Kelly RP (2001) Gender-related differences in left ventricular chamber function. Cardiovasc Res 49:340\u2013350. \nhttps:\/\/doi.org\/10.1016\/S0008-6363(00)00280-7","journal-title":"Cardiovasc Res"},{"key":"9824_CR62","doi-asserted-by":"publisher","first-page":"C1625","DOI":"10.1152\/ajpcell.00368.2006","volume":"292","author":"GM Kravtsov","year":"2007","unstructured":"Kravtsov GM, Kam KWL, Liu J, Wu S, Wong TM (2007) Altered Ca 2+ handling by ryanodine receptor and Na + -Ca 2+ exchange in the heart from ovariectomized rats: role of protein kinase A. Am J Physiol Physiol 292:C1625\u2013C1635. \nhttps:\/\/doi.org\/10.1152\/ajpcell.00368.2006","journal-title":"Am J Physiol Physiol"},{"key":"9824_CR63","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.pcad.2006.08.011","volume":"49","author":"V Regitz-Zagrosek","year":"2007","unstructured":"Regitz-Zagrosek V, Brokat S, Tschope C (2007) Role of gender in heart failure with normal left ventricular ejection fraction. Prog Cardiovasc Dis 49:241\u2013251. \nhttps:\/\/doi.org\/10.1016\/j.pcad.2006.08.011","journal-title":"Prog Cardiovasc Dis"},{"key":"9824_CR64","doi-asserted-by":"publisher","unstructured":"Elliott PM (2015) 2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy. Russ J Cardiol. \nhttps:\/\/doi.org\/10.15829\/1560-4071-2015-05-7-57","DOI":"10.15829\/1560-4071-2015-05-7-57"},{"issue":"2","key":"9824_CR65","first-page":"107","volume":"8","author":"P Charron","year":"1997","unstructured":"Charron P, Carrier L, Dubourg O et al (1997) Penetrance of familial hypertrophic cardiomyopathy. Genet Couns 8(2):107\u2013114","journal-title":"Genet Couns"},{"key":"9824_CR66","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.jjcc.2010.07.004","volume":"56","author":"T Kubo","year":"2010","unstructured":"Kubo T, Kitaoka H, Okawa M, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Yabe T, Doi YL (2010) Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population: results from Kochi RYOMA study. J Cardiol 56:314\u2013319. \nhttps:\/\/doi.org\/10.1016\/j.jjcc.2010.07.004","journal-title":"J Cardiol"},{"key":"9824_CR67","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.jacc.2005.04.043","volume":"46","author":"I Olivotto","year":"2005","unstructured":"Olivotto I, Maron MS, Adabag AS, Casey SA, Vargiu D, Link MS, Udelson JE, Cecchi F, Maron BJ (2005) Gender-related differences in the clinical presentation and outcome of hypertrophic cardiomyopathy. J Am Coll Cardiol 46:480\u2013487. \nhttps:\/\/doi.org\/10.1016\/j.jacc.2005.04.043","journal-title":"J Am Coll Cardiol"},{"key":"9824_CR68","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0167-5273(00)00401-0","volume":"77","author":"PP Dimitrow","year":"2001","unstructured":"Dimitrow PP, Czarnecka D, Strojny JA, Kawecka-Jaszcz K, Dubiel JS (2001) Impact of gender on the left ventricular cavity size and contractility in patients with hypertrophic cardiomyopathy. Int J Cardiol 77:43\u201348. \nhttps:\/\/doi.org\/10.1016\/S0167-5273(00)00401-0","journal-title":"Int J Cardiol"},{"key":"9824_CR69","doi-asserted-by":"crossref","unstructured":"Maron MS, Olivotto I, Betocchi S et al (2003) Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. Rev Port Cardiol","DOI":"10.1016\/S1062-1458(03)00180-6"},{"key":"9824_CR70","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1161\/circulationaha.111.078915","volume":"126","author":"FL Ruberg","year":"2012","unstructured":"Ruberg FL, Berk JL (2012) Transthyretin (TTR) cardiac amyloidosis. Circulation. 126:1286\u20131300. \nhttps:\/\/doi.org\/10.1161\/circulationaha.111.078915","journal-title":"Circulation."