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AA has served as a consultant to Kiniksa, MonterosaRx, and Novo Nordisk. DPF has received consultancy and speaker fees and lectures from AstraZeneca, Novartis, Roche Diagnostics, Pfizer, Vifor, Rovi, Bayer. JNV has received consultancy and speaker fees and lectures from AstraZeneca, Alleviant, Amgen, Bayer, Boehringer Ingelheim, CSL Vifor, Daiichi Sankyo, GSK, Lilly, Pfizer, Novartis, NovoNordisk, and Rovi. JB has received honoraria from Bayer, Boehringer Ingelheim, and AstraZeneca, Alleviant Medical and WhiteSwell. OC has received grants from Servier. ACS has received honoraria for lectures or consultancy from AstraZeneca, Novartis, Vifor, Bayer, Merck, Sanofi, Abbott, and Boehringer Ingelheim. GF has received lecture fees or was a committee member for trials and registries sponsored by Bayer, Vifor, Boehringer Ingelheim, Medtronic, Servier, and Amgen. JMTM reports speaker and\/or consultancy fees to institution from Novartis, Boehringer Ingelheim, Moderna, Roche, and Novo Nordisk, and receiving grants from Netherlands Heart Foundation, and Netherlands Organization for Scientific Research (NWO) outside the submitted work. MM received consulting honoraria from Abbott Structural, Astra-Zeneca, Bayer, Boehringer Ingelheim, Edwards LifeSciences, NovoNordisk, Richie Diagnostics in the last three years. MP has received personal fees from Abbott Vascular, AstraZeneca, Boehringer Ingelheim, Novartis, Roche Diagnostics and Vifor Pharma. The employer of AAV received consultancy fees and\/or research support from Adrenomed, Anacardio, AstraZeneca, Bayer AG, BMS, Boehringer Ingelheim, Corteria, EliLilly, Merck, Moderna, Novartis, Novo Nordisk, Roche diagnostics, SalubrisBio. AM has received grants from Roche Diagnostics, Abbott Laboratories, 4TEEN4, and Windtree Therapeutics; honoraria for lectures from Roche Diagnostics, Bayer, and MSD; is a consultant for Corteria Pharmaceuticals, S-form Pharma, FIRE-1, Implicity, 4TEEN4, and Adrenomed; and is coinventor of a patent on combination therapy for patients having acute or persistent dyspnoea. DLM is on the scientific advisory board for Tenaya Therapeutics, HAYA Therapeutics, Cardurion Therapeutics and is a consultant from Novo holdings and Tourmaline Therapeutics. ABG has participated in advisory boards and\/or lectured for Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, Novartis, Roche Diagnostics, Vifor. All other authors have nothing to disclose. CL has nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}