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Clinical inertia, defined as the lack of treatment intensification in a patient not at evidence-based goals for care, is an important underlying cause. Clinical inertia is extensively described in hypertension and type 2 diabetes mellitus, but increasingly recognized in heart failure as well. Given the well-established guidelines for the management of heart failure, these are still not being reflected in clinical practice. While the absolute majority of patients were treated by guideline-directed heart failure drugs, only a small percentage of these patients reached the correct guideline-recommended target dose of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, mineralocorticoid receptor antagonists, and angiotensin receptor-neprilysin inhibitors. This considerable under-treatment leads to a large number of avoidable hospitalizations and deaths. This review discusses clinical inertia in heart failure and explains its major contributing factors (i.e., physician, patient, and system) and touches upon some recommendations to prevent clinical inertia and ameliorate heart failure treatment.<\/jats:p>","DOI":"10.1007\/s10741-020-09979-z","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T15:02:30Z","timestamp":1590850950000},"page":"1359-1370","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Clinical inertia in the treatment of heart failure: a major issue to tackle"],"prefix":"10.1007","volume":"26","author":[{"given":"Caroline","family":"Verhestraeten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ward A.","family":"Heggermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Maris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,30]]},"reference":[{"key":"9979_CR1","first-page":"e67","volume":"137","author":"Heart Disease and Stroke Statistics","year":"2018","unstructured":"Heart Disease and Stroke Statistics (2018) Update: a report from the American Heart Association (2018). 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