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Mechanistically, it reduces central sympathetic overactivation, a process also relevant to heart failure. In this mini-review, we summarize the development of RDN for heart failure, discuss the current evidence supporting its effects, and provide an outlook on future developments.<\/jats:p>","DOI":"10.1007\/s10741-025-10489-z","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T05:11:46Z","timestamp":1738127506000},"page":"707-714","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Renal denervation in the setting of heart failure"],"prefix":"10.1007","volume":"30","author":[{"given":"Franziska","family":"Koppe-Schmei\u00dfer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Fengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Patrik","family":"Kresoja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Lurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Philipp","family":"Rommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"issue":"6","key":"10489_CR1","doi-asserted-by":"crossref","first-page":"005","DOI":"10.1016\/j.recesp.2021.11.027","volume":"75","author":"TA McDonagh","year":"2022","unstructured":"McDonagh TA et al (2022) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC. 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Dr.  Lurz reports speaker fees and institutional research funds from Medtronic and ReCor Medical. Dr. Fengler received institutional grants as well as institutional consultancy and speaker fees from Medtronic and ReCor Medical.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}