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Funding Acknowledgment: The Funding section has been updated to include the following statement: \"JL received funding from Mitacs Accelerate program (IT45411).\" 2. Equal First-Author Contribution: An author footnote has been added to state: \"Kate Haichin and Janie Leroux: These authors contributed equally and are joint first authors.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"not applicable.","order":1,"name":"Ethics","label":"Human ethics and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participation","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"AS: Advisory \/ consulting \/ speaking: Boehringer-Ingelheim, Eli Lilly, Bayer, HSL Therapeutics, Novartis, Servier, AstraZeneca, Amgen, Novo Nordisk, Vifor Pharma.Co-founder \/ equity: Aerocardia, AREA19, Percassist, FrontRx.","order":3,"name":"Ethics","label":"Disclosures","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"90"}}