{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:31:02Z","timestamp":1774384262185,"version":"3.50.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002352","name":"Ain Shams University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Fail Rev"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sudden cardiac death (SCD) and significant ventricular arrhythmias in patients with dilated cardiomyopathy (DCM) have been markedly reduced over the last couple of decades as a result of the advances in pharmacological and non-pharmacological treatment. Primary prevention implantable cardioverter-defibrillator (ICD) plays an important role in the treatment of patients at risk of SCD caused by ventricular arrhythmias. However, the arrhythmic risk stratification in patients with DCM remains extremely challenging, and the decision for primary prevention ICD implantation based on left ventricular ejection fraction (LVEF) solely appears to be insufficient. This review provides an update on current evidence for primary prevention ICD implantation, arrhythmic risk stratification, and left ventricular reverse remodeling (LVRR) prediction in patients with DCM in addition to most recent guideline recommendations for primary prevention ICD implantation in DCM patients and a proposed multiparametric algorithm based on arrhythmic risk stratification and left ventricular reverse remodeling (LVRR) prediction to better identify patients who are likely to benefit from primary prevention ICD.<\/jats:p>","DOI":"10.1007\/s10741-022-10246-6","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T07:02:42Z","timestamp":1652943762000},"page":"229-240","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["\ufeffPrimary prevention implantable cardioverter-defibrillator use in non-ischemic dilated cardiomyopathy based on arrhythmic risk stratification and left ventricular reverse remodeling prediction\ufeff"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-3607","authenticated-orcid":false,"given":"Ahmed","family":"Muhammed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-9772","authenticated-orcid":false,"given":"Mohamed","family":"Abdelazeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Gamaleldin","family":"Elewa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-0386","authenticated-orcid":false,"given":"Mohamed","family":"Sharief","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-8875","authenticated-orcid":false,"given":"Ahmed","family":"Ammar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"issue":"2","key":"10246_CR1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","volume":"29","author":"P Elliott","year":"2008","unstructured":"Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P et al (2008) Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases. Eur Heart J 29(2):270\u2013276","journal-title":"Eur Heart J"},{"key":"10246_CR2","doi-asserted-by":"crossref","unstructured":"Weintraub RG, Semsarian C, Macdonald P (2017) Dilated cardiomyopathy. Lancet 390(10092):400\u201314. Available from: http:\/\/www.thelancet.com\/article\/S0140673616317135\/fulltext","DOI":"10.1016\/S0140-6736(16)31713-5"},{"key":"10246_CR3","doi-asserted-by":"crossref","unstructured":"Hershberger RE, Hedges DJ, Morales A (2013) Dilated cardiomyopathy: the complexity of a diverse genetic architecture. Nat Rev Cardiol 10(9):531\u201347. Available from: https:\/\/www.nature.com\/articles\/nrcardio.2013.105","DOI":"10.1038\/nrcardio.2013.105"},{"issue":"31","key":"10246_CR4","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1093\/eurheartj\/ehy344","volume":"39","author":"RK Pathak","year":"2018","unstructured":"Pathak RK, Sanders P, Deo R (2018) Primary prevention implantable cardioverter-defibrillator and opportunities for sudden cardiac death risk assessment in non-ischaemic cardiomyopathy. Eur Heart J 39(31):2859\u20132866","journal-title":"Eur