{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:55:10Z","timestamp":1785293710246,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1007\/s10753-004-6052-1","type":"journal-article","created":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T06:06:14Z","timestamp":1124345174000},"page":"285-290","source":"Crossref","is-referenced-by-count":39,"title":["The Cyclooxygenase-2 Inhibitor Celecoxib Is a Potent Inhibitor of Human Carbonic Anhydrase II"],"prefix":"10.1007","volume":"28","author":[{"given":"James F.","family":"Knudsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uno","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hammarstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald H.","family":"Sokol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis R.","family":"Cantilena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"6052_CR1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00000441-200103000-00005","volume":"321","author":"J. Eras","year":"2001","unstructured":"Eras, J., and M. Perazella. 2001. NSAIDs and the kidney revisited: Are selective cyclooxygenase-2 inhibitors safe? [Review]. Am. J. Med. Sci. 321:181\u2013190.","journal-title":"Am. J. Med. Sci."},{"key":"6052_CR2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1001\/jama.286.8.954","volume":"286","author":"D. Mukherjee","year":"2001","unstructured":"Mukherjee, D., S. Nissen, and E. J. Topol. 2001. Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA 286:954\u2013959.","journal-title":"JAMA"},{"key":"6052_CR3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-2776(08)60430-7","volume":"62","author":"W. L. Smith","year":"1996","unstructured":"Smith, W. L., and D. L. DeWitt. 1996. Prostaglandin endoperoxide H synthases-1 and -2 [Review]. Adv. Immunol. 62:167\u2013 215.","journal-title":"Adv. Immunol."},{"key":"6052_CR4","unstructured":"Merck Announces Voluntary Worldwide Withdrawal of Vioxx [News Release]. September 30, 2004. Merck & Co., Whitehouse Station, NJ."},{"key":"6052_CR5","unstructured":"Pfizer Provides Information to Healthcare Professionals About its Cox-2 Medicine Bextra\u00ae (Valdecoxib) [News Release]. October 15, 2004. Pfizer, New York."},{"key":"6052_CR6","doi-asserted-by":"crossref","first-page":"33157","DOI":"10.1074\/jbc.271.52.33157","volume":"271","author":"W. L. Smith","year":"1996","unstructured":"Smith, W. L., R. M. Garavito, and D. L. DeWitt. 1996. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2 [Review]. J. Biol. Chem. 271:33157\u201333160.","journal-title":"J. Biol. Chem."},{"key":"6052_CR7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1592\/phco.23.1.9.31916","volume":"23","author":"S. Subongkot","year":"2003","unstructured":"Subongkot, S., D. Frame, W. Leslie, and D. Drajer. 2003. Selective cyclooxygenase-2 inhibition: A target in cancer prevention and treatment [Review]. Pharmacotherapy 23:9\u201328.","journal-title":"Pharmacotherapy"},{"key":"6052_CR8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1359-6446(03)02781-8","volume":"8","author":"G. M\u00fcller","year":"2003","unstructured":"M\u00fcller, G. 2003. Medicinal chemistry of target family-directed masterkeys [Review]. Drug Discov. Today 8:681\u2013691.","journal-title":"Drug Discov. Today"},{"key":"6052_CR9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0009-9236(03)90501-7","volume":"73","author":"J. F. Knudsen","year":"2003","unstructured":"Knudsen, J. F., G. H. Sokol, and L. R. Cantilena. 2003. Structure-activity relationships as predictors of adverse drug events (ADEs). Clin. Pharmacol. Ther. 73:39 (Abstract).","journal-title":"Clin. Pharmacol. Ther."},{"key":"6052_CR10","unstructured":"Physicians\u2019 Desk Reference, 55th ed., 2001. Medical Economics Company, Montvale, NJ, 2903."},{"key":"6052_CR11","volume-title":"Acid\u2013Base and Electrolyte Disorders. A Companion to Brenner and Rector\u2019s The Kidney","year":"2002","unstructured":"DuBose, T. D., and L. L. Hamm (eds.). 2002. Acid\u2013Base and Electrolyte Disorders. A Companion to Brenner and Rector\u2019s The Kidney, Saunders, Philadelphia."