{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:42:39Z","timestamp":1783690959330,"version":"3.55.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T00:00:00Z","timestamp":1252972800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1007\/s10753-009-9151-1","type":"journal-article","created":{"date-parts":[[2009,9,14]],"date-time":"2009-09-14T17:04:18Z","timestamp":1252947858000},"page":"419-425","source":"Crossref","is-referenced-by-count":47,"title":["Anti-inflammatory and Immunomodulatory Effects of Baccharis trimera Aqueous Extract on Induced Pleurisy in Rats and Lymphoproliferation In Vitro"],"prefix":"10.1007","volume":"32","author":[{"given":"Elisiane Lozza","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adroaldo","family":"Lunardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Caberlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Bernardes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Christ Vianna","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlei","family":"Biolchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Maria Alves","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Barbosa","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Bordignon","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Gosmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarbas Rodrigues","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,9,15]]},"reference":[{"key":"9151_CR1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0378-8741(01)00406-8","volume":"79","author":"S. Geetha","year":"2002","unstructured":"Geetha, S., M. Sai Ram, V. Singh, G. Ilavazhagan, and R. C. Sawhney. 2002. Anti-oxidant and immunomodulatory properties of seabuckthorn (Hippophae rhamnoides)-and in vitro study. J. Ethnopharmacol. 79:373\u2013378.","journal-title":"J. Ethnopharmacol"},{"key":"9151_CR2","volume-title":"Dicion\u00e1rio das plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas","author":"M. P. Corr\u00eaa","year":"1984","unstructured":"Corr\u00eaa, M. P. 1984. Dicion\u00e1rio das plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas. 1Imprensa Nacional, Instituto Brasileiro de Desenvolvimento Florestal, Rio de Janeiro.","edition":"1"},{"key":"9151_CR3","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0031-9422(00)00223-5","volume":"55","author":"L. M. Brand\u00e3o Torres","year":"2000","unstructured":"Brand\u00e3o Torres, L. M., M. T. Gamberini, N. F. Roque, M. T. Lima-Landman, C. Souccar, and A. J. Lapa. 2000. Diterpene from Baccharis trimera with a relaxant effect on rat vascular smooth muscle. Phytochemistry. 55:617\u2013619.","journal-title":"Phytochemistry"},{"key":"9151_CR4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-8741(98)00029-4","volume":"61","author":"B. Las Heras De","year":"1998","unstructured":"De Las Heras, B., K. Slowing, J. Benedi, E. Carretero, T. Ortega, C. Toledo, P. Bermejo, I. Iglesias, M. J. Abad, P. G. Serranillos, P. A. Liso, A. Villar, and X. Chiriboga. 1998. Anti-inflammatory and antioxidant activity of plants used in traditional medicine in Ecuador. J. Ethnopharmacol. 61:161\u2013166.","journal-title":"J. Ethnopharmacol"},{"issue":"1","key":"9151_CR5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1055\/s-2006-962613","volume":"53","author":"H. Soicke","year":"1987","unstructured":"Soicke, H., and A. Leng-Peschlow. 1987. Characterisation of flavonoids from Baccharis trimera and their antihepatotoxic properties. Planta Med. 53(1):37\u201339.","journal-title":"Planta Med"},{"key":"9151_CR6","first-page":"37","volume":"58","author":"R. M. Gen\u00e9","year":"1992","unstructured":"Gen\u00e9, R. M., E. Marin, and T. Adzet. 1992. Anti-inflammatory effect of aqueous extracts of three species of the genus Baccharis. Planta Med. 58:37\u201339.","journal-title":"Planta Med"},{"key":"9151_CR7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1055\/s-2006-957866","volume":"62","author":"R. M. Gen\u00e9","year":"1996","unstructured":"Gen\u00e9, R. M., C. Carta\u00f1\u00e1, T. Adzet, E. Marin, T. Parella, and S. Ca\u00f1igueral. 1996. Anti-inflammatory and analgesic activity of Baccharis trimera: identification of its active constituents. Planta Med. 62:232\u2013235.","journal-title":"Planta Med"},{"key":"9151_CR8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0378-8741(01)00333-6","volume":"78","author":"K. Srinivasan","year":"2001","unstructured":"Srinivasan, K., S. Muruganandan, J. Lal, S. Chandra, S. K. Tandan, and V. Ravi Prakash. 