Heart J"},{"issue":"23","key":"10246_CR5","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.1016\/j.jacc.2021.04.030","volume":"77","author":"A Di Marco","year":"2021","unstructured":"Di Marco A, Brown PF, Bradley J, Nucifora G, Claver E, de Frutos F et al (2021) Improved risk stratification for ventricular arrhythmias and sudden death in patients with nonischemic dilated cardiomyopathy. J Am Coll Cardiol 77(23):2890\u20132905","journal-title":"J Am Coll Cardiol"},{"key":"10246_CR6","doi-asserted-by":"crossref","unstructured":"&NA (2003) Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. Surv Anesthesiol 47(2):73","DOI":"10.1097\/00132586-200304000-00009"},{"key":"10246_CR7","doi-asserted-by":"crossref","unstructured":"Lee KL, Hafley G, Fisher JD, Gold MR, Prystowsky EN, Talajic M et al (2002) Effect of implantable defibrillators on arrhythmic events and mortality in the Multicenter Unsustained Tachycardia Trial. Available from: http:\/\/www.circulationaha.org","DOI":"10.1016\/S1062-1458(02)00956-X"},{"key":"10246_CR8","doi-asserted-by":"crossref","unstructured":"Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R et al (2005) Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352. Available from: www.nejm.org","DOI":"10.1056\/NEJMoa043399"},{"issue":"12","key":"10246_CR9","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1161\/01.CIR.0000012350.99718.AD","volume":"105","author":"D B\u00e4nsch","year":"2002","unstructured":"B\u00e4nsch D, Antz M, Boczor S, Volkmer M, Tebbenjohanns J, Seidl K et al (2002) Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the Cardiomyopathy Trial (CAT). Circulation 105(12):1453\u20131458","journal-title":"Circulation"},{"key":"10246_CR10","doi-asserted-by":"crossref","unstructured":"Kadish A, Dyer A, Daubert JP, Quigg R, Estes NAM, Anderson KP et al (2004) Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med 350. Available from: www.nejm.org","DOI":"10.1056\/NEJMoa033088"},{"issue":"2","key":"10246_CR11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/pace.14150","volume":"44","author":"YX Long","year":"2021","unstructured":"Long YX, Hu Y, Cui DY, Hu S, Liu ZZ (2021) The benefits of defibrillator in heart failure patients with cardiac resynchronization therapy: a meta-analysis. PACE - Pacing Clin Electrophysiol 44(2):225\u2013234","journal-title":"PACE - Pacing Clin Electrophysiol"},{"issue":"13","key":"10246_CR12","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1056\/NEJMoa1608029","volume":"375","author":"L K\u00f8ber","year":"2016","unstructured":"K\u00f8ber L, Thune JJ, Nielsen JC, Haarbo J, Videb\u00e6k L, Korup E et al (2016) Defibrillator implantation in patients with nonischemic systolic heart failure. N Engl J Med 375(13):1221\u20131230","journal-title":"N Engl J Med"},{"issue":"19","key":"10246_CR13","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1161\/CIRCULATIONAHA.117.028829","volume":"136","author":"MB Elming","year":"2017","unstructured":"Elming MB, Nielsen JC, Haarbo J, Videb\u00e6k L, Korup E, Signorovitch J et al (2017) Age and outcomes of primary prevention implantable cardioverter-defibrillators in patients with nonischemic systolic heart failure. Circulation 136(19):1772\u20131780","journal-title":"Circulation"},{"key":"10246_CR14","doi-asserted-by":"crossref","unstructured":"Barakat AF, Saad M, Elgendy AY, Mentias A, Abuzaid A, Mahmoud AN et al (2017) Primary prevention implantable cardioverter defibrillator in patients with non-ischaemic cardiomyopathy: a meta-analysis of randomised controlled trials. BMJ Open 7(6):e016352. Available from: https:\/\/bmjopen.bmj.com\/content\/7\/6\/e016352","DOI":"10.1136\/bmjopen-2017-016352"},{"key":"10246_CR15","doi-asserted-by":"publisher","unstructured":"Sutton MGSJ, Plappert T, Hilpisch KE, Abraham WT, Hayes DL, Chinchoy E (2006) Sustained reverse left ventricular structural remodeling with cardiac resynchronization