{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T06:17:13Z","timestamp":1766902633558},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T00:00:00Z","timestamp":1204070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1007\/s10753-008-9057-3","type":"journal-article","created":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T19:14:39Z","timestamp":1204053279000},"page":"121-132","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Traditional Chinese Medicine on Endotoxin and Its Receptors in Rats with Non-Alcoholic Steatohepatitis"],"prefix":"10.1007","volume":"31","author":[{"given":"Yuan","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Xuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao-Na","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Yan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jie","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,2,27]]},"reference":[{"issue":"6","key":"9057_CR1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","volume":"116","author":"C. A. Matteoni","year":"1999","unstructured":"Matteoni, C. A., Z. M. Younossi, T. Gramlich, N. Boparai, Y. C. Liu, and A. J. McCullough. 1999. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 116(6):1413\u20131419.","journal-title":"Gastroenterology"},{"issue":"6","key":"9057_CR2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0016-5085(00)70364-7","volume":"118","author":"V. Ratziu","year":"2000","unstructured":"Ratziu, V., P. Giral, F. Charlotte, E. Bruckert, V. Thibault, I. Theodorou, et al. 2000. Liver fibrosis in overweight patients. Gastroenterology 118(6):1117\u20131123.","journal-title":"Gastroenterology"},{"issue":"4","key":"9057_CR3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jhep.2004.02.013","volume":"40","author":"E. E. Powell","year":"2004","unstructured":"Powell, E. E., W. G. Cooksley, R. Hanson, J. Searle, J. W. Halliday, and L. W. Powell. 2004. The natural history of nonalcoholic steatohepatiti: a follow-up study of forty-two patients for up to 21 years. J. Hepatol. 40(4):578\u2013584.","journal-title":"J. Hepatol"},{"issue":"8","key":"9057_CR4","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.2337\/diabetes.50.8.1844","volume":"50","author":"G. Marchesini","year":"2001","unstructured":"Marchesini, G., M. Brizi, G. Bianchi, et al. 2001. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50(8):1844\u20131850.","journal-title":"Diabetes"},{"issue":"5","key":"9057_CR5","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1053\/gast.2001.23256","volume":"120","author":"A. J. Sanyal","year":"2001","unstructured":"Sanyal, A. J., C. Campbell-sargent, F. Mirshahi, et al. 2001. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gasteroenterology 120(5):1183\u20131192.","journal-title":"Gasteroenterology"},{"key":"9057_CR6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.70.2.163","volume":"70","author":"D. L. Laskin","year":"2001","unstructured":"Laskin, D. L., B. Weinverger, and J. D. Laskin. 2001. Functional heterogeneity of liver and lung macrophage. J. Leukoc. J. Leukoc. Biol. 70:163.","journal-title":"J. Leukoc. Biol"},{"key":"9057_CR7","first-page":"203","volume":"38","author":"P. Portincasa","year":"2005","unstructured":"Portincasa, P., L. Grattagliano, V. O. Palmieri, and G. Palasciano. 2005. Nonalcoholic steatohepatitis: recent advances from experimental models to clinical management. Clin. Clin. Biol. 38:203\u2013217.","journal-title":"Clin. Biol"},{"key":"9057_CR8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/gut.48.2.206","volume":"48","author":"A. J. Wigg","year":"2001","unstructured":"Wigg, A. J., I. C. Roberts-Thomson, R. B. Dymock, P. J. McCarthy, R. H. Grose, and A. G. Cummins. 2001. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxemia, and tumor necrosis factor \u03b1 in the pathogenesis of non-alcoholic steatohepatitis. Gut 48:206\u2013211.","journal-title":"Gut"},{"issue":"2","key":"9057_CR9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0016-5085(91)90224-9","volume":"100","author":"S. N. Lichtman","year":"1991","unstructured":"Lichtman, S. N., J. Keku, J. H. Schwab, and R. B. Sartor. 1991. Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline. Gastroenterology 100(2):513\u2013519.","journal-title":"Gastroenterology"},{"key":"9057_CR10","first-page":"97","volume":"23","author":"Z.-J. Xu","year":"2003","unstructured":"Xu, Z.-J., J.-G. Fan, G.-L. Wang, X.-D. Ding, L.-Y. Tian, and X.-Y. Zheng. 2003. The effect of lactulose on the establishment of a rat model of non-alcoholic steatohepatitis. Zhonghua Xiaohua Zazhi. 23:97\u2013100.","journal-title":"Zhonghua Xiaohua Zazhi"},{"issue":"3","key":"9057_CR11","first-page":"207","volume":"10","author":"G.-Q. Zou","year":"2002","unstructured":"Zou, G.-Q., S. He, C.-A. Liu, and J.-P. Gong. 2002. Expression of lipopolysaccaride receptor CD14 in experimental alcoholic liver disease. Chin. J. Hepatol. 10(3):207\u2013210.","journal-title":"Chin. J. Hepatol"},{"issue":"8","key":"9057_CR12","first-page":"952","volume":"22","author":"A.-Y. Qiao","year":"2005","unstructured":"Qiao, A.