},{"key":"6052_CR12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.clpt.2003.11.185","volume":"75","author":"J. F. Knudsen","year":"2004","unstructured":"Knudsen, J. F., U. Carlsson, P. Hammarstr\u00fcm, G. H. Sokol, and L. R. Cantilena. 2004. Cox-2 inhibitors and carbonic anhydrase activity.Clin. Pharmacol. Ther. 75:44. Abstract.","journal-title":"Clin. Pharmacol. Ther."},{"key":"6052_CR13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJM195307232490404","volume":"249","author":"H Belsky","year":"1953","unstructured":"Belsky, H. 1953. Use of new oral diuretic, diamox, in congestive heart disease. N. Engl. J. Med. 249:140\u2013143.","journal-title":"N. Engl. J. Med."},{"key":"6052_CR14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physrev.1967.47.4.595","volume":"47","author":"T. H. Maren","year":"1967","unstructured":"Maren, T. H. 1967. Carbonic anhydrase: Chemistry, physiology, and inhibition [Review]. Physiol. Rev. 47:595\u2013781.","journal-title":"Physiol. Rev."},{"key":"6052_CR15","first-page":"517","volume":"40","author":"K. Beyer","year":"1961","unstructured":"Beyer, K., and J. Baer. 1961. Physiological basis for the action of newer diuretic agents. Pharmacol. Rev. 40:517\u2013 562.","journal-title":"Pharmacol. Rev."},{"key":"6052_CR16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-0348-8446-4_2","volume-title":"The Carbonic Anhydrases. New Horizons","author":"W. R. Chegwidden","year":"2000","unstructured":"Chegwidden, W. R., and N. D. Carter. 2000. Introduction to the carbonic anhydrases. In: The Carbonic Anhydrases. New Horizons, W. R. Chegwidden, N. D. Carter, and Y. H. Edwards, eds. Birkh\u00e1user Verlag, Basel, Switzerland, pp. 13\u201328."},{"key":"6052_CR17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbadis.2004.06.001","volume":"1690","author":"H. H. Hsu","year":"2004","unstructured":"Hsu, H. H., and B. G. Abbo. 2004. Role of bicarbonate\/CO2 buffer in the initiation of vesicle mediated calcification: Mechanisms of aortic calcification related to atherosclerosis. Biochim. Biophys. Acta. 1690:118\u2013123.","journal-title":"Biochim. Biophys. Acta."},{"key":"6052_CR18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1023226616526","volume":"27","author":"S. S. Saini","year":"2003","unstructured":"Saini, S. S., D. L. Gessell-Lee, and J. W. Peterson. 2003. The Cox-2 specific inhibitor celecoxib inhibits adenylyl cyclase. Inflammation 27:79\u201388.","journal-title":"Inflammation"},{"key":"6052_CR19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2249.1995.tb03123.x","volume":"101","author":"A. R. Moore","year":"1995","unstructured":"Moore, A. R., and D. A. Willoughby. 1995. The role of cAMP regulation in controlling inflammation [Review]. Clin. Exp. Immunol. 101:387\u2013389.","journal-title":"Clin. Exp. Immunol."},{"key":"6052_CR20","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/jm030912m","volume":"47","author":"A. Weber","year":"2004","unstructured":"Weber, A., A. Casini, A. Heine, D. Kuhn, C. T. Supuran, A.Scozzafava, and G. Klebe. 2004. Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: New pharmacological opportunities due to related binding site recognition. J. Med. Chem. 47:550\u2013557.","journal-title":"J. Med. Chem."},{"key":"6052_CR21","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0021-9258(18)91392-X","volume":"239","author":"E. E. Rickli","year":"1964","unstructured":"Rickli, E. E., S. A. Ghazanfar, B. H. Gibbons, and J. T. Edsall. 1964. Carbonic anhydrases from human erythrocytes. Preparation and properties of two enzymes. J. Biol. Chem. 239:1065\u20131078.","journal-title":"J. Biol. Chem."},{"key":"6052_CR22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0014-5793(91)80922-P","volume":"289","author":"P. O. Freskg\u00e5rd","year":"1991","unstructured":"Freskg\u00e5rd, P. O., U. Carlsson, L. G. M\u00e5rtensson, and B. H. Jonsson. 1991. Folding around the C-terminus of human carbonic anhydrase II. Kinetic characterization by use of a chemically reactive SH-group introduced by protein engineering. FEBS Lett. 289:117\u2013122.","journal-title":"FEBS Lett."