{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:43:00Z","timestamp":1770482580831,"version":"3.49.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s10753-013-9746-4","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T02:43:10Z","timestamp":1380681790000},"page":"349-357","source":"Crossref","is-referenced-by-count":22,"title":["Increased Concentration of C-Reactive Protein in Obese Patients with Type 2 Diabetes Is Associated with Obesity and Presence of Diabetes but Not with Macrovascular and Microvascular Complications or Glycemic Control"],"prefix":"10.1007","volume":"37","author":[{"given":"Aneta","family":"Fronczyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Mol\u0119da","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Safranow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142aw","family":"Piechota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilianna","family":"Majkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,3]]},"reference":[{"issue":"4","key":"9746_CR1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1098-3597(09)80003-3","volume":"9","author":"GA Bray","year":"2009","unstructured":"Bray, G.A., M.B. Clearfield, D.J. Fintel, and D.S. Nelinson. 2009. Overweight and obesity: The pathogenesis of cardiometabolic risk. Clinical Cornerstone 9(4): 30\u201340. discussion 41\u201342.","journal-title":"Clinical Cornerstone"},{"issue":"5","key":"9746_CR2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.diabet.2010.07.001","volume":"36","author":"C Garcia","year":"2010","unstructured":"Garcia, C., B. Feve, P. Ferr\u00e9, et al. 2010. Diabetes and inflammation: Fundamental aspects and clinical implications. Diabetes & Metabolism 36(5): 327\u2013338.","journal-title":"Diabetes & Metabolism"},{"key":"9746_CR3","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","volume":"111","author":"MB Pepys","year":"2003","unstructured":"Pepys, M.B., and G.M. Hirschfield. 2003. C-reactive protein: A critical update. Journal of Clinical Investigation 111: 1805\u20131812.","journal-title":"Journal of Clinical Investigation"},{"issue":"12","key":"9746_CR4","first-page":"970","volume":"146","author":"IM Yosef-Levi","year":"2007","unstructured":"Yosef-Levi, I.M., E. Grad, and H.D. Danenberg. 2007. C-reactive protein and atherothrombosis\u2014a prognostic factor or a risk factor? Harefuah 146(12): 970\u2013974.","journal-title":"Harefuah"},{"issue":"8","key":"9746_CR5","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.2337\/db06-0116","volume":"55","author":"SE Kahn","year":"2006","unstructured":"Kahn, S.E., B. Zinman, S.M. Haffner, et al. 2006. Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes. Diabetes 55(8): 2357\u20132364.","journal-title":"Diabetes"},{"issue":"2","key":"9746_CR6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00592-009-0125-4","volume":"47","author":"JS Park","year":"2010","unstructured":"Park, J.S., M.H. Cho, J.S. Nam, et al. 2010. Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients. Acta Diabetologica 47(2): 113\u2013118.","journal-title":"Acta Diabetologica"},{"issue":"2","key":"9746_CR7","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s10753-011-9361-1","volume":"35","author":"H Belfki","year":"2012","unstructured":"Belfki, H., S. Ben Ali, S. Bougatef, et al. 2012. Association between C-reactive protein and type 2 diabetes in a Tunisian population. Inflammation 35(2): 684\u2013689.","journal-title":"Inflammation"},{"issue":"6","key":"9746_CR8","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1210\/jc.2008-2754","volume":"94","author":"A Mahajan","year":"2009","unstructured":"Mahajan, A., R. Tabassum, S. Chavali, et al. 2009. High-sensitivity C-reactive protein levels and type 2 diabetes in urban North Indians. Journal of Clinical Endocrinology and Metabolism 94(6): 2123\u20132127.