{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:56:28Z","timestamp":1762541788560},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T00:00:00Z","timestamp":1235433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1007\/s10753-009-9111-9","type":"journal-article","created":{"date-parts":[[2009,2,23]],"date-time":"2009-02-23T17:30:12Z","timestamp":1235410212000},"page":"130-137","source":"Crossref","is-referenced-by-count":42,"title":["Tetracyclines and Chemically Modified Tetracycline-3 (CMT-3) Modulate Cytokine Secretion by Lipopolysaccharide-Stimulated Whole Blood"],"prefix":"10.1007","volume":"32","author":[{"given":"Julia","family":"Cazalis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Grenier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,2,24]]},"reference":[{"key":"9111_CR1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-0757.1997.tb00191.x","volume":"14","author":"K. S. Kornman","year":"1997","unstructured":"Kornman, K. S., R. C. Page, and M. S. Tonetti. 1997. The host response to the microbial challenge in periodontitis: assembling the players. Periodontol 2000 14:33\u201353. doi: 10.1111\/j.1600-0757.1997.tb00191.x .","journal-title":"Periodontol. 2000"},{"key":"9111_CR2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-0757.1994.tb00021.x","volume":"5","author":"J. L. Ebersole","year":"1994","unstructured":"Ebersole, J. L., and M. Taubman. 1994. The protective nature of host responses in periodontal diseases. Periodontol 2000 5:112\u2013141. doi: 10.1111\/j.1600-0757.1994.tb00021.x .","journal-title":"Periodontol. 2000"},{"key":"9111_CR3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/10454411980090030101","volume":"9","author":"H. Okada","year":"1998","unstructured":"Okada, H., and S. Murakami. 1998. Cytokine expression in periodontal health and disease. Crit. Rev. Oral Biol. Med. 9:248\u2013266. doi: 10.1177\/10454411980090030101 .","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"9111_CR4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1600-0765.1993.tb02113.x","volume":"28","author":"H. Birkedal-Hansen","year":"1993","unstructured":"Birkedal-Hansen, H. 1993. Role of cytokines and inflammatory mediators in tissue destruction. J. Periodontal. Res. 28:500\u2013510. doi: 10.1111\/j.1600-0765.1993.tb02113.x .","journal-title":"J. Periodontal. Res."},{"key":"9111_CR5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/07853890600800103","volume":"38","author":"T. Sorsa","year":"2006","unstructured":"Sorsa, T., L. Tj\u00e4derhane, Y. T. Konttinen, et al. 2006. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann. Med. 38:306\u2013321. doi: 10.1080\/07853890600800103 .","journal-title":"Ann. Med."},{"key":"9111_CR6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","volume":"25","author":"S. S. Socransky","year":"1998","unstructured":"Socransky, S. S., A. D. Haffajee, M. A. Gugini, C. Smith, and R. L. Kent. 1998. Microbial complexes in subgingival plaque. J. Periodontol. 25:134\u2013144. doi: 10.1111\/j.1600-051X.1998.tb02419.x .","journal-title":"J. Periodontol."},{"key":"9111_CR7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/154405910608500306","volume":"85","author":"C. Bodet","year":"2006","unstructured":"Bodet, C., F. Chandad, and D. Grenier. 2006. Anti-inflammatory activity of a high-molecular-weight cranberry fraction on macrophages stimulated by lipopolysaccharides from periodontopathogens. J. Dent. Res. 85:235\u2013239. doi: 10.1177\/154405910608500306 .","journal-title":"J. Dent. Res."},{"key":"9111_CR8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1600-0722.2007.00415.x","volume":"115","author":"C. Bodet","year":"2007","unstructured":"Bodet, C., F. Chandad, and D. Grenier. 2007. Cranberry components inhibit interleukin-6, interleukin-8, and prostaglandin E2 production by lipopolysaccharide-activated gingival fibroblasts. Eur. J. Oral Sci. 115:64\u201370. doi: 10.1111\/j.1600-0722.2007.00415.x .","journal-title":"Eur. J. Oral Sci."},{"key":"9111_CR9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jcp.21018","volume":"212","author":"C. Bodet","year":"2007","unstructured":"Bodet, C., E. Andrian, S. I. Tanabe, and D. Grenier. 2007. Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction. J. Cell Physiol. 212:189\u2013194. doi: 10.1002\/jcp.21018 .","journal-title":"J. Cell Physiol."},{"key":"9111_CR10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2249.2005.02956.x","volume":"143","author":"C. Bodet","year":"2005","unstructured":"Bodet, C., F. Chandad, and D. Grenier. 2005. Porphyromonas gingivalis-induced inflammatory mediator profile in an ex vivo human whole blood model. Clin. Exp. Immunol. 143:50\u201357. doi: 10.1111\/j.1365-2249.2005.02956.x .","journal-title":"Clin. Exp. Immunol."},{"key":"9111_CR11","first-page":"515","volume":"73","author":"P. Bidault","year":"2007","unstructured":"Bidault, P., F. Chandad, and D. Grenier. 2007. Systemic antibiotic therapy in the treatment of periodontitis. J. Can. Dent. Assoc. 73:515\u2013520.","journal-title":"J. Can. Dent. Assoc."