2001. Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats. J Ethnopharmacol. 78:151\u2013157.","journal-title":"J Ethnopharmacol"},{"key":"9151_CR9","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(99)00086-8","volume":"20","author":"T. S. F. Saleh","year":"1999","unstructured":"Saleh, T. S. F., J. B. Calixto, and Y. S. Medeiros. 1999. Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carregeenan. Peptides. 20:949\u2013956.","journal-title":"Peptides"},{"key":"9151_CR10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.phrs.2003.10.009","volume":"49","author":"J. C. F. Alves Filho","year":"2004","unstructured":"Alves Filho, J. C. F., R. C. V. Santos, T. A. Castaman, and J. R. Oliveira. 2004. Anti-inflammatory effects of fructose-1,6-bisphosphate on carrageenan-induced pleurisy in rat. Pharmacol. Res. 49:245\u2013248.","journal-title":"Pharmacol. Res"},{"key":"9151_CR11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-3565(25)33046-6","volume":"221","author":"T. N. Lo","year":"1982","unstructured":"Lo, T. N., A. P. Almeida, and M. A. Braven. 1982. Dextran and carrageenan evoke different inflammatory responses in rat with respect to composition of infiltrates and effect of indomethacin. J. Pharmacol. Exp. Ther. 221:261\u2013267.","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"9151_CR12","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1476-5381.1996.tb15472.x","volume":"118","author":"T. S. Saleh","year":"1996","unstructured":"Saleh, T. S., J. B. Calixto, and I. S. Medeiros. 1996. Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy. Br. J. Pharmacol. 118:811\u2013819.","journal-title":"Br. J. Pharmacol"},{"key":"9151_CR13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00011-006-6044-8","volume":"55","author":"R. P. Lopes","year":"2006","unstructured":"Lopes, R. P., A. Lunardelli, T. Preissler, C. E. Leite, J. C. F. Alves-Filho, F. B. Nunes, J. R. Oliveira, and M. E. Bauer. 2006. The effects of fructose-1,6-bisphosphate and dexamethasone on acute inflammation and T-cell proliferation. Inflamm. Res. 55:354\u2013358.","journal-title":"Inflamm. Res"},{"issue":"1","key":"9151_CR14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10753-008-9102-2","volume":"32","author":"D. E. Severino","year":"2009","unstructured":"Severino, D. E., R. L. Pereira, I. Knysak, D. M. C\u00e2ndido, and F. H. Kwasniewski. 2009. Edematogenic activity of scorpion venoms from the Buthidae family and the role of platelet-activating factor and nitric oxide in paw edema induced by Tityus venoms. Inflammation. 32(1):57\u201364.","journal-title":"Inflammation"},{"key":"9151_CR15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1567-5769(02)00296-5","volume":"3","author":"E. M. Souza-Fagundes","year":"2003","unstructured":"Souza-Fagundes, E. M., G. Gazzinelli, G. G. Parreira, O. A. Martins-Filho, G. P. Amarante-Mendes, R. Correa-Oliveira, and C. L. Zani. 2003. In vitro activity of labdane diterpene from Alomia myriadenia (Asteraceae): immunosuppression via induction of apoptosis in monocytes. Int. Immunopharmacol. 3:383\u2013392.","journal-title":"Int. Immunopharmacol"},{"issue":"3","key":"9151_CR16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0165-2478(02)00066-4","volume":"83","author":"R. C. Dutta","year":"2002","unstructured":"Dutta, R. C. 2002. Peptide immunomodulators versus infection; an analysis. Immunol. Lett. 83(3):153\u2013161.","journal-title":"Immunol. Lett"},{"key":"9151_CR17","first-page":"29","volume":"39","author":"C. E. Leite","year":"2007","unstructured":"Leite, C. E., A. Lunardelli, T. A. Castaman, E. L. Paul, and J. R. Oliveira. 2007. Extrato aquoso de Baccharis trimera (Asteraceae) diminui a inflama\u00e7\u00e3o e o dano celular em pleurisia induzida por veneno de Dirphia sp. (Saturniidae). Rev. Bras. An\u00e1l. Cl\u00edn. 39:29\u201332.","journal-title":"Rev. Bras. An\u00e1l. Cl\u00edn"},{"key":"9151_CR18","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1080\/10826070600916609","volume":"29","author":"S. Q. Oliveira De","year":"2006","unstructured":"De Oliveira, S. Q., G. Barbon, S. Bordignon, and G. Gosmann. 2006. Diferentation of south Brazilian Baccharis species by TLC. J. Liq. Chromatogr. Relat. Technol. 29:2603\u20132609.","journal-title":"J. Liq. Chromatogr. Relat. Technol"},{"key":"9151_CR19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-3-642-68773-0_17","volume-title":"Drogenanalyse: Dunnschichtchromatographishe Analyse von Arzneidrogen","author":"H. Wagner","year":"1983","unstructured":"Wagner, H. 1983. Drogenanalyse: Dunnschichtchromatographishe Analyse von Arzneidrogen. Springer, Berlin, pp. 291\u2013293."