{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:17:29Z","timestamp":1791001049206,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,5,22]],"date-time":"2010-05-22T00:00:00Z","timestamp":1274486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s10753-010-9222-3","type":"journal-article","created":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T03:35:50Z","timestamp":1274412950000},"page":"184-192","source":"Crossref","is-referenced-by-count":65,"title":["A Role of Piperine on Monosodium Urate Crystal-Induced Inflammation\u2014An Experimental Model of Gouty Arthritis"],"prefix":"10.1007","volume":"34","author":[{"given":"Evan Prince","family":"Sabina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruthi","family":"Nagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahaboobkhan","family":"Rasool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,22]]},"reference":[{"key":"9222_CR1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00002281-200105000-00015","volume":"13","author":"CA Agudelo","year":"2001","unstructured":"Agudelo, C.A., and C.M. Wise. 2001. Gout: Diagnosis, pathogenesis, and clinical manifestations. Current Opinion in Rheumatology 13: 234\u2013239.","journal-title":"Current Opinion in Rheumatology"},{"key":"9222_CR2","doi-asserted-by":"crossref","first-page":"46S","DOI":"10.1016\/S0002-9343(97)89546-0","volume":"100","author":"HR Schumacher Jr","year":"1996","unstructured":"Schumacher Jr., H.R. 1996. Crystal-induced arthritis: An overview. The American Journal of Medicine 100: 46S\u201352S.","journal-title":"The American Journal of Medicine"},{"key":"9222_CR3","first-page":"2329","volume-title":"Arthritis and allied conditions","author":"RA Terkelaub","year":"2001","unstructured":"Terkelaub, R.A. 2001. Pathogenesis and treatment of crystal-induced inflammation. In Arthritis and allied conditions, 14th ed, ed. W.J. Koopman, 2329\u20132347. Philadelphia: Lippincott William & Wilkins.","edition":"14"},{"key":"9222_CR4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0889-857X(21)00969-8","volume":"14","author":"RA Terkeltaub","year":"1988","unstructured":"Terkeltaub, R.A., and M.H. Ginsberg. 1988. The inflammatory reaction to crystals. Rheumatic Diseases Clinics of North America 14: 53\u201364.","journal-title":"Rheumatic Diseases Clinics of North America"},{"key":"9222_CR5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI115142","volume":"87","author":"FS Giovine Di","year":"1991","unstructured":"Di Giovine, F.S., S.E. Malawista, E. Thornton, and G.W. Duff. 1991. Urate crystals stimulate production of tumour necrosis factor alpha from human blood monocytes and synovial cells: Cytokine mRNA and protein kinetics, and cellular distribution. The Journal of Clinical Investigation 87: 175\u2013181.","journal-title":"The Journal of Clinical Investigation"},{"key":"9222_CR6","first-page":"2357","volume-title":"Arthritis and allied conditions","author":"R Terkeltaub","year":"2004","unstructured":"Terkeltaub, R. 2004. Pathogenesis and treatment of crystal-induced inflammation. In Arthritis and allied conditions, ed. W.J. Koopman and L.W. Moreland, 2357\u20132372. Philadelphia, Lippincott: Williams and Wilkins."},{"key":"9222_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408398209527343","volume":"17","author":"VS Govindarajan","year":"1982","unstructured":"Govindarajan, V.S. 1982. Ginger\u2014chemistry technology and quality evaluation: Part 1 CRC. Critical Reviews in Food Science & Nutrition 17: 1\u201396.","journal-title":"Critical Reviews in Food Science & Nutrition"},{"key":"9222_CR8","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.intimp.2004.08.005","volume":"4","author":"CR Pradeep","year":"2004","unstructured":"Pradeep, C.R., and G. Kuttan. 2004. Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells. International Immunopharmacology 4: 1795\u20131803.","journal-title":"International Immunopharmacology"},{"key":"9222_CR9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1055\/s-2003-42652","volume":"35","author":"S Panda","year":"2003","unstructured":"Panda, S., and A. Kar. 2003. Piperine lowers the serum concentrations of thyroid hormones, glucose, hepatic 5\u2019D activity in adult male mice. Hormone and Metabolic Research 35: 523.","journal-title":"Hormone and Metabolic Research"},{"key":"9222_CR10","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1248\/cpb.53.832","volume":"53","author":"SA Lee","year":"2005","unstructured":"Lee, S.A., S.S. Hong, and X.H. Han. 2005. Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and anti-depressant like activity. Chemical &Pharmaceutical Bulletin 53: 832.","journal-title":"Chemical &Pharmaceutical Bulletin"},{"key":"9222_CR11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1055\/s-2006-959721","volume":"59","author":"IB Koul","year":"1993","unstructured":"Koul, I.B., and A. Kapil. 1993. Evaluation of the liver protective potential of piperine, an active principle of black and white peppers. Planta Medica 59: 413.","journal-title":"Planta Medica"},{"key":"9222_CR12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jep.2003.10.016","volume":"90","author":"ES Sunila","year":"2004","unstructured":"Sunila, E.S., and G. Kuttan. 