},{"key":"9111_CR12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-051X.1995.tb01767.x","volume":"22","author":"R. Seymour","year":"1995","unstructured":"Seymour, R., and P. A. Heasman. 1995. Tetracyclines in the management of periodontal diseases. J. Clin. Periodontol. 22:22\u201335.","journal-title":"J. Clin. Periodontol."},{"key":"9111_CR13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","volume":"54","author":"A. N. Sapadin","year":"2006","unstructured":"Sapadin, A. N., and R. Fleischmajer. 2006. Tetracyclines: Nonantibiotic properties and their clinical implications. J. Am. Acad. Dermatol. 54:258\u2013265. doi: 10.1016\/j.jaad.2005.10.004 .","journal-title":"J. Am. Acad. Dermatol."},{"key":"9111_CR14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/08959374980120010501","volume":"12","author":"L. M. Golub","year":"1998","unstructured":"Golub, L. M., H. M. Lee, M. E. Ryan, W. V. Giannobile, J. Payne, and T. Sorsa. 1998. Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv. Dent. Res. 12:12\u201326. doi: 10.1177\/08959374980120010501 .","journal-title":"Adv. Dent. Res."},{"key":"9111_CR15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1601-0825.2004.01038.x","volume":"10","author":"T. Sorsa","year":"2004","unstructured":"Sorsa, T., L. Tj\u00e4derhane, and T. Salo. 2004. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis. 10:311\u2013318. doi: 10.1111\/j.1601-0825.2004.01038.x .","journal-title":"Oral Dis."},{"key":"9111_CR16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0765.1991.tb01626.x","volume":"26","author":"W. L. Gabler","year":"1991","unstructured":"Gabler, W. L., and H. R. Creamer. 1991. Suppression of human neutrophil functions by tetracycline. J. Periodontal. Res. 26:52\u201358. doi: 10.1111\/j.1600-0765.1991.tb01626.x .","journal-title":"J. Periodontal. Res."},{"key":"9111_CR17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/10454411910020030201","volume":"2","author":"L. M. Golub","year":"1991","unstructured":"Golub, L. M., N. S. Ramamurthy, T. F. McNamara, R. A. Greenwald, and R. R. Rifkin. 1991. Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit. Rev. Oral Biol. Med. 2:297\u2013321.","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"9111_CR18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ijc.10168","volume":"98","author":"B. L. Lokeshwar","year":"2002","unstructured":"Lokeshwar, B. L., M. G. Selzer, B. Q. Zhu, N. L. Block, and L. M. Golub. 2002. Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral nonantimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model. Int. J. Cancer 98:297\u2013302. doi: 10.1002\/ijc.10168 .","journal-title":"Int. J. Cancer"},{"key":"9111_CR19","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1128\/JB.155.2.831-838.1983","volume":"155","author":"R. P. Darveau","year":"1983","unstructured":"Darveau, R. P., and R. E. Hancock. 1983. Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains. J. Bacteriol. 155:831\u2013838.","journal-title":"J. Bacteriol."},{"key":"9111_CR20","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.4049\/jimmunol.163.6.3459","volume":"163","author":"R. N. Patel","year":"1999","unstructured":"Patel, R. N., M. G. Attur, M. N. Dave, et al. 1999. A novel mechanism of action of chemically modified tetracyclines: inhibition of COX-2-mediated prostaglandin E2 production. J. Immunol. 163:3459\u20133467.","journal-title":"J. Immunol."},{"key":"9111_CR21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.4049\/jimmunol.176.1.567","volume":"176","author":"J. C. Hoyt","year":"2006","unstructured":"Hoyt, J. C., J. Ballering, H. Numanami, J. M. Hayden, and R. A. Robbins. 2006. Doxycycline modulates nitric oxide production in murine lung epithelial cells. J. Immunol. 176:567\u2013572.","journal-title":"J. Immunol."},{"key":"9111_CR22","first-page":"1807","volume":"25","author":"W. Pruzanski","year":"1998","unstructured":"Pruzanski, W., E. Stefanski, P. Vadas, T. F. McNamara, N. Ramamurthy, and L. M. Golub. 1998. Chemically modified non-antimicrobial tetracyclines inhibit activity of phospholipases A2. J. Rheumatol. 25:1807\u20131812.","journal-title":"J. Rheumatol."},{"key":"9111_CR23","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1902\/jop.2008.080051","volume":"79","author":"J. Cazalis","year":"2008","unstructured":"Cazalis, J., C. Bodet, G. Gagnon, and D. Grenier. 2008. Doxycycline reduces lipopolysaccharide-induced inflammatory mediator secretion in macrophage and ex vivo human whole blood models. J. Periodontol. 79:1762\u20131768. doi: 10.1902\/jop.2008.080051 .","journal-title":"J. Periodontol."},{"key":"9111_CR24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1177\/154411130301400605","volume":"14","author":"D. F. Kinane","year":"2003","unstructured":"Kinane, D. F., and T. C. Hart. 2003. Genes and gene polymorphisms associated with periodontal disease. Crit. Rev. Oral Biol. Med. 14:430\u2013449. doi: 10.1177\/154411130301400605 .","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"9111_CR25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1902\/jop.2003.74.3.391","volume":"74","author":"D. T. Graves","year":"2003","unstructured":"Graves, D. T., and D. Cochran. 