at one year is a function of etiology. Circulation 113(2):266\u201372. Available from: https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.104.520817","DOI":"10.1161\/CIRCULATIONAHA.104.520817"},{"key":"10246_CR16","doi-asserted-by":"crossref","unstructured":"Gras M, Bisson A, Bodin A, Herbert J, Babuty D, Pierre B et al (2020) Mortality and cardiac resynchronization therapy with or without defibrillation in primary prevention. EP Eur 22(8):1224\u201333. Available from: https:\/\/0811eqsag-1103-y-https-academic-oup-com.mplbci.ekb.eg\/europace\/article\/22\/8\/1224\/5864442","DOI":"10.1093\/europace\/euaa096"},{"key":"10246_CR17","doi-asserted-by":"publisher","unstructured":"van der Lingen ALCJ, Timmer SAJ, Allaart LJH, Rijnierse MT, van de Ven PM, van Rossum AC et al (2019) The benefit of prophylactic implantable cardioverter defibrillator implantation in asymptomatic heart failure patients with a reduced ejection fraction. Am J Cardiol 124(4):560\u20136. Available from: https:\/\/doi.org\/10.1016\/j.amjcard.2019.05.026","DOI":"10.1016\/j.amjcard.2019.05.026"},{"issue":"10","key":"10246_CR18","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/S0735-1097(03)00297-3","volume":"41","author":"SA Strickberger","year":"2003","unstructured":"Strickberger SA, Hummel JD, Bartlett TG, Frumin HI, Schuger CD, Beau SL et al (2003) Amiodarone versus implantable cardioverter-defibrillator: randomized trial in patients with nonischemic dilated cardiomyopathy and asymptomatic nonsustained ventricular tachycardia - AMIOVIRT. J Am Coll Cardiol 41(10):1707\u20131712","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10246_CR19","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1136\/heartjnl-2019-315942","volume":"106","author":"A Cannat\u00e0","year":"2020","unstructured":"Cannat\u00e0 A, De Angelis G, Boscutti A, Normand C, Artico J, Gentile P et al (2020) Arrhythmic risk stratification in non-ischaemic dilated cardiomyopathy beyond ejection fraction. Heart 106(9):656\u2013664","journal-title":"Heart"},{"key":"10246_CR20","doi-asserted-by":"crossref","unstructured":"Briongos\u2010Figuero S, Est\u00e9vez A, P\u00e9rez ML, Mart\u00ednez\u2010Ferrer JB, Garc\u00eda E, Vi\u00f1olas X et al (2020) Prognostic role of NYHA class in heart failure patients undergoing primary prevention ICD therapy. ESC Hear Fail 7(1):279. Available from:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7083467\/","DOI":"10.1002\/ehf2.12548"},{"issue":"5","key":"10246_CR21","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.repc.2015.11.014","volume":"35","author":"S Amorim","year":"2016","unstructured":"Amorim S, Campelo M, Martins E, Moura B, Sousa A, Pinho T et al (2016) Prevalence, predictors and prognosis of ventricular reverse remodeling in idiopathic dilated cardiomyopathy. Rev Port Cardiol 35(5):253\u2013260","journal-title":"Rev Port Cardiol"},{"key":"10246_CR22","doi-asserted-by":"crossref","unstructured":"Zabel M, Sticherling C, Willems R, Lubinski A, Bauer A, Bergau L et al (2019) Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation. ESC Hear Fail 6(1):182\u201393. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/30299600\/","DOI":"10.1002\/ehf2.12367"},{"issue":"18","key":"10246_CR23","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/j.jacc.2013.12.021","volume":"63","author":"JJ Goldberger","year":"2014","unstructured":"Goldberger JJ, Suba\u010dius H, Patel T, Cunnane R, Kadish AH (2014) Sudden cardiac death risk stratification in patients with nonischemic dilated cardiomyopathy. J Am Coll Cardiol 63(18):1879\u20131889","journal-title":"J Am Coll Cardiol"},{"key":"10246_CR24","doi-asserted-by":"crossref","unstructured":"Upton G, Cook I (2008) A Dictionary of Statistics. A Dict Stat","DOI":"10.1093\/acref\/9780199541454.001.0001"},{"key":"10246_CR25","doi-asserted-by":"crossref","unstructured":"JA M, JC M, SK P, WJ M, CH L, AJ C et al (2003) Differentiation of heart failure related to dilated cardiomyopathy and coronary artery disease using gadolinium-enhanced cardiovascular magnetic resonance. Circulation 108(1):54\u20139. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/12821550\/","DOI":"10.1161\/01.CIR.0000078641.19365.4C"},{"key":"10246_CR26","doi-asserted-by":"crossref","unstructured":"Selvanayagam JB, Hartshorne T, Billot L, Grover S, Hillis GS, Jung W et al (2017) Cardiovascular magnetic resonance-GUIDEd management of mild to moderate left ventricular systolic dysfunction (CMR GUIDE): study protocol for a randomized controlled trial. Ann Noninvasive Electrocardiol 22(4)","DOI":"10.1111\/anec.12420"},{"key":"10246_CR27","doi-asserted-by":"crossref","unstructured":"Kawakami S, Takaki H, Hashimoto S, Kimura Y, Nakashima T, Aiba T et al (2016) Utility of high-resolution magnetocardiography to predict later cardiac events in nonischemic cardiomyopathy patients with normal QRS duration. Circ J 81(1):44\u201351. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/27853097\/","DOI":"10.1253\/circj.CJ-16-0683"},{"key":"10246_CR28","doi-asserted-by":"crossref","unstructured":"Korhonen P, V\u00e4\u00e4n\u00e4nen H, M\u00e4kij\u00e4rvi M, Katila T, Toivonen L (2001) Repolarization abnormalities detected by magnetocardiography in patients with dilated cardiomyopathy and ventricular arrhythmias. J Cardiovasc Electrophysiol 12(7):772\u20137. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/11469426\/","DOI":"10.1046\/j.1540-8167.2001.00772.x"},{"key":"10246_CR29","doi-asserted-by":"crossref","unstructured":"Lachlan T, He H, Sharma K, Khan J, Rajappan K, Morley-Davies A et al (2020) MAGNETO cardiography parameters to predict future sudden cardiac death (MAGNETO-SCD) or ventricular events from implantable cardioverter defibrillators: study protocol, design and rationale. BMJ Open 10(10). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33040013\/","DOI":"10.1136\/bmjopen-2020-038804"},{"key":"10246_CR30","doi-asserted-by":"publisher","unstructured":"K\u00f8ber L, Thune JJ, Nielsen JC, Haarbo J, Videb\u00e6k L, Korup E et al (2016) Defibrillator implantation in patients with nonischemic systolic heart failure 375(13):1221\u201330. Available from: https:\/\/doi.org\/10.1056\/NEJMoa1608029","DOI":"10.1056\/NEJMoa1608029"},{"key":"10246_CR31","doi-asserted-by":"crossref","unstructured":"Aimo A, Januzzi JL, Vergaro GGV, Ripoli A, Latini R, Masson S et al (2018) Prognostic value of high-sensitivity troponin T in chronic heart failure: an individual patient data meta-analysis. Circulation 137(3):286\u201397. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/29335288\/","DOI":"10.1161\/CIRCULATIONAHA.117.031560"},{"key":"10246_CR32","unstructured":"Lup\u00f3 J, De Antonio M, Vila J, Pe\u00f1 Afiel J, Gal\u00e1 A, Zamora E et al (2021) Development of a novel heart failure risk tool: the Barcelona Bio-Heart Failure Risk Calculator (BCN Bio-HF Calculator). Available from: www.plosone.org"},{"issue":"10","key":"10246_CR33","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.jacc.2019.12.058","volume":"75","author":"BA Marrow","year":"2020","unstructured":"Marrow BA, Cook SA, Prasad SK, McCann GP (2020) Emerging techniques for risk stratification in nonischemic dilated cardiomyopathy: JACC review topic of the week. J Am Coll Cardiol 75(10):1196\u20131207","journal-title":"J Am Coll Cardiol"},{"key":"10246_CR34","doi-asserted-by":"crossref","unstructured":"Hammersley DJ, Halliday BP (2020) Sudden cardiac death prediction in non-ischemic dilated cardiomyopathy: a multiparametric and dynamic approach. Curr Cardiol Rep 22(9)","DOI":"10.1007\/s11886-020-01343-9"},{"key":"10246_CR35","doi-asserted-by":"crossref","unstructured":"Ebert M, Wijnmaalen AP, de Riva M, Trines SA, Androulakis AFA, Glashan CA et al (2020) Prevalence and prognostic impact of pathogenic variants in