2004. Immunomodulatory and anti-tumour activity of Piper longum Linn, and piperine. Journal of Ethanopharmacology 90: 339.","journal-title":"Journal of Ethanopharmacology"},{"key":"9222_CR13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2165\/00023210-200216110-00002","volume":"16","author":"YN Singh","year":"2002","unstructured":"Singh, Y.N., and N.N. Singh. 2002. Therapeutic potential of kava in the treatment of anxiety disorders. CNS Drugs 16: 731\u2013743.","journal-title":"CNS Drugs"},{"key":"9222_CR14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.bcp.2006.05.003","volume":"72","author":"N Pathak","year":"2006","unstructured":"Pathak, N., and S. Khandelwal. 2006. Modulation of cadmium-induced alterations in murine thymocytes by piperine: Oxidative stress, apoptosis, phenotyping and blastogenesis. Biochemical Pharmacology 72: 486\u2013497.","journal-title":"Biochemical Pharmacology"},{"key":"9222_CR15","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/ar2662","volume":"11","author":"JS Bang","year":"2009","unstructured":"Bang, J.S., D.H. Oh, H.M. Choi, B.J. Sur, S.L. Lim, J.Y. Kim, H.I. Yang, M.C. Yoo, D.H. Hahm, and K.S. Kim. 2009. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1\u03b2-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Research & Therapy 11: R49.","journal-title":"Arthritis Research & Therapy"},{"issue":"3","key":"9222_CR16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cbi.2006.09.011","volume":"164","author":"M Rasool","year":"2006","unstructured":"Rasool, M., and P. Varalakshmi. 2006. Suppressive effect of Withania somnifera root powder on MSU crystal-induced inflammation\u2014an in vivo and in vitro study. Chemico-Biological Interactions 164(3): 174\u2013180.","journal-title":"Chemico-Biological Interactions"},{"key":"9222_CR17","first-page":"191","volume-title":"Practical clinical enzymology","author":"J King","year":"1965","unstructured":"King, J. 1965. The hydrolases\u2014acid and alkaline phosphatases. In Practical clinical enzymology, ed. D. Van, 191\u2013208. London: Nostrand Company Limited."},{"key":"9222_CR18","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0005-2744(71)90234-8","volume":"242","author":"Y Kawai","year":"1971","unstructured":"Kawai, Y., and K. Anno. 1971. Mucopolysaccharide-degrading enzymes from the liver of the squad, Ommastrephes slonaipacificus. I. Hyaluronidase. Biochimica et Biophysica Acta 242: 428\u2013436.","journal-title":"Biochimica et Biophysica Acta"},{"key":"9222_CR19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3181\/00379727-145-37786","volume":"145","author":"PD Rosenblit","year":"1974","unstructured":"Rosenblit, P.D., R.P. Metzyer, and A.N. Wick. 1974. Effect of Streptozotocin diabetes on acid phosphatase and selected glycosidase activities of serum and various rat organs. Proceedings of the Society for Experimental and Biological Medicine 145: 244\u2013247.","journal-title":"Proceedings of the Society for Experimental and Biological Medicine"},{"key":"9222_CR20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0009-8981(76)90147-9","volume":"73","author":"D Marhun","year":"1976","unstructured":"Marhun, D. 1976. Rapid colorimetric assay of \u03b2-galactosidase and N-acetyl-\u03b2-galactosaminidase in human urine. Clinica Chimica Acta 73: 453\u2013461.","journal-title":"Clinica Chimica Acta"},{"key":"9222_CR21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry, O.H., N.J. Rosebrough, A.I. Farr, and R.J. Randall. 1951. Protein measurement with the folin phenol reagent. The Journal of Biological Chemistry 193: 265\u2013275.","journal-title":"The Journal of Biological Chemistry"},{"key":"9222_CR22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0009-8981(86)90247-0","volume":"155","author":"A Ledwozyw","year":"1986","unstructured":"Ledwozyw, A., J. Michalak, A. Stepien, and A. Kadziolka. 1986. The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clinica Chimica Acta 155: 275\u2013284.","journal-title":"Clinica Chimica Acta"},{"key":"9222_CR23","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/0006-291X(74)90681-0","volume":"56","author":"J Hogberg","year":"1974","unstructured":"Hogberg, J., R.E. Larson, A. Kristoferson, and S. Orrenius. 1974. NADPH-dependent reductase solubilised from microsomes of peroxidation and its activity. Biochemical and Biophysical Research Communications 56: 836\u2013842.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"9222_CR24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"SL Marklund","year":"1974","unstructured":"Marklund, S.L., and G. Marklund. 1974. Involvement of superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry 47: 469\u2013474.","journal-title":"European Journal of Biochemistry"},{"key":"9222_CR25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","volume":"47","author":"AK Sinha","year":"1972","unstructured":"Sinha, A.K. 1972. Colorimetric assay of catalase. Analytical Biochemistry 47: 389\u2013394.","journal-title":"Analytical Biochemistry"},{"key":"9222_CR26","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","volume":"179","author":"JT Rotruk","year":"1973","unstructured":"Rotruk, J.T., A.L. Pope, H.E. Ganther, A.B. Swanson, D.G. Hafeman, and W.G. Hekstra. 