{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:20:45Z","timestamp":1785428445673,"version":"3.56.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Fail Rev"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A subgroup of patients with noncompaction cardiomyopathy (NCCM) is at increased risk of ventricular arrhythmias and sudden cardiac death (SCD). In selected patients with NCCM, implantable cardioverter-defibrillator (ICD) therapy could be advantageous for preventing SCD. Currently, there is no complete overview of outcome and complications after ICD therapy in patients with NCCM. This study sought to present an overview using pooled data of currently available studies. Embase, MEDLINE, Web of Science, and Cochrane databases were searched and returned 915 studies. After a thorough examination, 12 studies on outcome and complications after ICD therapy in patients with NCCM were included. There were 275 patients (mean age 38.6\u00a0years; 47% women) with NCCM and ICD implantation. Most of the patients received an ICD for primary prevention (66%). Pooled analysis demonstrates that the appropriate ICD intervention rate was 11.95 per 100 person-years and the inappropriate ICD intervention rate was 4.8 per 100 person-years. The cardiac mortality rate was 2.37 per 100 person-years. ICD-related complications occurred in 10% of the patients, including lead malfunction and revision (4%), lead displacement (3%), infection (2%), and pneumothorax (2%). Patients with NCCM who are at increased risk of SCD may significantly benefit from ICD therapy, with a high appropriate ICD therapy rate of 11.95 per 100 person-years and a low cardiac mortality rate of 2.37 per 100 person-years. Inappropriate therapy rate of 4.8 per 100 person-years and ICD-related complications were not infrequent and may lead to patient morbidity.\n<\/jats:p>","DOI":"10.1007\/s10741-022-10250-w","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T22:02:35Z","timestamp":1654898555000},"page":"241-248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical outcomes of implantable cardioverter-defibrillator therapy in noncompaction cardiomyopathy: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"28","author":[{"given":"Martijn","family":"Tukker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend F. 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J Am Coll Cardiol 36:493\u2013500, Aug 2000.\u00a0https:\/\/doi.org\/10.1016\/s0735-1097(00)00755-5","DOI":"10.1016\/s0735-1097(00)00755-5"},{"issue":"24","key":"10250_CR2","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1161\/01.CIR.0000132478.60674.D0","volume":"109","author":"BC Weiford","year":"2004","unstructured":"Weiford BC, Subbarao VD, Mulhern KM (2004) Noncompaction of the ventricular myocardium. Circulation 109(24):2965\u20132971. https:\/\/doi.org\/10.1161\/01.CIR.0000132478.60674.D0","journal-title":"Circulation"},{"issue":"7","key":"10250_CR3","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.jacc.2017.12.019","volume":"71","author":"JI van Waning","year":"2018","unstructured":"van Waning JI et al (2018) Genetics, clinical features, and long-term outcome of noncompaction cardiomyopathy. J Am Coll Cardiol 71(7):711\u2013722. https:\/\/doi.org\/10.1016\/j.jacc.2017.12.019","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10250_CR4","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/j.ijcard.2013.03.039","volume":"168","author":"S Gati","year":"2013","unstructured":"Gati S, Papadakis M, Van Niekerk N, Reed M, Yeghen T, Sharma S (2013) Increased left ventricular trabeculation in individuals with sickle cell anaemia: physiology or pathology?. Int J Cardiol 168(2):1658\u20131660. https:\/\/doi.org\/10.1016\/j.ijcard.2013.03.039","journal-title":"Int J Cardiol"},{"key":"10250_CR5","volume-title":"Noncompaction cardiomyopathy","year":"2019","unstructured":"Caliskan OISK, ten Cate FJ (eds) (2019) Noncompaction cardiomyopathy. Springer, Cham"},{"key":"10250_CR6","doi-asserted-by":"publisher","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. PLoS Med 6(7):e1000097.\u00a0https:\/\/doi.org\/10.1371\/journal.pmed.1000097","DOI":"10.1371\/journal.pmed.1000097"},{"key":"10250_CR7","doi-asserted-by":"publisher","unstructured":"Neyeloff JL, Fuchs SC, Moreira LB (2012) Meta-analyses and forest plots using a Microsoft Excel spreadsheet: step-by-step guide focusing on descriptive data analysis. BMC Res Notes 5:52.\u00a0https:\/\/doi.org\/10.1186\/1756-0500-5-52","DOI":"10.1186\/1756-0500-5-52"},{"key":"10250_CR8","doi-asserted-by":"crossref","unstructured":"Stanton\u00a0C et al (2009) Isolated left ventricular noncompaction syndrome, (in English). 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Available: http:\/\/www.embase.com\/search\/results?subaction=viewrecord&from=export&id=L362346842, https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/j.1540-8167.2011.02015.x","DOI":"10.1111\/j.1540-8167.2011.02015.x"},{"key":"10250_CR11","unstructured":"St\u00f6llberger\u00a0C et al (2011) Cardiac devices and neuromuscular disorders in left ventricular non-compaction, (in English). J Kardiol (18)5:173. Available: http:\/\/www.embase.com\/search\/results?subaction=viewrecord&from=export&id=L70701053 , http:\/\/www.kup.at\/kup\/pdf\/9778.pdf"},{"key":"10250_CR12","unstructured":"Engberding R, St\u00f6llberger C, Schneider B, Nothnagel D, Fehske W, Gerecke BJ (2012) Heart failure in noncompaction cardiomyopathy-data from the German noncompaction registry (ALKK), (in English). Circulation (126)21. 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