patients with dilated cardiomyopathy referred for ventricular tachycardia ablation. JACC Clin Electrophysiol 6(9):1103\u201314. Available from: https:\/\/research.rug.nl\/en\/publications\/prevalence-and-prognostic-impact-of-pathogenic-variants-in-patien","DOI":"10.1016\/j.jacep.2020.04.025"},{"key":"10246_CR36","doi-asserted-by":"crossref","unstructured":"Verdonschot JAJ, Hazebroek MR, Wang P, Sanders-van Wijk S, Merken JJ, Adriaansen YA et al (2018) Clinical phenotype and genotype associations with improvement in left ventricular function in dilated cardiomyopathy. Circ Heart Fail 11(11):e005220. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/30571196\/","DOI":"10.1161\/CIRCHEARTFAILURE.118.005220"},{"key":"10246_CR37","doi-asserted-by":"crossref","unstructured":"Corden B, Jarman J, Whiffin N, Tayal U, Buchan R, Sehmi J et al (2019) Association of titin-truncating genetic variants with life-threatening cardiac arrhythmias in patients with dilated cardiomyopathy and implanted defibrillators. JAMA Netw Open 2(6):e196520\u2013e196520. Available from: https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2736938","DOI":"10.1001\/jamanetworkopen.2019.6520"},{"key":"10246_CR38","doi-asserted-by":"crossref","unstructured":"Merlo M, Cannat\u00e0 A, Gobbo M, Stolfo D, Elliott PM, Sinagra G (2018) Evolving concepts in dilated cardiomyopathy. Eur J Heart Fail 20(2):228\u201339. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/29271570\/","DOI":"10.1002\/ejhf.1103"},{"issue":"1","key":"10246_CR39","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jacc.2012.07.072","volume":"61","author":"M Kubanek","year":"2013","unstructured":"Kubanek M, Sramko M, Maluskova J, Kautznerova D, Weichet J, Lupinek P et al (2013) Novel predictors of left ventricular reverse remodeling in individuals with recent-onset dilated cardiomyopathy. J Am Coll Cardiol 61(1):54\u201363","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10246_CR40","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1002\/ehf2.13216","volume":"8","author":"Y Kimura","year":"2021","unstructured":"Kimura Y, Okumura T, Morimoto R, Kazama S, Shibata N, Oishi H et al (2021) A clinical score for predicting left ventricular reverse remodelling in patients with dilated cardiomyopathy. ESC Hear Fail 8(2):1359\u20131368","journal-title":"ESC Hear Fail"},{"key":"10246_CR41","doi-asserted-by":"crossref","unstructured":"M M, D S, M A, F N, B P, G B et al (2015) Persistent recovery of normal left ventricular function and dimension in idiopathic dilated cardiomyopathy during long\u2010term follow\u2010up: does real healing exist? J Am Heart Assoc 4(1). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/25587018\/","DOI":"10.1161\/JAHA.114.001504"},{"key":"10246_CR42","doi-asserted-by":"crossref","unstructured":"Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM et al (2022) AHA\/ACC\/HFSA guideline for the management of heart failure. J Am Coll Cardiol","DOI":"10.1016\/j.cardfail.2022.02.009"},{"issue":"36","key":"10246_CR43","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","volume":"42","author":"TA McDonagh","year":"2021","unstructured":"McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, B\u00f6hm M et al (2021) 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42(36):3599\u20133726","journal-title":"Eur Heart J"},{"key":"10246_CR44","doi-asserted-by":"crossref","unstructured":"Tsch\u00f6pe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB et al (2021) Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. Nat Rev Cardiol 18(3):169\u201393. Available from: https:\/\/kyushu-u.pure.elsevier.com\/en\/publications\/myocarditis-and-inflammatory-cardiomyopathy-current-evidence-and-","DOI":"10.1038\/s41569-020-00435-x"},{"key":"10246_CR45","doi-asserted-by":"crossref","unstructured":"Topkara VK, Garan AR, Fine B, Godier-Furn\u00e9mont AF, Breskin A, Cagliostro B et al (2016) Myocardial recovery in patients receiving contemporary left ventricular assist devices: results from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). Circ Heart Fail 9(7). Available from:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/\/pmc\/articles\/PMC4943678\/","DOI":"10.1161\/CIRCHEARTFAILURE.116.003157"},{"key":"10246_CR46","doi-asserted-by":"crossref","unstructured":"D\u2019Ambrosio A, Patti G, Manzoli A, Di Sciascio G, Sinagra G, Di Lenarda A et al (2001) The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy: a review. Heart 85(5):499\u2013504. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/11302994\/","DOI":"10.1136\/hrt.85.5.499"},{"key":"10246_CR47","doi-asserted-by":"publisher","unstructured":"Verdonschot JAJ, Hazebroek MR, Wang P, Sanders-van Wijk S, Merken JJ, Adriaansen YA et al (2018) Clinical phenotype and genotype associations with improvement in left ventricular function in dilated cardiomyopathy. Circ Heart Fail 11(11):e005220. Available from: https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.118.005220","DOI":"10.1161\/CIRCHEARTFAILURE.118.005220"},{"key":"10246_CR48","doi-asserted-by":"crossref","unstructured":"Choi JO, Kim EY, Lee GY, Lee SC, Park SW, Kim DK et al (2013) Predictors of left ventricular reverse remodeling and subsequent outcome in nonischemic dilated cardiomyopathy. Circ J 77(2):462\u20139","DOI":"10.1253\/circj.CJ-12-0507"},{"key":"10246_CR49","doi-asserted-by":"crossref","unstructured":"Tobita T, Nomura S, Fujita T, Morita H, Asano Y, Onoue K et al (2018) Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling. Sci 8(1). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/29386531\/","DOI":"10.1038\/s41598-018-20114-9"},{"key":"10246_CR50","doi-asserted-by":"crossref","unstructured":"Marume K, Noguchi T, Tateishi E, Morita Y, Miura H, Nishimura K et al (2020) Prognosis and clinical characteristics of dilated cardiomyopathy with family history via pedigree analysis. Circ J 84(8):1284\u201393. Available from: https:\/\/tohoku.pure.elsevier.com\/en\/publications\/prognosis-and-clinical-characteristics-of-dilated-cardiomyopathy-","DOI":"10.1253\/circj.CJ-19-1176"},{"key":"10246_CR51","doi-asserted-by":"crossref","unstructured":"Wouter Jukema J, Timal RJ, Rotmans JI, Hensen LCR, Buiten MS, De Bie MK et al (2019) Prophylactic use of implantable cardioverter-defibrillators in the prevention of sudden cardiac death in dialysis patients: the prospective, randomized, controlled ICD2 trial. Circulation 139(23):2628\u201338. Available from: http:\/\/ahajournals.org","DOI":"10.1161\/CIRCULATIONAHA.119.039818"},{"key":"10246_CR52","doi-asserted-by":"publisher","unstructured":"Dendale P, Scherrenberg M, Sivakova O, Frederix I (2019) Prevention: from the cradle to the grave and beyond. Eur J Prev Cardiol 26(5):507\u201311. Available from: https:\/\/doi.org\/10.1177\/2047487318821772","DOI":"10.1177\/2047487318821772"},{"key":"10246_CR53","doi-asserted-by":"crossref","unstructured":"Al-Gobari M, Al-Aqeel S, Gueyffier F, Burnand B (2018) Effectiveness of drug interventions to prevent sudden cardiac death in patients with heart failure and reduced ejection fraction: an overview of systematic reviews. BMJ Open 8(7):e021108. Available from: https:\/\/bmjopen.bmj.com\/content\/8\/7\/e021108","DOI":"10.1136\/bmjopen-2017-021108"},{"key":"10246_CR54","doi-asserted-by":"crossref","unstructured":"Wong JA, Roberts JD, Healey JS (2021) The optimal timing of primary prevention implantable cardioverter-defibrillator referral in the rapidly changing medical landscape. Can J Cardiol 37(4):644\u201354. Available from: http:\/\/www.onlinecjc.ca\/article\/S0828282X21000696\/fulltext","DOI":"10.1016\/j.cjca.2021.01.024"},{"key":"10246_CR55","doi-asserted-by":"crossref","unstructured":"Kramer DG, Trikalinos TA, Kent DM, Antonopoulos GV, Konstam MA, Udelson JE (2010) Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach. J Am Coll Cardiol 56(5):392\u2013406. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4523221\/","DOI":"10.1016\/j.jacc.2010.05.011"},{"key":"10246_CR56","doi-asserted-by":"crossref","unstructured":"Wang Y, Zhou R, Lu C, Chen Q, Xu T, Li D (2019) Effects of the angiotensin\u2010receptor neprilysin inhibitor on cardiac reverse remodeling: meta\u2010analysis. J Am Hear Assoc Cardiovasc Cerebrovasc Dis 8(13). Available from:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6662364\/","DOI":"10.1161\/JAHA.119.012272"},{"issue":"15","key":"10246_CR57","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1056\/NEJMoa2022190","volume":"383","author":"M Packer","year":"2020","unstructured":"Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P et al (2020) Cardiovascular and renal outcomes with empagliflozin in heart failure. N Engl J Med 383(15):1413\u20131424","journal-title":"N Engl J Med"},{"key":"10246_CR58","doi-asserted-by":"crossref","unstructured":"Greene SJ, Fonarow GC, DeVore AD et al (2019) Titration of Medical Therapy for Heart Failure With Reduced Ejection Fraction. J Am Coll Cardiol\u00a073(19):2365\u20132383. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7197490\/","DOI":"10.1016\/j.jacc.2019.02.015"},{"key":"10246_CR59","doi-asserted-by":"crossref","unstructured":"McMurray JJV, Packer M (2021) How should we sequence the treatments for heart failure and a reduced ejection fraction?: a redefinition of evidence-based medicine. Circulation 875\u20137","DOI":"10.1161\/CIRCULATIONAHA.120.052926"},{"issue":"41","key":"10246_CR60","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","volume":"36","author":"SG Priori","year":"2015","unstructured":"Priori SG, Blomstrom-Lundqvist C, Mazzanti A, Bloma N, Borggrefe M, Camm J et al (2015) 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the Europea. Eur Heart J 36(41):2793\u20132867l","journal-title":"Eur Heart J"},{"key":"10246_CR61","first-page":"272","volume":"2018","author":"SM Al-Khatib","year":"2017","unstructured":"Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB et al (2017) AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Vol. 138. Circulation 2018:272\u2013391","journal-title":"Circulation"},{"issue":"5","key":"10246_CR62","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.jacc.2011.08.078","volume":"59","author":"IAW Van Rijsingen","year":"2012","unstructured":"Van Rijsingen IAW, Arbustini E, Elliott PM, Mogensen J, Hermans-Van Ast JF, Van Der Kooi AJ et al (2012) Risk factors for malignant ventricular arrhythmias in lamin A\/C mutation carriers: a European cohort study. J Am Coll Cardiol 59(5):493\u2013500","journal-title":"J Am Coll Cardiol"},{"key":"10246_CR63","doi-asserted-by":"crossref","unstructured":"Ribera A, Gim\u00e9nez E, Oristrell G, Osorio D, Marsal JR, Garc\u00eda-P\u00e9rez L et al (2022) Cost-effectiveness of implantable cardioverter-defibrillators for primary prevention of sudden cardiac death. Rev Esp Cardiol (Engl Ed) 75(1):12\u201321. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/34099431\/","DOI":"10.1016\/j.rec.2021.05.004"}],"container-title":["Heart Failure Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10741-022-10246-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10741-022-10246-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10741-022-10246-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T06:19:43Z","timestamp":1675664383000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10741-022-10246-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,19]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["10246"],"URL":"https:\/\/doi.org\/10.1007\/s10741-022-10246-6","relation":{},"ISSN":["1573-7322"],"issn-type":[{"value":"1573-7322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,19]]},"assertion":[{"value":"4 May 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}