-Y., Y.-D. Qian, X. Yang, and J.-S. Li. 2005. Implication of TLR4 and CD14 mRNA expression in lung and hepatic tissues in sepsis rats. Chin. J. Exp. Surg. 22(8):952\u2013953.","journal-title":"Chin. J. Exp. Surg"},{"issue":"17","key":"9057_CR13","first-page":"726","volume":"12","author":"X.-H. Du","year":"2005","unstructured":"Du, X.-H., Y.-M. Yao, R. Li, C.-A. Shen, and H.-N. Yin. 2005. Effects of toll-like receptor 4 and MD-2 gene expression in the lungs in septic rats on sex differences. Chin. Crit. Care MED. 12(17):726\u2013728.","journal-title":"Chin. Crit. Care MED"},{"key":"9057_CR14","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0016-5085(00)70180-6","volume":"118","author":"H. Liu","year":"2000","unstructured":"Liu, H., Z. Ma, and S. S. Lee. 2000. Contribution of nitric oxide to the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Gastroenterology 118:937\u2013934.","journal-title":"Gastroenterology"},{"key":"9057_CR15","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1056\/NEJM200011163432007","volume":"343","author":"H. Tilg","year":"2000","unstructured":"Tilg, H., and A. Diehl. 2000. Cytokines in alcoholic and nonalcoholic steatohepatitis. N. Engl. J. Med. 343:1467\u20131476.","journal-title":"N. Engl. J. Med"},{"key":"9057_CR16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/hep.20304","volume":"40","author":"L. Romics","year":"2004","unstructured":"Romics, L., Jr., K. Kodys, A. Dolganiuc, L. Graham, A. Velayudham, P. Mandrekar, et al. 2004. Diverse regulation of NF-\u03baB and peroxisome proliferator-activated receptors in nonalcoholic fatty liver. Hepatology 40:376\u2013385.","journal-title":"Hepatology"},{"key":"9057_CR17","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1073\/pnas.94.6.2557","volume":"94","author":"S. Q. Yang","year":"1997","unstructured":"Yang, S. Q., H. Z. Lin, M. D. Lane, M. Clemens, and A. M. Diehl. 1997. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc. Natl. Proc. Natl. Acad. Sci. U.S.A. 94:2557\u20132562.","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"9057_CR18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3748\/wjg.v7.i1.128","volume":"7","author":"R. Q. Wu","year":"2001","unstructured":"Wu, R. Q., Y. X. Xu, X. H. Song, L. J. Chen, and X. J. Meng. 2001. Adhesion molecule and proinflammatory cytokine gene expression in hepatic sinusoidal endothelial cells following cecal ligation and puncture. World J. Grastroenterol. 7:128\u2013130.","journal-title":"World J. Grastroenterol"},{"key":"9057_CR19","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1128\/IAI.69.11.6942-6950.2001","volume":"69","author":"T. Gutsmann","year":"2001","unstructured":"Gutsmann, T., M. Muller, S. F. Carroll, R. C. Mackenzie, A. Wiese, and U. Seydel. 2001. Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells. Infect. Immun. 69:6942\u20136950.","journal-title":"Infect. Immun"},{"key":"9057_CR20","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1128\/IAI.69.1.378-385.2001","volume":"69","author":"D. Heumann","year":"2001","unstructured":"Heumann, D., Y. Adachi, D. Le Roy, N. Ohno, T. Yadomae, M. P. Glauser, et al. 2001. Role of plasma, lipopolysaccharide-binding protein, and CD14 in response of mouse peritoneal exudates macrophages to endotoxin. Infect. Immun. 69:378\u2013385.","journal-title":"Infect. Immun"},{"issue":"18","key":"9057_CR21","doi-asserted-by":"crossref","first-page":"10482","DOI":"10.1074\/jbc.270.18.10482","volume":"270","author":"P. S. Tobias","year":"1995","unstructured":"Tobias, P. S., K. Soldau, J. A. Gegner, D. Mintz, and R. J. Ulevitch. 1995. Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J. Biol. Chem. 270(18):10482\u2013101488.","journal-title":"J. Biol. Chem"},{"key":"9057_CR22","doi-asserted-by":"crossref","first-page":"21129","DOI":"10.1074\/jbc.M009164200","volume":"276","author":"C. J. da Silva","year":"2001","unstructured":"da Silva, C. J., K. Soldau, U. Christen, P. S. Tobias, and R. J. Ulevitch. 2001. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 276:21129\u201321135.","journal-title":"J. Biol. Chem"},{"key":"9057_CR23","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","volume":"86","author":"B. Lemaine","year":"1996","unstructured":"Lemaine, B., E. Nicolas, L. Micham, J. M. Reichhan, and J. A. Hoffmann. 1996. The dorsovemtrad regulatory gene casseue spaizle\/Toll\/cacuis controls the potent antifungal response in Drosophila adults. Cell 86:973\u2013983.","journal-title":"Cell"},{"key":"9057_CR24","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.95.2.588","volume":"95","author":"F. L. Rock","year":"1998","unstructured":"Rock, F. L., G. Hardiman, J. C. Timans, R. A. Kastelein, and J. F. Bazan. 1998. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. U.S.A. 95:588\u2013593.","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"6","key":"9057_CR25","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/01.ALC.0000167744.60838.4A","volume":"29","author":"L. J. Romics","year":"2005","unstructured":"Romics, L. J., P. Mandrekar, K. Kodys, A. Velayudham, Y. Drechsler, A. Dolganiuc, et al. 2005. Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression. Res. Soc. Alcohol 29(6):1018\u20131026.","journal-title":"Res. Soc. Alcohol"},{"key":"9057_CR26","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/jhep.2003.50182","volume":"37","author":"P. Yong-Han","year":"2003","unstructured":"Yong-Han, P., F. S. Robert, B. Ramon, P. R. Maria, J. Christian, and A. B. David. 2003. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37:1043\u20131055.","journal-title":"Hepatology"},{"issue":"11","key":"9057_CR27","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.189.11.1777","volume":"189","author":"R. Shimazu","year":"1999","unstructured":"Shimazu, R., S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, et al. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189(11):1777\u20131782.","journal-title":"J. Exp. Med"},{"issue":"4975","key":"9057_CR28","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1126\/science.1698311","volume":"249","author":"S. D. Wright","year":"1990","unstructured":"Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14. a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249(4975):1431\u20131433.","journal-title":"Science"},{"key":"9057_CR29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/09680519030090010801","volume":"9","author":"A. E. Medvedev","year":"2003","unstructured":"Medvedev, A. E., and S. N. Vogel. 2003. Overexpression of CD14, TLR4, and MD-2 in HEK 293T cells does not prevent induction of in vitro endotoxin tolerance. J. Endotoxin. Res. 9:60\u201364.","journal-title":"J. Endotoxin. Res"},{"issue":"7","key":"9057_CR30","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1084\/jem.20031076","volume":"198","author":"S. Akashi","year":"2003","unstructured":"Akashi, S., S. Saitoh, Y. Wakabayashi, T. Kikuchi, N. Takamura, Y. Nagai, et al. 2003. Lipopolysaccharide interaction with cell surface toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J. Exp. Med. 198(7):1035\u20131042.","journal-title":"J. Exp. Med"},{"key":"9057_CR31","doi-asserted-by":"crossref","first-page":"15587","DOI":"10.1074\/jbc.M212829200","volume":"278","author":"N. W. Schroder","year":"2003","unstructured":"Schroder, N. W., S. Morath, C. Alexander, L. Hamann, T. Hartung, U. Zahringer, et al. 2003. Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J. Biol. Chem. 278:15587\u201315594.","journal-title":"J. Biol. Chem"},{"key":"9057_CR32","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","volume":"14","author":"A. S. Baldwin","year":"1996","unstructured":"Baldwin, A. S. Jr. 1996. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649\u2013683.","journal-title":"Annu. Rev. Immunol"},{"key":"9057_CR33","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jhep.2006.02.013","volume":"45","author":"K. A. Tazi","year":"2006","unstructured":"Tazi, K. A., J. J. Quioc, V. Saada, A. Bezeaud, D. Lebrec, and R. Moreau. 2006. Upregulation of TNF-alpha production signaling pathways in monocytes from patients with advanced cirrhosis: possible role of Akt and IRAK-M. Hepatology 45:280\u2013289.","journal-title":"Hepatology"},{"key":"9057_CR34","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1006\/bbrc.1997.7031","volume":"236","author":"Y. M. Kim","year":"1997","unstructured":"Kim, Y. M., B. S. Lee, K. Y. Yi, and S. G. Paik. 1997. Upstream NF-\u03baB site is required for the maximal expression of mouse inducible nitric oxide synthase gene in interferon-\u03b3 plus lipopolysaccharide-induced RAW 264.7 macrophages. Biochem. Biophys. Res. Commun. 236:655\u2013660.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"9057_CR35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mce.2007.05.013","volume":"274","author":"P. Dejkhamron","year":"2007","unstructured":"Dejkhamron, P., J. Thimmarayappa, K. Kotlyarevska, J. Sun, C. Lu, E. L. Bonkowski, et al. 2007. Lipopolysaccharide (LPS) directly suppresses growth hormone receptor (GHR) expression through MyD88-dependent and -independent Toll-like receptor-4\/MD2 complex signaling pathways. Mol. Cell Endocrinol. 274:35\u201342.","journal-title":"Mol. Cell Endocrinol"},{"key":"9057_CR36","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bbrc.2006.05.170","volume":"346","author":"M. J. Song","year":"2006","unstructured":"Song, M. J., K. H. Kim, J. M. Yoon, J. B. Kim. 2006. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem. Biophys. Res. Commun. 346:739\u2013745.","journal-title":"Biochem. Biophys. Res. Commun"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-008-9057-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-008-9057-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-008-9057-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T17:43:13Z","timestamp":1684258993000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-008-9057-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,27]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["9057"],"URL":"https:\/\/doi.org\/10.1007\/s10753-008-9057-3","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,27]]}}}