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"9746_CR9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1475-2840-9-92","volume":"9","author":"B Lu","year":"2010","unstructured":"Lu, B., Y. Yang, Z. Yang, et al. 2010. Insulin resistance in Chinese patients with type 2 diabetes is associated with C-reactive protein independent of abdominal obesity. Cardiovascular Diabetology 9: 92.","journal-title":"Cardiovascular Diabetology"},{"issue":"2","key":"9746_CR10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.diabres.2008.07.006","volume":"82","author":"A Kanai","year":"2008","unstructured":"Kanai, A., T. Kawamura, T. Umemura, et al. 2008. Association between future events of brain infarction and soluble levels of intercellular adhesion molecule-1 and C-reactive protein in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice 82(2): 157\u2013164.","journal-title":"Diabetes Research and Clinical Practice"},{"key":"9746_CR11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1475-2840-5-27","volume":"5","author":"LJ Pu","year":"2006","unstructured":"Pu, L.J., L. Lu, X.W. Xu, et al. 2006. Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes. Cardiovascular Diabetology 5: 27.","journal-title":"Cardiovascular Diabetology"},{"issue":"6","key":"9746_CR12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1464-5491.2011.03560.x","volume":"29","author":"AJ Cox","year":"2012","unstructured":"Cox, A.J., S. Agarwal, D. M Herrington, J.J. Carr, B.I. Freedman, and D.W. Bowden. 2012. C-reactive protein concentration predicts mortality in type 2 diabetes: The Diabetes Heart Study. Diabetic Medicine 29(6): 767\u2013770.","journal-title":"Diabetic Medicine"},{"key":"9746_CR13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1475-2840-10-19","volume":"10","author":"G Su","year":"2011","unstructured":"Su, G., S. Mi, H. Tao, et al. 2011. Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes. Cardiovascular Diabetology 10: 19.","journal-title":"Cardiovascular Diabetology"},{"issue":"1\u20132","key":"9746_CR14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cca.2009.07.003","volume":"408","author":"C Jin","year":"2009","unstructured":"Jin, C., L. Lu, R.Y. Zhang, et al. 2009. Association of serum glycated albumin, C-reactive protein and ICAM-1 levels with diffuse coronary artery disease in patients with type 2 diabetes mellitus. Clinica Chimica Acta 408(1\u20132): 45\u201349.","journal-title":"Clinica Chimica Acta"},{"issue":"5","key":"9746_CR15","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1152\/ajpheart.01058.2004","volume":"288","author":"DC Lau","year":"2005","unstructured":"Lau, D.C., B. Dhillon, H. Yan, P.E. Szmitko, and S. Verma. 2005. Adipokines: Molecular links between obesity and atherosclerosis. American Journal of Physiology. Heart and Circulatory Physiology 288(5): 2031\u20132041.","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"issue":"18","key":"9746_CR16","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/01.CIR.102.18.2165","volume":"102","author":"V Pasceri","year":"2000","unstructured":"Pasceri, V., J.T. Willerson, and E.T. Yeh. 2000. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102(18): 2165\u20132168.","journal-title":"Circulation"},{"issue":"1","key":"9746_CR17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1055\/s-2007-948213","volume":"115","author":"H Abrahamian","year":"2007","unstructured":"Abrahamian, H., G. Endler, M. Exner, et al. 2007. Association of low-grade inflammation with nephropathy in type 2 diabetic patients: Role of elevated CRP-levels and 2 different gene-polymorphisms of proinflammatory cytokines. Experimental and Clinical Endocrinology and Diabetes 115(1): 38\u201341.","journal-title":"Experimental and Clinical Endocrinology and Diabetes"},{"issue":"4","key":"9746_CR18","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1046\/j.1523-1755.2000.00331.x","volume":"58","author":"A Festa","year":"2000","unstructured":"Festa, A., R. D'Agostino, G. Howard, L. Mykk\u00e4nen, R.P. Tracy, and S.M. Haffner. 2000. Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects: The Insulin Resistance Atherosclerosis Study. Kidney International 58(4): 1703\u20131710.","journal-title":"Kidney International"},{"issue":"1","key":"9746_CR19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0272-6386(03)00408-6","volume":"42","author":"JF Navarro","year":"2003","unstructured":"Navarro, J.F., C. Mora, M. Maca, and J. Garca. 