},{"issue":"2","key":"9824_CR71","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/qjmed\/91.2.141","volume":"91","author":"SW Dubrey","year":"1998","unstructured":"Dubrey SW, Cha K, Anderson J et al (1998) The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement. QJM 91(2):141\u2013157","journal-title":"QJM"},{"key":"9824_CR72","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jacc.2016.03.596","volume":"68","author":"MS Maurer","year":"2016","unstructured":"Maurer MS, Hanna M, Grogan M, Dispenzieri A, Witteles R, Drachman B, Judge DP, Lenihan DJ, Gottlieb SS, Shah SJ, Steidley DE, Ventura H, Murali S, Silver MA, Jacoby D, Fedson S, Hummel SL, Kristen AV, Damy T, Plant\u00e9-Bordeneuve V, Coelho T, Mundayat R, Suhr OB, Waddington Cruz M, Rapezzi C, THAOS Investigators (2016) Genotype and phenotype of transthyretin cardiac amyloidosis: THAOS (transthyretin amyloid outcome survey). J Am Coll Cardiol 68:161\u2013172. \nhttps:\/\/doi.org\/10.1016\/j.jacc.2016.03.596","journal-title":"J Am Coll Cardiol"},{"key":"9824_CR73","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/j.jacc.2018.02.070","volume":"71","author":"PE Scott","year":"2018","unstructured":"Scott PE, Unger EF, Jenkins MR, Southworth MR, McDowell TY, Geller RJ, Elahi M, Temple RJ, Woodcock J (2018) Participation of women in clinical trials supporting FDA approval of cardiovascular drugs. J Am Coll Cardiol 71:1960\u20131969. \nhttps:\/\/doi.org\/10.1016\/j.jacc.2018.02.070","journal-title":"J Am Coll Cardiol"},{"key":"9824_CR74","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1001\/archinte.167.9.905","volume":"167","author":"EL Ding","year":"2007","unstructured":"Ding EL, Powe NR, Manson JAE et al (2007) Sex differences in perceived risks, distrust, and willingness to participate in clinical trials: a randomized study of cardiovascular prevention trials. Arch Intern Med 167:905. \nhttps:\/\/doi.org\/10.1001\/archinte.167.9.905","journal-title":"Arch Intern Med"},{"issue":"2","key":"9824_CR75","first-page":"135","volume":"3","author":"L Shen","year":"2014","unstructured":"Shen L, Melloni C (2014) Representation of women in randomized clinical trials of cardiovascular disease prevention. Curr Cardiovasc Risk Rep 3(2):135\u2013142","journal-title":"Curr Cardiovasc Risk Rep"},{"key":"9824_CR76","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/00008571-200007000-00006","volume":"10","author":"L Labb\u00e9","year":"2000","unstructured":"Labb\u00e9 L, Sirois C, Pilote S et al (2000) Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates. Pharmacogenetics. 10:425\u2013438. \nhttps:\/\/doi.org\/10.1097\/00008571-200007000-00006","journal-title":"Pharmacogenetics."},{"key":"9824_CR77","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1001\/jama.289.7.871","volume":"289","author":"SS Rathore","year":"2003","unstructured":"Rathore SS, Curtis JP, Wang Y et al (2003) Association of serum digoxin concentration and outcomes in patients with heart failure. J Am Med Assoc 289:871. \nhttps:\/\/doi.org\/10.1001\/jama.289.7.871","journal-title":"J Am Med Assoc"},{"key":"9824_CR78","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/clpt.2009.89","volume":"86","author":"C Catananti","year":"2009","unstructured":"Catananti C, Liperoti R, Settanni S, Lattanzio F, Bernabei R, Fialova D, Landi F, onder G (2009) Heart failure and adverse drug reactions among hospitalized older adults. Clin Pharmacol Ther 86:307\u2013310. \nhttps:\/\/doi.org\/10.1038\/clpt.2009.89","journal-title":"Clin Pharmacol Ther"}],"container-title":["Heart Failure Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10741-019-09824-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10741-019-09824-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10741-019-09824-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:01:28Z","timestamp":1593561688000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10741-019-09824-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["9824"],"URL":"https:\/\/doi.org\/10.1007\/s10741-019-09824-y","relation":{},"ISSN":["1382-4147","1573-7322"],"issn-type":[{"value":"1382-4147","type":"print"},{"value":"1573-7322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]},"assertion":[{"value":"2 July 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The manuscript does not contain clinical studies or patient data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}