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Its etiology is multifactorial and includes surgical technique, ischemic time, primary graft dysfunction, pulmonary hypertension, pacemaker leads, and endomyocardial biopsies. Severe TR can significantly impair graft function, exercise capacity, and patient survival. This mini-review explores current management strategies, including surgical techniques such as annuloplasty and tricuspid valve replacement. HT patients are often high-risk surgical candidates due to factors such as immunosuppressive therapy, prior surgeries, and various comorbidities. Therefore, we primarily focus on the evidence regarding emerging interventional methods, such as transcatheter edge-to-edge repair. Although these interventions show promising early results, they remain relatively novel in HT recipients, and the current evidence is based on case reports and small studies. Further research is essential to evaluate the long-term efficacy and safety of these management strategies to enhance outcomes for HT recipients with TR.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s10741-025-10494-2","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T07:44:46Z","timestamp":1739432686000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tricuspid regurgitation after heart transplantation: where innovation and intervention are in hibernation"],"prefix":"10.1007","volume":"30","author":[{"given":"Emyal","family":"Alyaydin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gotschy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana\u00eb","family":"Parianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias P.","family":"N\u00e4gele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Tudorache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas J.","family":"Flammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Stehli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"issue":"9","key":"10494_CR1","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1016\/j.transproceed.2022.09.009","volume":"54","author":"R L\u00f3pez-Vilella","year":"2022","unstructured":"L\u00f3pez-Vilella R, Paniagua-Mart\u00edn MJ, Gonz\u00e1lez-V\u00edlchez F et al (2022) Prevalence of tricuspid regurgitation after orthotopic heart transplantation and its evolution in the follow-up period: a long-term study. 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A. reports educational and training grant from the European Society of Cardiology (ESC), congress grants from the Heart Failure Association of the ESC, congress grants from the German Society of Cardiology and German Society of Internal Medicine, all unrelated to this article. M.P.N. reports speaker fees by AstraZeneca and Vifor Pharma unrelated to the article, consultancy fees by Boehringer Ingelheim and Pierre Fabre, and congress travel support by Pfizer, all unrelated to the article. I. T. was a medical consultant for corlife oHG and was involved in approval of homografts. A.J.F. reports fees from Alnylam, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, Fresenius, Medtronic, MSD, Mundipharma, Novartis, NovoNordisk, Pierre Fabre, Pfizer, Roche, Vifor, and Zoll, as well as grant support by Novartis, AstraZeneca and Berlin Heart unrelated to this article. All other authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}