2003. Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus. American Journal of Kidney Diseases 42(1): 53\u201361.","journal-title":"American Journal of Kidney Diseases"},{"issue":"4","key":"9746_CR20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.endonu.2011.01.006","volume":"58","author":"FJ Ca\u00f1izo G\u00f3mez Del","year":"2011","unstructured":"Del Ca\u00f1izo G\u00f3mez, F.J., C. Fern\u00e1ndez P\u00e9rez, I. Moreno Ruiz, et al. 2011. Microvascular complications and the risk factors in patients with type 2 diabetes. Endocrinolog\u00eda y Nutrici\u00f3n 58(4): 163\u2013168.","journal-title":"Endocrinolog\u00eda y Nutrici\u00f3n"},{"issue":"3","key":"9746_CR21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10238-009-0084-7","volume":"10","author":"M Nowak","year":"2010","unstructured":"Nowak, M., T. Wielkoszy\u0144ski, B. Marek, et al. 2010. Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy. Clinical and Experimental Medicine 10(3): 185\u2013192.","journal-title":"Clinical and Experimental Medicine"},{"issue":"3","key":"9746_CR22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1530\/EJE-07-0388","volume":"157","author":"F Anan","year":"2007","unstructured":"Anan, F., T. Masaki, Y. Umeno, et al. 2007. Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetes patients. European Journal of Endocrinology 157(3): 311\u2013317.","journal-title":"European Journal of Endocrinology"},{"issue":"23","key":"9746_CR23","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.ehj.2004.09.008","volume":"25","author":"CG Gustavsson","year":"2004","unstructured":"Gustavsson, C.G., and C.D. Agardh. 2004. Markers of inflammation in patients with coronary artery disease are also associated with glycosylated haemoglobin A1c within the normal range. European Heart Journal 25(23): 2120\u20132124.","journal-title":"European Heart Journal"},{"issue":"3","key":"9746_CR24","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3390\/ijerph7030842","volume":"7","author":"F Huffman","year":"2010","unstructured":"Huffman, F., S. Whisner, G.G. Zarini, and S. Nath. 2010. Waist circumference and BMI in relation to serum high sensitivity C-reactive protein (hs-CRP) in Cuban Americans with and without type 2 diabetes. International Journal of Environmental Research and Public Health 7(3): 842\u2013852.","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"5","key":"9746_CR25","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1515\/CCLM.2006.108","volume":"44","author":"A Pf\u00fctzner","year":"2006","unstructured":"Pf\u00fctzner, A., E. Standl, H.J. Strotmann, et al. 2006. Association of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus. Clinical Chemistry and Laboratory Medicine 44(5): 556\u2013560.","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"issue":"3","key":"9746_CR26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S1056-8727(02)00204-0","volume":"17","author":"D Streja","year":"2003","unstructured":"Streja, D., P. Cressey, and S.W. Rabkin. 2003. Associations between inflammatory markers, traditional risk factors, and complications in patients with type 2 diabetes mellitus. Journal of Diabetes and its Complications 17(3): 120\u2013127.","journal-title":"Journal of Diabetes and its Complications"},{"issue":"3","key":"9746_CR27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","volume":"92","author":"P Trayhurn","year":"2004","unstructured":"Trayhurn, P., and I.S. Wood. 2004. Adipokines: Inflammation and the pleiotropic role of white adipose tissue. British Journal of Nutrition 92(3): 347\u2013355.","journal-title":"British Journal of Nutrition"},{"issue":"12","key":"9746_CR28","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","volume":"112","author":"SP Weisberg","year":"2003","unstructured":"Weisberg, S.P., D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Jr. 2003. Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 112(12): 1796\u20131808.","journal-title":"Journal of Clinical Investigation"},{"issue":"5","key":"9746_CR29","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2337\/dc08-1856","volume":"32","author":"S Sam","year":"2009","unstructured":"Sam, S., S. Haffner, M.H. Davidson, et al. 2009. Relation of abdominal fat depots to systemic markers of inflammation in type 2 diabetes. Diabetes Care 32(5): 932\u2013937.","journal-title":"Diabetes Care"},{"issue":"3","key":"9746_CR30","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1476-5381.2011.01404.x","volume":"165","author":"CY Miao","year":"2012","unstructured":"Miao, C.Y., and Z.Y. Li. 2012. The role of perivascular adipose tissue in vascular smooth muscle cell growth. British Journal of Pharmacology 165(3): 643\u2013658.","journal-title":"British Journal of Pharmacology"},{"issue":"1","key":"9746_CR31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0168-8227(02)00101-8","volume":"58","author":"OA Mojiminiyi","year":"2002","unstructured":"Mojiminiyi, O.A., N. Abdella, M.A. Moussa, A.O. Akanji, H. Mohammedi, and M. Zaki. 2002. Association of C-reactive protein with coronary heart disease risk factors in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice 58(1): 37\u201344.","journal-title":"Diabetes Research and Clinical Practice"},{"issue":"1","key":"9746_CR32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1527-3466.2006.00033.x","volume":"24","author":"K Prasad","year":"2006","unstructured":"Prasad, K. 2006. C-reactive protein (CRP)-lowering agents. Cardiovascular Drug Reviews 24(1): 33\u201350.","journal-title":"Cardiovascular Drug Reviews"},{"issue":"3","key":"9746_CR33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.amjhyper.2006.08.006","volume":"20","author":"W Palmas","year":"2007","unstructured":"Palmas, W., S. Ma, B. Psaty, D.C. Goff Jr., C. Darwin, and R.G. Barr. 2007. Antihypertensive medications and C-reactive protein in the multi-ethnic study of atherosclerosis. American Journal of Hypertension 20(3): 233\u2013241.","journal-title":"American Journal of Hypertension"},{"issue":"9","key":"9746_CR34","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.2337\/dc10-0201","volume":"33","author":"T Sathyapalan","year":"2010","unstructured":"Sathyapalan, T., S.L. Atkin, and E.S. Kilpatrick. 2010. Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with type 2 diabetes. Diabetes Care 33(9): 1948\u20131950.","journal-title":"Diabetes Care"},{"issue":"2","key":"9746_CR35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF03345357","volume":"28","author":"M Bahceci","year":"2005","unstructured":"Bahceci, M., A. Tuzcu, C. Ogun, N. Canoruc, K. Iltimur, and C. Aslan. 2005. Is serum CRP concentration correlated with HbA1c and insulin resistance in type 2 diabetic men with or without coronary heart disease? Journal of Endocrinological Investigation 28(2): 145\u2013150.","journal-title":"Journal of Endocrinological Investigation"},{"issue":"5","key":"9746_CR36","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2337\/diacare.26.5.1535","volume":"26","author":"DE King","year":"2003","unstructured":"King, D.E., A.G. Mainous 3rd, T.A. Buchanan, and W.S. Pearson. 2003. C-reactive protein and glycemic control in adults with diabetes. Diabetes Care 26(5): 1535\u20131539.","journal-title":"Diabetes Care"},{"issue":"11","key":"9746_CR37","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1001\/jama.2009.1347","volume":"302","author":"AD Pradhan","year":"2009","unstructured":"Pradhan, A.D., B.M. Everett, N.R. Cook, N. Rifai, and P.M. Ridker. 2009. Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: The LANCET randomized trial. JAMA 302(11): 1186\u20131194.","journal-title":"JAMA"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-013-9746-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-013-9746-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-013-9746-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T22:53:28Z","timestamp":1553640808000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-013-9746-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,3]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["9746"],"URL":"https:\/\/doi.org\/10.1007\/s10753-013-9746-4","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,3]]}}}