1973. Selenium, biochemical role as a component of glutathione peroxidase purification and assay. Science 179: 588\u2013590.","journal-title":"Science"},{"key":"9222_CR27","first-page":"83","volume-title":"Practical clinical enzymology","author":"J King","year":"1965","unstructured":"King, J. 1965. The dehydrogenase or oxidoreductase-lactate dehydrogenase. In Practical clinical enzymology, ed. D. Van, 83\u201393. London: Nostrand."},{"key":"9222_CR28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/ajkd.2002.33911","volume":"40","author":"HM Kramer","year":"2002","unstructured":"Kramer, H.M., and G. Curhan. 2002. The association between gout and nephrolithiasis: The national health and nutrition examination survey III, 1988\u20131994. American Journal of Kidney Diseases 40: 37\u201342.","journal-title":"American Journal of Kidney Diseases"},{"issue":"3","key":"9222_CR29","first-page":"370","volume":"38","author":"A Saflna","year":"1992","unstructured":"Saflna, A., T. Korolenko, G. Mynkina, M. Dushkin, and G. Krasnoselskaya. 1992. Liver and serum lysosomal enzymes activity during zymosan-induced inflammation in mice. Agents and Actions 38(3): 370\u2013375.","journal-title":"Agents and Actions"},{"key":"9222_CR30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.vph.2005.02.001","volume":"42","author":"VR Ramprasad","year":"2005","unstructured":"Ramprasad, V.R., P. Shanthi, and P. Sachdanandam. 2005. Evaluation of antioxidant effect of Semecarpus anacardium Linn. nut extract on thecomponents of immune system in adjuvant arthritis. Vascular Pharmacology 42: 179\u2013186.","journal-title":"Vascular Pharmacology"},{"key":"9222_CR31","first-page":"443","volume":"31","author":"JN Dhully","year":"1993","unstructured":"Dhully, J.N., P.H. Raman, A.M. Mujumdar, and S.R. Naik. 1993. Inhibition of lipid peroxidation by piperine during experimental inflammation in rats. Indian Journal of Experimental Biology 31: 443\u20135.","journal-title":"Indian Journal of Experimental Biology"},{"key":"9222_CR32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/10408390601062054","volume":"47","author":"K Srinivasan","year":"2007","unstructured":"Srinivasan, K. 2007. Black pepper and its pungent principle-piperine: A review of diverse physiological effects. Critical Reviews in Food Science & Nutrition 47: 735\u2013748.","journal-title":"Critical Reviews in Food Science & Nutrition"},{"key":"9222_CR33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0367-326X(02)00304-0","volume":"74","author":"K Selvendiran","year":"2003","unstructured":"Selvendiran, K., P.V. Singh, and K. Baba Krishnan. 2003. Cytoprotective effect of piperine against benzo(a)pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice. Fitoterapia 74: 109\u2013115.","journal-title":"Fitoterapia"},{"key":"9222_CR34","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/ard.47.9.768","volume":"47","author":"FS Giovine Di","year":"1988","unstructured":"Di Giovine, F.S., G. Nuki, and G.W. Duff. 1988. Tumour necrosis factor in synovial exudates. Annals of the Rheumatic Diseases 47: 768\u2013772.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"9222_CR35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/art.1780250210","volume":"25","author":"S Abramson","year":"1982","unstructured":"Abramson, S., S.T. Hoffstein, and G. Weissmann. 1982. Superoxide anion generation by human neutrophils exposed to monosodium urate. Arthritis and Rheumatism 25: 174\u2013180.","journal-title":"Arthritis and Rheumatism"},{"key":"9222_CR36","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/art.21634","volume":"54","author":"R Liu Bryan","year":"2006","unstructured":"Liu Bryan, R., and R. Terkeltaub. 2006. Evil humors take their toll as innate immunity makes gouty joints TREM-ble. Arthritis and Rheumatism 54: 383\u2013386.","journal-title":"Arthritis and Rheumatism"},{"key":"9222_CR37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1084\/jem.133.1.100","volume":"133","author":"WR Wallingford","year":"1971","unstructured":"Wallingford, W.R., and D.T. McCarty. 1971. Differential membronolytic effects of sodium urate and calcium pyro phosphate dihydrate crystals. The Journal of Experimental Medicine 133: 100.","journal-title":"The Journal of Experimental Medicine"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-010-9222-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-010-9222-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-010-9222-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T02:16:17Z","timestamp":1635387377000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-010-9222-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,22]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["9222"],"URL":"https:\/\/doi.org\/10.1007\/s10753-010-9222-3","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,22]]}}}