},{"key":"9151_CR20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00011-006-0008-x","volume":"55","author":"A. Lunardelli","year":"2006","unstructured":"Lunardelli, A., C. E. Leite, M. G. S. Pires, and J. R. Oliveira. 2006. Extract of the bristles of Dirphia sp. increases nitric oxide in a rat pleurisy model. Inflamm. Res. 55:129\u2013135.","journal-title":"Inflamm. Res"},{"key":"9151_CR21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1567-5769(02)00295-3","volume":"3","author":"F. B. Nunes","year":"2003","unstructured":"Nunes, F. B., C. M. Graziottin, J. C. F. Alves-Filho, A. Lunardelli, E. Caberlon, A. Peres, and J. R. Oliveira. 2003. Immunomodulatory effect of fructose-1,6-bisphosphate on T-lymphocytes. Int. Immunopharmacol. 3:267\u2013272.","journal-title":"Int. Immunopharmacol"},{"key":"9151_CR22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1020563913045","volume":"19","author":"A. F. Suffredini","year":"1999","unstructured":"Suffredini, A. F., G. Fantuzzi, R. Badolato, J. J. Oppnheim, and N. P. O\u2019Grady. 1999. New insights into the biology of the acute phase response. J. Clin. Immunol. 19:203\u2013214.","journal-title":"J. Clin. Immunol"},{"key":"9151_CR23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-8741(00)00234-8","volume":"72","author":"Z. Amirghofran","year":"2000","unstructured":"Amirghofran, Z., M. Azadbakht, and M. H. Karimi. 2000. Evaluation of the immunomodulatory effects of five herbal plants. J. Ethnopharmacol. 72:167\u2013172.","journal-title":"J. Ethnopharmacol"},{"key":"9151_CR24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-8741(97)00106-2","volume":"58","author":"E. Mongelli","year":"1997","unstructured":"Mongelli, E., C. Desmarchelier, T. J. Rodrigues, J. Coussio, and G. Ciccia. 1997. In vitro antioxidant and cytotoxic activity of extracts of Baccharis coridifolia DC. J. Ethnopharmacol. 58:157\u2013163.","journal-title":"J. Ethnopharmacol"},{"key":"9151_CR25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/lsm.20658","volume":"40","author":"E. S. Boschi","year":"2008","unstructured":"Boschi, E. S., C. E. Leite, V. C. Saciura, E. Caberlon, A. Lunardelli, S. Bitencourt, D. A. S. Melo, and J. R. Oliveira. 2008. Anti-inflammatory effects of low-level laser therapy (660\u00a0nm) in the early phase in carrageenan-induced pleurisy in rat. Lasers Surg. Med. 40:500\u2013508.","journal-title":"Lasers Surg. Med"},{"issue":"3","key":"9151_CR26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10753-008-9064-4","volume":"31","author":"F. Aimbire","year":"2008","unstructured":"Aimbire, F., A. P. L. Oliveira, R. Albertini, J. C. Corr\u00eaa, C. B. L. Campos, J. P. Lyon, J. A. Silva Jr., and M. S. Costa. 2008. Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1\u03b2 levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation. 31(3):189\u2013197.","journal-title":"Inflammation"},{"key":"9151_CR27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1211\/jpp.60.4.0010","volume":"60","author":"F. Spiller","year":"2008","unstructured":"Spiller, F., M. K. Alves, S. M. Vieira, T. A. Carvalho, C. E. Leite, A. Lunardelli, J. A. T. Poloni, F. Q. Cunha, and J. R. Oliveira. 2008. Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation. J. Pharm. Pharmacol. 60:473\u2013478.","journal-title":"J. Pharm. Pharmacol"},{"key":"9151_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-2797(01)00285-X","volume":"139","author":"P. Hodek","year":"2002","unstructured":"Hodek, P., P. Trefil, and M. Stiborov\u00e1. 2002. Flavonoids-potent and versatile biologically active componds interacting with cytochromes P450. Chem.-Biol. Interact. 139:1\u201321.","journal-title":"Chem.-Biol. Interact"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-009-9151-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-009-9151-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-009-9151-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T04:11:03Z","timestamp":1739333463000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-009-9151-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,15]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["9151"],"URL":"https:\/\/doi.org\/10.1007\/s10753-009-9151-1","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,15]]}}}