2003. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J. Periodontol. 74:391\u2013401. doi: 10.1902\/jop.2003.74.3.391 .","journal-title":"J. Periodontol."},{"key":"9111_CR26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4049\/jimmunol.160.1.403","volume":"160","author":"R. Assuma","year":"1998","unstructured":"Assuma, R., T. Oates, D. Cochran, S. Amar, and D. T. Graves. 1998. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J. Immunol. 160:403\u2013409.","journal-title":"J. Immunol."},{"key":"9111_CR27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1902\/jop.1994.65.2.147","volume":"65","author":"K. Takahashi","year":"1994","unstructured":"Takahashi, K., S. Takashiba, A. Nagai, et al. 1994. Assessment of interleukin-6 in the pathogenesis of periodontal disease. J. Periodontol. 65:147\u2013153.","journal-title":"J. Periodontol."},{"key":"9111_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(02)00915-8","volume":"32","author":"O. Kudo","year":"2003","unstructured":"Kudo, O., A. Sabokbar, A. Pocock, I. Itonaga, Y. Fujikawa, and N. A. Athanasou. 2003. Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. Bone 32:1\u20137. doi: 10.1016\/S8756\u20133282(02)00915\u20138 .","journal-title":"Bone"},{"key":"9111_CR29","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1210\/endo.139.3.5818","volume":"139","author":"K. Kusano","year":"1998","unstructured":"Kusano, K., C. Miyaura, M. Inada, et al. 1998. Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption. Endocrinology 139:1338\u20131345. doi: 10.1210\/en.139.3.1338 .","journal-title":"Endocrinology"},{"key":"9111_CR30","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1034\/j.1600-051X.2002.290704.x","volume":"29","author":"L. J. Jin","year":"2002","unstructured":"Jin, L. J., W. K. Leung, E. F. Corbet, and B. Soder. 2002. Relationship of changes in interleukin-8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens following non-surgical periodontal therapy in subjects with chronic periodontitis. J. Clin. Periodontol. 29:604\u2013614. doi: 10.1034\/j.1600-051X.2002.290704.x .","journal-title":"J. Clin. Periodontol."},{"key":"9111_CR31","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1034\/j.1600-0765.2001.360309.x","volume":"36","author":"J. Gamonal","year":"2001","unstructured":"Gamonal, J., A. Acevedo, A. Bascones, O. Jorge, and A. Silva. 2001. Characterization of cellular infiltrate, detection of chemokine receptor CCR5 and interleukin-8 and RANTES chemokines in adult periodontitis. J. Periodontal. Res. 36:194\u2013203. doi: 10.1034\/j.1600-0765.2001.360309.x .","journal-title":"J. Periodontal. Res."},{"key":"9111_CR32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S8756-3282(97)00221-4","volume":"22","author":"R. A. Greenwaldm","year":"1998","unstructured":"Greenwaldm, R. A., L. M. Golub, N. S. Ramamurthy, M. Chowdhury, S. A. Moak, and T. Sorsa. 1998. In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation. Bone 22:33\u201338. doi: 10.1016\/S8756-3282(97)00221-4 .","journal-title":"Bone"},{"key":"9111_CR33","doi-asserted-by":"crossref","first-page":"31054","DOI":"10.1074\/jbc.272.50.31504","volume":"272","author":"R. Hanemaaijer","year":"1997","unstructured":"Hanemaaijer, R., T. Sorsa, Y. T. Konttinen, et al. 1997. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. J. Biol. Chem. 272:31054\u201331059. doi: 10.1074\/jbc.272.50.31504 .","journal-title":"J. Biol. Chem."},{"key":"9111_CR34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1034\/j.1600-051x.2000.027001053.x","volume":"27","author":"D. Sakellari","year":"2000","unstructured":"Sakellari, D., J. M. Goodson, S. S. Socransky, A. Kolokotronis, and A. Konstantinidis. 2000. Concentration of 3 tetracyclines in plasma, gingival crevice fluid and saliva. J. Clin. Periodontol. 27:53\u201360. doi: 10.1034\/j.1600-051x.2000.027001053.x .","journal-title":"J. Clin. Periodontol."},{"key":"9111_CR35","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1902\/jop.2000.71.9.1472","volume":"71","author":"J. Thomas","year":"2000","unstructured":"Thomas, J., C. Walker, and M. Bradshaw. 2000. Long-term use of subantimicrobial dose doxycycline does not lead to changes in antimicrobial susceptibility. J. Periodontol. 71:1472\u20131483. doi: 10.1902\/jop.2000.71.9.1472 .","journal-title":"J. Periodontol."}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-009-9111-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-009-9111-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-009-9111-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T03:59:00Z","timestamp":1684900740000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-009-9111-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,24]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["9111"],"URL":"https:\/\/doi.org\/10.1007\/s10753-009-9111-9","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,24]]}}}