},{"key":"6052_CR23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1021\/bi00052a029","volume":"32","author":"L. G. M\u00e5rtensson","year":"1993","unstructured":"M\u00e5rtensson, L. G., B. H. Jonsson, P. O. Freskg\u00e5rd, A. Kihlgren, M. Svensson, and U. Carlsson. 1993. Characterization of folding intermediates of human carbonic anhydrase II: Probing substructure by chemical labeling of SH groups introduced by site-directed mutagenesis. Biochemistry 32:224\u2013231.","journal-title":"Biochemistry"},{"key":"6052_CR24","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/jnci\/94.23.1745","volume":"94","author":"J. Zhu","year":"2002","unstructured":"Zhu, J., X. Song, H. P. Lin, D. C. Young, S. Yan, V. E. Marquez, and C. S. Chen. 2002. Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents. J. Natl. Cancer Inst. 94:1745\u20131757.","journal-title":"J. Natl. Cancer Inst."},{"key":"6052_CR25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbadis.2003.09.004","volume":"1639","author":"P. Maderna","year":"2003","unstructured":"Maderna, P., and C. Godson. 2003. Phagocytosis of apoptotic cells and the resolution of inflammation. Biochim. Biophys. Acta. 1639:141\u2013151.","journal-title":"Biochim. Biophys. Acta."},{"key":"6052_CR26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2165\/00003495-199141040-00003","volume":"41","author":"K. McCormack","year":"1991","unstructured":"McCormack, K., and K. Brune. 1991. Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy. Drugs 41:533\u2013547.","journal-title":"Drugs"},{"key":"6052_CR27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/jnci\/94.8.585","volume":"94","author":"X. Song","year":"2002","unstructured":"Song, X., H. P. Lin, A. J. Johnson, P. H. Tsang, Y. T. Yang, and S. K. Kulp. 2002. Cyclooxygenase-2, a player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostatic cancer cells. J. Natl. Cancer Inst}. 94:585\u2013591.","journal-title":"J. Natl. Cancer Inst."},{"key":"6052_CR28","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/0016-5085(93)90900-W","volume":"105","author":"M. Mori","year":"1993","unstructured":"Mori, M., R. J. Staniunas, G. F. Barnard, J. M. Jessup, G. D. Steele Jr., and L. B. Chen. 1993. The significance of carbonic anhydrase expression in human colorectal cancer. Gastroenterology 105:820\u2013826.","journal-title":"Gastroenterology"},{"key":"6052_CR29","first-page":"133","volume":"27","author":"S. Parkkila","year":"1995","unstructured":"Parkkila, S., A. K. Parkkila, T. Juvonen, V. P. Lehto, and H. Rajaniemi. 1995. Immunohistochemical demonstration of the carbonic anhydrase isoenzymes I and II in pancreatic tumors. Histochem. J. 27:133\u2013138.","journal-title":"Histochem. J."},{"key":"6052_CR30","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1073\/pnas.040554897","volume":"97","author":"S. Parkkila","year":"2000","unstructured":"Parkkila, S., H. Rajaniemi, A. K. Parkkila, J. Kivel\u00e1, A. Waheed, S. Pastorekov\u00e1, J. Pastorek, and W. S. Sly. 2000. Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro. Proc. Natl. Acad. Sci. U.S.A. 97:2220\u20132224.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"6052_CR31","first-page":"1464","volume":"277","author":"I. Puscas","year":"1996","unstructured":"Puscas, I., M. Coltau, and R. Pasca. 1996. Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action. J. Pharmacol. Exp. Ther. 277:1464\u20131466.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"6052_CR32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physiol.00005.2004","volume":"19","author":"P. Paroutis","year":"2004","unstructured":"Paroutis, P., N. Touret, and S. Grinstein. 2004. The pH of secretory pathways: Measurement, determinants and regulation. Physiology 19:207\u2013215.","journal-title":"Physiology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-004-6052-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-004-6052-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-004-6052-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T22:13:42Z","timestamp":1626387222000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-004-6052-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["6052"],"URL":"https:\/\/doi.org\/10.1007\/s10753-004-6052-1","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}